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Treatment of Acute Leukemia with L-Asparaginase

  • Ellen Loeb
  • J. M. Hill
  • N. O. Hill
  • A. MacLellan
  • A. Khan
  • T. R. Alexander
  • M. Adachi
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 33)

Abstract

The Wadley Institutes of Molecular Medicine are now in the third year of clinical investigation and treatment with the first known enzyme capable of depriving tumor cells of their vital nutrition, asparagine.

Keywords

Acute Lymphocytic Leukemia Acute Pancreatitis Acute Leukemia Complete Remission Rate Enzyme Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Hill, J. M., Roberts, J., Loeb, Ellen, Khan, A., MacLellan, A., Hill, R. W.: L-asparaginase therapy for leukemia and other malignant neoplasms. J. Amer. med. Ass. 202, 882–888 (1967).CrossRefGoogle Scholar
  2. 2.
    Oettgen, H. F., Old, L. J., Boyse, E. A., Campbell, H. A., Phillips, F. S., Clarkson, B. D., Tallal, Lisa, Leeper, R. D., Schwartz, M. K., Kim, J. H.: Inhibition of leukemias in man by L-asparaginase: Presented at American Society of Hematology meeting from Sloan-Kettering Institute for Cancer Research and Memorial Hospital for Cancer and Allied Diseases, New York, N. Y., December 1967.Google Scholar
  3. 3.
    Hill, J. M., Loeb, Ellen, Roberts, J., MacLellan, A., Khan, A., Hill, N. O.: L-asparaginase therapy of leukemia: Presented at International Society of Hematology meeting from Wadley Institutes of Molecular Medicine, New York, N. Y., September 1968.Google Scholar
  4. 4.
    Burchenal, J. H., Karnofsky, D. A., Murphy, M. L., Oettgen, H. F.: Presented at International Society of Hematology meeting from Sloan-Kettering Institute for Cancer Research and Memorial Hospital for Cancer and Allied Diseases, New York, N. Y., September 1968.Google Scholar
  5. 5.
    Tallal, L., Tan, C., Oettgen, H., McCarthy, M., Helson, L., Murphy, L.: L-asparaginase in 111 children with leukemias and solid tumors: Presented at 60th Annual Meeting of American Association for Cancer Research, San Francisco, Calif., March 1969.Google Scholar
  6. 6.
    Jamra, M., Cunha, Luciana, Patto, G., Lorenzi, Therezinha F.: Emprego da L-asparaginase em leukemia aguda: Presented at II Congresso Nacional, Colegio Brasileiro de Hematologia, Sao Paulo, Brazil, May 1969.Google Scholar
  7. 7.
    Hill, J. M.: Treatment of acute leukemia with L-asparaginase: Presented at II Congresso Nacional, Colegio Brasileiro de Hematologia, Sao Paulo, Brazil, May 1969.Google Scholar
  8. 8.
    Roberts, J., Burson, G., Hill, J. M.: New procedures for purification of L-asparaginase with high yield from Escherichia coli. J. Bact. 95, 2117–2123 (1968).PubMedGoogle Scholar
  9. 9.
    Hill, J. M., Pennington, Karen: A new method for determining toxicity of E. coli L-asparaginase preparations: From Wadley Institutes of Molecular Medicine, May 1969. To be published.Google Scholar
  10. 10.
    Haskell, C. M., Canellos, G. P., Leventhal, B. G., Carbone, P. P.: L-asparaginase toxicity, Cancer Res. 29, 974–975 (1969).PubMedGoogle Scholar
  11. 11.
    Hill, J. M., Loeb, Ellen, MacLellan, A., Khan, A., Roberts, J., Shields, Wilma F., Hill, N. O.: Enzyme therapy of acute leukemia: Response to Highly Purified L-asparaginase. Cancer Res. 1969.Google Scholar
  12. 12.
    Broome, J. D.: Studies on the mechanism of tumor inhibition by L-asparaginase. Effects of the Enzyme on Asparagine Levels in the Blood, Normal Tissues, and 6C3HED Lymphomas of Mice: Differences in Asparagine Formation and Utilization in Asparagin-ase. Sensitive and Resistant Lymphoma Cells. J. exp. Med. 127, 1053–1080 (1968).CrossRefGoogle Scholar
  13. 13.
    Schwartz, J. H.: Differences in the production of L-asparagine in asparaginasesensitive and resistant lymphoma cells. Biochim. biophys. Acta (Amst.) 138, 637–639 (1967).Google Scholar
  14. 14.
    McCoy, T. A., Maxwell, M., Kruse, P. F., Jr.: The amino acid requirements of the Jensen sarcoma in vitro. Cancer Res. 19, 591–595 (1959).PubMedGoogle Scholar
  15. 15.
    Kidd, J. G.: Regression of transplanted lymphomas induced in vivo by means of normal guinea-pig serum. I. Course of Transplanted Cancers of Various Kinds in Mice and Rats Given Guinea Pig Serum, Horse Serum, or Rabbit Serum. J. exp. Med. 98, 565–582 (1953).PubMedCrossRefGoogle Scholar
  16. 16.
    Hill, J. M.: Advances en el tratamiento de las neoplasias de tejido linfoiedo: Read before the 17th National Assembly of Surgeons, Mexico City, DF, November 14, 1966.Google Scholar
  17. 17.
    Old, L. J.: Treatment of Lymphosarcoma in the Dog With L-asparaginase. Lancet 1967 I, 447–448.CrossRefGoogle Scholar
  18. 18.
    Mashburn, L. T., Wriston, J. C., Jr.: Tumor inhibitory effect of L-asparaginase from Escherichia coli. Arch. Biochem. 105, 451–452 (1964).CrossRefGoogle Scholar
  19. 19.
    Whelan, Helen A., Wriston, J. C., Jr.: Purification and properties of L-asparaginase from Escherichia coli B. Fed. Proc. 27, 586 (1968). Abstract.Google Scholar
  20. 20.
    Cedar, H., Schwartz, J. H.: Production of L-asparaginase II by Escherichia coli. J. Bact. 96, 2043–2048 (1968).PubMedGoogle Scholar
  21. 21.
    Milner, K. C., Finkelstein, R. A.: Bioassay of endotoxin: Correlation between pyrogenicity for rabbits and lethality for chick embryo. J. infect. Dis. 116, 529–536 (1966).PubMedCrossRefGoogle Scholar
  22. 22.
    Naraine, M.: The developing chick embryo as an experimental model for the bioassay of endotoxin in E. coli: Thesis. The Graduate Research Institute of Baylor University, and Wadley Institutes of Molecular Medicine, Dallas, Texas, 1968.Google Scholar
  23. 23.
    Liu, Y. P.: Isolation, purification, and characterization of E.coli L-asparaginase: Ph. D. Thesis. The Graduate Research Institute of Baylor University, and Wadley Institutes of Molecular Medicine, Dallas, Texas, 1969.Google Scholar
  24. 24.
    Benson, J. V., Jr., Gordon, M. J., Patterson, J. A.: Accelerated Chromatographic analysis of amino acids in physiological fluids containing glutamine and asparagine. Analyt. Biochem. 18, 228–240 (1967).CrossRefGoogle Scholar
  25. 25.
    Stein, W. H., Moore, S.: The free amino acids of human blood plasma. J. biol. Chem. 211, 915–926 (1954).PubMedGoogle Scholar
  26. 26.
    Ohnuma, T., Holland, J. F., Freeman, A., Sinks, L.: Studies of asparaginase and asparagine in acute leukemia: Presented at 60th Annual Meeting of American Association for Cancer Research, San Francisco, Calif., March 1969.Google Scholar
  27. 27.
    Tan, C., Oettgen, H.: Clinical experience with L-asparaginase administered intrathecally: Presented at 60th Annual Meeting of American Association for Cancer Research, San Francisco, Calif., March 1969.Google Scholar
  28. 28.
    Astaldi, G., Eridani, S., Ponti, G. B., Valentini, R., Giangrande, A.: Influence of antiblastic agents applied either in vivo or in vitro on human lymphocyte transformation in cell culture. Blut Band XIX, Heft 1, pp. 8-16, April 1969.Google Scholar
  29. 29.
    Ohno, R.: Inhibition of lymphocyte blastogenesis by L-asparaginase (LA): Presented at 60th Annual Meeting of American Association for Cancer Research, San Francisco, Calif., March 1969.Google Scholar
  30. 30.
    Khan, A., Hill, J. M.: Neutralizing precipitin in the serum of a patient treated with L-asparaginase. The J. Lab. clin. Med. 73, 846–852 (1969).Google Scholar
  31. 31.
    — — Steroid-Induced pancreatitis. From Wadley Institutes of Molecular Medicine. To be published elsewhere.Google Scholar
  32. 32.
    Riemenschneider, T. A., Wilson, J. F., Vernier, R. L.: Glucocorticoid-Induced pancreatitis in children. J. Pediat. 41, 428 (1968).Google Scholar
  33. 33.
    Khan, A., Adachi, M., Hill, J. M.: Diabetogenic effect of L-asparaginase. From Wadley Institutes of Molecular Medicine, Dallas, Texas. To be published elsewhere.Google Scholar
  34. 34.
    De Almeida, A. L., Grossman, M. I.: Experimental production of pancreatitis with ethionine. Gastroenterology 20, 554–577 (1952).Google Scholar
  35. 35.
    Khan, A., Hill, J. M.: Potentiation of the diabetogenic effect of L-asparaginase by prednisolone. From Wadley Institutes of Molecular Medicine, Dallas, Texas. To be published elsewhere.Google Scholar
  36. 36.
    Hill, J. M.: Acute pancreatitis associated with asparaginase therapy: Treatment With Plasmaphoresis. From Wadley Institutes of Molecular Medicine, Dallas, Texas. To be published elsewhere.Google Scholar

Copyright information

© Springer-Verlag Berlin • Heidelberg 1970

Authors and Affiliations

  • Ellen Loeb
    • 1
  • J. M. Hill
    • 1
  • N. O. Hill
    • 1
  • A. MacLellan
    • 1
  • A. Khan
    • 1
  • T. R. Alexander
    • 1
  • M. Adachi
    • 1
  1. 1.Granville C. Morton Cancer and Research Hospital of the Wadley Institutes of Molecular MedicineDallasUSA

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