Abstract
During the last year several papers were published dealing with an immunosuppressive action of Escherichia coli L-asparaginase. Hobik described the inhibition of the graft-versus-host reaction in rats and mice. Bertelli, Donati and Trabucchi, using very high doses of L-asparaginase, found a prolongation of the rejection time of allogeneic and xenogeneic skin grafts in mice. Schulten, Giraldo, Boyse and Oettgen showed an effect of L-asparaginase on the homograft response. These experiments were presented by Dr. Schulten during this symposium. Several other reports deal with the inhibition of phythaemagglutinin-induced blastic transformation of human lymphocytes in vitro by L-asparaginase.
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Lauenstein, K., Grundmann, E., Hobik, H.P., Madaus, WP. (1970). Experimental Immunosuppression with L-Asparaginase. In: Grundmann, E., Oettgen, H.F. (eds) Experimental and Clinical Effects of L-Asparaginase. Recent Results in Cancer Research, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-99984-0_20
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DOI: https://doi.org/10.1007/978-3-642-99984-0_20
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