Abstract
Between 1st of August 1968 and the 30th of April 1969 we treated 84 patients with L-asparaginase. This report deals with the results obtained.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Adamson, R. M., Fabros: Antitumor activity and other biologic properties of L-asparaginase, a revue. Cancer Chemother. Rep. 52, 6 (1968).
Bernard, J., Boiron, M., Jacquillat, Cl., Najean, Y., Weil, M., Thomas, M.: Traitement des leucémies aigues lymphoblastiques de première atteinte par une association de Prednisone-Vincristine-Rubidomycine. Colloque International sur la Rubidomycine et la Daunomycine Paris Hôpital Saint-Louis 11, mars 1967. Path. et Biol. 15, 915–920 (1967).
Boiron, M., Jacquillat, Cl., Weil, M., Tanzer, J., Bernard, J.: L-asparaginase. Presse. méd. 76, 44, 2095–2101 (1968).
Broome, J. D.: Evidence that the L-asparaginase activity of Guinea Pig Serum is responsible for ills antilymphoma effects. Nature (Lond.) 191, 1114–1115 (1961).
— Factors which may influence the effectiveness of L-asparaginase as Tumor inhibitors. Brit. J. Cancer XXII, 595 (1968).
Burchenal, J. H., Oettgen, H. F.: Present states of L-asparaginase. Med. News (N. Y.), June 1968.
Canellos, G. P., Haskell, C. M., Arseneau, J., Carbone, P.: Hypoalbuminemic and hypocholesterolemic Effect of L-asparaginase (NSX-109229) Treatment on man: a preliminary report. Cancer Chemother. Rep. (in press).
Dolowy, Coll: Toxic and antineoplastic effects of L-asparaginase. Cancer Res. 19, 1813–1819 (1966).
Gralnick, H. R., Henry, P. H.: L-asparaginase induced coagulopathy. Proc. Amer. Ass. Cancer Res. 123, 32 (1969).
Grundmann, E.: L-asparaginase und Leukämie. Klin. Wschr. 2, 61–64 (1969).
Harris, J. E., Whitecar, J. P., Bobey, G. P., Freireich, E. J.: L-asparaginase (ASP) in the treatment of adult acute leukemia. Proc. Amer. Ass. Cancer Res. 136, 35 (1969).
Haskell, C. M., Canellos, G. P.: Mechanisms of L-asparaginase resistance: asparagine synthetase in animal and human neoplasma. Proc. Amer. Ass. Cancer Res. 142, 36 (1969).
Leventhal, B. G., Carbone, P.: L-asparaginase toxicity. Cancer Res. 29, 974–975 (1969).
Hill, J. M., Loeb, E., Roberts, J., MacLellan, A., Khan, A., Hill, N. O.: L-asparaginase therapy of Leukemia. Program of the XII Congress of the International Society of Hematology New York, (Abstract) 8 (1968).
Loeb, E., Roberts, J., MacLellan, A., Khan, A., Hill, N. O. — Robert, J., Loeb, E., Khan, A., MacLellan, A., Hill, R. W.: L-asparaginase therapy for leukemia and other malignant neoplasma. J. Amer. med. Ass. 202, 882–888 (1967).
Ho, D. H., Frei, E.: Clinical Pharmacologic studies of L-asparaginase. Proc. Amer. Ass. Cancer Res. 151, 39 (1969).
Kidd, J. G.: Regression of transplanted lymphomas induced in vivo by means of normal guinea pig serum: I. Course of transplanted cancers of various kinds on mice and rats given guinea pig serum, horse serum or rabbit serum. J. exp. Med. 98, 565–582 (1953).
Jacobs, S. P., Wodinsky, I., Kensler, C. J., Venditti, J., Little, A. D.: Therapy of experimental leukemias with combinations of L-asparagine and glutamine antagonists. Proc. Amer. Ass. Cancer Res. 168, 43 (1969).
Lash, E., Schwartz, M. K., Tallal, L., Oettgen, H. F.: Serum lipids in patients receiving L-asparaginase. Program of the XII congress of International Society of Hematology. New York (Abstract) 10, 1968.
Leventhal, B. G.: Asparaginase plus Azaserine in Acute lymphatic leukemia. Proc. Amer. Ass. Cancer Res. 193, 49 (1969).
Mashburn, L. T., Wriston, J. C., Jr.: Tumor inhibitory effect of L-asparaginase from Escherichia coli. Arch. Biochem. 105, 451–452 (1964).
Mathé, G., Amiel, J. L., Schwartzenberg, L., Schneider, M., Cattan, A., Schlumberger, J. R., Hayart, M., de Vassai, F., Jasmin, C., Rosenfeld, C.: Essai de traitement de la leucémie aigue lymphoblastique par la L-asparaginase. Presse méd. 77, 461–463 (1968).
Oettgen, H. F.: Inhibition of leukemias in man by L-asparaginase. Cancer Res. 27, 2619–2631 (1967).
— Plasma levels of L-asparaginase. Cancer Res. 27, 2630 (1967).
— Therapeutic effects of L-asparaginase on asparagine-dependent neoplasmas laboratory and clinical studies. J. Clin. Invest. 47, 74 a (1968).
— Schulten, H. K.: Hemmuning maligner neoplasien des Menschen durch L-asparaginase. Klin. Wschr. 2, 65–71 (1969).
Ohnuma, T., Holland, J. F., Freeman, A., Sinks, L.: Studies of asparaginase and asparagine in acute leukemia. Proc. Amer. Ass. Cancer Res. 262, 66 (1969).
Schmidt, C. G., Gallmeier, W. M.: Zur Enzymtherapie der Leukämien. Dtsch. med. Wschr. 48, 2299 (1968).
Sobin, L. H., Kidd, J. G.: A metabolic difference between two lines of lymphoma 6C3HED cells in relation to asparagine. Proc. Soc. exp. Biol. (N. Y.) 119, 325–327 (1965).
Tallal, L., Tan, C., Oettgen, H. F., Mac Carty, M., Helson, L., Murphy, L.: L-asparaginase in 111 children with leukemias and solids tumors. Proc. Amer. Ass. Cancer Res. 394, 92 (1969).
Tan, C., Oettgen, H. F., Mac Carty, M., Helson, L., Murphy, L. —Oettgen, H. F.: Treatment of acute leukemia in children with L-asparaginase. Proc. Amer. Soc. Cancer Res. 9, 70 (1968).
Tan, C., Oettgen, H. F.: Clinical experience with L-asparaginase administrated intrathecally. Proc. Amer. Ass. Cancer Res. 365, 92 (1969).
Tarmowski, G. S., Mointain, I. M., Stock, C. C.: Combination therapy of animal tumors with L-asparaginase and glutamine antagonists. Proc. Amer. Ass. Cancer Res. 366, 92 (1969).
Tomas, R. A., Schwartz, M. K., Lash, E., Oettgen, H. F., Krakoff, I. H.: Blood Levels and distribution of L-asparaginase in man. Proc. Amer. Ass. Cancer Res. 371, 94 (1969).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1970 Springer-Verlag Berlin • Heidelberg
About this chapter
Cite this chapter
Jacquillat, C. et al. (1970). Treatment of Acute Leukemia with L-Asparaginase — Preliminary Results on 84 Cases. In: Grundmann, E., Oettgen, H.F. (eds) Experimental and Clinical Effects of L-Asparaginase. Recent Results in Cancer Research, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-99984-0_31
Download citation
DOI: https://doi.org/10.1007/978-3-642-99984-0_31
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-99986-4
Online ISBN: 978-3-642-99984-0
eBook Packages: Springer Book Archive