Abstract
The Wadley Institutes of Molecular Medicine are now in the third year of clinical investigation and treatment with the first known enzyme capable of depriving tumor cells of their vital nutrition, asparagine.
Read before the Symposium on Experimental and Clinical Effects of L-asparaginase at Wuppertal-Elberfeld, Germany — from October 24 to 26, 1969, by Ellen Loeb, M.D.
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References
Hill, J. M., Roberts, J., Loeb, Ellen, Khan, A., MacLellan, A., Hill, R. W.: L-asparaginase therapy for leukemia and other malignant neoplasms. J. Amer. med. Ass. 202, 882–888 (1967).
Oettgen, H. F., Old, L. J., Boyse, E. A., Campbell, H. A., Phillips, F. S., Clarkson, B. D., Tallal, Lisa, Leeper, R. D., Schwartz, M. K., Kim, J. H.: Inhibition of leukemias in man by L-asparaginase: Presented at American Society of Hematology meeting from Sloan-Kettering Institute for Cancer Research and Memorial Hospital for Cancer and Allied Diseases, New York, N. Y., December 1967.
Hill, J. M., Loeb, Ellen, Roberts, J., MacLellan, A., Khan, A., Hill, N. O.: L-asparaginase therapy of leukemia: Presented at International Society of Hematology meeting from Wadley Institutes of Molecular Medicine, New York, N. Y., September 1968.
Burchenal, J. H., Karnofsky, D. A., Murphy, M. L., Oettgen, H. F.: Presented at International Society of Hematology meeting from Sloan-Kettering Institute for Cancer Research and Memorial Hospital for Cancer and Allied Diseases, New York, N. Y., September 1968.
Tallal, L., Tan, C., Oettgen, H., McCarthy, M., Helson, L., Murphy, L.: L-asparaginase in 111 children with leukemias and solid tumors: Presented at 60th Annual Meeting of American Association for Cancer Research, San Francisco, Calif., March 1969.
Jamra, M., Cunha, Luciana, Patto, G., Lorenzi, Therezinha F.: Emprego da L-asparaginase em leukemia aguda: Presented at II Congresso Nacional, Colegio Brasileiro de Hematologia, Sao Paulo, Brazil, May 1969.
Hill, J. M.: Treatment of acute leukemia with L-asparaginase: Presented at II Congresso Nacional, Colegio Brasileiro de Hematologia, Sao Paulo, Brazil, May 1969.
Roberts, J., Burson, G., Hill, J. M.: New procedures for purification of L-asparaginase with high yield from Escherichia coli. J. Bact. 95, 2117–2123 (1968).
Hill, J. M., Pennington, Karen: A new method for determining toxicity of E. coli L-asparaginase preparations: From Wadley Institutes of Molecular Medicine, May 1969. To be published.
Haskell, C. M., Canellos, G. P., Leventhal, B. G., Carbone, P. P.: L-asparaginase toxicity, Cancer Res. 29, 974–975 (1969).
Hill, J. M., Loeb, Ellen, MacLellan, A., Khan, A., Roberts, J., Shields, Wilma F., Hill, N. O.: Enzyme therapy of acute leukemia: Response to Highly Purified L-asparaginase. Cancer Res. 1969.
Broome, J. D.: Studies on the mechanism of tumor inhibition by L-asparaginase. Effects of the Enzyme on Asparagine Levels in the Blood, Normal Tissues, and 6C3HED Lymphomas of Mice: Differences in Asparagine Formation and Utilization in Asparagin-ase. Sensitive and Resistant Lymphoma Cells. J. exp. Med. 127, 1053–1080 (1968).
— Schwartz, J. H.: Differences in the production of L-asparagine in asparaginasesensitive and resistant lymphoma cells. Biochim. biophys. Acta (Amst.) 138, 637–639 (1967).
McCoy, T. A., Maxwell, M., Kruse, P. F., Jr.: The amino acid requirements of the Jensen sarcoma in vitro. Cancer Res. 19, 591–595 (1959).
Kidd, J. G.: Regression of transplanted lymphomas induced in vivo by means of normal guinea-pig serum. I. Course of Transplanted Cancers of Various Kinds in Mice and Rats Given Guinea Pig Serum, Horse Serum, or Rabbit Serum. J. exp. Med. 98, 565–582 (1953).
Hill, J. M.: Advances en el tratamiento de las neoplasias de tejido linfoiedo: Read before the 17th National Assembly of Surgeons, Mexico City, DF, November 14, 1966.
Old, L. J.: Treatment of Lymphosarcoma in the Dog With L-asparaginase. Lancet 1967 I, 447–448.
Mashburn, L. T., Wriston, J. C., Jr.: Tumor inhibitory effect of L-asparaginase from Escherichia coli. Arch. Biochem. 105, 451–452 (1964).
Whelan, Helen A., Wriston, J. C., Jr.: Purification and properties of L-asparaginase from Escherichia coli B. Fed. Proc. 27, 586 (1968). Abstract.
Cedar, H., Schwartz, J. H.: Production of L-asparaginase II by Escherichia coli. J. Bact. 96, 2043–2048 (1968).
Milner, K. C., Finkelstein, R. A.: Bioassay of endotoxin: Correlation between pyrogenicity for rabbits and lethality for chick embryo. J. infect. Dis. 116, 529–536 (1966).
Naraine, M.: The developing chick embryo as an experimental model for the bioassay of endotoxin in E. coli: Thesis. The Graduate Research Institute of Baylor University, and Wadley Institutes of Molecular Medicine, Dallas, Texas, 1968.
Liu, Y. P.: Isolation, purification, and characterization of E.coli L-asparaginase: Ph. D. Thesis. The Graduate Research Institute of Baylor University, and Wadley Institutes of Molecular Medicine, Dallas, Texas, 1969.
Benson, J. V., Jr., Gordon, M. J., Patterson, J. A.: Accelerated Chromatographic analysis of amino acids in physiological fluids containing glutamine and asparagine. Analyt. Biochem. 18, 228–240 (1967).
Stein, W. H., Moore, S.: The free amino acids of human blood plasma. J. biol. Chem. 211, 915–926 (1954).
Ohnuma, T., Holland, J. F., Freeman, A., Sinks, L.: Studies of asparaginase and asparagine in acute leukemia: Presented at 60th Annual Meeting of American Association for Cancer Research, San Francisco, Calif., March 1969.
Tan, C., Oettgen, H.: Clinical experience with L-asparaginase administered intrathecally: Presented at 60th Annual Meeting of American Association for Cancer Research, San Francisco, Calif., March 1969.
Astaldi, G., Eridani, S., Ponti, G. B., Valentini, R., Giangrande, A.: Influence of antiblastic agents applied either in vivo or in vitro on human lymphocyte transformation in cell culture. Blut Band XIX, Heft 1, pp. 8-16, April 1969.
Ohno, R.: Inhibition of lymphocyte blastogenesis by L-asparaginase (LA): Presented at 60th Annual Meeting of American Association for Cancer Research, San Francisco, Calif., March 1969.
Khan, A., Hill, J. M.: Neutralizing precipitin in the serum of a patient treated with L-asparaginase. The J. Lab. clin. Med. 73, 846–852 (1969).
— — Steroid-Induced pancreatitis. From Wadley Institutes of Molecular Medicine. To be published elsewhere.
Riemenschneider, T. A., Wilson, J. F., Vernier, R. L.: Glucocorticoid-Induced pancreatitis in children. J. Pediat. 41, 428 (1968).
Khan, A., Adachi, M., Hill, J. M.: Diabetogenic effect of L-asparaginase. From Wadley Institutes of Molecular Medicine, Dallas, Texas. To be published elsewhere.
De Almeida, A. L., Grossman, M. I.: Experimental production of pancreatitis with ethionine. Gastroenterology 20, 554–577 (1952).
Khan, A., Hill, J. M.: Potentiation of the diabetogenic effect of L-asparaginase by prednisolone. From Wadley Institutes of Molecular Medicine, Dallas, Texas. To be published elsewhere.
Hill, J. M.: Acute pancreatitis associated with asparaginase therapy: Treatment With Plasmaphoresis. From Wadley Institutes of Molecular Medicine, Dallas, Texas. To be published elsewhere.
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Loeb, E. et al. (1970). Treatment of Acute Leukemia with L-Asparaginase. In: Grundmann, E., Oettgen, H.F. (eds) Experimental and Clinical Effects of L-Asparaginase. Recent Results in Cancer Research, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-99984-0_26
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DOI: https://doi.org/10.1007/978-3-642-99984-0_26
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