Abstract
In summer of 1967 the first reports of remissions of acute leukemia in patients treated with L-asparaginase extracted from E. coli were published in the USA [9]. But these were only rare cases owing to the scarcity of the pure enzyme. It was therefore necessary to develop a technical process for the production of the enzyme.
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Rauenbusch, E., Bauer, K., Kaufmann, W., Wagner, O. (1970). Isolation and Crystallisation of L-Asparaginase from E. coli. In: Grundmann, E., Oettgen, H.F. (eds) Experimental and Clinical Effects of L-Asparaginase. Recent Results in Cancer Research, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-99984-0_5
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DOI: https://doi.org/10.1007/978-3-642-99984-0_5
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