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Critical Influence of an Enzyme-Elevating Virus upon Long-Term Remissions of Mouse Leukemia Following Asparaginase Therapy

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Experimental and Clinical Effects of L-Asparaginase

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 33))

Abstract

Although the possibility of a carcinolytic virus as a potential therapeutic agent against cancer is not a new concept, the observed beneficial influence of a non-cytopathic, and otherwise benign replicating agent as an adjunct in asparaginase therapy was somewhat unexpected and to our knowledge has no theoretical antecedent. This virus is variously known as the lactate dehydrogenase-elevating virus, the LDH-virus, the enzymes-elevating virus and by other designations [65, 671].

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Authors and Affiliations

  1. Department of Microbiology, Pacific Northwest Research Foundation, Seattle, Washington, 98104, USA

    Vernon Riley, Darrel H. Spackman & M. A. Fitzmaurice

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  1. Vernon Riley
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  2. Darrel H. Spackman
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  3. M. A. Fitzmaurice
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Editors and Affiliations

  1. Institute of Experimental Pathology of Farbenfabriken Bayer AG, Wuppertal-Elberfeld, Germany

    E. Grundmann

  2. Sloan-Kettering Institute for Cancer Research, New York, N.Y., USA

    H. F. Oettgen

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Riley, V., Spackman, D.H., Fitzmaurice, M.A. (1970). Critical Influence of an Enzyme-Elevating Virus upon Long-Term Remissions of Mouse Leukemia Following Asparaginase Therapy. In: Grundmann, E., Oettgen, H.F. (eds) Experimental and Clinical Effects of L-Asparaginase. Recent Results in Cancer Research, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-99984-0_11

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