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Die Gestagene pp 680-1025 | Cite as

Chemische Konstitution und pharmakologische Wirkung

  • F. Neumann
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 22 / 1)

Zusammenfassung

In diesem Kapitel wird über die biologischen Aktivitäten der natürlich vorkommenden Steroide mit gestagenen Eigenschaften und der synthetischen Gestagene berichtet.

Literatur

  1. [1]
    Abderhalden, R.: Die Hormone. Berlin-Gdttingen-Heidelberg: Springer 1952.Google Scholar
  2. [1a]
    Ackroyd, M., W. J. Adams, B. Ellis, V. Petrow, and I. A. Stuart-Webb: Modified steroid hormones. Part V. 6-methylandrostane derivatives. J. chem. Soc. 1957, III, 4099.Google Scholar
  3. [2]
    Albert, S., and H. Selye: The effect of various pharmacological agents on the morpho-genetic actions of estradiol. J. Pharmacol, exp. Ther. 75, 308 (1942).Google Scholar
  4. [3]
    Albright, R., E. Bloomberg, and P. H. Smith: Post-menopausal osteoporosis. Trans. Ass. Amer. Phycns 55, 298 (1940).Google Scholar
  5. [4]
    Alexander, D. P., and J. F. D. Frazer: The effect of spaying in the pregnant rat. J. Physiol. (Lond.) 124, 36 (1954).Google Scholar
  6. [5]
    Alexander, D. P., and J. Lee: The effect of steroids on the maintenance of pregnancy in the spayed rat. J. Physiol. (Lond.) 130, 148 (1955).Google Scholar
  7. [6]
    Alibrandi, A., G. Bruni, A. Ercoli, R. Gardi, and A. Meli: Factors influencing the biological activity of orally administered steroid compounds: effect of the medium and of esterification. Endocrinology 66, 13 (1960).PubMedGoogle Scholar
  8. [6a]
    Allen G. R. jr., and M. J. Weiss: The base-catalyzed condensation of progesterone with ethyl oxalate. J. Amer. chem. Soc. 82, 1709 (1960).Google Scholar
  9. [7]
    Allen, W. M.: Some effect of estrin and progestin in the rabbit. Cold Spr. Harb. Symp. quant. Biol. 5, 66 (1937).Google Scholar
  10. [8]
    Allen, W. M. Discussion. In: Lloyd, ed., Recent progress in the endocrinology of reproduction, p. 248. New York and London: Academic Press 1959.Google Scholar
  11. [9]
    Allen, W. M., and G. W. Corner: Physiology of the corpus luteum. III. Normal growth and implantation of embryos after very early ablation of the ovaries under the influence of extracts of the corpus luteum. Amer. J. Physiol. 88, 340 (1929).Google Scholar
  12. [10]
    Allen, W. M. Physiology of the corpus luteum. VII. Maintenance of pregnancy in rabbits after very early castration by corpora lutea extracts. Proc. Soc. exp. Biol. (N.Y.) 27, 403 (1929).Google Scholar
  13. [11]
    Allen, E., and E. A. Doisy: An ovarian hormone — preliminary report on its localization, extraction and partial purification, and action in test animals. J. Amer. med. Ass. 81, 819 (1923).Google Scholar
  14. [12]
    Allen, W. M., and M. Ehrenstein: 10-norprogesterone, a physiologically active lower homolog of progesterone. Science 100, 251 (1944).PubMedGoogle Scholar
  15. [13]
    Allen, W. M., and G. P. Heckel: The effect of continued injections of progestin and combinations of oestrin and progestin on the endometrium of the castrated rabbit. Anat. Rec. 64, Suppl. 1, 2 (1936).Google Scholar
  16. [14]
    Allen, W. M., and G. P. Heckel. Failure of progesterone to prevent resorption of embryos in rabbits castrated in very early pregnancy. Science 86, 409 (1937).Google Scholar
  17. [15]
    Allen, W. M., and G. P. Heckel Maintenance of pregnancy by progesterone in rabbits castrated on the 11th day. Amer. J. Physiol. 125, 31 (1939).Google Scholar
  18. [16]
    Allen, W. M., and R. K. Meyer: The quantitative separation of progestin from oestrin in extracts of the corpus luteum. Amer. J. Physiol. 106, 55 (1933).Google Scholar
  19. [17]
    Allen, W. M., and R. K. Meyer: Physiology of the corpus luteum. IX. The inhibition of oestrin by progestin-containing extracts of the corpus luteum. Anat. Rec. 61, 427 (1936).Google Scholar
  20. [18]
    Allen, W. M., and O. Wintersteiner: Crystalline progestin. Science 80, 190 (1934).PubMedGoogle Scholar
  21. [18a]
    Allen, W. S., and S. Bernstein: 16-hydroxylated steroids. III. The preparation of 16α-hydroxyhydrocortisone and related compounds. J. Amer. ehem. Soc. 78, 1909 (1956).Google Scholar
  22. [19]
    Alloiteau, J. J.: Déciduome chez la ratte cyclique ou en début de gestation malgré un traitement oestrogénique dans les jours précédant le traumatisme. Importance de la préparation oestrogénique dans cette résistance à l’oestradiol. C. R. Soc. Biol. (Paris) 157, 1204 (1963).Google Scholar
  23. [20]
    Andrews, M. C.: Medical treatment of endometriosis. Clin. Obstet. Gynec. 8, 492 (1960).Google Scholar
  24. [21]
    Andrews, M. C. and M. C. Andrews: Reduction of side effects from ovulation suppression by the use of newer progestin combinations. Fertil. and Steril. 15, 75 (1964).Google Scholar
  25. [22]
    Anliker, R., M. Müller, M. Perelman, J. Wohlfahrt u. H. Heusser: Die Synthese von 18-Nor-progesteron und des 13α-17α-18-Norprogesterons. Helv. chim. Acta 42, 1071 (1959).Google Scholar
  26. [22a]
    Ansari, A. H., and G. H. Arronet: Clinical and laboratory evaluation of a new progestational compound. Fertil. and Steril. 17, 302 (1966).Google Scholar
  27. [23]
    Apostolakis, M., and H. J. Napp: Some endocrinological effects of ethinyl-19-nortestosterone in males. Acta endocr. (Kbh.), Suppl. 51, 931 (1960).Google Scholar
  28. [24]
    Arai, H.: On the cause of hypertrophy of the surviving ovary after semi-spaying (albino rat) and on the number of ova in it. Amer. J. Anat. 28, 59 (1920).Google Scholar
  29. [25]
    Aroari, G., G. Baldratti, and G. Sala: Progestational activity of 4-hydroxy-17α-acetoxyprogesterone. Nature (Lond.) 197, 292 (1963).Google Scholar
  30. [26]
    Arcos, M., E. Gurpide, R. L. van de Wiele, and S. Lieberman: Precursors of urinary pregnanediol and their influence on the determination of the secretory rate of progesterone. J. clin. Endocr. 24, 237 (1964).PubMedGoogle Scholar
  31. [27]
    Abko, H., and U. K. Rinne: The kidney and adrenal cortex of the methyl-andro-stenediol-treated rat. Ann. Med. exp. Fenn. 36, 328 (1958).Google Scholar
  32. [28]
    Arnold, A., A. L. Beyler, and G. O. Potts: Andro-stanazole, a new orally active anabolic steroid. Proc. Soc. exp. Biol. (N.Y.) 102, 184 (1959).Google Scholar
  33. [28a]
    Arnold, A., A. L. Beyler, and G. O. Potts: Oral anabolic and androgenic effects of 19-nortestosterone and 17α-methyl-19-nortestosterone. Fed. Proc. 23, 412 (1964).Google Scholar
  34. [29]
    Aspinall, R. L., R. K. Meyer, and M. A. Rao: Effect of various steroids on the development of the bursa fabricii in chick embryos. Endocrinology 68, 944 (1961).PubMedGoogle Scholar
  35. [30]
    Astwood, E. B.: An assay method for progesterone based upon the decidual reaction in the rat. J. Endocr. 1, 49 (1939).Google Scholar
  36. [31]
    Astwood, E. B.: Induction of deciduomata in rats by means of progesterone. Anat. Ree. 73, Suppl. 2, 4–5 (1939).Google Scholar
  37. [32]
    Astwood, E. B.: Changes in the weight and water content of the uterus of the normal adult rat. Amer. J. Physiol. 126, 162 (1939).Google Scholar
  38. [33]
    Astwood, E. B. and H. L. Fevold: Action of progesterone on the gonadotropic activity of the pituitary. Amer. J. Physiol. 127, 192 (1939).Google Scholar
  39. [34]
    Axelrod, B. I., I. E. Cates, B. B. Johnson, and I. A. Luetscher jr.: Bioassay of mineralocorticoids: relationship of structure to physiological activity. Endocrinology 55, 568 (1954).Google Scholar
  40. [35]
    Babcock, J. C.: Synthetic progestational agents. Chem. Abstr. 61, 7297 (1964).Google Scholar
  41. [36]
    Babcock, J. C., E. S. Gutsell, M. E. Herr, J. A. Hoog, J. C. Stucke, L. E. Barnes, and W. E. Dulin: 6α-methyl-17α-hydroxyprogesterone 17-aeylates; a new class of potent progestins. J. Amer. chem. Soc. 80, 2904 (1958).Google Scholar
  42. [37]
    Baker, B. L., R. H. Kahn, and D. B. Zanotti: Influence of norethynodrel on the adrenal cortex of rats. Endocrinology 77, 155 (1965).Google Scholar
  43. [38]
    Balant, Ch. P., and M. Ehrenstein: Investigations on Steroids. XX. 6β- and 6α- acetoxy- and hydroxy-derivatives of progesterone and androstenedione. J. Org. Chem. 17, 1587 (1952).Google Scholar
  44. [39]
    Baldratti, G., G. Arcari, V. Clini, F. Tani e G. Sala: Proprietà biologiche di un nuovo steroide anabolizzante attivo per via orale. Sperimentale 109, 383 (1959).PubMedGoogle Scholar
  45. [40]
    Baldratti, G., G. Arcari, V. Clini, F. Tani, and G. Sala: Pregnancy-maintaining activity of 4-hydroxy-17α-acetoxyprogesterone. Acta endocr. (Kbh.) Suppl. 67, 113 (1962).Google Scholar
  46. [41]
    Baldratti, G., G. Arcari, V. Clini, F. Tani, A. Acerbi, and G. Arcari: Biological activities of a series of analogs of 6α-methyl-17α-acetoxy-progesterone. Chem. Abstr. 60, 9555 (1964).Google Scholar
  47. [42]
    Balfour, W. E., R. S. Comline, and R. V. Short: Secretion of progesterone by the adrenal gland. Nature (Lond.) 180, 1480 (1957).Google Scholar
  48. [43]
    Banik, U.K., and G. Pincus: Effect of steroidal anti-progestins on implantation of fertilized eggs of rats and mice. Proc. Soc. exp. Biol. (N.Y.) 111, 595 (1962).Google Scholar
  49. [44]
    Baran, J. S.: Esters of some steroidal 3β-hydroxy-4,6-dienes and their biological activity. J. med. Chem. 6, 329 (1963).PubMedGoogle Scholar
  50. [45]
    Barber, G. W., u. M. Ehrenstein: Untersuchungen über Steroide. XXVIII Synthese von 19-Nor-10ζ,14β. 17α-progesteron und 19-nor-ll-desoxy-10£,14β. 17α-Cortico- steron aus Strophanthidin. Justus Liebigs Ann. Chem. 608, 89 (1957).Google Scholar
  51. [46]
    Barfield, W. E., and R. B. Greenblatt: Clinical experience with provest in manage ment of adolescent menstrual disorders. Int. J. Fertil. 8, 641 (1963).PubMedGoogle Scholar
  52. [47]
    Barnes, L. E., and R. K. Meyer: Delayed implantation in intact rats treated with medroxyprogesterone acetate. J. Reprod. Fertil. 7, 139 (1964).PubMedGoogle Scholar
  53. [48]
    Barnes, L. E., and R. K. Meyer, F. L. Schmidt, and W. E. Dulin: Progestational activity of 6α-methyl-17α-acetoxyprogesterone. Proc. Soc. exp. Biol. (N.Y.) 100, 820 (1959).Google Scholar
  54. [49]
    Barnes, L. E., and R. K. Meyer, F. L. Schmidt, and W. E. Dulin, R. O. Stafford, M. E. Guild, and K. J. Olson: Comparison of myotrophic and androgenic activities of 19-nortestosterone cyclopentylpropionate, androstanolone, and methylandrostenediol. Proc. Soc. exp. Biol. (N.Y.) 87, 35 (1954).Google Scholar
  55. [50]
    Barnes, L. E., and R. K. Meyer, F. L. Schmidt, and W. E. Dulin, L. C. Thole, and K. J. Olson: A comparison of myotrophic and androgenic activities of testosterone propionate with 19-nortestosterone and its esters. Endocrinology 55, 77 (1954).PubMedGoogle Scholar
  56. [51]
    Barraclotjgh, C. A.: Specific hypothalamic sites at which progesterone acts to facilitate ovulation in the rat. J. Endocr. 24, XIX (1962).Google Scholar
  57. [52]
    Barrnett, R. J., A. J. Ladman, N. J. McAllaster, and E. R. Siperstein: The localization of glycoprotein hormones in the pituitary glands of rats investigated by differential protein solubilities, histological stains and bioassays. Endocrinology 59, 398 (1956).PubMedGoogle Scholar
  58. [52a]
    Barry, R. D., F. Kraft, P. K. Besch, D. J. Watson, and M. Pflaumer: Steroid oxydations. I. A convenient synthesis of Δ 4-3,6-diones. Steroids 2, 379 (1963).Google Scholar
  59. [52b]
    Barton, D. H. R., J. M. Beaton, L. E. Geller, and M. M. Pechet: A new photochemical reaction. J. Amer. chem. Soc. 83, 4076 (1961).Google Scholar
  60. [53]
    Barton, S. P., D. Burn, G. Cooley. B. Ellis, and V. Petrow: Modified steroid hormones. XI. Some ethisterone homologues. J. chem. Soc. 1959, 1957.Google Scholar
  61. [54]
    Bartter, F. C., A. P. Forbes, W. M. Jefferies, E. L. Carroll, and F. Albright: The mechanism of action of testosterone in the therapy of Cushing’s syndrome. J. clin. Endocr. 9, 663 (1949).Google Scholar
  62. [55]
    Baunach, A., u. M. Baunach: Erfahrungen mit Ovulen, einem neuen Ovulationshemmer. Med. Welt 41, 2207 (1964).PubMedGoogle Scholar
  63. [56]
    Beatty, C. H., R. M. Bocek, and R. D. Peterson: Water tolerance test for functioning adrenal cortical tissue in the rat. Amer. J. Physiol. 177, 287 (1954).PubMedGoogle Scholar
  64. [57]
    Bengtsson, L. Ph.: On the relation between progesterone and the maintenance of human pregnancy. Acta endocr. (Kbh.) Suppl. 88, 54 (1958).Google Scholar
  65. [58]
    Bengtsson, L. Ph. Effect of synthetic progestins on myometrial activity in human midpregnancy. J. Endocr. 24, XXI (1962).Google Scholar
  66. [58a]
    Bergstrom, C. G., and R. T. Nicholson: 9,11-dihalosteroids. J. org. Chem. 25, 1263 (1960).Google Scholar
  67. [59]
    Bergstrom, C. G., and R. T. Nicholson, R. L. Elton, and R. M. Dodson: 17α-acetoxy-9-halo-ll-oxygenated-progesterones. A new class of orally active progestins. J, Amer. chem. Soc. 81, 4432 (1959).Google Scholar
  68. [59a]
    Bergstrom, C. G., P. B. Sollman, R. T. Nicholson, and R. M. Dodson: 21-halo-17-acyloxypro- gesterones. J. Amer. chem. Soc. 82, 2322 (1960).Google Scholar
  69. [60]
    Bernard, J.: L’ethynodiol diaeetat (SC-11800) dans le traitement de l’insuffisance luteale. Ann. Endocr. (Paris) 25, 179 (1964).Google Scholar
  70. [61]
    Bernstein, S., E. W. Canwall, J. P. Duszy, and J. P. Joseph: C16-methyl derivatives of progesterone and 17α-acetoxyprogesterone: preparation and biological activities. Experientia (Basel) 17, 454 (1961).Google Scholar
  71. [62]
    Berswordt-Wallrabe, R. v., and F. Neumann: Failure to induce effects in the testis of hypophysectomized rats with a FSH preparation concomitantly treated with the antiandrogen cyproterone acetate. Fifth World Congr. Fertil. and Steril., Stockholm 1966. Excerpta med. (Amst.) Int. Congr. Ser. 109, Abstr. 227, 1966.Google Scholar
  72. [63]
    Berswordt-Wallrabe, R. v., and F. Neumann: Ansprechbarkeit „feminisierter männlicher Ratten” auf eine Progesteron/Oestrogen-Behandlung und Induktion einer Lactation. 36. Tagg Dtsch. Ges. Gynäk., Hannover 1966. Arch. Gynäk. 204, Abstr. 62, H. 2–3.Google Scholar
  73. [64]
    Berswordt-Wallrabe, R. v., and F. Neumann: Influence of an testosterone antagonist (Cyproterone) on pituitary and serum FSH-content in juvenile male rats. Neuroendocrinology 2, 107 (1967).Google Scholar
  74. [65]
    Beyler, A. L., and R. O. Clinton: Uterine growth stimulating and testicular growth suppressing activities of 17α-ethinyl-androstane-3α,17β-diol, its Δ 5-analog and derivatives. Proc. Soc. exp. Biol. (N.Y.) 92, 404 (1956).Google Scholar
  75. [65a]
    Beyler, A. L., and G. O. Potts: The effects of ethinylandrostenediol 3-cyclohexylpropionate on the reproductive tract of male and female rats. Endocrinology 60, 519 (1957).PubMedGoogle Scholar
  76. [66]
    Bickenbach, W., u. E. Paulikovics: Hemmung der Follikelreifung durch Progesteron bei der Frau. Zbl. Gynäk. 68, 153 (1944).Google Scholar
  77. [67]
    Bickers, W.: Progesterone: A comparison of intramuscular, oral and sublingual routes of administration. J. clin. Endocr. 9, 736 (1949).PubMedGoogle Scholar
  78. [68]
    Biddulph, C., and R. K. Meyer: Gonadotropine hormone secretion in immature hypo- physectomized parabiotic rats. Proc. Soc. exp. Biol. (N.Y.) 68, 92 (1946).Google Scholar
  79. [69]
    Biddulph, C., and R. K. Meyer and L. G. Gumbreck: The influence of estriol, estradiol and progesterone on the secretion of gonadotropic hormones in parabiotic rats. Endocrinology 26, 280 (1940).Google Scholar
  80. [70]
    Biggers, J. D., and P. J. Claringbold: Criteria of the vaginal response to oestrogens. J. Endocr. 11, 277 (1954).PubMedGoogle Scholar
  81. [71]
    Bindon, B. M., and J. Roberts: Control of ovarian activity in ewes with progestagens. J. Reprod. Fertil. 7, 397 (1964).PubMedGoogle Scholar
  82. [72]
    Binks, R., P. Cambourn, and R. A. Papworth: Preliminary report of a clinical trial of oral norethynodrel for fertility control. Med. J. Aust. 1, 716 (1962).Google Scholar
  83. [73]
    Birch, A. J.: Homocyclic compounds. Annual Rep. Progr. Chem. 47, 177 (1950).Google Scholar
  84. [74]
    Birch, A.: Hydroaromatic steroid hormones. I. 10-nortestosterone. J. chem. Soc. 1, 367 (1950).Google Scholar
  85. [75]
    Birch, A. J., and H. Smith: Hydroaromatic steroid. II. Some hydroehrysene derivatives. J. chem. Soc. 2, 1882 (1951).Google Scholar
  86. [76]
    Biskind, G. R., and M. A. Meyer: The comparative androgenic potency of testosterone, methyl testosterone and testosterone propionate administered in pellet form. Endocrinology 28, 217 (1941).Google Scholar
  87. [77]
    Black, J. A., and J. F. R. Bentley: Effect on the foetus of androgens given during pregnancy. Lancet 1959 I, 21.Google Scholar
  88. [78]
    Blackburn, C. M., and A. Albert: Effects of 2-methyl-dihydrotestosterone and of testosterone on human pituitary gonadotropin. J. clin. Endocr. 19, 603 (1959).PubMedGoogle Scholar
  89. [79]
    Blaquier, I. A.: Action de divers stéroides progestatifs sur l’oviducte du crapaud. C. R. Soc. Biol. (Paris) 153, 1275 (1959).Google Scholar
  90. [80]
    Bloom, B. M., Y. V. Bogert, and R. jr Pinson: A new synthesis of 6-fluoro steroids. Chem. and Indust. 2, 1317 (1959).Google Scholar
  91. [81]
    Blye, R. P., R. E. Homm, and T. O. King: Biological characterization of norethindrone and norethynodrel alone and in combination with ethynylestradiol-3-methyl ether. VI Congreso Panamer. Endocr., New Mexico 1965. Excerpta med. (Amst.) Int. Congr. Ser. 99, Abstr. 317, p. E 143, 1965.Google Scholar
  92. [82]
    Bockner, V.: The contraceptive pill: A clinical evaluation of its long-term use. Med. J. Aust. 6, 809 (1963).Google Scholar
  93. [83]
    Bologna, U., and S. Bettocchi: Antagonism of a synthetic oxytocin by parenteral progesterone and oral 6α-methyl-17α-hydroxyprogesterone acetate. Chem. Abstr. 54, 25298 (1960).Google Scholar
  94. [84]
    Bompiani, A., et E. Moneta: Attività progestativa dell’isopregnenolone in casi di amenorrea secondaria. Ann. Ostet. Ginec. 84, 607 (1962).PubMedGoogle Scholar
  95. [85]
    Bomskov, Ch.: Methodik der Hormonforschung. Leipzig: Georg Thieme 1939.Google Scholar
  96. [86]
    Bongiovanni, A. M.: The effect of endocrine drugs on the human fetus. Helv. paediat. Acta 15, 399 (1960).Google Scholar
  97. [87]
    Borglin, N. E.: Progestative effect of allyl-oestrenol. Acta endocr. (Kbh.) Suppl. 51, 929 (1960).Google Scholar
  98. [87]
    Borglin, N. E. and G. E. Eliasson: Analysis of the pregnancy-maintaining effect of allylestrenol in threatened and habitual abortion. Fertil. and Steril. 13, 411 (1962).Google Scholar
  99. [89]
    Boris, A., R. H. Stevenson, and Th. Trmal: Some studies of the endocrine properties of dydrogesterone. Steroids 7, 1 (1966).PubMedGoogle Scholar
  100. [89a]
    Borrevang, P.: 21-derivatives of compound S, cortisone and hydrocortisone. Acta chem. scand. 9, 587 (1955).Google Scholar
  101. [90]
    Boschann, H. W.: Cytologische Untersuchungen über die Wirkung von Androgenen am atrophischen Vaginalepithel in Abhängigkeit von Dosierung und Applikationsart. Arch. Gynäk. 187, 39 (1955).Google Scholar
  102. [91]
    Boschann, H. W. Observations on the role of progestational agents in human gynecoligic disorders and pregnancy. Ann. N.Y. Acad. Sci. 71, 727 (1958).PubMedGoogle Scholar
  103. [92]
    Boschann, H. W., and R. Drews: Effect of 6α-methyl-17α-aeetoxy-progesterone on the endometrium. Progesterone, Brook Lodge Symp., p. 133, Kalamazoo/Mich. 1961.Google Scholar
  104. [93]
    Boschann, H. W., u. S. Kur: Über die Wirkung des 17-Äthinyl-19-nor-testosteronönanthats, eines neuen Gestagens mit Depotcharakter auf das menschliche Endometrium und das atrophische Vaginalepithel. Geburtsh. u. Frauenheilk. 17, 928 (1957).Google Scholar
  105. [93a]
    Bowers, A., E. Denot. R. Urquiza, and L. M. Sanchez-Hidalgo: Some fission reactions of steroid 5,6-epoxides induced by boron trifluoride etherate. Tetrahedron 8, 116 (1960).Google Scholar
  106. [94]
    Bowers, A., L. C. Ibanez, and H. J. Ringold: A new route to 6-nitro steroid hormones. 6α-nitro-17α-acetoxyprogesterone and 6α-nitrocortisone. J. Amer. chem. Soc. 81, 3707 (1959).Google Scholar
  107. [95]
    Bowers, A., L. C. Ibanez, and H. J. Ringold: Synthesis of halogenated steroid hormones: 6α-fluoro-17α-acetoxyprogesterone and some unsuturated analogs. A new class of highly active oral progestational hormones. J. Amer. chem. Soc. 81, 5991 (1959).Google Scholar
  108. [96]
    Bowers, A., L. C. Ibanez, and H. J. Ringold: Steroids. CIII. A new class of potent cortical hormones, 6α-fluoro-corticoids. J. Amer. chem. Soc. 80, 4423 (1958).Google Scholar
  109. [97]
    Bowers, A., L. C. Ibanez, and H. J. Ringold: Steroids. XCIL Synthesis of halogenated steroid hormones-II. 6α- and 6β-fluoro-testosterone and 6α-and 6β-fluoroprogesterone. Tetrahedron 3, 14 (1958).Google Scholar
  110. [98]
    Bowers, A., L. C. Ibanez, and H. J. Ringold: Studies in nitro steroids. Part. 3. The synthesis of 21-nitroprogesterone. J. Amer. chem. Soc. 81, 3710 (1959).Google Scholar
  111. [99]
    Bowers, A., L. C. Ibanez and R. L. Dorfman: 19-nordihydrotestosterone derivatives. A potent class of antiestrogenic compounds. J. Amer. chem. Soc. 79, 4556 (1957).Google Scholar
  112. [100]
    Bowers, A., M. B. Sánchez, and H. J. Ringold: The synthesis of 6α- and 6β-nitrotestosterone and 6α- and 6β-nitroproges t erone. J. Amer. chem. Soc. 81, 3702 (1959).Google Scholar
  113. [100a]
    Bowers, A., R. Villotti, J. A. Edwards. E. Denot, and O. Halpern: A new route to 19-nor steroids. J. Amer. chem. Soc. 84, 3204 (1962).Google Scholar
  114. [101]
    Bowman, R.: Some clinical experience in the oral control of conception. Med. J. Aust. 1962, 715.Google Scholar
  115. [102]
    Bowman, R., and R. O. Stafford: Influence of nortestosterone cyclopentylpropionate on erythropoiesis in castrated male rats. Proe. Soc. exp. Biol. (N.Y.) 87, 136 (1954).Google Scholar
  116. [103]
    Brehm, H.: Circulation, blood coagulation and clinical observations during hormonal suppression of ovulation. Int. J. Fértil. 9, 45 (1964).PubMedGoogle Scholar
  117. [104]
    Brendler, H., and B. S. Winkler: Effect of norethandrolone on 17-ketosteroid excretion in prostatic cancer patients. J. clin. Endoer. 19, 183 (1959).Google Scholar
  118. [105]
    Brennan, D.M., and R. J. Kraay: Chlormadinone acetate, a new highly active gestation-supporting agent. Acta endocr. (Kbh.) 44, 367 (1963).Google Scholar
  119. [106]
    Bretschneider, L. H., u. J. J. Duyvéne de Wit: Über die Hormonkette: Wirksame Harnsubstanz — Ovar — Legeröhre bei Rhodeus amaras; bewiesen durch die histologische Stufenzählmethode. Proc. roy. Acad. Amst. 40, 624 (1937).Google Scholar
  120. [107]
    Bridge, R. W., and W. W. Scott: A new antiandrogen, SH-714. Invest. Urol. 2, 99 (1964).PubMedGoogle Scholar
  121. [108]
    Brinkley, H. J., H. W. Norton, and A. V. Nalbandov: Is ovulation alone sufficient to cause formation of corpora lutea. Endocrinology 74, 14 (1964).PubMedGoogle Scholar
  122. [109]
    Brøchner-Mortensen, K., S. Gjørup, and J. Thaysen: The metabolic effect of new anabolic 19-nor-steroids. Metabolic studies on patients with chronic rheumatoid arthritis during combined therapy with prednisone and anabolic steroid. Acta med. scand. 165, 197 (1959).Google Scholar
  123. [110]
    Brooks, R. V.: The influence of the administration of 17α-ethyl-19-nortestosterone on the excretion of steroids in the human male. J. Endocr. 13, XXXIV (1956).Google Scholar
  124. [111]
    Brooks, R. V., and F. T. G. Prunty: The suppression of adrenocortical secretion with 17α-ethyl-19-nortestosterone. J. Endocr. 15, 385 (1957).PubMedGoogle Scholar
  125. [111a]
    Brooks, S. G., R. M. Evans, G. F. H. Green, J. S. Hunt, A. G. Long. B. Mooney, and L. J. Wyman: Use of 20-oximes and 20-semiearbazones in making Cortisol and 4:5α-dihydrocortisol. J. chem. Soc. 1958 IV, 4614.Google Scholar
  126. [112]
    Brown, P. S., M. Wells, and A. Youngson: Effect of norethynodrel on pituitary gonadotropic potency in intact male rats. Nature (Lond.) 205, 88 (1965).Google Scholar
  127. [112a]
    Brückner, K., B. Hampel U. Johnsen: Darstellung und Eigenschaften mono- halogenierter 3-Keto-Δ 4,6-dien-steroide. Chem. Ber. 94, 1225 (1961).Google Scholar
  128. [113]
    Brunkenhorst, W. K., and E. L. Hess: Interactions of hormones with thymus-cell fractions. Biochim. biophys. Acta (Amst.) 82, 385 (1964).Google Scholar
  129. [114]
    Bryan, H. S.: Utility of 17α-acetoxyprogesterone in delaying estrus in the bitch. Proc. Soc. exp. Biol. (N.Y.) 105, 23 (1960).Google Scholar
  130. [115]
    Buchholz, R.: Die Wirkung des Aethinyl-Nor-Testosterons auf die Ausscheidung der Gesamtgonadotropine und des ICSH beim Menschen. Acta endocr. (Kbh.) 51, 927 (1960).Google Scholar
  131. [116]
    Buchholz, R., L. Nocke, u. W. Nocke: Untersuchungen über den Wirkungsmechanismus von Aethinylnortestosteron bei der Unterdrückung der Ovulation. Geburtsh. u. Frauen- heilk. 22, 923 (1962).Google Scholar
  132. [117]
    Buchholz, R., L. Nocke,; u. W. Nocke: The influence of gestagens on the urinary excretion of pituitary gonado tropins, estrogens and pregnandiol in woman in the postmonopause and during the menstrual cycle. Int. J. Fértil. 9, 231 (1964).PubMedGoogle Scholar
  133. [118]
    Buckle, R. M.: Fluoxymesterone — a new oral androgen. Brit. med. J. 1959, 1378.Google Scholar
  134. [119]
    Büttner, W., u. R. Trappmann: Der Einfluß von Progesteron auf die Ausscheidung des gonadotropen Hormons im Harn von Frauen außerhalb der Geschlechtsreife. Arch. Gynäk. 170, 413 (1940).Google Scholar
  135. [120]
    Bunster, E., and R. K. Meyer: An improved method of parabiosis. Anat. Ree. 57, 339 (1933).Google Scholar
  136. [121]
    Burdick, H. O., and B. Emerson: Regression and résorption of the corpora lutea of early pregnancy following injections of testosterone propionate. Endoerinology 25, 913 (1939).Google Scholar
  137. [122]
    Burdick, H. O., and R. Whitney: Ovulation induced in mice by single injections of follutein or untreated human pregnancy urine. Amer. J. Physiol. 132, 405 (1941).Google Scholar
  138. [123]
    Burn, D., B. Ellis, V. Petrow, I. A. Stuart-Webb, and D. Williamson: Modified Steroid hormones. IV. 6-methyl-pregnane derivatives. J. chem. Soc. 1957, 4092.Google Scholar
  139. [124]
    Burstein, R., and H. C. Wasserman: The effect of provera on the fetus. Obstet, and Gynec. 23, 931 (1964).Google Scholar
  140. [125]
    B)utenandt, A.: Über das Pregnadiol, einen neuen Sterin-Abkömmling aus Schwangeren-Harn. Ber. dtsch. ehem. Ges. 63, 659 (1930).Google Scholar
  141. [126]
    B)utenandt, A.: Neue Ergebnisse auf dem Gebiet der Sexualhormone. Wien. klin. Wschr. 47, 934 (1934).Google Scholar
  142. [127]
    B)utenandt, A.: Zur Physiologie des Δ 5-Androstendiols-(3,17). Naturwissenschaften 24, 15 (1936).Google Scholar
  143. [128]
    B)utenandt, A.: Recherches chimiques sur la spécificité physiologique du groupe des hormones génitales. Bull. Soc. clin. Biol. 19, 1477 (1937).Google Scholar
  144. [129]
    B)utenandt, A.: Entwicklungslinien in der künstlichen Darstellung natürlicher Steroidhormone. Naturwissenschaften 30, 4 (1942).Google Scholar
  145. [130]
    Butenandt, A., u. H. Cobler: Über Androsteron. IV. Abbau des Stigmasterins zu Iso-Androsteron und Androstandion; die Verknüpfung des Corpus luteum-Hormons und allo- Pregnanolons mit Androsteron. Hoppe-Seylers Z. physiol. Chem. 234, 218 (1935).Google Scholar
  146. [131]
    Butenandt, A., u. H. Dannenbaum: Isolierung eines neuen physiologisch unwirksamen Sterin- derivates aus Männerharn, seine Verknüpfung mit Dehydro-androsteron und Androsteron: ein Beitrag zur Konstitution des Androsterons. Hoppe-Seylers Z. physiol. Chem. 229, 192 (1934).Google Scholar
  147. [132]
    G. Hanisch u. H. Kudszus: Über Dehydro-androsteron. Hoppe-Seylers Z. physiol. Chem. 237, 57 (1935).Google Scholar
  148. [133]
    G. Hanisch u. H. Kudszus: Über Δ 1-Androsten-dion-(3,17). Ber. dtsch. chem. Ges. 69, 1158 (1936).Google Scholar
  149. [134]
    G. Hanisch u. H. Kudszus: Über Δl1-Androsten-ol-(17)-on (3), ein Isomeres des Testosterons. Ber. dtsch. chem. Ges. 71, 1681 (1938).Google Scholar
  150. [134a]
    G. Hanisch, u. G. Fleischer: Über 17-iso-Δ 5-pregnenol-(3)-on-(20). Ber. dtsch. chem. Ges. 70, 96 (1937).Google Scholar
  151. [134b]
    G. Hanisch, u. W. Grosse: Über den Ersatz der 3-ständigen Hydroxylgruppe im Pregnenolon und Androstendiol durch Chlor. Ber. dtsch. chem. Ges. 70, 1446 (1937).Google Scholar
  152. [135]
    G. Hanisch, u. G. Hanisch: Umwandlung des Dehydro-androsterons in Androstendiol und Testosteron. Ein Weg zur Darstellung des Testosterons aus Cholesterin. Hoppe- Seylers Z. physiol. Chem. 237, 89 (1935).Google Scholar
  153. [136]
    G. Hanisch, E. Hausmann u. J. Paland: Über Δ 5,7-Androstadien-diol-(3,17). Ber. dtsch. chem. Ges. 71, 1316 (1938).Google Scholar
  154. [136a]
    G. Hanisch, L. Karlson-Poschmann, G. Fajler, U. Schiedt u. E. Biekert: Über die Konstitution der Lumisteroide. Justus Liebigs Ann. Chem. 575, 123 (1952).Google Scholar
  155. [137]
    G. Hanisch, u. H. Kudszus: Über Androstendion, einen hochwirksamen männlichen Prägungs stoff. Ein Beitrag zur Genese der Keimdrüsenhormone. Hoppe-Seylers Z. physiol. Chem. 287, 75 (1935).Google Scholar
  156. [138]
    G. Hanisch, u. L. Mamoli: Notiz über ein isomeres allo-Pregnanol-(3)-on-(20). Ber. dtsch. chem. Ges. 68, 1847 (1935).Google Scholar
  157. [139]
    G. Hanisch, u. L. Mamoli: Über Δ 1-allo-Pregnendion-(3,20); ein weiterer Beitrag zur Spezifität der Corpusluteum-Wirkung. Ber. dtsch. chem. Ges. 68, 1850 (1935).Google Scholar
  158. [140]
    G. Hanisch, u. L. Mamoli u. A. Heusner: Δ 16-allo-Pregnen-dion-(3,20). Ber. dtsch. chem. Ges. 72, 1614 (1939).Google Scholar
  159. [141]
    L. W. Masch u. J. Paland: Zur Kenntnis der Δ 1-ungesättigten Steroidketone. Ber. dtsch. chem. Ges. 72, 1617 (1939).Google Scholar
  160. [142]
    L. W. Masch, u. L. Poschmann: Über Lumiandrosteron. Ber. dtsch. chem. Ges. 77, 394 (1944).Google Scholar
  161. [143]
    L. W. Masch, u. B. Riegel: Über 6-Oxotestosteron und verwandte Verbindungen. Ber. dtsch. chem. Ges. 69, 1163 (1936).Google Scholar
  162. [144]
    L. W. Masch, u. J. Schmidt: Über die polymorphen Modifikationen des Corpus-luteum-Hormons. Ber. dtsch. chem. Ges. 67, 2088 (1934).Google Scholar
  163. [145]
    L. W. Masch, u. J. Schmidt: Über Δ 4-Pregnenol-(20)-on-(3); ein Beitrag zur Spezifität der Corpus-luteum-Wirkung. Ber. dtsch. chem. Ges. 67, 2092 (1934).Google Scholar
  164. [146]
    L. W. Masch, u J. Schmidt-Thomé: Über die Darstellung von β,γ-(Δ 5-ungesättigten Ketonen der Sterin-Reihe; zugleich ein Beitrag zur Kenntnis des 17-Äthyl-testosterons. Ber. dtsch. chem. Ges. 69, 882 (1936).Google Scholar
  165. [147]
    Butenandt, A., u. J. Schmidt-Thome: Überführung von Dehydroandrosteron in Progesteron, ein einfacher Weg zur künstlichen Darstellung des Schwangerschafts- hormons aus Cholesterin. Ber. dtsch. ehem. Ges. 72, 182 (1939).Google Scholar
  166. [148]
    Butenandt, A., u. J. Schmidt-Thome, u. T. Weiss: Über ein 16-Oxy-testosteron. Ber. dtsch. ehem. Ges. 72, 417 (1939).Google Scholar
  167. [149]
    Butenandt, A., u. J. Schmidt-Thome,u. H. Paul: Umwandlung des Dehydro-androsterons in 17-iso-Progesteron und Progesteron. Ber. dtsch. ehem. Ges. 72, 1112 (1939).Google Scholar
  168. [150]
    Butenandt, A., u. K. Tscherning: Über Androsteron. V. Androstandiol, ein physiologisch hoch aktives Reduktionsprodukt des Androsterons. Hoppe-Seylers Z. physiol. Chem. 234, 224 (1935).Google Scholar
  169. [151]
    Butenandt, A., u. K. Tscherning u. G. Hanisch: Über einige neue Vertreter der Androsteron-Gruppe. Ber. dtsch. chem. Ges. 68, 2097 (1935).Google Scholar
  170. [152]
    Butenandt, A., u. K. Tscherning, u. U. Westphal: Zur Isolierung und Charakterisierung des Corpus-luteum-Hor- mons. Ber. dtsch. ehem. Ges. 67, 1440 (1934).Google Scholar
  171. [153]
    Butenandt, A., u. K. Tscherning, u. H. Cobler: Über einen Abbau des Stigmasterins zu eorpus-luteum-wirksamen Stoffen; ein Beitrag zur Konstitution des Corpus-luteum-Hormons. Ber. dtsch. chem. Ges. 67, 1611 (1934).Google Scholar
  172. [154]
    Butenandt, A., u. K. Tscherning, u. W. Hohlweg: Über das Hormon des Corpus luteum. Hoppe-Seylers Z. physiol. Chem. 227, 84 (1934).Google Scholar
  173. [154a]
    Buzzetti, F., W. Wicki, J. Kalvoda u. O. Jeger: Einführung einer Sauerstofffunktion an die quarternäre Methyl-Gruppe C-18 im intakten Steroid-Gerüst. Helv. chim. Acta 42, 388 (1959).Google Scholar
  174. [155]
    Bygdeman, M., and R. Eliasson: Effect of progesterone and oestrone on the motility and reactivity of the pregnant human myometrium in vitro. J. Reprod. Fertil. 7, 47 (1964).PubMedGoogle Scholar
  175. [156]
    Byrnes, W. W., and R. K. Meyer: The inhibition of gonadotrophin hormone secretion by physiological doses of estrogens. Endocrinology 48, 133 (1951).PubMedGoogle Scholar
  176. [157]
    Byrnes, W. W., and E. G. Shipley: Estrogenic and gonadotropic hormone inhibiting activity of some adrenal cortical substances. Proc. Soc. exp. Biol. (N.Y.) 74, 308 (1950).Google Scholar
  177. [158]
    Byrnes, W. W., and E. G. Shipley: Guinea pig copulatory reflex in response to adrenal steroids and similar compounds. Endocrinology 57, 5 (1955).PubMedGoogle Scholar
  178. [159]
    Byrnes, W. W., R. O. Stafford, and K. I. Olson: Anti-gonadal hormone activity of lla-hydr- oxyprogesterone. Proc. Soc. exp. Biol. (N.Y). 82, 243 (1953).Google Scholar
  179. [160]
    Caie, E., and A. Klopper: The urinary excretion of pregnanediol after the administra tion of an oral gestagen (Progesterone cyclopentyl enol ether). J. Endocr. 28, 221 (1963).Google Scholar
  180. [161]
    Callantine, M. R., S. L. Lee. R. Humphrey, and B. Windsor: Action of progesterone in inhibiting gonadotropin-induced ovulation. Fed. Proc. 23, 463 (1964).Google Scholar
  181. [162]
    Callow, R. K, and A. S. Parkes: Growth and maintenance of the fowl’s comb by administration of androsterone. Biochem. J. 29, 1414 (1935).PubMedGoogle Scholar
  182. [162a]
    Camerino, B., R. Modelli, and B. Patelli: Synthesis of analogs to steroid hormones substituted in position 4. IV. Chem. Abstr. 52, 13786 (1958).Google Scholar
  183. [162b]
    Camerino, B., R. Modelli, u. C. Spalla: Die Oxidation von Steroiden mit Penicillium notatum Westling. Chem. Zbl. 1958, 4500.Google Scholar
  184. [162c]
    Camerino, B., B. Patelli, and R. Sciaky: Oxidation of 3-keto steroids in alkaline medium. Tetrahedron Let. 16, 554 (1961).Google Scholar
  185. [163]
    Camerino, B., B. Patelli and A. Vercellone: Synthesis and anabolic activity of 4-substituted testo sterone analogs. J. Amer. chem. Soc. 78, 3540 (1956).Google Scholar
  186. [164]
    Campbell, J. A., J. C. Babcock, and J. A. Hogg: 6-methyl steroids in the androstane series. J. Amer. chem. Soc. 80, 4717 (1958).Google Scholar
  187. [165]
    Capitaine, J., R. Deghenghi, and Ch. R. Engel: Steroids and related products. XVIII. The Synthesis of 11β,12α-dibromoprogesterone. J. med. Chem. 6, 79 (1963).PubMedGoogle Scholar
  188. [166]
    Carmichael, E. S., and F. H. A. Marshall: On the occurrence of compensatory hypertrophy in the ovary. J. Physiol. (Lond.) 86, 431 (1908).Google Scholar
  189. [167]
    Carter, A. C., S. Weisenfeld, and M. G. Goldner: Failure of 17α-ethyl-19-nor-testosterone to affect plasma 17-hydroxycorticosteroids and ACTH responsiveness in man. Proc. Soc. exp. Biol. (N.Y.) 98, 593 (1958).Google Scholar
  190. [168]
    Casaglia, G., e L. Gualandi: Steroidi progestativi e fenomeno di diastasi della sinfisi. Folia endocr. (Roma) 14, 272 (1961).Google Scholar
  191. [169]
    Castren, O., L. Kalliomäki, A. Pekkarinen. K. Soiva, and S. Vhkari: Effect of norethandrolone on the urinary excretion of 17-ketosteroids, total 17-hydroxy- corticosteroids and uropepsin and on the gastric secretion activity. Acta endocr. (Kbh.) 35, 426 (1960).Google Scholar
  192. [170]
    Cavallero, A., A. Martini e L. Pecile: Progestativi ed ipofisi morfologia e funzione. Ann. Ostet. Genec. 82, 335 (1960).Google Scholar
  193. [171]
    Cavalli, P., G. Candotti, and G. Boselu: Antiovulatory activity of 6α-methyl-17α- hydroxyprogesterone acetate. Chem. Abstr. 55, 7654 (1961).Google Scholar
  194. [172]
    Öekan, Z., M. Seda. J. MikulIskovi, and K. Syhora: On the progestational activity of 6-dehydro-16-methylene-17α-aeetoxyprogesterone. Steroids 4, 415 (1964).Google Scholar
  195. [172a]
    Öekan, Z., M. Seda. J. MikulIskovi, and K. Syhora: Oral progestational activity of 6-ehloro-17 a-hydroxy-16-methylene-pregna-4,6-diene-3,20-dione acetate. Steroids 8, 205 (1966).Google Scholar
  196. [172b]
    Cella, J. A., E. A. Brown, and R. R. Burtner: Steroidal aldosterone blockers. I. J. org. Chem. 24, 743 (1959).Google Scholar
  197. [172c]
    Cella, J. A., and C. M. Kagawa: Steroidal lactones. J. Amer. chem. Soc. 79, 4808 (1957).Google Scholar
  198. [173]
    Chambon, Y.: Sur le conditionnement endocrinien du déciduome traumatique chez la rate castrée. C. R. Soc. Biol. (Paris) 146, 1095 (1952).Google Scholar
  199. [174]
    Chambon, Y. Action de trois dérivés de la 17α-acétoxyprogéstérone sur l’installation de la gestation chez la lapine castrée. C. R. Acad. Sei. (Paris) 260, 690 (1965).Google Scholar
  200. [175]
    Chambon, Y, et S. Le Bars: Activités antiovulatoire et antigonadotrope de la Chlormadinone chez le lapin et chez le rat. C. R. Soc. Biol. (Paris) 159, 2479 (1965).Google Scholar
  201. [175 a]
    Chambon, Y, et S. Le Bars: Action progestogène de la Δ-6,6-chloro-17 a-acétoxyprogestérone chez la lapine et la ratte castrees. Ann. Endoer. (Paris) 26, 327 (1965).Google Scholar
  202. [176]
    Chang, M.: The effects of low temperature on fertilized rabbit ov. i. vitro, and the normal development of ova kept at low temperature for several days. J. gen. Physiol. 31, 385 (1948).PubMedGoogle Scholar
  203. [177]
    Chang, M. C.: Maintenance of pregnancy in intact rabbits in the absence of corporalutea. Endocrinology 48, 17 (1951).PubMedGoogle Scholar
  204. [178]
    Chappel, C. I., C. Revesz, and R. Gaudry: Biological studies on new orally active 6,17-halogenated progesterones. Acta endocr. (Kbh.), Suppl. 51, 915 (1960)Google Scholar
  205. [178 a]
    Charney, W., A. Nobile, C. Federbush, D. Sutter, P. L. Perlman, H. L. Herzog, C. C. Payne, M. E. Tully, M. J. Gentles, and E. B. Hershberg: Microbiological transformation of steroids. XI. The action of Cornynebacterium simplex on non- corticoid steroid substrates. Tetrahedron 18, 591 (1962).Google Scholar
  206. [179]
    Charollais, E.-J., K. Ponse, et M.-F. Jayle: Méthode de dosage des 17-eétostéroides dans les urines de cobay. Application au cycle oestral. Ann. Endocr. (Paris) 18, 109 (1957).Google Scholar
  207. [180]
    Chinnatambi, S.: I. Clinical trial of oral contraceptives enovid and conovid E. II. Effect of oral contraceptive (Conovid E) on lactation. Proc. Conf. Int. Planned Parenthood Fed., Singapore 1963. Excerpta med. (Amst.) Int. Congr. Ser. 72, 319 (1964).Google Scholar
  208. [180a]
    Chirasaka, M., and M. Tsuruta: Microbiological transformation of steroid. VII. Hydroxylation of steroid by Gibberella saubinettii, 6β- and 15α-hydroxylation. Chem. pharm. Bull. 9, 238 (1961).Google Scholar
  209. [181]
    Clark, S. L., and R. B. Greenblatt: The effect of progestational agents in human gynecologic and adrenal disorders. Ann. N.Y. Acad. Sci. 71, 710 (1957).Google Scholar
  210. [182]
    Clarke, E., and H. Selye: The action of steroid compounds on the vaginal epithelium of the rat. Amer. J. med. Sci. 204, 401 (1942).Google Scholar
  211. [183]
    Clarke, E., and H. Selye: The overt and masked manifestations of folliculoid hormones. J. Pharmacol. exp. Ther. 78, 187 (1943).Google Scholar
  212. [184]
    Clauberg, C.: Der biologische Test für das Corpus-luteum-Hormon. Klin. Wschr. 9, 2004 (1930).Google Scholar
  213. [185]
    Clauberg, C. Das Hormon des Corpus luteum. Zbl. Gynäk. 54, 7 (1930).Google Scholar
  214. [186]
    Clauberg, C. Experimentelle Untersuchungen zur Frage eines Mäusetestes für das Hormon des Corpus luteum. Zbl. Gynäk. 54, 1154 (1930).Google Scholar
  215. [187]
    Clauberg, C. Zur Physiologie und Pathologie der Sexualhormone, im besonderen des Hormons des Corpus luteum. 1. Mitt.: Der biologische Test für das Luteohormon (das spezifische Hormon des Corpus luteum) am infantilen Kaninchen. Zbl. Gynäk. 54, 2757 (1930).Google Scholar
  216. [188]
    Clauberg, C., u. Z. Üstün: Menstruation — per os erzeugt. Beweise der Wirksamkeit von Progynon C, einem neuen Follikelhormonderivat, und Proluton C., einem neuen Luteo- hormonpräparat, bei peroraler Verabreichung. Zbl. Gynäk. 62, 1745 (1938).Google Scholar
  217. [189]
    Clausen, H. J.: Effect of progesterone and desoxyeortieosterone on accessory sex organs of the castrate male guinea pig. Endocrinology 31, 187 (1942).Google Scholar
  218. [190]
    Clinton, R. O., A. J. Manson, F. W. Stonner, A. L. Beyler, G. O. Potts, and A. Arnold: Steroidal (3,2-c) pyrazoles. J. Amer. chem. Soc. 81, 1513 (1959).Google Scholar
  219. [191]
    H. C. Neumann, R. G. Christiansen, R. L. Clarke, J. H. Ackerman, D. F. Page, J. W. Dean, W. B. Dickinson, and C. Carabateas: Steroidal (3.2-e) pyrazoles. II. Androstanes, 19-norandrostanes and their unsaturated analogs. J. Amer, chem. Soc. 83, 1478 (1961).Google Scholar
  220. [191a]
    Clinton, R. O., H. C. Neumann, A. J. Manson, S. C. Laskowski, and R. G. Christiansen: D-Homosteroids. III. The synthesis of D-homocortisone acetate and related compounds. J. Amer. chem. Soc. 80, 3395 (1958).Google Scholar
  221. [192]
    Cohen, M. R., and I. F. Stein: Laboratory and clinical experience with oral pregneninolone. Amer. J. Obstet. Gynec. 40, 713 (1940).Google Scholar
  222. [193]
    Collins, V. J., J. L. Boling, E. W. Dempsey, and W. C. Young: Quantitative studies of experimentally induced sexual receptivity in the spayed guinea-pig. Endocrinology 23, 188 (1938).Google Scholar
  223. [194]
    Colton, F. B.: 17-alkyl-derivatives of 19-nortestosterone. Chem. Abstr. 50, 7890 (1956).Google Scholar
  224. [195]
    Colton, F. B., and P. Klimstra: The chemistry and biology of 17-substituted estrene, 3,17-diols. Int. Congr. Hormonal Steroids. Excerpta med. (Amst.) Int. Congr. Ser. 51, 57, Abstr. 48 (1962).Google Scholar
  225. [196]
    Colton, F. B., L. N. Nysted. B. Riegel, and A. I. Raymond: 17-alkyl-19-nortestosterones. J. Amer. chem. Soc. 79, 1123 (1957).Google Scholar
  226. [197]
    Conte, J. C.: Therapeutische Sterilität. Orientación, med. 11, 550 (1962).Google Scholar
  227. [198]
    Cook, H. H., C. J. Gamble, and A. P. Satterthwaite: Oral contraception by nor-ethynodrel. Amer. J. Obstet. Gynec. 82, 437 (1961).PubMedGoogle Scholar
  228. [198a]
    Cooley, G., B. Ellis. F. Hartley, and V. Petrow: Hydroxylation of pregn-16-en- 20-ones. I. Permanganate oxidation of pregn-16-en-20-ones. J. chem. Soc. 4, 4273 (1955).Google Scholar
  229. [199]
    Coppola, J. A., and J. W. Perrine: Inhibition of gonadotrophs induced ovulation by norethynodrel in immature rats. J. Reprod. Fértil. 9, 109 (1965).PubMedGoogle Scholar
  230. [200]
    Cormillot, A. E. J.: Hormonelle Regulation der Fertilität. Orientación, med. 14, 461 (1965).Google Scholar
  231. [201]
    Corner, G. W.: Physiology of the corpus luteum. I. The effect of very early ablation of the corpus luteum upon embryos and uterus. Amer. J. Physiol. 86, 74 (1928).Google Scholar
  232. [202]
    Corner, G. W., and W. M. Allen: Physiology of the corpus luteum. II. Production of a special uterine reaction (progestational proliferation) by extracts of the corpus luteum. Amer. J. Physiol. 88, 326 (1929).Google Scholar
  233. [203]
    Courrier, R.: Interactions between estrogens and progesterone. Yitam. u. Horm. 8, 179 (1950).Google Scholar
  234. [204]
    Courrier, R., et A. Jost: Sur l’analyse quantitative de l’endocrinologie de la gestation chez la lapine. C. R. Soc. Biol. (Paris) 130, 726 (1939).Google Scholar
  235. [204a]
    Courrier, R., et A. Jost: La prégnèninolone assure le maintien de la grossesse chez la lapine gestante castrée. C. R. Soc. Biol. (Paris) 130, 1162 (1939).Google Scholar
  236. [205]
    Courrier, R., et R. Kehl: Données préliminaires sur le besoin quantitativ en progestine chez la lapine gestante castrée. Réalisation de grossesses partielles. C. R. Soc. Biol. (Paris) 127, 529 (1938).Google Scholar
  237. [206]
    Csapo, A.: The mechanism of myometrial function and its disorder. In:,Modern Trends on Obstetrics and Gynaecology Ser. 2, Chapt. 2, p. 20, London: Butterworth & Co. 1955.Google Scholar
  238. [207]
    Cutuly, E., E. C. Cutuly, and D. R. McCullagh: Spermatogenesis in immature hypophyseetomized rats injected with androgens. Proc. Soc. exp. Biol. (N.Y.) 38, 818 (1938).Google Scholar
  239. [208]
    Czyba, J. C., M. Chiris et P. Dubois: Déeidualisation chez la lapine castrée soumise à un conditionnement par la progestérone et la sérotonine. C. R. Soc. Biol. (Paris) 157, 295 (1963).Google Scholar
  240. [209]
    Dantschakoff, Y.: Der Aufbau des Geschlechts bei höheren Wirbeltieren. Jena: Gustav Fischer 1941.Google Scholar
  241. [210]
    Dauria, P.: Hormonelle Ovulationshemmung. Sem. méd. (B.Aires) 126, 196 (1965).Google Scholar
  242. [211]
    David, A., K. Edwards, K. P. Fellowes, and J. M. Plummer: Anti-ovulatory and other biological properties of megestrol acetate. J. Reprod. Fértil. 5, 331 (1963).Google Scholar
  243. [212]
    David, A. K. P. Fellowes, and D. R. Millson: Some biological properties of dimethisterone „seerosteron”, a new orally active progestational agent. J. Pharm. Pharmacol. 11, 491 (1959).PubMedGoogle Scholar
  244. [213]
    David, A. F. Hartley, D. R. Millson, and V. Petrow: Preparation and progestational activity of some alkylated ethisterones. Pharm. J. 179, 259 (1957).Google Scholar
  245. [214]
    David, A. F. Hartley, D. R. Millson, and V. Petrow The preparation and progestational activity of some alkylated ethiste rones. J. Pharm. Pharmacol. 9, 929 (1957).PubMedGoogle Scholar
  246. [215]
    David, K, E. Dingmanse u. E. Laqueur: Über krystallinisches männliches Hormon aus Hoden (Testosteron) wirksamer als aus Harn oder Cholesterin bereitetes Andro- steron. Hoppe-Seylers Z. physiol. Chem. 233, 281 (1935).Google Scholar
  247. [216]
    Davis, B. K.: Termination of pregnancy in the rat with norethynodrel. Nature (Lond.) 197, 308 (1963).Google Scholar
  248. [217]
    Davis, F. W., W. R. Scarborough, B. M. Baker, M. L. Singewald, and R. E. Mason: Experimental hormonal therapy of atherosclerosis: preliminary observation on the effects of two new compounds. Johns Hopk. Hosp. Bull. 100, 294 (1957).Google Scholar
  249. [218]
    Davis, M. E., and G. L. Wied: 17α-hydroxyprogesterone-caproate: a new substance with prolonged progestational activity. A comparison with chemically pure progesterone. J. clin. Endoer. 15, 923 (1955).Google Scholar
  250. [219]
    Davis, M. E., and G. L. Wied 17α-hydroxyprogesterone: an effective progestational substance on oral administration. J. clin. Endoer. 17, 1237 (1957).Google Scholar
  251. [220]
    Davis, M. E., and G. L. Wied Long-acting progestational agents 17-ethinyl-19-nortestosterone enanthate, 17α-hydroxy-progesterone caproate and 17α-hydroxy-progesterone acetate. Ge- burtsh. u. Frauenheilk. 17, 916 (1957).Google Scholar
  252. [221]
    Day, B. N., P. E. Romack, and J. P. Lasley: Influence of progesterone-estrogen implants on early embryonic mortality in swine. J. anim. Sei. 22, 637 (1963).Google Scholar
  253. [222]
    Deanesly, R., and A. S. Parkes: XLVI. Comparative activities of compounds of the androsterone-testosterone series. Biochem. J. 30, 291 (1936).PubMedGoogle Scholar
  254. [223]
    Deghenghi, R., and R. Gaudry: Sterically controlled grignard reactions. A new simpleroute to 17α-methylated steroid analogs. J. Amer. chem. Soc. 83, 4668 (1961).Google Scholar
  255. [224]
    Deghenghi, R., and R. Gaudry: A direct angular alkylation in the pregnane series. Tetrahedron Letters No 11, 489 (1962).Google Scholar
  256. [225]
    Deghenghi, R., Y. Lefebvre, P. Mitchell, P. F. Morand, and R. Gaudry: The synthesis of 17α-methylprogesterone derivatives. A new class of orally active gestagens. Tetrahedron 19, 289 (1963).Google Scholar
  257. [226]
    P. F. Morand, and R. Gaudry: Sterically controlled grignard reactions — I — The preparation of 17-methylated progesterone derivatives. Int. Congr. Hormonal Steroids, Mailand 1962. Excerpta med. (Amst.) Int. Congr. Ser. 51, Abstr. 56, 1962.Google Scholar
  258. [227]
    P. F. Morand, and C. Revesz: The oral activity of 17α-substituted pregnenolones and their sulphates. J. Endocr. 31, 301 (1965).Google Scholar
  259. [228]
    P. F. Morand, and C. Revesz and R. Gaudry: New synthesis and structure activity relationship in the 17-alkylated progesterone series. J. med. Chem. 6, 301 (1963).Google Scholar
  260. [229]
    Demol, R., and J. Ferin: The urinary gonadotropin content during treatment with lynestrenol. Int. J. Fértil. 9, 197 (1964).PubMedGoogle Scholar
  261. [230]
    Dempsey, E. W., R. Hertz, and W. C. Young: The experimental induction of oestrus (sexual receptivity) in the normal and ovariectomized guinea pig. Amer. J. Physiol. 116, 201 (1936).Google Scholar
  262. [231]
    Desaulles, P.A.: Diskussion, in: H. Nowakowski, Hrsg., Moderne Entwicklungen auf dem Gestagengebiet. 6. Symp. Dtsch. Ges. Endokrinologie, Kiel 1959, 29. Berlin-Göttingen-Heidelberg: Springer 1960.Google Scholar
  263. [232]
    Desaulles, P.A., u. Ch. Krähenbühl: Moderne Entwicklung auf dem Gebiet der Gestagentherapie, in: H. Nowakowski, Ed., Moderne Entwicklungen auf dem Gestagengebiet. 6. Symp. Dtsch. Ges. Endokrinologie, Kiel 1959, 5—10, Berlin-Göttingen-Heidelberg: Springer 1960.Google Scholar
  264. [233]
    Desaulles, P.A., u. Ch. Krähenbühl Comparaison du spectre d’activité de certains gestagenes de synthèse. Acta endocr. (Kbh.) 40, 217 (1962).Google Scholar
  265. [234]
    Desaulles, P.A., u. Ch. Krähenbühl Comparison of the antifertility and sex hormones activities of sex hormones and their derivatives. Acta endocr. (Kbh.) 47, 444 (1964).Google Scholar
  266. [235]
    W. Schuler et H. J. Bein: Étude expérimentale du dianabol, un nouvel ana bolisant 17α-méthyl-17β-hydroxy-androsta-l,4-diene-3-one. Schweiz, med. Wschr. 89, 1313 (1959).Google Scholar
  267. [236]
    Desclin, L.: Action du benzoate d’oestradiol et du propionate de testostérone sur la structure de l’ovaire implanté dans la rate. Ann. Endocr. (Paris) 20, 222 (1959).Google Scholar
  268. [237]
    Devenish-Mears, M.: Oral contraceptives. Med. J. Aust. 52, 283 (1965).Google Scholar
  269. [238]
    Diamond, M., and W. C. Young: Differential responsiveness of pregnant guinea pigs to the masculinizing action of testosterone propionate. Endocrinology 72, 429 (1963).PubMedGoogle Scholar
  270. [238 a]
    Diassi, P.A., J. Fried, R. M. Palmere, and E. F. Sabo: The synthesis of 12 a- fluorohydrocortisone 21-acetate and 12a-ehlorohydrocortisone. J. Amer. chem. Soc. 83, 4249 (1961).Google Scholar
  271. [239]
    Dickinson, J. H., and G. G. Smith: A new and practical oral contraceptive agent: Norethindrone with mestranol. Canad. med. Ass. J. 89, 242 (1963).PubMedGoogle Scholar
  272. [240]
    Diczfalusy, E.: A new class of long-acting steroid hormone esters. Acta endocr. (Kbh.) 35, 59 (1960).Google Scholar
  273. [241]
    Dingle, J. T.: Preliminary report on provest study. Int. J. Fértil. 8, 711 (1963).PubMedGoogle Scholar
  274. [242]
    D’Inzerti Bouini, L.: L’assoeiazione anidro-idrossi-progesterone ed etinilestradiolo nella pratica clinica. Ann. Ostet. Ginee. 85, 95 (1963).Google Scholar
  275. [243]
    Dirscherl, W., J. Kraus u. H. E. Voss: Neue Stoffe mit starker Wirkung auf die Vesikulardrüsen der kastrierten männlichen Maus. Z. physiol. Chem. 241, 1 (1936).Google Scholar
  276. [243a]
    Djerassi, C., R. R. Engle, and A. Bowers: The direct conversion of steroidal Δ 5-3β- aleohols to Δ 5- and Δ 4-3-ketones. J. org. Chem. 21, 1547 (1956).Google Scholar
  277. [244]
    Djerassi, C., A. E. Lippman, and J. Grossman: 1 -methyl- 19-norprogesterone and l-methyl-19-nor-17α-hydroxyprogesterone. J. Amer. ehem. Soc. 78, 2479 (1956).Google Scholar
  278. [245]
    Djerassi, C., and A. J. Manson: 8-isoprogesterone. J. org. Chem. 21, 490 (1956).Google Scholar
  279. [246]
    Djerassi, C., and A. J. Manson and H. Bendas: The synthesis of 8-isoprogesterone and 8-isotestosterone. Tetrahedron 1, 22 (1957).Google Scholar
  280. [247]
    Djerassi, C., L. Miramontes, and G. Rosenkranz: 19-norprogesterone, a potent progestational hormone. J. Amer. chem. Soc. 75, 4440 (1953).Google Scholar
  281. [248]
    Djerassi, C., L. Miramontes, and G. Rosenkranz and F. Sondheimer: Synthesis of 19-nor-17α-ethynyltestosterone and 19-nor-17α-methyltestosterone. J. Amer. chem. Soc. 76, 4092 (1954).Google Scholar
  282. [249]
    Doctor, V. M., W. W. Sutow, and J. B. Trunnell: Effect of steroid hormones on urinary excretion of citrovorum factor by patients with prostatic cancer or leukennia. Proc. Soc. exp. Biol. (N.Y.) 113, 737 (1963).Google Scholar
  283. [249b]
    Dodson, R. M., and R. D. Muir: Microbiological transformations. VII. The hydroxy - lation of steroids at C-9. J. Amer. chem. Soc. 83, 4631 (1961).Google Scholar
  284. [250]
    Döring, K., L. Akhundzaden u. B. Herzing: Über den Bremseffekt von Methyl-nortestosteron auf die Ovarialfunktion weißer Ratten. Arch. Gynäk. 192, 129 (1959).Google Scholar
  285. [251]
    Doménico, A., u. P. Neumann: Wirkung von antiandrogen wirksamen Steroiden auf die Funktion und Morphologie der Nebennieren von Ratten. 12. Symp. Dtsch. Ges. Endokrinologie, Wiesbaden 1966, S. 328—331. Berlin-Göttingen-Heidelberg: Springer.Google Scholar
  286. [252]
    Donnet, V., J. M. Chevalier et A. Pruneyre: Étude comparée de l’action frénatrice hypophyso - ovarienne de divers stéroides corticosurrénaux. C. R. Soc. Biol. (Paris) 154, 1030 (1960).Google Scholar
  287. [253]
    Dorfman, R. I.: Studies on the bioassay of hormones. The assay of testosterone propionate and androsterone by a chick comb inunction method. Endocrinology 42, 1 (1948).PubMedGoogle Scholar
  288. [254]
    Dorfman, R. I. Studies on the bioassay of hormones. The relative reactivity of the comb of various breeds of chicks to androgens. Endocrinology 42, 7 (1948).PubMedGoogle Scholar
  289. [255]
    Dorfman, R. I. Androgenic activity of C21 steroids. Proc. Soc. exp. Biol. (N.Y.) 73, 223 (1950).Google Scholar
  290. [256]
    Dorfman, R. I. The anti-androgenic activity of a phenantrene derivative in the chick. Endocrinology 64, 464 (1959).PubMedGoogle Scholar
  291. [257]
    Dorfman, R. I. A subcutaneous injection assay for anti-androgens in the chick. Acta endocr. (Kbh.) 41, 268 (1962).Google Scholar
  292. [258]
    Dorfman, R. I. An anti-androgen assay using the castrated mouse. Proc. Soc. exp. Biol. (N.Y.) 111, 441 (1962).Google Scholar
  293. [259]
    Dorfman, R. I. Anti-estrogenic compounds. In: R. I. Dorfman, Methods in hormone research, vol. II, p. 113—126. New York and London: Academic Press 1962.Google Scholar
  294. [260]
    Dorfman, R. I. Androgens and anabolic agents. In: R. I. Dorfman, Methods in hormone research, vol. II, p. 275—313. New York and London: Academic Press 1962.Google Scholar
  295. [261]
    Dorfman, R. I. Anti-androgenic substances. In: s. 260, p. 315—323.Google Scholar
  296. [262]
    Dorfman, R. I. Corticoids. In: s. [260], p. 325—367.Google Scholar
  297. [263]
    Dorfman, R. I. Anti-androgens in a castrated mouse test. Steroids 2, 185 (1963).Google Scholar
  298. [264]
    Dorfman, R. I. Antiandrogenie activity of tetra-n-butyllead in a mouse assay. Proc. Soc. exp. Biol. (N.Y.) 116, 1055 (1964).Google Scholar
  299. [265]
    Dorfman, R. I. The anti-androgenic activity of a phenanthrene derivative in the chick. Endocrinology 64, 464 (1964).Google Scholar
  300. [266]
    Dorfman, R. I., and A. S. Dorfman: A test for anti-androgens. Acta endocr. (Kbh.) 33, 308 (1960).Google Scholar
  301. [267]
    Dorfman, R. I. A. S. Dorfman Thymolytic activity of corticoids in combination with other steroids. Endocrinology 71, 271 (1962).PubMedGoogle Scholar
  302. [268]
    Dorfman, R. I. A. S. Dorfman Assay of androgens administered by inunction to the chick’s comb. Acta endocr.(Kbh.) Suppl. 74, 1 (1963).Google Scholar
  303. [269]
    Dorfman, R. I. A. S. Dorfman The assay of subcutaneously injected androgens in the castrated rat. Acta endocr. (Kbh.) 42, 245 (1963).Google Scholar
  304. [270]
    Dorfman, R. I. J. Fajkos, and J. Joska: Biological activity of various steroids including b-nor-steroids. Steroids 3, 675 (1964).Google Scholar
  305. [271]
    Dorfman, R. I., and F. A. Kincl: Steroid anti-estrogens. Steroids 1, 185 (1963).Google Scholar
  306. [272]
    Dorfman, R. I. F. A. Kincl Relative potency of 3-deoxy C19-steroids in a chick’s comb inunction assay. Steroids 3, 173 (1964).Google Scholar
  307. [273]
    Dorfman, R. I. F. A. Kincl, and H. J. Ringold: Anti-estrogen assay of neutral steroids administered by subcutaneous injection. Endocrinology 68, 17 (1961).PubMedGoogle Scholar
  308. [274]
    Dorfman, R. I. F. A. Kincl H. J. Ringold Anti-estrogen assay of neutral steroids administered by gavage. Endocrinology 68, 43 (1961).PubMedGoogle Scholar
  309. [275]
    Dorfman, R. I. A. M. Potts, and M. L. Feil: Studies on the bioassay of hormones: The use of radiosodium for the detection of small quantities of desoxycorticosterone. Endocrinology 41, 464 (1947).PubMedGoogle Scholar
  310. [276]
    Dorfman, R. I., and R. A. Shipley: Androgens: Biochemistry, physiology, and clinical significance. New York and London: Pergamon Press 1956.Google Scholar
  311. [277]
    Dorfman, R. I., and D. Stevens: Some biological properties of a perhydro-phenanthrene derivative. Endocrinology 67, 394 (1960).PubMedGoogle Scholar
  312. [278]
    Dowben, R. M.: Prolonged survival of dystrophic mice treated with norethandrolone. J. Lab. clin. Med. 54, 806 (1959).Google Scholar
  313. [279]
    Drill, Y. A.: Biological effects of some steroids with progestational activity. Fed. Proc. 18, 1040 (1959).PubMedGoogle Scholar
  314. [280]
    Drill, Y. A. Endocrine properties of norethynodrel and related steroids. J. Endocr. 24, XYII (1962).Google Scholar
  315. [281]
    Drill, Y. A. Contraceptive effect of oral progestins: Properties of compound SC-11800, a new oral inhibitor. J. Reprod. Fertil. 5, 462 (1963).Google Scholar
  316. [282]
    Drill, Y. A. Endocrine properties and long-term safety of oral contraceptives. Metabolism 14, 295 (1965).PubMedGoogle Scholar
  317. [283]
    Drill, Y. A., and B. Riegel: Structural and hormonal activity of some new steroids. Recent Progr. Hormone Res. 14, 29 (1958).Google Scholar
  318. [284]
    Duncan, W. G., St. C. Lyster, and J. A. Campbell: Effect of 7α-methylation on biological activities of norethindrone. Proc. Soc. exp. Biol. (N.Y.) 116, 800 (1964).Google Scholar
  319. [285]
    Duyvene de Wit, J. J.: Experimental morphology: Biologischer Nachweis zweier neuer Hormone durch Rhodeus amarus als Eichungsobjekt. Proc. roy. Acad. Amst. 40, 559 (1937).Google Scholar
  320. [286]
    Duyvene de Wit, J. J. Die Reaktion des weiblichen und männlichen Bitterlings auf einige reine Sexualhormone. Klin. Wschr. 17, 376 (1938).Google Scholar
  321. [287]
    Duyvene de Wit, J. J. Ein neuer Test zum qualitativen und quantitativen Nachweis des Corpus luteum-Hormons. Klin. Wschr. 17, 660 (1938).Google Scholar
  322. [288]
    Duyvene de Wit, J. J. Ovipositor lengthening of the female bitterling produced by administration of progesterone. J. Endocr. 24, 580 (1939).Google Scholar
  323. [289]
    Duyvene de Wit, J. J. A quantitative and qualitative test for steroid hormones based on the ovipositor reaction of the female bitterling (Rhodeus Amarus Bloch). J. Endocr. 2, 141 (1940).Google Scholar
  324. [290]
    Dyke, H. B. van, and I. S. Chen: The assay of progesterone by the production of an artificial pregnancy-response of the feline uterus. Endocrinology 25, 337 (1939).Google Scholar
  325. [291]
    Dziuk, P. J.: Control of oestrus and ovulation in farm animals with the aid of orally active progestins. J. Endocr. 24, XXI (1962).Google Scholar
  326. [292]
    Dziuk, P. J. Induction of ovulation in anestrous ewes. J. anim. Sei. 22, 1138 (1963).Google Scholar
  327. [293]
    Eckstein, P., J. A. H. Waterhouse, G. K. Bond, W. G. Mills, D. M. Sandilands, and D. M. Chotton: The Birmingham oral contraceptive trial. Brit. med. J. 1961 II, 1172.Google Scholar
  328. [294]
    Edgren, R. A.: Notes on impeded estrogens. Proc. Soc. exp. Biol. (N.Y.) 92, 569 (1956).Google Scholar
  329. [295]
    Edgren, R. A. Oestrogen antagonisms: The effects of testosterone propionate and 17-ethyl-19-nortestosterone on oestrone-induced changes in vaginal cytology. Acta endocr. (Kbh.) 25, 365 (1957).Google Scholar
  330. [296]
    Edgren, R. A. The uterine growth-stimulating activities of 17α-ethynyl-17-hydroxy-5(10)-estren-3-one (norethynodrel) and 17α-ethynyl-19-nortestosterone. Endocrinology 62, 689 (1958).PubMedGoogle Scholar
  331. [297]
    Edgren, R. A. Estrogen antagonisms: Inhibition of estrone-indueed uterine growth and vaginal smear effects with testosterone derivatives. Proc. Soc. exp. Biol. (N.Y.) 104, 662 (1960).Google Scholar
  332. [298]
    Edgren, R. A. Estrogen antagonisms: Effects of a series of 19-nortestosterone derivatives on vaginal changes induced by estrone. Proc. Soc. exp. Biol. (N.Y.) 105, 252 (1960).Google Scholar
  333. [299]
    Edgren, R. A. Oestrogen antagonisms: Temporal modalities in steroid block of oestrone-induced changes in vaginal smears of mice. Acta endocr. (Kbh.) 34, 536 (1960).Google Scholar
  334. [300]
    Edgren, R. A. Oestrogen antagonisms: 19-norprogesterone and 18,19-dinortestosterone as oestrone antagonists. Nature (Lond.) 190, 353 (1961).Google Scholar
  335. [301]
    Edgren, R. A. A comparative study of the anabolic and androgenic effects of various steroids. Acta endocr. (Kbh.), Suppl. 87, 3 (1963).Google Scholar
  336. [301 a]
    Edgren, R. A. Estrogen antagonisms: Relationship between estrogen antagonistic and progestational potencies of zl4–3-oxo-steroids. Proc. Soc. exp. Biol. (N.Y.) 123, 788 (1966).Google Scholar
  337. [302]
    Edgren, R. A., and D. W. Calhoun: Iso-response lines for steroid interactions: Experimental determination and implications. Anat. Ree. 128, 542 (1957).Google Scholar
  338. [303]
    Edgren, R. A. D. W. Calhoun Estrogen antagonisms: Inhibition of estrone-indueed uterine growth by test osterone propionate, progesterone and 17-ethyl-19-nortestosterone. Proc. Soc. exp. Biol. (N.Y.) 94, 537 (1957).Google Scholar
  339. [304]
    Edgren, R. A. D. W. Calhoun Estrogen antagomisms: Effects of gluco- and mineralocorticoids on estroneindueed uterine growth. Proc. Soc. exp. Biol. (N.Y.) 103, 294 (1960).Google Scholar
  340. [305]
    Edgren, R. A., D. W. Calhoun, R. L. Elton, and F. B. Colton: Estrogen antagonisms: The effects of a series of relatives of 19-nortestosterone on estrone-indueed uterine growth. Endocrinology 65, 265 (1959).PubMedGoogle Scholar
  341. [306]
    Edgren, R. A., and D. L. Carter: Failure of various steroids to block gonadotrophin-induced ovulation in rabbits. J. Endocr. 24, 525 (1962).PubMedGoogle Scholar
  342. [307]
    Edgren, R. A., and R. L. Elton: Estrogen antagonisms: Effects of several steroidal spirolactones on estrogen-induced uterine growth in mice. Proc. Soc. exp. Biol. (N.Y.) 104,664 (1960).Google Scholar
  343. [308]
    Edgren, R. A. W. E. Hambourger, and D. W. Calhoun: Production of adrenal atrophy by 6-methyl-17-acetoxy-progesterone, with remarks on the adrenal effects of other progestational agents. Endocrinology 65, 505 (1959).PubMedGoogle Scholar
  344. [308 a]
    Edgren, R. A., and W.F. Johns: Estrogenic effects of 18-norestradiol-11β and 18-norestrone. Proc. Soc. exp. Biol. (N.Y.) 105, 286 (1960).Google Scholar
  345. [309]
    Edgren, R. A. D. L. Peterson, R. C. Jones, C. L. Nagra, H. Smith, and G. A. Hughes: Biological effects of synthetic gonanes. Recent Progr. Hormone Res. 22, 305 (1966).PubMedGoogle Scholar
  346. [310]
    Edgren, R. A., and H. Smith: Wy 3475, a new potent, orally active anabolic agent. Int. Congr. Hormonal Steroids, Mailand 1962. Excerpta med. (Amst.) Int. Congr. Ser. 51, Abstr. 63, 1962.Google Scholar
  347. [311]
    Edgren, R. A. H. Smith G.A. Hughes, Ll. Smith, and G. Greenspan: Biological effects of racemic and resolved 13β-ethyl-4-gonen-3-ones. Steroids 2, 731 (1963).Google Scholar
  348. [312]
    Edgren, R. A. H. Smith D. L. Peterson, and D. L. Carter: The biological effects of a series of 13β-substituted gonanes related to norethisterone (17α-ethynyl-19-nortestosterone). Steroids 2, 319 (1963).Google Scholar
  349. [313]
    Edwards, J., and H. L. Ringold: 2-fluoro and 21,21-difluoro steroids. J. Amer. chem. Soc. 81, 5262 (1959).Google Scholar
  350. [314]
    Eguchi, Y.: Interrelationships between fetal adrenals and maternal ovaries: Atrophy of the fetal rat adrenal following ovariectomy of the mother rat. Endocrinology 71, 31 (1962).Google Scholar
  351. [315]
    Ehrenstein, M.: Acetolysis of the steroisomeric 5,6-oxides and preparation of the acetates of 4-androstene-3,17-dione-6(α)-ol and 6(α)-hydroxy-11-desoxycorticosterone. J. org. Chem. 6, 630 (1941).Google Scholar
  352. [316]
    Ehrenstein, M. Lower homologs of hormones of the pregnane series: 10-nor-ll-desoxy-eortieo-sterone acetate and 10-norprogesterone. J. org. Chem. 9, 435 (1944).Google Scholar
  353. [317]
    Ehrenstein, M. Synthesis of steroids of the progesterone series. Chem. Rev. 42, 457 (1948).PubMedGoogle Scholar
  354. [318]
    Ehrenstein, M. Investigations on steroids. X. Revision of nomenclature of previously described compounds. J. org. Chem. 13, 214 (1948).PubMedGoogle Scholar
  355. [319]
    Ehrenstein, M. G. W. Barber, and R. Hertz: Progestational activity of various steroisomers of 19-nor-progesterone. Endocrinology 60, 681 (1957).PubMedGoogle Scholar
  356. [320]
    Ehrenstein, M., and T. O. Stevens: Investigations on steroids. II. 6(α)-hydroxy-progesterone. J. org. Chem. 5, 318 (1940).Google Scholar
  357. [321]
    Ehrenstein, M. T. O. Stevens Investigations on steroids. VI. New method of preparing 6(α)-Acetoxyprogesterone. J. org. Chem. 6, 908 (1941).Google Scholar
  358. [322]
    Eichner, E.: The clinical uses of 17α-hydroxy-16α-methylprogesterone acetate (Provera) in gynecologic and obstetric practice. Int. Congr. Hormonal Steroids, Mailand 1962. Excerpta med. Int. Congr. Ser. 51, Abst. 272, p. 203, 1962.Google Scholar
  359. [323]
    Eichner, E. Control of fertility. J. Ky med. Ass. 1964, March.Google Scholar
  360. [324]
    Eisenberg, E., and G. Gordan: The levator ani muscle of the rat as an index of myotrophic activity of steroidal hormones. J. Pharmacol, exp. Ther. 99, 38 (1950).Google Scholar
  361. [325]
    Eisenstadt, H. B.: Embolism associated with norethynodrel. New Engl. J. Med. 269, 1265 (1963).Google Scholar
  362. [326]
    Elger, W.: Die Rolle der fetalen Androgene in der Sexualdifferenzierung des Kaninchens und ihre Abgrenzung gegen andere hormonale und somatische Faktoren durch Anwendung eines starken Antiandrogens. Arch. Anat. micr. Morph, exp. 55,657 (1966).Google Scholar
  363. [327]
    Elger, W., and F. Neumann: (intr. by R. A. Edgren), The role of androgens in the differentiation of the mammary gland in male mouse fetuses. Proc. Soc. exp. Biol. (N.Y.) 123, 637 (1966).Google Scholar
  364. [328]
    Elton, R. L.: Metrotropic activity of some 21-haloprogesterone derivatives. Proc. Soc. exp. Biol. (N.Y.) 101, 677 (1959).Google Scholar
  365. [329]
    Elton, R. L., and R. A. Edgren: Biological actions of 17α-(2-methallyl)-19-nortestosterone, an orally active progestational agent. Endocrinology 63, 464 (1958).PubMedGoogle Scholar
  366. [330]
    Elton, R. L. R. A. Edgren, and D. W. Calhoun: Biological activities of some 6-methylated progesterones. Proc. Soc. exp. Biol. (N.Y.) 103, 175 (1960).Google Scholar
  367. [331]
    Elton, R. L., and F. Nutting: 17-ethynyl-4-estrene-3,17-diol diacetate: a unique steroidal „Progestin“. Proc. Soc. exp. Biol. (N.Y.) 107, 991 (1961).Google Scholar
  368. [332]
    Elton, R. L. F. Nutting, and F. J. Saunders: Effects of reduction of the 3-ketone of 17α-ethynyl-19-nortestosterone on its endocrine properties. Acta endocr. (Kbh.) 41, 381 (1962).Google Scholar
  369. [333]
    Emery, F. E., and P. P. Greco: The comparative activity of desoxycorticosterone acetate and progesterone in adrenalectomized rats. Endocrinology 27, 473 (1940).Google Scholar
  370. [334]
    Emmens, C. W.: Some biological properties of anhydroxy-progesterone (ethinyl test osterone). J. Endoer. 1, 332 (1939).Google Scholar
  371. [335]
    Emmens, C. W. Precursors of estrogens. J. Endocr. 2, 444 (1941).Google Scholar
  372. [336]
    Emmens, C. W. Hormones of corpus luteum. In: C. W. Emmens, ed., Hormone assay, p. 419—441, New York: Academic Press 1950.Google Scholar
  373. [337]
    Emmens, C. W. Estrogens. In: R. I. Dorfman, Methods in hormone research, vol. II, p. 59—108. New York and London: Academic Press 1962.Google Scholar
  374. [338]
    Emmens, C. W. R. I. Cox, and L. Martin: Oestrogen inhibitors of the stilboestrol series. J. Endocr. 18, 372 (1959).PubMedGoogle Scholar
  375. [339]
    Emmens, C. W., and A. S. Parkes: Some biological properties of anhydro-hydroxyprogesterone (ethinyl testosterone). J. Endocr. 1, 332 (1939).Google Scholar
  376. [340]
    Emmens, C. W. A. S. Parkes Multiple activities of anhydro-oxy-progesterone. Nature (Lond.) 143,1064 (1939).Google Scholar
  377. [341]
    Engel, Ch. R.: The influence of substituents in position 17α of the steroid molecule on corticoid and progestational activities. Acta endocr. (Kbh.), Suppl. 51, 913 (1960).Google Scholar
  378. [342]
    Engel, Ch. R., and R. Deghenghi: Steroids and related products. XIII. The synthesis of 6α-fluoro-17α-bromoprogesterone. Canad. J. Chem. 38, 452 (1960).Google Scholar
  379. [343]
    Engel, Ch. R., and H. Jahnke: Steroids and related products. X. 17α-bromoprogesterone, a new potent gestagen. Canad. J. Biochem. 35, 1047 (1957).PubMedGoogle Scholar
  380. [344]
    Engel, Ch. R. K. F. Jennings, and G. Just: Steroids and related products. YI. The synthesis of 11-dehydro-17α-methyl-progesterone, a highly active gestogen. J. Amer. chem. Soc. 78, 6153 (1956).Google Scholar
  381. [345]
    Engel, Ch. R., and R. L. Noble: Steroids and related products. YI. The progestational activity of 17α-methyldesoxycorticosterone acetate. J. Endocr. 14, 16 (1956).PubMedGoogle Scholar
  382. [346]
    Engel, Ch. R. R. L. Noble Concerning the progestational activity of 21-halogenated progesterones. Endocrinology 61, 318 (1957).PubMedGoogle Scholar
  383. [347]
    Engle, E. T.: The effect of daily transplants of the anterior lobe from gonadectomized rats on immature test animals. Amer. J. Physiol. 88, 101 (1929).Google Scholar
  384. [348]
    Epstein, J. A., H. S. Kupperman, and A. Cutler: Comparative pharmacological and clinical activity of 19-nortestosterone and 17-hydroxyprogesterone derivatives in man. Ann. N.Y. Acad. Sei. 71, 560 (1958).Google Scholar
  385. [348a]
    Eppstein, S. H., P. D. Meister, D. H. Peterson, H. C. Murray, H. M. Leigh Osborn, A. Weintraub, L. M. Reineke, and R. C. Meeks: Tertiary hydroxylation of steroids by fungi of the order Mucorales. J. Amer. chem. Soc. 80, 3382 (1958).Google Scholar
  386. [349]
    Ercoli, A., G. Bruni, G. Falconi, F. Galletti, and R. Gardi: Biological effectivnesse of enol ethers of A 4–3-ketosteroidal hormones and their paradoxical dependency on administration route. Acta endocr. (Kbh.), Suppl. 51, 857 (1960).Google Scholar
  387. [350]
    Ercoli, A. G. Bruni G. Falconi R. Gardi, and A. Meli: Biological activities of some steroid ethers: Methyl-testosterone enol ethers. Endocrinology 67, 521 (1960).PubMedGoogle Scholar
  388. [351]
    Ercoli, A., and R. Gardi: Δ 4-3-keto steroidal enol ethers. Paradoxial dependency of their effectiveness on the administration route. J. Amer. chem. Soc. 82, 746 (1960).Google Scholar
  389. [352]
    Ericsson, R. J., and R. H. Dutt: Progesterone and 6α-methyl-17α-hydroxyprogeste-rone acetate as inhibitors of spermatogenesis and accessory gland function in the ram. Endocrinology 77, 203 (1965).Google Scholar
  390. [353]
    Euw, J. v., u. T. Reichstein: Über Bestandteile der Nebennierenrinde und verwandte Stoffe. 51. Mitt. 11β-Oxyprogesteron. Helv. chim. Acta 24, 879 (1941).Google Scholar
  391. [354]
    Euw, J. v. T. Reichstein Über Gallensäuren und verwandte Stoffe. Herstellung von Au-ungesättigten Steroiden mit Hilfe von Sulfoestern. Helv. chim. Acta 29, 655 (1946).Google Scholar
  392. [354a]
    Evans, R. M., G. F. H. Green, J. S. Hunt, A. G. Long, B. Mooney, and G. H. Phillipps: Preparation of Cortisol acetate and 21-acetoxy-17α-hydroxypregna-4: 9-diene-3: 20-dione from 5α-steroids. J. chem. Soc. 1958 II, 1529.Google Scholar
  393. [355]
    Everett, J.: The influence of oestriol and progesterone on the endometrium of the guinea-pig in vitro. J. Endocr. 24, 491 (1962).PubMedGoogle Scholar
  394. [356]
    Everett, J. Action of oestrogens and progesterone on uterine epithelial mitosis in organ culture. Nature (Lond.) 198, 896 (1963).Google Scholar
  395. [357]
    Everett, J. W.: Hormonal factors responsible for deposition of cholesterol in the corpus luteum of the rat. Endocrinology 41, 364 (1947).PubMedGoogle Scholar
  396. [358]
    Everse, J. W. R., and P. de Fremery: On a method of measuring fatigue in rats and its application for testing the suprarenal cortical hormone (Cortin). Acta neerl. Physiol. 2, 152 (1932).Google Scholar
  397. [359]
    Everse, J. W. R. P. de Fremery Eine Methode, um die Ermüdung von Ratten zu messen und ihre Anwendung zum Nachweis von NNR-Hormonen. Ned. T. Geneesk. 77, 600 (1933).Google Scholar
  398. [360]
    Eversole, W. I.: The effects of pregneninolone and related steroids on sexual development in fish (Lebistes reticulatus). Endocrinology 28, 603 (1941).Google Scholar
  399. [361]
    Falcone, G., and G. Bruni: Studies on steroidal enol ethers: Antigonadotrophic activity of cyclopentyl derivatives of some orally active progestins. J. Endocr. 25, 169 (1962).Google Scholar
  400. [362]
    Falcone, G., and A. Ercoli: Effect of enol etherification on antiestrual and contraceptive activity of some progestins in rats. Proc. Soc. exp. Biol. (N.Y.) 108, 3 (1961).Google Scholar
  401. [363]
    Falcone, G. R. Gardi, G. Brijni, and A. Ercoli: Studies on steroidal enol ethers: An attempt to dissociate progestational from contraceptive activity in oral gestagens. Endocrinology 69, 638 (1961).Google Scholar
  402. [364]
    Panard, A. E. G., et A. Chilain: Étude clinique comparative de la méthyloestrénolone et de la progestérone administrées par voia parentérale. Bull. Soc. roy. belge Gynéc. Obstét. 26, 709 (1956).Google Scholar
  403. [365]
    Färber, E., and A. Segaloff: Effect of androgens and growth and other hormones on ethionine fatty liver in rats. J. biol. Chem. 216, 471 (1955).PubMedGoogle Scholar
  404. [366]
    Farnworth, W. E., and J. R. Brown: Androgen on prostate biosynthetic reactions. Endocrinology 68, 978 (1961).Google Scholar
  405. [367]
    Feo, Y. J. de: Temporal aspect of uterine sensitivity in the pseudopregnant or pregnant rat. Endocrinology 72, 305 (1963).Google Scholar
  406. [368]
    Ferin, J.: A new substance with progestational activity. Comparative assays in ovariectomized women. Clinical results. Acta endocr. (Kbh.) 22, 303 (1956).Google Scholar
  407. [369]
    Ferin, J. Découverte d’un stéroide progestogène très actif chez la femme. Ann. Endocr. (Paris) 17, 261 (1956).Google Scholar
  408. [370]
    Ferin, J. Progestational activity of certain 19-nor steroids. Comparative assays in oophorectomized women. J. clin. Endocr. 17, 1252 (1957).PubMedGoogle Scholar
  409. [371]
    Ferin, J. Vergleichende Wirksamkeit der neuen Gestagene bei der ovariektomierten Frau. In: H. Nowakowski, Hrsg., Moderne Entwicklungen auf dem Gestagengebiet. 6. Symp. Dtsch. Ges. Endokrinologie, Kiel 1959, 2, 32—39, Berlin-Göttingen- Heidelberg: Springer 1960.Google Scholar
  410. [372]
    Ferin, J. Hypoestrogenic amenorrhoa and/or sterility induced by lynestrenol. Int. J. Fertil. 9, 29 (1964).PubMedGoogle Scholar
  411. [373]
    Fernholz, E.: Zur Synthese des Corpus-luteum-Hormons. Ber. dtsch. chem. Ges. 67, 1855 (1934).Google Scholar
  412. [374]
    Fernholz, E. Die Darstellung des Corpus-luteum-Hormons aus Stigmasterin. Ber. dtsch. chem. Ges. 67, 2027 (1934).Google Scholar
  413. [375]
    Fernholz, E., u. P. N. Chakravorty: Die Isolierung von Androstanon aus den neutralen Oxydationsprodukten von Cholestan. Ber. dtsch. chem. Ges. 68, 353 (1935).Google Scholar
  414. [376]
    Fevold, H.: Functional synergism of the follicle stimulating and luteinizing hormones of the pituitary. Anat. Ree. 73, Suppl. 2, 19 (1939).Google Scholar
  415. [377]
    Fichera, G.: Sur l’hypertrophie de la glande pituitaire consécutive à la castration. Arch. ital. Biol. (Pisa) 43, 405 (1905).Google Scholar
  416. [378]
    Field-Richards, S., and L. Snaith: Allylestrenol: A new oral progestogen. Lancet 1961 I, 134.Google Scholar
  417. [379]
    Fieser, L. F., and M. Fieser: Steroids — Chapter 1 —22. New York: Reinhold Publ. Corporation; London: Chapman & Hall Ltd. 1959.Google Scholar
  418. [380]
    Figge, D. C.: The endocrine stimulation of in vitro endometrium. Acta cytol. (Philad.) 7, 245 (1963).Google Scholar
  419. [381]
    Figueroa, S., and A. Lipschütz: The comparative antiluteinizing potency of progesterone derivatives with oxidation at C-11, C-21 and C-17. Endocrinology 61, 657 (1957).PubMedGoogle Scholar
  420. [382]
    Fischer, A.: La spécificité des hormones sexuelles. Rev. franç. Endocr. 16, 1 (1938).Google Scholar
  421. [383]
    Fischer, A., et M. Engel: Progestérone et hormone corticosurrénale. Rev. franç. Endocr. 16, 400 (1938).Google Scholar
  422. [384]
    Fleischmann, W., u. S. Kann: Zur Frage der Spezifität des Legeröhrentestes für Follikelhormon. Klin. Wschr. 14, 644 (1935).Google Scholar
  423. [385]
    Folch Pi, F., A. Oriol, L. H. Lasso, M. Maqueo, R. I. Dorfman, and F. A. Kincl: Inhibition of fertility in mice by steroid implants. Acta endocr. (Kbh.) 48, 602 (1965).Google Scholar
  424. [386]
    Forbes, T. R.: Bioassay of progestins. In: A.C. Barnes, Guest ed.,,Brook Lodge Symp., Progesterone‘, p. 71—76, Kalamazoo/Mich. 1961. Augusta/Mich.: Brook Lodge Press 1961.Google Scholar
  425. [387]
    Forbes, Th. R.: Antagonisms and synergisms in progestin: Progestin mixtures. Endo crinology 75, 799 (1964).Google Scholar
  426. [388]
    Foss, G. L.: Clinical experience with norethisterone and norethisterone-acetate. Brit. med. J. 1960, No 5207, 1187.Google Scholar
  427. [389]
    Fraenkel, L.: Versuche über den Einfluß der Ovarien auf die Insertion des Eies. Verh. dtsch. Ges. Gynäk. 1901, 571.Google Scholar
  428. [390]
    Fraenkel, L. Zur Funktion des corpus luteum. Arch. Gynäk. 68, 438 (1902).Google Scholar
  429. [391]
    Fraenkel, L.: Weitere Mitteilungen über die Funktion des corpus luteum. Zbl. Gynäk. 1904, 28.Google Scholar
  430. [392]
    Fraenkel, L. Über innere Sekretion des Ovarium. Z. Geburtsh. Gynäk. 64, 426 (1909).Google Scholar
  431. [393]
    Fraenkel, L. Neue Experimente zur Funktion des corpus luteum. Arch. Gynäk. 91, 705 (1910).Google Scholar
  432. [394]
    Fraenkel, L., and F. Cohn: Experimentelle Untersuchungen über den Einfluß des corpus luteum auf die Insertion des Eies. Anat. Anz. 20, 294 (1901).Google Scholar
  433. [395]
    France, E. S., and G. Pincus: Biologically active substances affecting gonadotrophin-induced ovulation in immature rats. Endocrinology 75, 359 (1964).PubMedGoogle Scholar
  434. [396]
    Frank, R. T., and H. Sobotka: Biological assay of pregnandiol. Proc. Soc. exp. Biol. (N.Y.) 29, 1026 (1932).Google Scholar
  435. [397]
    Franklin, J. B., A. F. Goldfarb, R. M. Matsumoto, and R. L. Brent. Modification by progestational compounds of the teratogenic effect of uterine vascular clamping. Fertil. and Steril. 14, 365 (1963).Google Scholar
  436. [398]
    Fraps, R. M., and A. Dury: Occurrence of premature ovulation in the domestic fowl following administration of progesterone. Proc. Soc. exp. Biol. (N.Y.) 52, 346 (1943).Google Scholar
  437. [399]
    Frazer, J. F. D.: The effect of spaying in the pregnant rat. J. Physiol. 124, 36 P (1954).PubMedGoogle Scholar
  438. [400]
    Freeman, J. J., R. Hilf, A. J. Iovtno, and I. Michel: Effects of steroids upon the weight, protein and nucleic acid concentration of the preputial glands of the female rat. Endocrinology 74, 990 (1964).PubMedGoogle Scholar
  439. [401]
    Fremery, P. de, S. Kober, and M. Tausk: Inhibition of oestrogenic effect of the follicular hormone by progestin. Acta brev. neerl. Physiol. 5, 119 (1934).Google Scholar
  440. [402]
    Fremery, P. de and R. W. Spanhoff: The comparative activity of desoxyeorticosterone acetate by various routes in the rat, and its progestational effect in the young rabbit. Acta brev. neerl. Physiol. 9, 79 (1939).Google Scholar
  441. [403]
    Fried, J.: Structure-activity relationships in the field of halogenated steroids. Cancer (Philad.) 10, 752 (1957).Google Scholar
  442. [403a]
    Fried, J. H., T. S. Bry, A. E. Oberster, R. E. Beyler, T. B. Windholz, J. Hannah, L. H. Sarett, and S. L. Steelman: Novel gonadotrophs inhibitors in the 19-nor- steroid series. J. Amer. chem. Soc. 83, 4663 (1961).Google Scholar
  443. [403b]
    Fried, J. H., K. Florey, E. F. Sabo, J. E. Herz, A. R. Restivo, A. Borman, and F. M. Singer: Synthesis and biological activity of 1- and 6-dehydro-9α-halocortieoids. J. Amer. chem. Soc. 77, 4180 (1955).Google Scholar
  444. [404]
    Fried, J. H., M. A. Guiducci, P. A. Diassi, E. F. Sabo, I. Bacso, and P. Grabowich: Cyclic ketals and sulphites of 6-substituted 16α-,17α-dihydroxyprogesterone. Chem. a. Ind. (Lond.) 15, 466 (1961).Google Scholar
  445. [405]
    Fried, J. H., J. E. Herz, E. F. Sabo, A. Borman, F. M. Singer, and P. Numerof: 9α-halo-llß- hydroxy and 11-keto derivatives of progesterone, desoxycortieosterone and 17α- hydroxyprogesterone. J. Amer. chem. Soc. 77, 1068 (1955).Google Scholar
  446. [406]
    Fried, J. H., W. B. Kessler, and A. Borman: Some biological activities of certain progestogens: II. 9- and 12-halo-11-oxygenated progesterones. Ann. N.Y. Acad. Sei. 71, 494 (1958).Google Scholar
  447. [406a]
    Fried, J. H., and E. F. Sabo: Synthesis of 17α-hydroxyeortieosterone and its 9α-halo derivatives from 11-epi-17α-hydrocorticosterone. J. Amer. chem. Soc. 75, 2273 (1953).Google Scholar
  448. [406b]
    Fried, J. H., and E. F. Sabo: 9α-fluoro derivatives of cortisone and hydrocortisone. J. Amer. ehem. Soc. 76, 1455 (1954).Google Scholar
  449. [406c]
    Fried, J. H., and E. F. Sabo: 9α-halogen derivatives of cortisone and hydrocortisone. J. Amer. chem. Soc. 79, 1130 (1957).Google Scholar
  450. [407]
    Fried, J. H., E. F. Sabo, P. Grabowich, L. J. Lerner, W. B. Kessler, D. M. Brennan, and A. Borman: Progestational active acetals and ketals of 16α,17α-dihydroxypro- gesterone. Chem. a. Ind. (Lond.) 15, 465 (1961).Google Scholar
  451. [408]
    Fried, J. H., E. F. Sabo, and L. J. Lerner: Stereochemistry and progestational activity of unsymmetri- cally substituted 16α,17α-methylene-dioxyprogesterones. Int. Congr. Hormonal Steroids, Mailand 1962. Excerpta med. Int. Congr. Ser. 51, Abstr. 46, 1962.Google Scholar
  452. [409]
    Frieden, E. H., E. H. Cohen, and A. A. Harper: The effects of steroid hormones upon amino acid incorporation into mouse kidney homogenates. Endocrinology 68, 862 (1961).PubMedGoogle Scholar
  453. [410]
    Friedman, M. H.: On the mechanism of ovulation in the rabbit. VI- Quantitative observations on the action of extracts of urine of pregnancy. J. Pharmacol, exp. Ther. 45, 7 (1932).Google Scholar
  454. [411]
    Friedman, M. H.: The assay of gonadotropic extracts in the postpartum rabbit. Endocrinology 24, 617 (1939).Google Scholar
  455. [412]
    Froewis, I., H. Leeb u. R. Ulm: Die Therapie der funktionellen Blutung mit den neuen Gestagenen. Wien. klin. Wschr. 72, 881 (1960).Google Scholar
  456. [413]
    Fuchs, F., and A.-R. Fuchs: Induction and inhibition of labour in the rabbit. Acta endocr. (Kbh.) 29, 615 (1958).Google Scholar
  457. [414]
    Fuchs, F., and F. Koch: Inhibition of oxytocin-induced labour in rabbits with various gestagens. Acta endocr. (Kbh.) 42, 403 (1963).Google Scholar
  458. [415]
    Fuenzalida, F.: Absorption of steroids from subcutaneously implanted tablets of the pure hormone and of the hormone mixed with cholesterol. J. elin. Endocr. 10, 1511 (1950).Google Scholar
  459. [416]
    Fuenzalida, F., and A. Llpschutz: Absorption of eorticoids and related steroids from subcutaneously implanted pellets in the guinea pig. J. clin. Endocr. 13, 1201 (1953).PubMedGoogle Scholar
  460. [417]
    Fujii, K.: Effectiveness of various luteoid substances on the maintenance of pregnancy. 3rd World Congr. Fertil. and Steril, Amsterdam 1959, Excerpta med. Foundation Amsterdam-New York, Abstr. F S. E 67, p. 66, 1959.Google Scholar
  461. [418]
    Fujii, K.: Maintenance of pregnancy by progestins. Lit. J. Fertil. 6, 15 (1961).Google Scholar
  462. [418a]
    Fukushima, D. K, and Sh. Dobriner: Partial synthesis of 19-norandrosterone. J. org. Chem. 26, 3022 (1961).Google Scholar
  463. [418b]
    Fukushima, D. K, Sh. Dobriner, M. S. Heffler, T. H. Kritchevsky, F. Herling, and G. Roberts: The D-homo-annulation of 17α-hydroxy-20-ketosteroids. J. Amer. chem. Soc. 77, 6585 (1955).Google Scholar
  464. [419]
    Fuse, K.: Histological studies on mammary glands in an experimental hypersteroid hormone milieu. Hirosaki med. J. 13, 517 (1961).Google Scholar
  465. [420]
    Fussgänger, R.: Ein Beitrag zum Wirkungsmechanismus des männlichen Sexual hormons. Med. u. Chem. 2, 194 (1934).Google Scholar
  466. [421]
    Gallagher, T. F., and F. C. Koch: The quantitative assay for the testicular hormone by the comb-growth reaction. Second communication. J. Pharmacol, exp. Ther. 55, 97 (1935).Google Scholar
  467. [422]
    Gans, E.: The FSH content of serum of intact and of gonadectomized rats and of rats treated with sex hormones. Acta endocr. (Kbh.) 32, 362 (1959).Google Scholar
  468. [423]
    Gans, E., and S. Jong, de: Factors determining the sex differences in pituitary and serum FSH-contents after gonadectomy. Acta endocr. (Kbh.) 43, 323 (1963).Google Scholar
  469. [424]
    Gans, E., and G. P. van Rees: A sensitive and specific assay for follicle stimulating hormone (FSH): Testicular growth in hypophysectomized immature rats treated concomitantly with human chorionic gonadotropin (HCG). Acta endocr. (Kbh.) 106, 116 (1965).Google Scholar
  470. [425]
    Garcia, C. R., G. Pincus, and J. Rock: Effects of three 19-norsteroids on human ovulation and menstruation. Amer. J. Obstet. Gynee. 75, 82 (1958).Google Scholar
  471. [426]
    Gardi, R., and R. Gandolfi: Synthesis of 16α-hydroxy testosterone and 16α-hydro- cyandrostene-3,17-dione. Gazz. chim. ital. 91, 1258 (1961).Google Scholar
  472. [426a]
    Gardi, R., C. Pedrali e A. Ercoli: Su l’aromatizzazione dei 3-cheto-19-norsteroidi disosti- tuiti nelle posizioni 5 e 10 e degli analoghi 10-ossi-⊿4-derivati. Gazz. chim. ital. 93, 1503 (1963).Google Scholar
  473. [426b]
    Gardi, R., R. Vitali, and A. Ercoli: Corticosteroid 17α-monoesters from 17α,21-cyclic orthoesters. Tetrahedron Let. 13, 448 (1961).Google Scholar
  474. [426c]
    Gardi, R., R. Vitali, and A. Ercoli: Derivati di condensazione nella catena laterale di corticosteroid!. — Nota III. Preparazione e reazioni dei 17-monoesteri. Gazz. chim. ital. 93, 431 (1963).Google Scholar
  475. [427]
    Gardner, J. N., O. Gnoj, A. S. Watnick, and J. Gibson: New contraceptive agents with high activity in rats. Steroids 4, 801 (1964).Google Scholar
  476. [428]
    Gardner, W. U., and R. T. Hill: Effect of progestin upon the mammary glands of the mouse. Proc. Soc. exp. Biol. (N.Y.) 34, 718 (1934).Google Scholar
  477. [429]
    Gasche, P., u. W. Schuler: Zur Wirkung von Pregnenolon [⊿5-pregnen-ol-(3ß)-on- (20)] und Testosteronpropionat (Perandren) auf Rattenorgane. Helv. physiol. Pharmacol. Acta 4 C 11 (1946).PubMedGoogle Scholar
  478. [430]
    Gaunt, R., and H. H. Hays: The life-maintaining effect of crystalline progesterone in adrenalectomized ferrets. Science 88, 576 (1938).PubMedGoogle Scholar
  479. [431]
    Gaunt, R., W. O. Nelson, and E. Loomis: Cortical hormone-like action of progesterone and non-effect of sex hormones on “water intoxication”. Proc. Soc. exp. Biol. (N.Y.) 39, 319 (1938).Google Scholar
  480. [432]
    Gebhard, J., R. Itterheim u. R. Kiesewetter: Zur Pharmakologie des 4-Chlor-testosteronacetat. Endokrinologie 42, 160 (1962).PubMedGoogle Scholar
  481. [433]
    Gellhorn, A., J. Holland, J. B. Herrmann, J. Moss, and A. Smelin: An evaluation of stanolone in treatment of advanced mammary cancer. J. Amer. med. Ass. 154, 1274 (1954).Google Scholar
  482. [434]
    Gerbrandy, J., and H. B. A. Hellendoorn: The diagnostic value of caleiuria during hormonal treatment of metastasized mammary carcinoma. Acta endocr. (Kbh.) 31, 275 (1957).Google Scholar
  483. [435]
    Ghione, M.: Anti-infective action of an anabolic steroid. Proc. Soc. exp. Biol. (N.Y.) 97, 773 (1958).Google Scholar
  484. [436]
    Gimeno, A. L., M. Gimeno, and J. L. Webb: Sex hormone studies: The effects on the cellular membrane potentials and contractility of isolated rat atrium. Calif. Med. 98, 67 (1963).PubMedGoogle Scholar
  485. [437]
    Gjørup, S., and J. H. Thaysen: Anabolic steroids in treatment of uraemia. Lancet 1958 II, 886.Google Scholar
  486. [438]
    Glaser, E., u. O. Haempel: Das experimentell hervorgerufene Hochzeitskleid des kastrierten Fisches als Stigma einer Test- und Standardisierungsmethode des männlichen Sexualhormons. Pflügers Arch. ges. Physiol. 229, 1 (1931).Google Scholar
  487. [439]
    Glaser, E., u. O. Haempel: Unser Fischtest als Standardisierungsmethode des männlichen Sexualhormons. Endocrinology 11, 81 (1932).Google Scholar
  488. [440]
    Glaser, E., u. O. Haempel: Der Nachweis des männlichen Sexualhormons mit dem Fischtest. Dtsch. med. Wsehr. 58, 1247 (1932).Google Scholar
  489. [441]
    Glaser, E., u. O. Haempel: Testierung von männlichem Sexualhormon mit Fischen. Klin. Wsehr. 38, 1491 (1933).Google Scholar
  490. [442]
    Glaser, E., u. O. Haempel: Lassen sich durch die Ausscheidung von Corpus luteum-Hormon im Harne die Thesen von Knaus-Ogino von der periodischen Fruchtbarkeit bzw. Unfruchtbarkeit des Weibes bestätigen? Klin. Wsehr. 13, 1711 (1934).Google Scholar
  491. [443]
    Glaser, E., u. O. Haempel: Zur Frage der biologischen Grundlagen der periodischen Frucht- bzw. Unfruchtbarkeit der Frau. Zbl. Gynäk. 60, 702 (1936).Google Scholar
  492. [444]
    Glaser, E., u. O. Haempel: Über Hormonbefunde bei einer virilisierenden Ovarialgesehwulst. Klin. Wsehr. 16, 858 (1937).Google Scholar
  493. [444a]
    Glazier, E. R.: Bromination with cupric bromide. II. Bromination in the presence of an olefinie bond. J. org. Chem. 27, 4397 (1962).Google Scholar
  494. [445]
    Gleason, C. H., and J. Parker: The duration of activity of the benziloyl hydrazones of testosterone-17-heptanoate, estrone-3-heptanoate and 17α-hydroxy-progesterone- 17-heptanoate. Endocrinology 65, 508 (1959).PubMedGoogle Scholar
  495. [446]
    Glenister, T. W., and W. J. Hamilton: The embryology of sexual differentiation in relation to the possible effects of administering steroid hormones during pregnancy. J. Obstet. Gynaec. Brit. Cwlth 70, 13 (1963).Google Scholar
  496. [447]
    Glenn, E. M., S. L. Richardson, and B. J. Bowman: Biologic activity of 6a-methyl compounds corresponding to progesterone, 17α-hydroxyprogesterone acetate and compound S. Metabolism 8, 265 (1959).PubMedGoogle Scholar
  497. [448]
    Glenn, E. M., S. L. Richardson, and B. J. Bowman: A method of assay of antitumor activity using a rat mammary fibroadenoma. Endocrinology 64, 379 (1959).PubMedGoogle Scholar
  498. [449]
    Glenn, E. M., S. L. Richardson, S. C. Lyster, and B. J. Bowman: Inhibition of mammary fibroadenoma of female rats by steroids of the androstane series. Endocrinology 64, 390 (1959).PubMedGoogle Scholar
  499. [450]
    Goisis, M., e G. Candotti: Considerazioni sul test della carbonicoanidrasi endometriale nella donna. Minerva ginec. 11, 710 (1959).PubMedGoogle Scholar
  500. [451]
    Goisis, M., e G. Candotti and L. Mosca: Histological effects on pituitary and ovaries of long treatment with the cyclopentyl enol ether of 17α-acetoxyprogesterone in the monkey. Quart. J. exp. Physiol. 47, 299 (1962).Google Scholar
  501. [452]
    Gold, J. J., L. Smith, A. Scommegna, and S. Borushek: The efficacy of pro vest in inhibiting ovulation. Int. J. Fertil. 8, 725 (1963).PubMedGoogle Scholar
  502. [453]
    Goldberg, W. M.: Embolism associated with norethynodrel. New Engl. J. Med. 269, 1265 (1963).Google Scholar
  503. [454]
    Goldberg, M. W., u. R. Monnier: Herstellung des d-Homodihydro-testosterons. Helv. chim. Acta 23, 840 (1940).Google Scholar
  504. [455]
    Goldberg, M. W., u. E. Wydler: Über d-Homo-androstan-Derivate, eine Gruppe stark wirksamer Androgene. Helv. chim. Acta 26, 1142 (1943).Google Scholar
  505. [456]
    Goldman, J. N., J. A. Epstein, and H. S. Kupperman: A comparison of the pituitary-inhibiting, anabolic and androgenic effects of norethandrolone in the parabiotic rat. Endocrinology 61, 166 (1957).PubMedGoogle Scholar
  506. [457]
    Goldschmidt, R.: Die sexuellen Zwischenstufen. Jena u. Berlin: Gustav Fischer 1931.Google Scholar
  507. [458]
    Goldzieher, J. W.: Lack of androgenicity of 17-hydroxy-progesterone or its 17-capro-ate esters. J. clin. Endocr. 17, 323 (1957).PubMedGoogle Scholar
  508. [459]
    Goldzieher, J. W.: Newer drugs in oral conception. Med. Clin. N. Amer. 48, 529 (1964).PubMedGoogle Scholar
  509. [460]
    Goldzieher, J. W., N. B. Livingston jr., J. Martinez Manautou, and L. E. Moses: The use of sequential estrogen and progestin to inhibit fertility. Proc. seventh Conf. Int. Planned Parenthood Fed., Singapore 1963. Excerpta med. (Amst.) Int. Congr. Ser. 72, 325 (1964).Google Scholar
  510. [461]
    Goldzieher, J. W., C. Becerra, C. Guall, N. B. Livingston, M. Maqueo, L. E. Moses u. C. Tietze: Ein neues orales Antikonzipiens: Die Zweiphasenbehandlung mit Oestrogen und Gestagen. Fortschr. Med. 83, 161 (1965).Google Scholar
  511. [462]
    Goldzieher, J. W., L. E. Moses, and L. T. Ellis: Study on norethindrone in contraception. J. Amer. med. Ass. 180, 359 (1962).Google Scholar
  512. [463]
    Goldzieher, J. W., L. E. Moses, and L. T. Ellis: A field trial with a physiological method of conception control in research on family planning, C. V. Kiser, ed. Princeton: University Press 1962.Google Scholar
  513. [464]
    Goldzieher, J. W., W. F. Peterson, and R.A. Gilbert: Comparison of the endometrial activities in man of anhydrohydroxyprogesterone and 17-aeetoxyproge- sterone, a new oral progestational compound. Ann. N.Y. Acad. Sci. 71, 722 (1958.)PubMedGoogle Scholar
  514. [465]
    Goldzieher, J. W., E. Rice-Wray, M. Schulz-Contreras, and A. Aranda-Rosell: Fertility following termination of contraception with norethindrone. Amer. J. Obstet. Gynec. 84, 1474 (1962).Google Scholar
  515. [466]
    Goodfried, T. L., and N. O. Kaplan: Effects of hormone administration on lactic dehydrogenase. J. biol. Chem. 239, 130 (1964).Google Scholar
  516. [467]
    Gordan, G. S.: Androgen therapy. J. Amer. med. Ass. 162, 600 (1956).Google Scholar
  517. [468]
    Gordan, G. S.: Experimental basis for anabolic therapy. Arch, intern. Med. 100, 744 (1957).Google Scholar
  518. [469]
    Gordan, G. S., E. Eisenberg, H. D. Moon, and W. Sakamoto: Methylandrostenediol: A protein-anabolic steroid with little androgenic activity. J. clin. Endocr. 11, 209 (1951).PubMedGoogle Scholar
  519. [470]
    Goswami, A., A. B. Kar, and S. R. Chowdhury: Uterine lipid metabolism in mice during the oestrous cycle: Effect of ovariectomy and replacement therapy. J. Reprod. Fertil. 6, 287 (1963).PubMedGoogle Scholar
  520. [471]
    Gould, J.: Control of ovulation with provest. Int. J. Fertil. 8, 737 (1963).PubMedGoogle Scholar
  521. [472a]
    Graber, R. P., and M. B. Meyers: 6,16α-dimethylprogesterones. Chem. and Ind. 1960 II, 1478.Google Scholar
  522. [471b]
    Graber, R. P., and M. B. Meyers: 17α-acetoxy-6,16α-dimethyl-progesterones. J. org. Chem. 26, 4774 (1961).Google Scholar
  523. [472]
    Greenblatt, R. B.: Testosterone propionate pellet implantation in gynecic disorders. J. Amer. med. Ass. 121, 17 (1943).Google Scholar
  524. [473]
    Greenblatt, R. B.: Sublingual absorption of progesterone and anhydrohydroxyprogesterone. J. clin. Endocr. 4, 156 (1944).Google Scholar
  525. [474]
    Greenblatt, R. B.: Perlingual absorption of progesterone and anhydrohydroxyprogesterone. J. clin. Endocr. 4, 321 (1944).Google Scholar
  526. [475]
    Greenblatt, R. B.: The progestational activity of 17α-ethinyl-19-nortestosterone. J. clin. Endocr. 16, 869 (1956).PubMedGoogle Scholar
  527. [476]
    Greenblatt, R. B.: A new clinical test for the efficacy of progesterone compounds. Amer. J. Obstet. Gynec. 76, 626 (1958).PubMedGoogle Scholar
  528. [477]
    Greenblatt, R. B.: Comparative studies with oral progesterone and 6-dehydro-retroprogesterone. Int. Congr. Hormonal Steroids, Mailand 1962. Exerpta med. (Amst.) Int. Congr. Ser. 51, Abstr. 274, p. 204, 1962.Google Scholar
  529. [478]
    Greenblatt, R. B., and W. E. Bariteld: The progestational activity of 6-methyl-17-acetoxypro- gesterone. Sth. med. J. (Bgham., Ala.) 52, 345 (1959).Google Scholar
  530. [479]
    Greenblatt, R. B., E. C. Jungok, and W. E. Bariteld: A new test for efficacy of progestational compounds. Ann. N.Y. Acad. Sci. 71, 717 (1958).PubMedGoogle Scholar
  531. [480]
    Greenblatt, R. B., E. C. Jungok, J. T. Bigger, and M. Y. Greer: Progestational activity of a new acetoxy-progesterone derivative (6α-methyl-6-dehydro-17α-acetoxyprogesterone). Fertil. and Steril. 14, 393 (1963).Google Scholar
  532. [480a]
    Greenblatt, R. B., E. C. Jungok, R. A. Puebla, and M.C. Ward: A new progestogen: The 18-homologue of norethisterone. Clin. Pharmacol. Ther. 7, 490 (1966).Google Scholar
  533. [481]
    Greene, R. R., and M. W. Burrill: Maintenance of gestation in the castrate pregnant rat with androgens. Proc. Soc. exp. Biol. (N.Y.) 42, 585 (1938).Google Scholar
  534. [482]
    Greene, R. R., J. A. Wells, and A. C. Ivy: Progesterone will maintain adrenalectomized rats. Proc. Soc. exp. Biol. (N.Y.) 40, 83 (1939).Google Scholar
  535. [483]
    Greenspan, F. S., C.H. Li, and H.M. Evans: Disappearance rate of adrenocorticotropic hormone from rat’s plasma after intravenous injection. Endocrinology 46, 261 (1950).PubMedGoogle Scholar
  536. [484]
    Greenwald, G. S.: Formation of deciduomata in the lactating mouse. J. Endocr. 17, 24 (1958).PubMedGoogle Scholar
  537. [485]
    Greenwald, G. S.: Mechanism by which norethynodrel and ethynyloestradiol inhibit ovulation in the hamster. Acta endocr. (Kbh.) 47, 10 (1964).Google Scholar
  538. [486]
    Greenwood, A. W., J. S. S. Blyth, and R. K. Callow: Quantitative studies on the response of the capon’s comb to androsterone. Biochem. J. 29, 1400 (1935).PubMedGoogle Scholar
  539. [487]
    Greep, R. O., and F. L. Hisaw: Pseudopregnancies from electrical stimulation of the cervix in the diestrum. Proc. Soc. exp. Biol. (N.Y.) 39, 359 (1938).Google Scholar
  540. [488]
    Greep, R. O., and J. Ch. Jones: Steroid control of pituitary function. Recent Progr. Hormone Res. 5, 197 (1950).Google Scholar
  541. [489]
    Groot, B. de, and J. J. Duyvené de Wit: On the artificial induction of ovipositor growth in the bitterling (Rhodeus Amarus Bl.) I. Seasonal variations in the response of the ovipositor to progesterone. Acta endocr. (Kbh.) 3, 251 (1949).Google Scholar
  542. [490]
    Groot, B. de, and J. J. Duyvené de Wit: On the artificial induction of ovipositor growth in the bitterling (Rhodeus Amarus Bl). II. Ovipositor growth caused by different chemical and physical agents. Acta endocr. (Kbh.) 3, 266 (1949).Google Scholar
  543. [491]
    Groot, B. de, and J. J. Duyvené de Wit: III. The relation between artificially induced ovipositor growth and the adaptation syndrome of Selye. Acta endocr. (Kbh.) 3, 289 (1949).Google Scholar
  544. [492]
    Gros, G., J. Benoit, R. Kehl, et R. Paris: L’action androgénique de la progestérone chez le chat maie castré. C. R. Soc. Biol. (Paris) 180, 535 (1942).Google Scholar
  545. [493]
    Groves, T. W.: Controlled oestrus and ovulation in pigs. Vet. Ree. 77, 326 (1965).Google Scholar
  546. [494]
    Grumbach, M. M., J. R. Ducharme, and R. E. Moloshok: On the fetal masculinizing action of certain oral progestins. J. clin. Endoer. 19, 1369 (1959).Google Scholar
  547. [494a]
    Guillemin, R., and B. Rosenberg: Humoral hypothalamic control of anterior pituitary: A study with combined tissue cultures. Endocrinology 57, 599 (1955).PubMedGoogle Scholar
  548. [494b]
    Gut, M.: Zur Synthese von radioaktivem Progesteron. Helv. ehim. Acta 36, 906 (1953).Google Scholar
  549. [495]
    Gut, M.: 3β-hydroxypregn-4-en-20-one. J. org. Chem. 21, 1327 (1956).Google Scholar
  550. [496]
    Haberlandt, L.: Über hormonale Sterilisierung des weiblichen Tierkörpers. Münch. med. Wsehr. 68, 1577 (1921).Google Scholar
  551. [497]
    Häusler, G.: Histochemischer Nachweis der Carboanhydrase. Histochemie 1, 29 (1958).Google Scholar
  552. [498]
    Hafez, E. S. E., and G. Pincus: Hormonal requirements of implantation in the rabbit. Proc. Soc. exp. Biol. (N.Y.) 91, 531 (1956).Google Scholar
  553. [498a]
    Hagiwara, H.: Steroids. XIV. Microbiological oxidation of Reiehstein’s substance S by Corticium sasakii. 1. Isolation of hydrocortisone and 11-epihydrocortisone. Chem. Abstr. 54, 22724 (1960).Google Scholar
  554. [499]
    Hagler, S., A. Schultz, H. Hanein, and R. H. Kunstadter: Fetal effects of steroid therapy during pregnancy. Amer. J. Dis. Child. 106, 586 (1963).PubMedGoogle Scholar
  555. [500]
    Hahn, E. W.: Modification of the secondary sex ratio in the albino rat by progesterone and oestrogen therapy. J. Reprod. Fértil. 6, 409 (1963).PubMedGoogle Scholar
  556. [501]
    Hall, K.: Maintenance of pregnancy, parturition and rearing of litters in mice ovari- ectomized and injected with progesterone, oestradiol and relaxin. J. Physiol. (Lond.) 134, 17 P (1956).Google Scholar
  557. [502]
    Hall, K.: The effect of relaxin extracts, progesterone and oestradiol on maintenance of pregnancy, parturition and rearing of young after ovariectomy in mice. J. Endocr. 15, 108 (1957).PubMedGoogle Scholar
  558. [503]
    Hall, K. and W. H. Newton: The effect of oestrone and relaxin on the X-ray appearance of the pelvis of the mouse. J. Physiol. (Lond.) 106, 18 (1947).Google Scholar
  559. [504]
    Haller, J.: Über die Einwirkung von 17α-Äthinyl-19-nortestosteronönanthat auf Hypophysenzwischenhirnsystem und Uteruswachstum virgineller Meerschweinchen. Acta endocr. (Kbh.), Suppl. 51, 907 (1960).Google Scholar
  560. [505]
    Haller, J.: Das Eingreifen von Pflanzenextrakten in die hormonellen Wechselbeziehungen zwischen Hypophyse und Ovar, eine tierexperimentelle Studie — Teil I. Z. Geburtsh. Gynäk. 156, 274 (1961).Google Scholar
  561. [506]
    Haller, J.: Vergleichende Prüfung der Wirkung neuer synthetischer Gestagene auf Hypophyse und Genitalorgane im „Milzovar-Planimetertest“. Verh. 3. Weltkongreß Gynäk. Geburtsh. Bd. I, S. 75, Wien: Verlag d. Wien. med. Akad. ärztl. Fortb. 1961.Google Scholar
  562. [507]
    Haller, J.: Beeinflussung der Ovulation durch Gestagene. Geburtsh. u. Frauenheilk. 22,211 (1962).Google Scholar
  563. [508]
    Haller, J.: Kerngrößenmessungen in Milzovar und Hypophyse; eine tierexperimentelle endo- krinologische Studie — Teil II. Z. Geburtsh. Gynäk. 158, 1 (1962).Google Scholar
  564. [509]
    Haller, J.: Ovulationshemmung durch Hormone. Stuttgart: Georg Thieme 1965.Google Scholar
  565. [509a]
    Halpern, O., and J. A. Zderic: 17α-Hydroxypregn-3,5-diene-20-one 17-acetate: A new 3-deoxy progestin. Chem. and Ind. 1962, 1540.Google Scholar
  566. [510]
    Hamada, H., F. Neumann u. K. Junkmann: Intrauterine antimaskuline Beeinflussung von Rattenfeten durch ein stark gestagen wirksames Steroid. Acta endocr. (Kbh.) 44, 380 (1963).Google Scholar
  567. [511]
    Hamblen, E. C., N. B. Powell, W. K. Cuyler, and J. C. Patte: Oral use of preg- neninonol in functional meno-metrorrhagia. Endocrinology 26, 201 (1940).Google Scholar
  568. [512]
    Hamilton, J. B., and J. M. Wolfe: The effect of male hormone substances upon birth and prenatal development in the rat. Anat. Ree. 70, 433 (1938).Google Scholar
  569. [513]
    Hamilton, J. B., and J. M. Wolfe: The effect of synthetic androgen upon the gonadotropic potency of the anterior pituitary. Endocrinology 22, 360 (1938).Google Scholar
  570. [514]
    Harper, M. J. K.: Action of 6-chloro-17α-acetoxy-6-dehydroprogesterone upon ovulation and mating in the rabbit. J. Endocr. 24, XX (1962).Google Scholar
  571. [515]
    Harris, G. W.: Sex hormones, brain development and brain function. Endocrinology 75, 627 (1964).PubMedGoogle Scholar
  572. [516]
    Harris, L. H.: The protein anabolic action of mestanolone. J. clin. Endocr. 21,1099 (1961).PubMedGoogle Scholar
  573. [517]
    Harris, R. G., and J. J. Pfiffner: Extracts of corpora lutea in relation to pregnancy. Anat. Ree. 44, 205 (1929).Google Scholar
  574. [518]
    Harris, T. W., and N. Wolchuk: The suppression of estrus in the dog and cat with long-term administration of synthetic progestational steroids. Amer. J. vet. Res. 24, 1003 (1963).PubMedGoogle Scholar
  575. [519]
    Hartley, F.: Analogues of ethisterone and 17-aeetoxy-progesterone. J. Endocr. 24 XVI (1962).Google Scholar
  576. [520]
    Hartman, C. G.: Observations on the functional compensatory hypertrophy of the opossum ovary. Amer. J. Anat. 35, 1 (1925).Google Scholar
  577. [520a]
    Hartman, J. A., A. J. Tomasewski, and A. S. Dreiding: The partial degradation and reconstitution of the “A” ring of estradiol. J. Amer. chem. Soc. 78, 5662 (1956).Google Scholar
  578. [521]
    Hartmann, M., u. A. Wettstein: Ein kristallisiertes Hormon aus corpus luteum. Helv. ehim. Acta 17, 878 (1934).Google Scholar
  579. [522]
    Haskins, A. L., and J. T. Leong: Rabbit endometrial response to intravenously administered progesterone. Proc. Soc. exp. Biol. (N.Y.) 99, 750 (1958).Google Scholar
  580. [523]
    Hass, T.: Experience with provest in private practice. Int. J. Fertil. 8, 743 (1963).PubMedGoogle Scholar
  581. [524]
    Haterius, H. O.: Reduction of litter size and maintenance of pregnancy in the oophor- ectomized rat: Evidence concerning the endocrine role of the placenta. Amer. J. Physiol. 114, 399 (1936).Google Scholar
  582. [525]
    Hauser, G. A.: Praktische Erfahrungen mit Ovulationshemmern. Bibl. Gynaec. (Basel) 21, 123 (1965).Google Scholar
  583. [526]
    Hawk, H. W., T. H. Brinsfield, and H. P. Righter: Control by ovarian hormones of vascular permeability in normal and experimentally-infected sheep uteri. J. Reprod. Fertil. 6, 71 (1963).PubMedGoogle Scholar
  584. [527]
    Hawk, H. W., G. D. Turner, and T. H. Brinsfield: Endocrine control of vascular permeability and induced leukocytic emigration in the rabbit uterus. Amer. J. vet. Res. 24, 595 (1963).PubMedGoogle Scholar
  585. [528]
    Hawker, R. W., V. S. Roberts, and C. F. Walmsley: Oxytocin and oxytocic sub stance in blood extracts before, and following, copulation in sheep. Endocrinology 64, 309 (1959).PubMedGoogle Scholar
  586. [529]
    Hayes, K. J.: The so-called „levator ani“ of the rat. Acta endocr. (Kbh.) 48, 337 (1965).Google Scholar
  587. [530]
    Hayles, A. B., and R. B. Nolan: Female pseudohermaphroditism: Report of case in an infant born of a mother receiving methyltestosterone during pregnancy. Proc. Mayo Clin. 32, 41 (1957).Google Scholar
  588. [531]
    Hayles, A. B., and R. B. Nolan: Masculinization of female fetus, possibly related to administration of progesterone during pregnancy. Proc. Mayo Clin. 33, 200 (1958).Google Scholar
  589. [532]
    Hays, R. L., and C. H. Carlevaro: Induction of estrus by electrical stimulation. Amer. J. Physiol. 196, 899 (1959).PubMedGoogle Scholar
  590. [533]
    Hays, R. L., and K. A. Kendall: Maintenance of pregnancy with prolactin or progesterone in rats on a sucrose diet. Endocrinology 68, 177 (1961).Google Scholar
  591. [534]
    Heaney, R. P., and G. D. Whedon: Impairment of hepatic bromsulphalein clearance by two 17-substituted testosterones. J. Lab. clin. Med. 52, 169 (1958).PubMedGoogle Scholar
  592. [535]
    Heard, R. D. H.: Chemistry and metabolism of the adrenal cortical hormones. VI. Relationship between chemical structure and physiological action. In: G. Pincus and K. V. Thimann, eds., The Hormones, vol. I, p. 550—629. New York: Academic Press 1950.Google Scholar
  593. [536]
    Hecht-Lucari, G.: Circa la sistematica dei progestativa. Monit. ostet. ginee. 2,1 (1960).Google Scholar
  594. [537]
    Hecht-Lucari, G., H. G. Kraft, and H. Kieser: Estrogenic, Anti-estrogenic and antifertility activity of chlormadinone acetate and other steroidal and non-steroidal compounds. „Research on Steroids“ Transact. Second Meeting Int. Study Group for Steroid Hormones, Rome 1965.Google Scholar
  595. [538]
    Hecht-Lucari, G., and F. Lucisano: Biological interactions between progesterone and some gestagens. Acta endocr. (Kbh.), Suppl. 51, 909 (1960).Google Scholar
  596. [539]
    Hecht-Lucari, G., e L. Scarpellint: Interazione fra il progesterone e 1’etere eiclopentilenolice del progesterone nel test di Clauberg-MePhail. Int. Congr. Hormonal Steroids, Milan 1962. Excerpta med. (Amst.) Int. Congr. Ser. 51, Abstr. 268, p. 200, 1962.Google Scholar
  597. [540]
    Hegner, P., u. T. Reichstein: Uber Bestandteile der Nebennierenrinde und verwandte Stoffe. 60. Mitt.: 11-Dehydro-progesteron. Helv. chim. Acta 26, 715 (1943).Google Scholar
  598. [541]
    Heinen, G.: Orale Kontrazeption. Med. Welt 40, 2089 (1962).PubMedGoogle Scholar
  599. [542]
    Heinen, G.: Hormonale Ovulationshemmung mit Ovulen. Med. Welt 49, 2631 (1964).PubMedGoogle Scholar
  600. [543]
    Heller, C. G.: Effect of enovid and 17α-ethinyl-19-nortestosterone on daily urinary gonadotropin and estrogen excretion and on premenstrual tension and other menstrual disorders. Proc. 19-Nor-progestational Steroids, Chicago 1957, Searle Res. Lab. 97, 1957.Google Scholar
  601. [544]
    Heller, C. G., W. M. Laidlaw, H. T. Harvey, and W. O. Nelson: Effects of progestational compounds on the reproductive processes of the human male. Ann. N.Y. Acad. Sci. 71, 649 (1958).PubMedGoogle Scholar
  602. [545]
    Heller, C. G., D. J. Moore, C. A. Paulsen, W. O. Nelson, and W. M. Laidlaw: Effects of progesterone and synthetic progestins on reproductive physiology of normal men. Fed. Proc. 18, 1057 (1959).PubMedGoogle Scholar
  603. [546]
    Heller, C. G., G. A. Paulsen, and D. I. Moore: Alteration in spermatogenesis of normal men with synthetic and natural progestins. Acta endocr. (Kbh.), Suppl. 51, 925 (1960).Google Scholar
  604. [547]
    Hempel, R., u. F. Neumann: Hemmung der Uteruswirkung von Oxytocin durch was serlösliche Steroide. Acta endocr. (Kbh.) 48, 656 (1965).Google Scholar
  605. [548]
    Henderson, E., M. Weinberg, and W. A. Wright: Endocrine review. Pregnenolone. J. clin. Endocr. 10, 455 (1950).PubMedGoogle Scholar
  606. [549]
    Henderson, E., M. Weinberg,: Methylandrostenediol. J. clin. Endocr. 11, 641 (1951).PubMedGoogle Scholar
  607. [550]
    Henzl, M., J. Jirasek, J. Horsky, and J. Presl: The proliferative effects of 17α-ethynyl- 19-nortestosterone. Arch. Gynäk. 199, 335 (1964).Google Scholar
  608. [551]
    Herr, M. E., J. A. Hogg, and R. H. Levin: Synthesis of potent oral anabolic-andro- genic steroids. J. Amer. chem. Soc. 78, 500 (1956).Google Scholar
  609. [552]
    Herrmann, U.: Zur gestagenen Wirkung von 6-Chlor-acetoxy-progesteron. Gynaeco- logia (Basel) 155, 87 (1963).Google Scholar
  610. [553]
    Hershberger, L. G., E. Shipley, and R. K. Meyer: Myotrophie activity of 19-nor testosterone and other steroids determined by modified levator ani muscle method. Proc. Soc. exp. Biol. (N.Y.) 83, 175 (1953).Google Scholar
  611. [554]
    Hertz, R., C. D. Larsen, and W. Tullner : Inhibition of estrogen-induced tissue growth with progesterone. J. nat. Cancer Inst. 8, 123 (1947).PubMedGoogle Scholar
  612. [555]
    Hertz, R., R.K. Meyer, and M. A. Spielman: The specificity of progesterone in inducing sexual receptivity in the ovariectomized guinea pig. Endocrinology 21, 533 (1937).Google Scholar
  613. [556]
    Hertz, R., R.K. Meyer : The effect of testosterone, testosterone-propionate and dehydroandrosterone on the secretion of the gonadotropic complex as evidenced in parabiotic rats. Endocrinology 21, 756 (1937).Google Scholar
  614. [557]
    Hertz, R., and W. W. Tullner: Progestational activity of halogenated corticosteroids and related compounds in rabbit and monkey. Proc. Soc. exp. Biol. (N.Y.) 91, 76 (1956).Google Scholar
  615. [558]
    Hertz, R., and W. W. Tullner: Progestational activity of certain steroid-17-spirolactones. Proc. Soc. exp. Biol. (N.Y.) 99, 451 (1958).Google Scholar
  616. [559]
    Hertz, R., and W. W. Tullner and E. Raffelt: Progestational activity of orally administered 17α-ethinyl-19-nortestosterone. Endocrinology 54, 228 (1954).PubMedGoogle Scholar
  617. [560]
    Hertz, R., J. H. Waite, and L. B. Thomas: Progestational effectiveness of 19-nor-ethinyl- testosterone by oral route in women. Proc. Soc. exp. Biol. (N.Y.) 91, 418 (1956).Google Scholar
  618. [561]
    Hertz, R., J. Fried, and E. F. Sabo: 12a-halo derivatives of llß-hydroxyprogesterone. J. Amer. chem. Soc. 78, 2017 (1956).Google Scholar
  619. [561a]
    Herzog, H. L., M. J. Gentles, H. Marshall, and E. B. Hershberg: Weak acid- catalyzed rearrangement of the dehydroxyacetone side chain in steroids. J. Amer. chem. Soc. 83, 4073 (1961).Google Scholar
  620. [561b]
    Heusler, K., J. Kalvoda, P. Wieland, G. Anneru, A. Wettstein: Reaktionen von Steroid-Hypojoditen. IV. Über den Verlauf intramolekularer Substitutionsreaktionen, insbesondere bei 2ß- und 4ß-Hydroxysteroiden. Helv. chim. Acta 45, 2575 (1962).Google Scholar
  621. [562]
    Heusser, H., K. Eichenberger u. A. B. Kulkarni: Über die Synthese von 14-allo-17-epi-testosteron. Helv. chim. Acta 32, 2145 (1949).Google Scholar
  622. [563]
    Heusser, H., Ch. R. Engel, P. Th. Herzig u. P. A. Plattner: Über 17-Methyl-progesteron A, ein hoch aktives Gestagen, und seine Bereitung aus 21- bzw. 17-Halogen-pregneno- lon. Helv. chim. Acta 33, 2229 (1950).Google Scholar
  623. Heusser, H., Ch. R. Engel u. Pl. A. Plattner: Synthese des 17-Methyl-progesterons B. Helv. chim. Acta 33, 2237 (1950).Google Scholar
  624. Heusser, H., M. Feurer, K. Eichenberger u. V. Prelog: Über 16,17α-Oxido-Verbindungen der Oestran- und Androstan-Reihe; ein Beitrag zur Stereochemie der isomeren Oestriole. Helv. chim. Acta 33, 2243 (1950).Google Scholar
  625. [564]
    Heusser, H., N. Wahba, u. F. Winternitz: 17α-Methyl-d-homotestosteron, ein hoch aktives männliches Sexualhormon. Helv. chim. Acta 37, 1052 (1954).Google Scholar
  626. [565]
    Heuverswyn, J. Van, V. J. Collins, W. L. Williams, and W. U. Gardner: The progesterone-like activity of desoxycorticosterone. Proc. Soc. exp. Biol. (N.Y.) 41, 552 (1939).Google Scholar
  627. [566]
    Hillemans, H. G., J. E. Ayre u. J. M. le Guerrier: Die Einwirkung von Steroiden auf Krebsvorstadien an der Cervix. Arzneimittel-Forsch. 14, 784 (1964).Google Scholar
  628. [567]
    Hisaw, F. L.: Experimental relaxation of the symphysis pubis of the guinea-pig. Anat. Ree. 37, 126 (1927).Google Scholar
  629. [568]
    Hisaw, F. L., R. Greep, and H. L. Fevold: Effects of progesterone on the female genital tract after castration atrophy. Proc. Soc. exp. Biol. (N.Y.) 36, 840 (1937).Google Scholar
  630. [569]
    Hisaw, F. L., R. Greep: The inhibition of uterine bleeding with estradiol and progesterone and associated endometrial modifications. Endocrinology 23, 1 (1938).Google Scholar
  631. [570]
    Hisaw, F. L., R. K. Meyer, and C. K. Weichert: Inhibition of ovulation and associated histo logical changes. Proc. Soc. exp. Biol. (N.Y.) 25, 754 (1928).Google Scholar
  632. [571]
    Hisaw, F. L., and J. T. Velardo: Influence of a potentiator of estrogen in the inhibition of progesterone in development of deeiduomata. Endocrinology 54, 409 (1954).PubMedGoogle Scholar
  633. [572]
    Höhn, E. O., and J. M. Robson: The response of the rabbit’s endometrium to uterine implants of progesterone and other steroids. J. Physiol. (Lond.) Ill, 174 (1950).Google Scholar
  634. [573]
    Hoffmann, F., C. Overzier u. G. Uhde: Zur Frage der hormonalen Erzeugung fötaler Zwitterbildungen beim Mensehen. Geburtsh. u. Frauenheilk. 15, 1061 (1955).Google Scholar
  635. [573a]
    Hoffmann, F., u. P. Treite: Vergleichende Untersuchungen über die Wirkung von weiblichen und männlichen Keimdrüsenhormonen und von Nebennierenrindenhormonen auf den Uterus. Zbl. Gynäk. 64, 1603 (1940).Google Scholar
  636. [574]
    Hoffmann, J. C., and N. B. Schwartz: „Progesterone-withdrawal“ ovulation in the rat. Fed. Proc. 23, 109 (1964).Google Scholar
  637. [575]
    Hofhansl, W., u. K. Baumgarten: Die Behandlung des Abortus imminens mit Gestagenen. Wien. klin. Wschr. 72, 853 (1960).PubMedGoogle Scholar
  638. [575a]
    Hogg, J. A., F. H. Lincoln, A. H. Nathan, A. R. Hanze, W. P. Schneider, P. F. Real, and J. Korman: The adrenal hormones and related compounds. II. Synthesis of l-dehydro analogs. J. Amer. chem. Soc. 77, 4438 (1955).Google Scholar
  639. [576]
    Hohensee, F., u. G. Lungbein: Darstellung eines Isomeren von Reichsteins Substanz S und Untersuchungen zu dessen Wirkungsweise. Z. physiol. Chem. 315, 83 (1959).Google Scholar
  640. [576a]
    Hohensee, F., u. H. Weifenbach: Zur biologischen Wirkung in 15a-Stellung oxydierter Progesteronderivate. Klin. Wschr. 35, 891 (1957).Google Scholar
  641. [577]
    Hohlweg, W.: Veränderungen des Hypophysenvorderlappens und des Ovariums nach Behandlung mit großen Dosen von Follikelhormon. Klin. Wschr. 13, 92 (1934).Google Scholar
  642. [578]
    Hohlweg, W.: Über die Corpus-luteum-Hormon-Wirkung des Desoxycorticosterons. Zbl. Gynäk. 63, 1143 (1939).Google Scholar
  643. [579]
    Hohlweg, W., u. H. H. Inhoffen: Pregneninolon, ein neues per os wirksames corpus-luteum- Hormonpräparat. Klin. Wschr. 18, 77 (1939).Google Scholar
  644. [580]
    Hohlweg, W., u. K. Junkmann: Die hormonal-nervöse Regulierung der Funktion des Hypo physenvorderlappens. Klin. Wschr. 11, 321 (1932).Google Scholar
  645. [581]
    Hohlweg, W., and G. Reifenstuhl: LH-secretion before, during and after treatment with ovula tion inhibitors. Acta endocr. (Kbh.), Suppl. 100, 203 (1965).Google Scholar
  646. [582]
    Hohlweg, W., u. J. Schmidt: Zur Chemie und Biologie des neuen Corpus-luteum-Hormones „Progesteron”. Klin. Wschr. 15, 1 (1936).Google Scholar
  647. [583]
    Hollifield, G., K. R. Crispell, and W. Parson: A study of the anabolic effect of nortestosterone cyclopentylpropionate and its effect on the excretion of N15 administered intravenously as N15 glycine. Metabolism 5, 165 (1956).PubMedGoogle Scholar
  648. [584]
    Holmes, R. L., and A. M. Mandl: The effect of norethynodrel on the ovaries and pituitary gland of adult female rats. J. Endocr. 24, 497 (1962).PubMedGoogle Scholar
  649. [585]
    Holmstrom, E. G.: The long-term use of ovulen for contraception. Metabolism 14, 444 (1965).PubMedGoogle Scholar
  650. [586]
    Holub, D. A., F. H. Katz, and J. W. Jailer: Inhibition by 6-methyl-17-acetoxy- progesterone of ACTH-synthesis and release in the rat. Endocrinology 68,173 (1961).PubMedGoogle Scholar
  651. [586a]
    Holysz, R. P.: Preparation and dehydrohalogenation of 4-halo-3-ketosteroids. J. Amer. chem. Soc. 75, 4432 (1953).Google Scholar
  652. [587]
    Homburger, F., R. M. Dart, C. D. Bonner, G. Branche, S. C. Kasdon, and W. H. Fishman: Some metabolic and biochemical effects of methyl-androstenediol. J. clin. Endocr. 13, 704 (1953).PubMedGoogle Scholar
  653. [588]
    Homburger, F., I. Forbes, and R. Desjardins: Renotropic effects of some androgens upon experimental hydronephrosis and upon the clitoris in the mouse. Endocrinology 47, 19 (1950).PubMedGoogle Scholar
  654. [589]
    Homburger, F., S. C. Kasdon, and W. H. Fishman: Methylandrostenediol: A non-virilizing derivative of testosterone in metastatic cancer of the breast. Proc. Soc. exp. Biol. (N.Y.) 74, 162 (1950).Google Scholar
  655. [590]
    Hooker, Ch. W.: Effects of progesterone upon the uterus of the mouse. Proc. Soc. exp. Biol. (N.Y.) 54, 270 (1940).Google Scholar
  656. [591]
    Hooker, Ch. W.: Production of deciduomata in ovarieetomized mice receiving progesterone. Proc. Soc. exp. Biol. (N.Y.) 46, 698 (1941).Google Scholar
  657. [592]
    Hooker, Ch. W.: A criterion of luteal activity in the mouse. Anat. Ree. 93, 333 (1945).Google Scholar
  658. [593]
    Hooker, Ch. W. and Th. R. Forbes: A bio-assay for minute amounts of progesterone. Endocrinology 41, 158 (1947).PubMedGoogle Scholar
  659. [594]
    Hooker, Ch. W.: and Th. R. Forbes: Specificity of the intrauterine test for progesterone. Endocrinology 45, 71 (1949).PubMedGoogle Scholar
  660. [595]
    Hopkins, T. F., and G. Pincus: Effects of reserpine on gonadotrophin-induced ovulation in immature rats. Endocrinology 73, 775 (1963).PubMedGoogle Scholar
  661. [596]
    Hortling, H., and K. Wahlfors: Long-term treatment of dwarfism with androgens and thyroid hormone. Acta endocr. (Kbh.) 32, 563 (1959).Google Scholar
  662. [597]
    Houssay, B. A., E. I. Saurer, and R. Lucini: Action of pituitary hormones upon the estrogenic function of adrenal tumors in castrated mice. Acta physiol. lat.-amer. 12, 295 (1962).PubMedGoogle Scholar
  663. [598]
    Howard, P., and R. H. Furman: Metabolic and serum lipid effects of methylandrostane and methylandrostene pyrazoles. J. clin. Endocr. 22, 43 (1962).PubMedGoogle Scholar
  664. [599]
    Howard, P., E. C. Reifenstein, and C. L. Courtright: The prolonged anabolic activity of certain testosterone esters in man. J. clin. Endocr. 13, 832 (1953).Google Scholar
  665. [600]
    Hren, M.: Clinical experiences with ciclofarlutal. Acta endocr. (Kbh.), Suppl. 100, 104 (1965).Google Scholar
  666. [601]
    Hsia, D. Y. Y., S. Riabov, and R. M. Dowben: Inhibition of glueuronosyl transferase by steroid hormones. Arch. Biochem. 103, 181 (1963).PubMedGoogle Scholar
  667. [601a]
    Huang-Minlon, Zan-Wei Kin, Chew-Hwa Wu, and Zei-Zan Chow: Synthesis of hydrocortisone acetate. Chem. Abstr. 55, 2739 (1961).Google Scholar
  668. [602]
    Huffman, J. W., and L. H. Bos: The mode of action of testosterone propionate on the female genital tract. Endocrinology 26, 259 (1940).Google Scholar
  669. [603]
    Huggins, Ch., and E. V. Jensen: Significance of the hydroxyl groups of steroids in promoting growth. J. exp. Med. 100, 241 (1954).PubMedGoogle Scholar
  670. [604]
    Huggins, Ch., and E. V. Jensen: The depression of growth of the uterus, adrenals, and ovaries by fluorinated steroids in the pregnane series. J. exp. Med. 102, 347 (1955).PubMedGoogle Scholar
  671. [605]
    Huggins, Ch., and E. V. Jensen, and A. S. Cleveland: Chemical structure of steroids in relation to promotion of growth of the vagina and uterus of the hypophysectomized rat. J. exp. Med. 100, 225 (1954).PubMedGoogle Scholar
  672. [606]
    Huggins, Ch., and K. Mainzer: Hormonal influences on mammary tumors of the rat. J. exp. Med. 105, 485 (1957).PubMedGoogle Scholar
  673. [607]
    Huggins, Ch., R. C. Moon, and S. Morii: Extinction of experimental mammary cancer. I. Estra diol- and progesterone. Proc. nat. Acad. Sci. (Wash.) 48, 379 (1962).Google Scholar
  674. [608]
    Huggins, Ch., F. Parsons, and E. Y. Jensen: Promotion of growth of preputial glands by steroids and the pituitary growth hormone. Endocrinology 57, 25 (1955).PubMedGoogle Scholar
  675. [609]
    Huggins, Ch., Y. Torralba, and K. Mainzer: Hormonal influences on mammary tumors of the rat. J. exp. Med. 104, 525 (1955).Google Scholar
  676. [610]
    Hues in’t Veld, L. G., B. Louwerens, and P. A. F. van der Spek: The influence of 17α-methyl-19-nortestosterone on the excretion of neutral 17-ketosteroids, 17- hydroxycorticosteroids and gonadotrophs in the urine. IV. Int. Congr. Biochem. Wien, S. 115, 1958.Google Scholar
  677. [611]
    Hunter, J.: An experiment to determine the effect of extirpating one ovarium upon the number of young produced. Phil. Trans. B. 77, 233 (1787).Google Scholar
  678. [612]
    Hutcherson, W. P.: Norethindrone with estrogen as an oral contraceptive. Sth. med. J. (Bgham, Ala.) 56, 1357 (1963).Google Scholar
  679. [613]
    Iglesias, R.: Tumores experimentales uterinos y extragenitales provocados por el benzoato de estradiol. Tesis, Universidad de Chile 1938.Google Scholar
  680. [614]
    Iglesias, R.: Antitumorigenic and tumor-stimulating actions of steroid hormones. Cancer (Philad.) 10, 734 (1957).Google Scholar
  681. [615]
    Iglesias, R.: Hormones and tumours. Proc. 2. Int. Congr. Endocr., London 1964. Excerpta med. (Amst.) Int. Congr. Ser. 83, pp. 1072—84, 1964.Google Scholar
  682. [616]
    Iglesias, R., and A. Lipschutz: Relations of steroid hormones and anhydrohydroxy-progeste- rone to fibromatosis. Lancet 1946 II, 488.Google Scholar
  683. [617]
    Iglesias, R., A. Lipschutz and E. Mardones: Antitumorigenic action of steroids as an “independent” faculty of these compounds. Nature (Lond.) 167, 235 (1951).Google Scholar
  684. [618]
    Iglesias, R., A. Lipschutz and G. Rojas: Experiments with the local action of oestrogen on the intra-splenie ovarian graft. Endocrinology 46, 414 (1950).PubMedGoogle Scholar
  685. [619]
    Ijzerman, G. L., M. N. G. Dukes u. H. Kopera: Klinische Ergebnisse der Fertilitats-kontrolle nach cyclischer Anwendung von Lynestrenol in Kombination mit einem Oestrogen. Arzneimittel-Forsch. 13, 507 (1963).Google Scholar
  686. [620]
    Ingle, D. J.: The work-performance of adrenaleetomized rats treated with cortico- sterone and chemically related components. Amer. J. Physiol. 126, 543 (1939).Google Scholar
  687. [621]
    Ingle, D. J.: The quantitative assay of adrenal cortical hormones by the muscle-work test in the adrenalectomized-nephrectomized rat. Endocrinology 34, 191 (1944).Google Scholar
  688. [622]
    Ingle, D. J., D. F. Beary, and A. Purmalis: Comparison of the effect of 11β-hydroxy-pro- gesterone and of 11β,17α-dihydroxyprogesterone upon the glycosuria of the partially depancreatized rat. Metabolism 2, 510 (1953).PubMedGoogle Scholar
  689. [623]
    Ingle, D. J., and R. Meeks: Comparison of some metabolic and morphologic effects of cortisone and hydrocortisone given by continuous injection to rats. Amer. J. Physiol. 170, 77 (1952).PubMedGoogle Scholar
  690. [624]
    Inhoffen, H. H., u. W. Hohlweg: Neue per os-wirksame weibliche Keimdrusen- hormon-Derivate: 17-athinyl-oestradiol und Pregnen-in-on-3-ol-17. Naturwissen- schaften 26, 96 (1938).Google Scholar
  691. [625]
    Ingle, D. J., W. Logemann, W. Hohlweg u. A. Serine: Untersuchungen in der Sexualhormon- Reihe. Ber. dtsch. chem. Ges. 71, 1024 (1938).Google Scholar
  692. [625a]
    Iriarte, J., C. Djerassi, and H. J. Ringold: Steroids. CVII. ⊿5(6)-19-nor steroids, a new class of potent anabolic agents. J. Amer. ehem. Soc. 81, 436 (1959).Google Scholar
  693. [626]
    Iriarte, J., and M. L. Franco: Steroids. CLXÏV. Preparation of 6a,16α-dimethylprogestational and cortical hormone analogues. J. org. Chem. 26, 2047 (1961).Google Scholar
  694. [627]
    Ishiztjka, N.: 17α-oxyprogesterone capronate (Proluton-depot), a depot preparation with action of corpus luteum hormone. Japan-Germany med. Reports 1, 2 (1956).Google Scholar
  695. [628]
    Jackson, M. C. N.: Oral contraception in practice. J. Reprod. Fertil. 6, 153 (1963).PubMedGoogle Scholar
  696. [629]
    Jacobsohn, D.: Mammary gland growth in relation to hormones with metabolic actions. Proc. roy. Soc. B 149, 325 (1958).Google Scholar
  697. [630]
    Jacobson, I.: Perorale Gestagen/Östrogen-Behandlung — Übersicht und eigene Minische Erfahrungen mit dem Präparat Anovlar. Svenska Läk.-Tidn. 61, 22 (1964).Google Scholar
  698. [631]
    Jadrijeyic, D., S. Girardi, R. Iglesias, and A. Lipschütz: Antifibromatogenic and antihysterotrophie activities of synthetic androgens (19-nor-methyltestosterone, 19-nor-testosterone phenylpropionate, ⊿1-testosterone and ⊿1-androstenedione). Proc. Soc. exp. Biol. (N.Y.) 96, 259 (1957).Google Scholar
  699. [632]
    Jadrijeyic, D., E. Mardones, and A. Lipschütz: Antifibromatogenic activity of 19-nor-a-ethinyl- testosterone in the guinea pig. Proc. Soc. exp. Biol. (N.Y.) 91, 38 (1956).Google Scholar
  700. [633]
    Jaensch-Zander, W.: Die Ovulationsunterdriickung in der gynäkologischen Praxis. Med. Mitt. (Schering) 24, 4 (1963).Google Scholar
  701. [634]
    Joel, C. A.: Dosage of female sex hormones, estradiol and anhydrohydroxy-progeste- rone by sublingual application. J. clin. Endoer. 2, 639 (1942).Google Scholar
  702. [635]
    Johns, W. F.: Synthesis of 18,19-dinor steroids. Amer. chem. Soc. 80, 6456 (1958).Google Scholar
  703. [636]
    Johnson, B. B.: Bioassay of adrenal cortical steroids on the basis of elect rolyte excretion by rats: effects of 11-desoxy and 11-oxy-steroids. Endocrinology 54, 196 (1954).PubMedGoogle Scholar
  704. [637]
    Johnson, D. C.: Effect of hypothalamic extract on hypophyseal LH in immature male rats. Proc. Soc. exp. Biol. (N.Y.) 117, 160 (1964).Google Scholar
  705. [638]
    Johnson, G. E., and J. S. Challans: Ovariectomy and eorpus-luteum-extraet experiments in pregnant rats. Anat. Ree. 47, 300 (1930).Google Scholar
  706. [638a]
    Johnson, K. R., and R. E. Erb: Maintenance of pregnancy in ovariectomized cattle with progestin compounds and their effect on progestin levels in the corpus luteum. J. Dairy Sei. 45, 633 (1962).Google Scholar
  707. [639]
    Johnstone, E. E., and R. R. Franklin: Assay of progestins for fetal virilizing properties using the mouse. Obstet, and Gynee. 23, 359 (1964).Google Scholar
  708. [640]
    Jones, H. W., and L. Welkins: The genital anomaly associated with prenatal exposure to progestagens. Fertil. and Steril. 11, 148 (1960).Google Scholar
  709. [641]
    Jost, A.: Rôle des gonades foetales dans la différenciation sexuelle somatique. Arch. Anat. micr. Morph, exp. 36, 271 (1947).Google Scholar
  710. [642]
    Jost, A.: Über die Erzeugung fötaler Zwitterbildung bei der Ratte mit Methylandrostendiol. Geburtsh. u. Frauenheilk. 14, 687 (1954).Google Scholar
  711. [643]
    Jost, A.: Croissance des embryons chez des femelles de rat injectées d’androstènediol et de méthylandrosténediol ou castrées. Ann. Endoer. (Paris) 16, 283 (1955).Google Scholar
  712. [644]
    Jost, A.: Propriétés progestatives de la 9α-fluoro-11β-hydroxy-17α-méthyltestostérone. Ann. Endoer. (Paris) 19, 584 (1958).Google Scholar
  713. [645]
    Jost, A.: Développement des foetus, accouchement et allaitement chez des rattes castrées en fin de gestation. Arch. Anat. micr. Morph, exp. 48, 133 (1959).Google Scholar
  714. [646]
    Jost, A.: Action de divers stéroides sexuels et voisins sur la croissance et la différenciation sexuelle des foetus. Acta endocr. (Kbh.), Suppl. 50, 119 (1960).Google Scholar
  715. [647]
    Jost, A.: Maintien de la gestation chez le rat par la 17α-(2 méthallyl)19-nortestostérone. Action sur les foetus femelles. C. R. Soc. Biol. (Paris) 155, 967 (1961).Google Scholar
  716. [648]
    Jost, A.: Maintien de la gestation chez la lapine par un stéréo-isomère voisin de la progesté rone (6-déhydro-rétro-progestérone). Action sur les foetus. Acta endocr. (Kbh.) 43, 539 (1963).Google Scholar
  717. [649]
    Jost, A., et P. Grandou: Action opposée sur la surrénale du rat, de l’hydrocortisone et de la 9α-fluoro-11ß-hydroxy- 17α-méthyltestostérone. C. R. Soe. Biol. (Paris) 152, 896 (1958).Google Scholar
  718. [650]
    Juhn, M., and P. C. Harris: Responses in molt and lay of fowl to progestins and go nadotropins. Proc. Soc. exp. Biol. (N.Y.) 92, 709 (1956).Google Scholar
  719. [651]
    Julian, P. L., E. W. Meyer, and I. Ryden: 17α-hydroxyprogesterone. J. Amer. chem. Soc. 72, 367 (1950).Google Scholar
  720. [652]
    Jungck, E. C., W. E. Bareield, R. B. Greenblatt, Y. B. Mahesh, and C. K. Aydar: The relationship of structure to function of the acetoxyprogesterone compounds. 43. Meeting Endocr. Society, New York 1963.Google Scholar
  721. [653]
    Junkmann, K: Steroidhormone mit protrahierter Wirkung. XIV. Japan Medical Congr. I, 59—76, Osaka 1955.Google Scholar
  722. [654]
    Junkmann, K.: Über protrahiert wirksame Oestrogene. Naunyn-Schmiedebergs Arch exp. Path. Pharmak. 220, 358 (1953).Google Scholar
  723. [655]
    Junkmann, K.: Über protrahiert wirksame Gestagene. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 223, 244 (1954).Google Scholar
  724. [656]
    Junkmann, K.: Long-acting steroids in reproduction. Recent Progr. Hormone Res. 13, 389 (1957).PubMedGoogle Scholar
  725. [657]
    Junkmann, K.: Über Entwicklungen auf dem Gestagengebiet. 15. Meeting Gen. Assembly of the Japan Medical Congr., vol. I, p. 697—706, Tokyo 1959.Google Scholar
  726. [658]
    Junkmann, K.: Experimental aspects in the study of synthetic progestogens. Symp. Family Planning, Cairo 1962. Jour. Egypt. Med. Assoc., Spec. Number, p. 38—60, 1963.Google Scholar
  727. [659]
    Junkmann, K.: Experimentelle Gesichtspunkte bei der Prüfung synthetischer Gestagene. Dtseh. med. Wschr. 88, 629 (1963).Google Scholar
  728. [660]
    Junkmann, K., Die tierexperimentelle Prüfung antikonzeptioneller Steroide. Internist (Berl.) 5, 237 (1964).Google Scholar
  729. [661]
    Junkmann, K., u. F. Neumann: Zum Wirkungsmechanismus von an Feten antimaskulin wirksamen Gestagenen. Acta endocr. (Kbh.), Suppl. 90, 139 (1964).Google Scholar
  730. [662]
    Junkmann, K., u. H. Witzel: Chemie und Pharmakologie von Steroidhormon-Estern. Z. Vitamin-, Hormon- u. Fermentforseh. 9, 97 (1958).Google Scholar
  731. [663]
    Junkmann, K., u. H. Witzel: Chemie und Pharmakologie von Steroidhormon-Estern (Fortsetzung und Schluß). Z. Vitamin-, Hormon- u. Fermentforsch. 9, 227 (1958).Google Scholar
  732. [664]
    Kagawa, C. M.: Mineraloeortieoid-blocking properties of a progesterone-like derivative (SC-11835). Endocrinology 74, 724 (1964).PubMedGoogle Scholar
  733. [665]
    Kagawa, C. M., J. A. Cella, and G. G. van Arman: Action of new steroids in blocking effects of aldosterone and deoxycorticosterone on salt. Science 126, 1015 (1957).PubMedGoogle Scholar
  734. [666]
    Kagawa, C. M., E- Shipley, and R. K. Meyer: A biological method for determining small quantities of sodium retaining substances. Proc. Soc. exp. Biol. (N.Y.) 80, 281 (1952).Google Scholar
  735. [667]
    Kaiser, R.: Über die progestative Wirkung von 19-Nortestosteronverbindungen bei oraler Verabreichung. Geburtsh. u. Frauenheilk. 17, 24 (1957).Google Scholar
  736. [668]
    Kaiser, R.: Klinische Erfahrungen mit Norprogesteron-Derivaten. Zbl. Gynäk. 82, 2009 (1960).Google Scholar
  737. [669]
    Kaiser, R.: Zur Frage der Menstruationsvorverlegung durch Beeinflussung der Ovulation. Geburtsh. u. Frauenheilk. 22, 2 (1962).Google Scholar
  738. [670]
    Kallas, H.: Zur Frage nach der innersekretorischen Tätigkeit des infantilen Eierstockes. Klin. Wsehr. 9, 1345 (1930).Google Scholar
  739. [671]
    Kambara, S.: Effect of progesterone on the activity of alkaline phosphatase in the oviduct of the newt, trituras pyrrhogaster. Zool. Mag. 71, 328 (1962).Google Scholar
  740. [672]
    Kaminetzky, H. A., and M. Swerdlow: Sex steroids and experimental invasive atypia in mice. Amer. J. Obstet. Gynec. 89, 716 (1964).PubMedGoogle Scholar
  741. [673]
    Kaplan, A. A.: Jaundice due to methyltestosterone therapy. Gastroenterology 31, 384 (1956).PubMedGoogle Scholar
  742. [674]
    Kasdon, S. C., W. H. Fishman, R. M. Dart, C. D. Bonner, and F. Homburger: Methylandrostenediol in palliative treatment of breast cancer. J. Amer. med. Ass. 148, 1212 (1952).Google Scholar
  743. [674a]
    Kaspar, E., u. R. Wiechert: Über die Einwirkung von Haloform auf Steroidcarbonyl- funktionen. Chem. Ber. 91, 2664 (1958).Google Scholar
  744. [675]
    Kassenar, A. A. H., D. W. van Berkum, and A. Querido: On the metabolic action of testosterone and related compounds. Acta endocr. (Kbh.) 12, 153 (1953).Google Scholar
  745. [676]
    Kaupmann, C.: Umwandlung der Uterusschleimhaut einer kastrierten Frau aus dem atrophischen Stadium in das der sekretorischen Funktion durch Ovarialhormone. Zbl. Gynäk. 56, 2058 (1932).Google Scholar
  746. [677]
    Kaupmann, C.: Verhandlung der Gesellschaft für Geburtshilfe und Gynäkologie zu Berlin. Z. Geburtsh. Gynäk. 104, 516 (1933).Google Scholar
  747. [678]
    Kaupmann, C.: Echte menstruelle Blutung bei kastrierten Frauen nach Zufuhr von Follikel- und Corpus-luteum-Hormon. Klin. Wschr. 12, 217 (1933).Google Scholar
  748. [679]
    Kehl, R., R. Paris, J. Benoit et G. Gros: Action de l’acétate de désoxyeorticostérone sur le maintien de la grossesse chez la ratte gestante castrée et surreralectomisée. C. R. Soc. Biol. (Paris) 136, 527 (1942).Google Scholar
  749. [680]
    Keilin, D., and T. Mann: Carbonic anhydrase. Purification and nature of the enzyme. Biochem. J. 34, 1163 (1940).PubMedGoogle Scholar
  750. [681]
    Kennedy, B. J.: A progestogen for treatment of advanced endometrial cancer. J. Amer. med. Ass. 184, 758 (1963).Google Scholar
  751. [682]
    Kessler, W. B., and A. Borman: Comparison of duration of action of progesterone and 17α-hydroxyprogesterone-17-n-eaproate. Proc. Soc. exp. Biol. (N.Y.) 94, 820 (1957).Google Scholar
  752. [683]
    Kessler, W. B., and A. Borman: Some biological activities of certain progestogens: I. 17α-hydroxyprogesterone-17-eaproate. Ann. N.Y. Acad. Sei. 71, 486 (1958).Google Scholar
  753. [684]
    Kimming, J.: Klinische Beobachtungen zur Diagnose und Therapie der Leydig-Zell- insuffizienz. Klin. Wschr. 37, 1165 (1959). [6851 Kincl, F. A.: Steroide CLY progestative Wirksamkeit von 6-substituierten 17α- Acetoxyprogesteron-Derivaten. Endokrinologie 40, 257 (1961).Google Scholar
  754. [685]
    Kincl, F. A.: Steroide CLV progestative Wirksamkeit von 6-substituierten 17α-Acetoxyprogesteron-Derivaten. Endokrinologie 40, 257 (1961).PubMedGoogle Scholar
  755. [686]
    Kimming, J.: Notiz über den Mechanismus der Anti-Ovulation mit 6-Chloro-zl6-17α-aeetoxy- progesteron in Kaninchen. Endokrinologie 44, 67 (1963).Google Scholar
  756. [687]
    A. J. Berch, and R. I. Dorfman: Pituitary gonadotropic inhibitory activity of various steroids in ovariectomized-intact female rats in parabiosis. Proc. Soc. exp. Biol. (N.Y.) 117, 549 (1964).Google Scholar
  757. [688]
    A. J. Berch, R. I. Dorfman and R. I. Dorfman: Pituitary gonadotropin inhibition by certain new steroids. Acta endocr. (Kbh.), Suppl. 51, 855 (1960).Google Scholar
  758. [689]
    A. J. Berch, and R. I. Dorfman: Copulatory reflex in guinea pigs induced by progesterone and related steroids. Acta endocr. (Kbh.) 38, 257 (1961).Google Scholar
  759. [690]
    A. J. Berch, R. I. Dorfman and R. I. Dorfman: Anti-ovulatory activity of subcutaneously injected steroids in the adult oestrus rabbit. Acta endocr. (Kbh.), Suppl. 73, 3 (1963).Google Scholar
  760. [691]
    A. J. Berch, and R. I. Dorfman: Anti-ovulatory activity of steroids administered by gavage in the adult oestrus rabbit. Acta endocr. (Kbh.), Suppl. 73, 17 (1963).Google Scholar
  761. [692]
    A. J. Berch, and R. I. Dorfman: Orally active steroidal ovulation inhibitors in the adult estrus rabbit. Steroids 2, 521 (1963).Google Scholar
  762. [693]
    A. J. Berch, and R. I. Dorfman: Pituitary gonadotrophin inhibitory action of neutral steroids. Acta endocr (Kbh.) 46, 300 (1964).Google Scholar
  763. [694]
    A. J. Berch, and R. I. Dorfman: Antifertility activity of various steroids in the female rat. J. Reprod. Fértil. 10, 105 (1965).Google Scholar
  764. [695]
    A. J. Berch, and R. I. Dorfman: The biological activity of estrogen-free norethindrone. Proc. Soc. exp. Biol. (N.Y.) 119, 340 (1965).Google Scholar
  765. [696]
    A. J. Berch, u. A. Folch Pi: Gestagene Wirkung einiger Pregnan-Derivate. Ciencia (Méx.) 22, 31 (1962).Google Scholar
  766. [697]
    A. J. Berch, M. Maqueo, and R. I. Dorfman: Influence of various steroids on testes and acces sory sex organs in the rat. Acta endocr. (Kbh.) 49, 145 (1965).Google Scholar
  767. [698]
    A. J. Berch, H. J. Ringold, and R. I. Dorfman: Pituitary gonadotrophin inhibition by sub cutaneously administered steroids. Acta endocr. (Kbh.) 36, 83 (1961).Google Scholar
  768. [699]
    King, E. J., and I. D. P. Wooton: Microanalysis in medical biochemistry. London: Churchill 1956.Google Scholar
  769. [700]
    Kirkpatrick, R. L., N. L. First, and L. E. Casida: Effect of estradiol-17/5 on follicular development and pituitary potence in gilts fed 6-methyl-17-acetoxyprogesterone. J. anim. Sei. 22, 767 (1963).Google Scholar
  770. [701]
    Kistner, R. W.: Conservative treatment of endometriosis. Postgrad, med. J. 24, 505 (1958).Google Scholar
  771. [702]
    Kistner, R. W.: The use of newer progestins in the treatment of endometriosis. Amer. J. Obstet. Gynee. 75, 264 (1958).Google Scholar
  772. [703]
    Kleibel, F., u. J. Becker: Die funktionelle Hypophysektomie mit Aethinyl-nortest- osteron bei 130 klinischen Fallen. Acta endocr. (Kbh.), Suppl. 51, 935 (1960).Google Scholar
  773. [704]
    Klein, M.: Action analogue du propionate de testostérone et de la progestérone sur les transformations progestatives de l’endomètre chez la lapine. C. R. Soc. Biol. (Paris) 127, 915 (1938).Google Scholar
  774. [705]
    Klein, M., and A. S. Parkes: The progesterone-like action of testosterone and certain related compounds. Proc. roy. Soc. B. 121, 574 (1936/37).Google Scholar
  775. [706]
    Klopper, A.: A comparison of the clinical effects of various progestational compounds, in: ‘Eteri steroidali enolici e fenolici in cliniea e in biología’, 286—93, Roma: Il Pensiero Scientifieo.Google Scholar
  776. [707]
    Klopper, A., E. Michie, and J. B. Brown: A method for the determination of urinary pregnane- diol. J. Endocr. 12, 209 (1955).PubMedGoogle Scholar
  777. [708]
    Klopper, A., J. A. Strong, and L. R. Cook: The excretion of pregnanediol and adrenocortical activity. J. Endocr. 15, 180 (1957).PubMedGoogle Scholar
  778. [708a]
    Klüger, B., R. Siebert u. A. Schubert: Mikrobielle Oxydation von Steroiden in 15α-Stellung durch Fusarien. Naturwissenschaften 44, 40 (1957).Google Scholar
  779. [709]
    Knaus, H. H.: The action of pituitary extract upon the pregnant uterus of the rabbit. J. Physiol. (Lond.) 61, 383 (1926).Google Scholar
  780. [710]
    Knaus, H. H.: Zur Frage der Standardisation des Corpus luteum-Extraktes. Naunyn-Schmiede- bergs. Arch. exp. Path. Pharmak. 151, 371 (1930).Google Scholar
  781. [711]
    Knigge, K. M.: Cytology and hormone content of rat pituitary glands following adrenalectomy. Proc. Soc. exp. Biol. (N.Y.) 94, 640 (1957).Google Scholar
  782. [711a]
    Knörr, K.: Bisherige Erfahrungen bei der oralen Anwendung neuer Substanzen mit progestativer Aktivität (Nortestosteron-Derivate). Medizinische 51, 1898 (1957).Google Scholar
  783. [711b]
    Knox, L. H., J. A. Zderic, J. P. Ruelas, C. Djerassi, and H. J. Ringold: Derivatives of 17α-ethynyltestosterone and 17α-ethynyl-19-nortestosterone. J. Amer, ehem. Soc. 82, 1230 (1960).Google Scholar
  784. [711c]
    Kobayashi, F., and T. Miyake: Biological activities of Chlormadinone acetate (Ill), prenatal effects on the rat sexual functions. Folia endocr. jap. 42, 140 (1966).PubMedGoogle Scholar
  785. [712]
    Kochakian, Ch. D.: The tolerance of male and female mice respectively to estrogens and androgens. Endocrinology 26, 54 (1940).Google Scholar
  786. [713]
    Kochakian, Ch. D., Renotrophic-androgenic and somatotrophs properties of further steroids. Amer. J. Physiol. 158, 51 (1949).PubMedGoogle Scholar
  787. [714]
    Kochakian, Ch. D.: Comparison of protein anabolic property of various androgens in the castrated rat. Amer. J. Physiol. 160, 53 (1950).PubMedGoogle Scholar
  788. [715]
    Kochakian, Ch. D.: Renotrophic-androgenic properties of orally administered androgens. Proc. Soc. exp. Biol. (N.Y.) 80, 386 (1952).Google Scholar
  789. [716]
    Kochakian, Ch. D.: Summation of protein anabolic effects of testosterone propionate and growth hormone. Proc. Soc. exp. Biol. (N.Y.) 103, 196 (1960).Google Scholar
  790. [717]
    Kochakian, Ch. D.: Die anabole und androgene Aktivität von Androgenen. Klin. Wschr. 39, 881 (1961).PubMedGoogle Scholar
  791. [718]
    Kochakian, Ch. D., and B. R. Endahl: Influence of androgens on transaminase activities of different tissues. Amer. J. Physiol. 186, 460 (1956).PubMedGoogle Scholar
  792. [719]
    Kochakian, Ch. D.: and J. R. Murlen: The effect of male hormone on the protein and energy meta bolism of castrated dogs. J. Nutr. 10, 437 (1935).Google Scholar
  793. [720]
    Kochakian, Ch. D., and C. Tillotson: Influence of several C19 steroids on the growth of individual muscles of the guinea pig. Endocrinology 60, 607 (1957).PubMedGoogle Scholar
  794. [721]
    Koff, A. K., and M. E. Davis: The mechanism of the prolongation of pregnancy in the rabbit. Amer. J. Obstet. Gynee. 34, 26 (1937).Google Scholar
  795. [722]
    Kopera, H: The therapeutic usefulness of some estrenols (3-desoxo-nor-testosterone derivatives). Int. Congr. Hormonal Steroids, Mailand 1962. Excerpta med. (Amst.) Int. Congr. Ser. 51, Abstr. 275, p. 204, 1962.Google Scholar
  796. [723]
    Kopera, H., K. Dukes, and G. Ijzerman: Critical evaluation of clinical data on lyndiol. Int. J. Fertil. 9, 69 (1964).PubMedGoogle Scholar
  797. [724]
    Kopera, H., u. F. J. Huix: Über die therapeutische Verwendbarkeit einiger Oestrenole (3-Des- oxy-19-nor-testosteron-Verbindungen). Ther. d. Gegenw. 102, 181 (1963).Google Scholar
  798. [725]
    Kopera, H., u. G. L. Ijzerman: Über Erfahrungen mit einer neuen ovulationshemmenden Kom bination von Lynestrenol und Mestranol. Ther. d. Gegenw. 103, 657 (1964).Google Scholar
  799. [726]
    Korenchevsky, V., M. Dennison, and S. L. Simpson: The effects of water-soluble preparations of androsterone and androsterone-diol on castrated rats. Biochem. J. 29, 2131 (1935).PubMedGoogle Scholar
  800. [727]
    Körner, A., and F. G. Young: The influence of methylandrostenediol on the body weight and carcass composition of the rat. J. Endocr. 13, 78 (1955).PubMedGoogle Scholar
  801. [728]
    Kory, R. C., C. H. Bradley, R. N. Watson, R. Callahan, and B. J. Peters: A six- month evaluation of an anabolic drug, norethandrolone, in underweight persons. Amer. J. Med. 26, 243 (1959).PubMedGoogle Scholar
  802. [729]
    Kotsalo, K.: Metyioestrenolon, ein neues Steroid mit gestagener Wirksamkeit. Nord. Med. 21, 1813 (1957).Google Scholar
  803. [730]
    Kowalewski, K.: Effect of certain androgenic steroids and cortisone on gastric uleero- genesis in fasting rats. Proc. Soc. exp. Biol. (N.Y.) 101, 147 (1959).Google Scholar
  804. [731]
    Kraay, R. J., and D. M. Brennan: Evaluation of Chlormadinone acetate and other progestogens for foetal masculinization in rats. Acta endocr. (Kbh.) 43, 412 (1963).Google Scholar
  805. [732]
    Krähenbühl, C.: Effets de la fluoxymesterone et de la methyltestosterone appliqués par voie orale chez le rat male hypophysectomise. Acta endocr. (Kbh.) 37, 394 (1961).Google Scholar
  806. [733]
    Kraft, H. G., u. H. Brückner: Anabole und androgene Wirksamkeit von thio-sub- stituierten Steroiden der Androstan-Reihe. Arzneimittel-Forsch. 14, 328 (1964).Google Scholar
  807. [734]
    Kraft, H. G., u. H. Kieser: Experimentelle Untersuchungen mit la-Bis-[aeetylthio-17ß-hydroxy- 17α-methyl-androsten-(4)]-on-(3). Arzneimittel-Forsch. 14, 330 (1964).Google Scholar
  808. [734a]
    Kraft, H. G., u. H. Kieser: Anti-estrogenie and anti-androgenie activities of Chlormadinone acetate and related compounds. II. Int. Congr. Hormonal Steroids, Mailand 1966. Excerpta med. (Amst.), Int. Congr. Ser. 111, 346 (1966) (Abstract No 681).Google Scholar
  809. [735]
    Kraft, H. G., and G. Hecht-Lucari: Relationship between anti-fertility and anti-estrogenic activity of a number of steroids. Fifth World Congr. Fertil. and Steril., Stockholm 1966. Excerpta med. (Amst.) Int. Congr. Ser. 109, Abstr. 253, 1966.Google Scholar
  810. [736]
    Kramer, M., F. Neumann u. W. Elger: Feminisierung männlicher Ratten durch das Antiandrogen l,2a-Methylen-6-chlor-Zl46-pregnadien-17α-ol-3,20-dion-17α-acetat. Herbsttagg Dtsch. Pharmakol. Ges., Göttingen 1965.Google Scholar
  811. [737]
    Kramer, M., F. Neumann u. W. Elger: Zur Bedeutung fetaler Androgene für die Geschlechtsdifferenzierung. Nau-nyn-Schmiedebergs Arch. exp. Path. Pharmak. 251, 124 (1965).Google Scholar
  812. [738]
    Kritchevsky, Th. H., and R. F. Gallagher: Partial synthesis of compounds related to adrenal cortical hormones. XIV. Preparation of the dihydroxyaeetone side chain; 17α-hydroxy-progesterone and “substances L. and P”. J. Amer. chem. Soc. 73, 184 (1951).Google Scholar
  813. [739]
    Kroc, R. L., B. G. Steinetz, and V. L. Beach: The effects of estrogens, progestogens, and relaxin in pregnant and nonpregnant laboratory rodents. Ann. N.Y. Acad. Sei. 75, 942 (1959).Google Scholar
  814. [740]
    Krüskemper, H.-L.: Anabole Steroide. Stuttgart: Georg Thieme 1963.Google Scholar
  815. [741]
    Krüskemper, H.-L., u. H. Breuer: Untersuchungen über die klinische Wirksamkeit und den Stoffwechsel neuer methylierter Androstenolon-Derivate. 67. Kongr. Dtsch. Ges. Inn. Med., Wiesbaden 1961, S. 387—94. München: J. F. Bergmann 1962.Google Scholar
  816. [742]
    Krymskaya, M. L., and N. T. Starkova: Prednisolone therapy of some forms of sterility in women. Ref. in: Ber. ges. Gynäk. Geburtsh. 88, 8 (1965).Google Scholar
  817. [743]
    Kulkanek, W.: Erfahrungen mit Anovlar in der täglichen Sprechstunde. Med. Mitt. (Schering) 25, 4 (1964).Google Scholar
  818. [744]
    Kumar, D., and A. C. Barnes: Studies on the mechanism of action of progesterone on the human myometrium. Johns Hopk. Hosp. Bull. 113, 330 (1963).Google Scholar
  819. [745]
    Kumar, D., J. A. Goodno, and A. C. Barnes: In vivo effects of intravenous progesterone infusion on human gravid uterine contractility. Johns Hopk. Hosp. Bull. 113,53 (1963).Google Scholar
  820. [746]
    Kunz, H.A., u. W. Wilbrandt: Antagonistische Wirkung zwischen Herzglykosiden und Steroiden auf die Kaliumabgabe des Herzmuskels. Helv. physiol. pharmacol. Acta 21, 83 (1963).PubMedGoogle Scholar
  821. [747]
    Kupperman, H. S., and J.A. Epstein: Gonadotropic-inhibiting and uterotropic effects of enovid. Proc. Symp. 19-Nor-Progestational Steroids, p. 32—45. Chicago 1957.Google Scholar
  822. [748]
    Kurata, Y.: Histochemical demonstration of carbonic anhydrase activity: Stain Technol. 28, 231 (1953).PubMedGoogle Scholar
  823. [749]
    Kurogochi, Y., and G. Pincus: Progesterone assay in the rabbit by the local intrauterine response. Endocrinology 70, 940 (1962).PubMedGoogle Scholar
  824. [750]
    Läuppi, E., u. A. Studer: Hemmung der experimentellen, testosteron-bedingten Epidermisproliferation an der weiblichen Ratte durch ein synthetisches Phenan- threnderivat mit antiandrogener Wirksamkeit. Experientia (Basel) 15, 264 (1959).Google Scholar
  825. [751]
    Lagier, R.: Action du méthylandrostènediol sur le métabolisme de l’anzote: Étude par la méthode des bilans. Ann. Endoer. (Paris) 14, 1024 (1953).Google Scholar
  826. [752]
    Lambillon, J.: Le phénylpropionate de norandrosténolone. Doses élevées et leurs effets secondaires. Brux.-méd. 38, 817 (1958).PubMedGoogle Scholar
  827. [753]
    Lamond, D. R.: Quantitative studies of the interaction between progesterone and pregnant mare serum on ovarian function in the ewe. J. Reprod. Fertil. 7,171 (1964).PubMedGoogle Scholar
  828. [754]
    Landau, R. L., D. M. Bergenstal, K. Lugibihl, and A. B. Kascht: The metabolic effects of progesterone in man. J. clin. Endoer. 15, 1194 (1955).Google Scholar
  829. [755]
    Landau, R. L., K. Lugibihl, and D. F. Dimick: Metabolic effects in man of steroids with pro gestational activity. Ann. N.Y. Acad. Sei. 71, 588 (1958).Google Scholar
  830. [756]
    Lauritzen, C.: Zur Wirkung des Aethinyl-nor-testosterons auf die Basaltemperatur in der Schwangerschaft. Geburtsh. u. Frauenheilk. 17, 807 (1957).Google Scholar
  831. [757]
    Lauritzen, C.: Biologische Wirkungen des 20ß-hydroxy-pregn-4-en-3-on. Acta endoer. (Kbh.) 44, 225 (1963).Google Scholar
  832. [758]
    Lauson, H. D., C. G. Heller, J. B. Golden, and E. L. Sevringhaus: The immature rat uterus in the assay of estrogenic substances, and a comparison of estradiol, estrone and estriol. Endocrinology 24, 35 (1939).Google Scholar
  833. [759]
    Lauterwein, C.: Perorale Progesterontherapie. Zbl. Gynäk. 64, 108 (1940).Google Scholar
  834. [760]
    Leathem, J. H., and B. J. Brent: Influence of pregneninolone and pregnenolone on spermatogenesis in hypophyseetomized adult rats. Proc. Soc. exp. Biol. (N.Y.) 52, 341 (1943).Google Scholar
  835. [761]
    Lee, A. E., and P. C. Williams: Oestrogen antagonists: Assay by inhibition of vaginal eornification. J. Endocr. 28, 199 (1964).PubMedGoogle Scholar
  836. [762]
    Leeebvre, Y., et R. Gaudry: La réaction du pentachlorure de phosphore sur les acyloxy-3ß-⊿4-ceto-6 stéroides. Canad. J. Chem. 43, 1990 (1965).Google Scholar
  837. [763]
    Léger, J., et G. Masson: Propriétés pharmacologiques de dérivés du ⊿4-androstènediol. Rev. canad. Biol. 5, 478 (1946).PubMedGoogle Scholar
  838. [764]
    Lehmann, J.: Über das Strukturbild der Hypophyse kastrierter und nicht kastrierter Ratten unter dem Einfluß parenteral zugeführter Placentarsubstanzen. Virchows Arch. path. Anat. 268, 346 (1928).Google Scholar
  839. [765]
    Lehmann, J.: Erfahrungen mit einem neuen Ovulationshemmer. Med. Welt 36, 1915 (1964).Google Scholar
  840. [766]
    Leonhard, S. L., V. Sager, and J. B. Hamilton: Effect of male hormone upon uterine motility and the uterus. Proc. Soc. exp. Biol. (N.Y.) 37, 362 (1937).Google Scholar
  841. [767]
    Lerner, L., A. Bianchi, and A. Borman: Anti-androgenie activity of a-norprogesterone in the intact male rat. Acta endocr. (Kbh.), Suppl. 51, 869 (1960).Google Scholar
  842. [768]
    Lerner, L., A. Bianchi, and A. Borman: A norprogesterone, an androgen antagonist. Proc. Soc. exp. Biol. (N.Y.) 103, 172 (1960).Google Scholar
  843. [769]
    Lerner, L., D. M. Brennan, and A. Borman: Biological activities of 16α, 17α-dihydroxy progesterone derivatives. Proc. Soc. exp. Biol. (N.Y.) 106, 231 (1961).Google Scholar
  844. [770]
    Lerner, L., D. M. Brennan, M. de Phillipo, and E. Yiacas: Comparison of biological activities of progesterone, norethisterone and the acetophenone derivatives of 16α,17α-dihydroxy- progesterone. Fed. Proc. 20, 200 (1961).Google Scholar
  845. [771]
    Lerner, L., D. M. Brennan, E. Yiacas, M. de Phillipo, and A. Borman: Pregnancy maintenance in ovari- ectomized rats with 16α,17α-dihydroxyprogesterone derivatives and other progestogens. Endocrinology 70, 283 (1962).PubMedGoogle Scholar
  846. [772]
    Lerner, L., M. de Phillipo, E. Yiacas, D. M. Brennan, and A. Borman: Comparison of the acetophenone derivative of 16α,17α-dihydroxyprogesterone with other progestational steroids for masculinization of the rat fetus. Endocrinology 71, 448 (1962).PubMedGoogle Scholar
  847. [773]
    Lerner, L., F. J. Holthaus jr., and Ch. R. Thompson: A non-steroidal estrogen antagonist 1 - (p-2-diethylaminoethoxyphenyl)-1 -phenyl-2-p-methoxyphenyl ethanol. Endocrinology 63, 295 (1958).PubMedGoogle Scholar
  848. [774]
    Lerner, L., F. J. Holthaus jr., and Ch. R. Thompson: A myotrophie agent and gonadotrophs inhibitor 19-nortestosterone-17- benzoate. Endocrinology 64, 1010 (1959).PubMedGoogle Scholar
  849. [775]
    Lerner, L., F. J. Holthaus jr., and Ch. R. Thompson, Lerner, L., E. Yiacas, A. Bianchi, D. Turkheimer, M. De Phillipo, and A. Borman: Anti- fertility activities of the acetophenone derivative of 16α,17α-dihydroxyprogesterone in the rat. Int. Congr. Hormonal Steroids, Mailand 1962. Excerpta med. (Amst.) Int. Congr. Ser. 51, Abstr. 248, p. 188, 1962.Google Scholar
  850. [776]
    Lerner, L., F. J. Holthaus jr., and Ch. R. Thompson, A. R., M. de Phillipo, and A. Borman: Effect of the acetophenone derivative of 16α,17α-dihydroxyprogesterone on the estrous cycle, mating and fertility in the rat. Fertil. and Steril. 15, 63 (1964).Google Scholar
  851. [777]
    Lerner, L., F. J. Holthaus jr., and A. Borman: Biological activities of the 2-acetofuran derivative of 16α,17α-dihydroxyprogesterone. Proc. Soc. exp. Biol. (N.Y.) 113, 663 (1963).Google Scholar
  852. [778]
    Liddle, G. W.: Sodium diuresis induced by steroidal antagonists of aldosterone. Science 126, 1016 (1957).PubMedGoogle Scholar
  853. [778a]
    Lieberman, S., D. K. Fukushima, and K. Dobriner: Studies in steroid metabolism. VII. Identification and characterization of additional ketosteroids isolated from urine of healthy and diseased persons. J. biol. Chem. 182, 299 (1950).Google Scholar
  854. [779]
    Lindsay, D. R., and T. J. Robinson: Oestrogenic and anti-oestrogenie activity of androgens in the ewe. J. Reprod. Fertil. 7, 267 (1964).PubMedGoogle Scholar
  855. [779a]
    Lindner, F., R. Junk, H. Kehl, G. Nesemann u. J. Schmidt-Thomé: Dehydrierung von ⊿4-3-Ketosteroiden zu l,4-Dien-3-ketonen durch Bakterien der Subtilis- Gruppe. Naturwissenschaften 43, 39 (1956).Google Scholar
  856. [780]
    Lipp, R. G.: A controlled evaluation of parenteral medroxyprogesterone acetate in habitual abortion. Clin. Med. 70, 1279 (1963).Google Scholar
  857. [781]
    Lepschütz, A.: Dynamics of ovarian hypertrophy under experimental conditions. Brit. J. exp. Biol. 2, 331 (1925).Google Scholar
  858. [782]
    Lepschütz, A.: New experimental aspects of the antitumorigenic action of steroid hormones. Acta Un. int. Cancr. 6, 85 (1948).Google Scholar
  859. [783]
    Lepschütz, A.: Steroid hormones and tumors. Baltimore: Williams & Wilkins Co., 1950.Google Scholar
  860. [784]
    Lepschütz, A.: Experimentelle Forschung über endokrine Störungen und Geschwulstbildungen. Münch, med. Wschr. 97, 1007, 1023 (1955).Google Scholar
  861. [785]
    Lepschütz, A.: Steroid homeostasis, hypophysis and tumorigenesis. Cambridge: Heffer & Sons 1957.Google Scholar
  862. [786]
    Lepschütz, A.: Ovarian tumours and other tumoral responses induced by subtotal castration (“ovarian fragmentation”) in mice. Acta Un. int. Cancr. 16, 149 (1960).Google Scholar
  863. [787]
    Lepschütz, A., et A. Adamberg: Nouvelles expériences sur la loi de la constance folliculaire. C. R. Soc. Biol. (Paris) 93, 4164 (1925).Google Scholar
  864. [788]
    Lepschütz, A., et A. Adamberg, M. Thtso u. S. Veshniakov: Das Gesetz der konstanten Follikelzahl. Pflügers Arch. ges. Physiol. 211, 682 (1926).Google Scholar
  865. [789]
    Lepschütz, A., S. Bruzzone, and F. Fuenzalida: Comparative antifibromatogenic activity of progesterone and related artificial steroids. Cancer Res. 4, 179 (1944).Google Scholar
  866. [790]
    Lepschütz, A., and S. Figueroa: Halogenated progesterone derivatives as antiluteinizers. Acta endocr. (Kbh.) 26, 371 (1957).Google Scholar
  867. [791]
    Lepschütz, A., et R. Iglesias: Multiples tumeurs utérines et estrogénitales provoqués par le benzoate d’oestradiol. C. R. Soc. Biol. (Paris) 129, 915 (1938).Google Scholar
  868. [792]
    Lepschütz, A., et R. Iglesias: Recovery of fertility after protracted steroid-induced sterility in mice. Nature (Lond.) 190, 174 (1961).Google Scholar
  869. [793]
    Lepschütz, A., et R.Iglesias, S. Bruzzone, F. Fuenzalida, and A. Riesco: New experimental aspects of the antitumorigenic action of steroid hormones. Acta Un. int. Cancr. 6, 85 (1948).Google Scholar
  870. [794]
    Lepschütz, A., et R. Iglesias, S. Bruzzone, J. Humerez, and J. M. Penaranda: Progesterone and desoxycorticosterone in the steroid control of the gonadotrophs function of the hypophysis. Endocrinology 42, 201 (1948).Google Scholar
  871. [795]
    Lipschütz, A., R. Iglesias et E. Mardones: Nouvelles reeherches sur le mode d’aetion antitumorale des steroides. Bull. Ass. franç. Cancer 38, 394 (1950).Google Scholar
  872. [796]
    Lipschütz, A., and S. Salinas: Further studies on the recovery of fertility in mice after protracted steroid-induced sterility. J. Reprod. Fertil. 6, 99 (1963).PubMedGoogle Scholar
  873. [797]
    Lipschütz, A., D. Jadrijevic, A. Figtteroa, and S. Girardi: Resistance of 9α-fluoro-11 β-hydroxy- progesterone to inactivation in the liver of the guinea pig. Nature (Lond.) 180, 508 (1957).Google Scholar
  874. [798]
    Lipschütz, A., D. Jadrijevic, S. Girardi, S. Bruzzone, and E. Mardones: Antifibromatogenie potency of 9α-fluoro derivatives of progesterone. Nature (Lond.) 178, 1396 (1956).Google Scholar
  875. [799]
    Lipschütz, A., D. Jadrijevic, E. Mardones, S. Figueroa, and S. Girardi: Comparative antioestrogenic potencies of progesterone and esterified 17oc-hydroxyprogesterone in the guinea-pig. J. Endocr. 15, 248 (1957).PubMedGoogle Scholar
  876. [800]
    Lipschütz, A., and M. Maas: Progesterone treatment of uterine and other abdominal fibroids induced in the guinea pig by a-estradiol. Cancer Res. 4, 18 (1944).Google Scholar
  877. [801]
    Lipschüt, A. E. Mardones, R. Iglesias, F. Fuenzalida, and S. Bruzzone: Comparative antifibromatogenie action of cortical steroids. Science 116, 448 (1952).PubMedGoogle Scholar
  878. [802]
    Lipschütz, A. R- Murillo, and L. Vargas jr.: Antitumorigenic action of progesterone. Lancet 1939 II, 420.Google Scholar
  879. [803]
    Lipschütz, A. and L. Vargas jr.: Prevention of experimental uterine and extrauterine fibroids by testosterone and progesterone. Endocrinology 28, 669 (1951).Google Scholar
  880. [804]
    Lipschütz, A. L. Vargas, and O. Ruz: Antitumorigenic action of testosterone. Lancet 1939 II, 867.Google Scholar
  881. [805]
    Lipschütz, A., et H. E. Voss: Dynamique de l’hypertrophie ovarienne. C. R. Soc. Biol. (Paris) 90, 199 (1924).Google Scholar
  882. [806]
    Lipschütz, A. H. E. Voss Further developments on the dynamics of ovarian hypertrophy: Brit. J. exp. Biol. 3, 35 (1925).Google Scholar
  883. [807]
    Lipschütz, A. Ch. Wagner et R. Tamm: Sur l’hypertrophie des fragments ovariens dans la castration partielle. C. R. Soc. Biol. (Paris) 86, 240 (1922).Google Scholar
  884. [808]
    Lipschütz, A. Ch. Wagner R. Tamm and F. Bormann: Further experimental investigations on the hypertrophy of the sexual glands. Proc. roy. Soc. B. 94, 83 (1922).Google Scholar
  885. [809]
    Little, B., and E. Lincoln: Effect of estrogen, progesterone and testosterone on the incorporation of l-valine-l-C14 into protein of the rat liver and uterus. Endocrinology 74, 1 (1964).PubMedGoogle Scholar
  886. [810]
    Livingston, N. B.: Medroxyprogesterone acetate and estrogen to inhibit fertility. Int. J. Fertil. 8, 699 (1963).PubMedGoogle Scholar
  887. [811]
    Loeb, L.: Über die experimentelle Erzeugung von Knoten von Deeiduagewebe im Uterus des Meerschweinchens nach stattgefundener Kopulation. Zbl. allg. Path. Anat. 18, 563 (1907).Google Scholar
  888. [812]
    Loeb, L. Über die künstliche Erzeugung der Decidua und über die Beurteilung der Ovarien für die Deciduabildung. Zbl. Physiol. 22, 498 (1908).Google Scholar
  889. [813]
    Loeb, L. The experimental production of the maternal placenta. J. Amer. med. Ass. 53, 1471 (1909).Google Scholar
  890. [814]
    Loeb, L. Über die Bedeutung des Corpus luteum. Zbl. Physiol. 23, 73 (1909).Google Scholar
  891. [815]
    Loeb, L. The function of corpus luteum, the experimental production of the maternal placenta and the mechanism of the sexual cycle in the female organism. Med. Ree. (N.Y.) 77, 1083 (1910).Google Scholar
  892. [816]
    Loeb, L. The reaction of the uterine mucosa towards foreign bodies introduced into the uterine cavity. Proc. Soc. exp. Biol. (N.Y.) 7, 90 (1910).Google Scholar
  893. [817]
    Loeb, L. The experimental production of the maternal placenta. Proc. path. Soc. Philad., 1910, 94.Google Scholar
  894. [818]
    Loeb, L. Über die Bedeutung des Corpus luteum für die Periodizität des sexuellen Zyklus beim weiblichen Säugetierorganismus. Dtseh. med. Wschr. 1, 17 (1911).Google Scholar
  895. [819]
    Löken, H., M. Uskokoviö, M. Hagopian, and R. I. Dorfman: 3β-Hydroxy-6α-methyl- pregn-4-en-20-one. Steroids 2, 81 (1963).Google Scholar
  896. [820]
    Logothetopotjlos, J., B. Shamra, and J. Kraicer: Effects produced in rats by the administration of 6α-methyl-17α-hydroxyprogesterone acetate from birth to maturity. Endocrinology 68, 417 (1961).Google Scholar
  897. [821]
    Longchampt, J. E., K. Hayano, M. Ehrenstein, and R.I. Dorfman: Comparison of the uterotrophic activities of various steroids with their utilization in vitro estrogen biosynthetic systems. Endocrinology 67, 843 (1960).PubMedGoogle Scholar
  898. [822]
    Looney, J. M.: Testosterone isobutyrate and testosterone phenylacetate: Two long- acting androgens for clinical use. J. clin. Endocr. 14, 800 (1954).Google Scholar
  899. [823]
    Loraine, J. A., E. T. Bell, R. A. Harkness, E. Mears, and M. C. Jackson: Effects of long-term administration on hormone excretion in normally menstruating women. Lancet 1963 II, 902.Google Scholar
  900. [824]
    Ludwig, D. J.: The effect of androgen on spermatogenesis. Endocrinology 46,453 (1950).PubMedGoogle Scholar
  901. [825]
    Lunenfeld, B., S. Sulimovici, and E. Babau: Mechanism of action of anti-ovulatory compounds. J. clin. Endocr. 28, 391 (1963).Google Scholar
  902. [826]
    Lutwak-Mann, C.: Carbonic anhydrase in the female reproductive tract. Occurrence, distribution and hormonal dependence. J. Endocr. 13, 26 (1955).PubMedGoogle Scholar
  903. [827]
    Lutwak-Mann, C., and C. E. Adams: Carbonic anhydrase in the female reproductive tract. II. Endo metrial carbonic anhydrase as indicator of luteoid potency: Correlation with progestational proliferation. J. Endocr. 15, 43 (1957).PubMedGoogle Scholar
  904. [828]
    Lutwak-Mann, C. C. E. Adams The effect of methyloestronolone on endometrial carbonic anhydrase and its ability to maintain pregnancy in the castrated rabbit. Acta endocr. (Kbh.) 25, 405.Google Scholar
  905. [829]
    Lutwak-Mann, C., and H. Laser: Bicarbonate content of the blastocyst fluid and carbonic anhydrase in the pregnant rabbit uterus. Nature (Lond.) 173, 268 (1954).Google Scholar
  906. [830]
    Lyons, W. R.: Pregnancy maintenance in hypophysectomized-oophorectomized rats injected with estrone and progesterone. Proc. Soc. exp. Biol. (N.Y.) 54, 65 (1943).Google Scholar
  907. [831]
    Lyons, W. R. C. H. Li, and R. E. Johnson: The hormonal control of mammary growth and lactation. Recent Progr. Hormone Res. 14, 219 (1958).Google Scholar
  908. [832]
    Lysiak, M.: The effects of sex hormones injections on pH of the gastric juice after hist amine administration in rats. Endokr. pol. 13, 459 (1962).PubMedGoogle Scholar
  909. [833]
    Lyster, S. C., G. H. Lund, W. E. Dulin, and R. O. Stafford: Ability of some progestational steroids to stimulate male accessory glands of reproduction in the rat. Proc. Soc. exp. Biol. (N.Y.) 100, 540 (1959).Google Scholar
  910. [834]
    Lyster, S. C. G. H. Lund, and R. O. Stafford: Androgenic and myotrophic properties of orally administerred 9-fluoro-11-oxy-methyltestosterones. Endocrinology 58, 781 (1956).PubMedGoogle Scholar
  911. [835]
    Machione, C., and A. Walton: Fecundity of rabbits as determined by “dummy matings”. J. agric. Sci. 28, 122 (1938).Google Scholar
  912. [836]
    MacMaster, D. R., and K. Alamin: Treatment of severe weight loss with methandro-stenolone-A less virilizing anabolic agent. Amer. J. Psychiat. 120, 179 (1963).Google Scholar
  913. [836a]
    Madaeva, O. S.: Some properties of esters of p-toluenesulfonates of 17β-hydroxy steroids. VIII. Location of the secondary-tertiary double bond in 3-β-acetates of 17-methyl-18-norandrostenol and androstadienol. Chem. Abstr. 52, 7341 (1958).Google Scholar
  914. [837]
    Madjerek, Z.: Deciduoma formation in mice as a criterion of progestational activity. Acta endocr. (Kbh.), Suppl. 51, 901 (1960).Google Scholar
  915. [837a]
    Madjerek, Z. J. de Visser, J. van der Vies, and G. A. Overbeek: Allylestrenol, a pregnancy maintaining oral gestagen. Acta endocr. (Kbh.) 8, 35 (1960).Google Scholar
  916. [837b]
    Madjerek, Z. An investigation of the substances with prolonged progestational activity. Acta physiol. pharmacol. neerl. 13, 366 (1964).Google Scholar
  917. [838]
    Maekawa, K.: Effect of progesterone on duration of vaginal response to estrogen. J. Fac. Sci. Tokyo, Sect. 4, 7, 455 (1954/56).Google Scholar
  918. [839]
    Magnus, E. M.: Weiblicher Pseudohermaphroditisms im Anschluß an Hormonbehandlung der Mutter während der Schwangerschaft. T. norske Laegeforen. 80, 92 (1960).PubMedGoogle Scholar
  919. [840]
    Magrath, D., V. Petrow, and R. Royer: The preparation of 17α-propargyltesto-sterone. J. chem. Soc. 1951, 845.Google Scholar
  920. [841]
    Makepeace, A. W., G. L. Weinstein, and M. H. Friedman: The effect of progestin and progesterone on ovulation in the rabbit. Amer. J. Physiol. 119, 512 (1937).Google Scholar
  921. [842]
    Manautou, J. M., M. Maqueo, R. A. Gilbert, and J. W. Goldzieher: Human endometrial activity of several new derivatives of 17-aeetoxyprogesterone. Fertil. and Steril. 13, 169 (1962).Google Scholar
  922. [843]
    Mancera, D., and H. J. Ringold: The synthesis of halogenated steroid hormones, 4-chloro-19-nor-hormone analogs. Canad. J. Chem. 37, 1785 (1959).Google Scholar
  923. [844]
    Mancini, R. E., I. Izquierdo et P. Kirschbaum: Action de la testostérone sur la captation du 35 S par les mucopolysaccharides du connectif de la crete du coq. C. R. Soc. Biol. (Paris) 152, 190 (1958).Google Scholar
  924. [845]
    Mandelstamm, R., and W. K. Tschaikowski: Cit. by F. Fuchs and A. Fuchs in: Induction and inhibition of labour in the rabbit. Acta endocr. (Kbh.) 29, 615.Google Scholar
  925. [846]
    Mandl, A.M., S. Zuckerman, and H.D. Patterson: The number of oocytes in ovarian fragments after compensatory hypertrophy. J. Endocr. 8, 347 (1952).PubMedGoogle Scholar
  926. [847]
    Maneschi, M., E. Cittadini, and P. Quartararo: Effetti della somministrazione de alcuni progestative di sintesi sulla funzionalita tiroidea. Sicilia sauit. 4, 135 (1962).Google Scholar
  927. [848]
    Mangili, G., L. Martini, and A. Pecile: Pituitary action of some steroidal enol ethers. Chem. Abstr. 61, 7310 (1964).Google Scholar
  928. [848a]
    Mannhardt, H. J., F. v. Werder, K. H. Bork, H. Metz u. K. Brückner: Darstellung von 16-Methylen-Steroiden der Corticoid- und Progesteronreihe. Tetrahedron Lett. 16, 21 (1960).Google Scholar
  929. [849]
    Mansani, F. E.: II metilestrenolone, nuova sostanza progestogena piu attiva del progesterone. Minerva ginec. 9, 935 (1957).PubMedGoogle Scholar
  930. [850]
    Maqueo, M., F. A. Kincl, and P. Alto: Macro- and microscopic elevation of the feminization or masculinization of rats treated with various steroids. Vlth Pan Amer. Congr. Endocrinology, Mexico 1965. Excerpta med. (Amst.) Int. Congr. Ser. 99, Abstr. 412, p. E. 186, 1965.Google Scholar
  931. [851]
    Marchetti, E., e P. Doneni: Bintesi di alcuni derivati isossazolici dell’androstano. Gazz. Chim. ital. 91. 1133 (1961).Google Scholar
  932. [852]
    Mardones, E., S. Bruzzone, R. Iglesias, and A. Lipschütz: The non-concomitancy of the progestational and antiluteinizing actions of steroids. Endocrinology 49, 817 (1951).PubMedGoogle Scholar
  933. [853]
    Mardones, E. R. Iglesias, F. Fuenzalida, S. Bruzzone, and A. Lepschütz: Structural features of antitumorigenic corticoids. Nature (Lond.) 170, 917 (1952).Google Scholar
  934. [854]
    Mardones, E. R. Iglesias, and A. Lepschütz: Comparative antifibromatogenie action of progesterone and zlu- dehy droprogesterone. Experientia (Basel) 9, 303 (1953).Google Scholar
  935. [855]
    Mardones, E. R. Iglesias, ;A. Lepschütz Antiestrogenic potencies of various progesterone derivatives with oxidation at Cu. Nature (Lond.) 174, 839 (1954).Google Scholar
  936. [856]
    Mardones, E. R. Iglesias, A. Lepschütz Physiological action of 19-norprogesterone in the guinea pig. Proc. Soc. exp. Biol. (N.Y.) 86, 451 (1954).Google Scholar
  937. [857]
    Mardones, E. R. Iglesias, A. Lepschütz The antiluteinizing potency of five derivatives of progesterone. Endocrinology 58, 212 (1956).PubMedGoogle Scholar
  938. [858]
    Mardones, E. D. Jadrijevic, and A. Lepschütz: Comparative antiestrogenic potencies of progesterone and 17α-hydroxyprogesterone. Nature (Lond.) 177, 478 (1956).Google Scholar
  939. [859]
    Margulis, R. R., J. E. Ladd, M. F. Fahey, and H. C. Walser: The prevention of ovulation with norethindrone acetate. Int. Fed. Gynäkologie und Geburtshilfe, 3. Weltkongress Wien 1961, Bd. I, Abstr. 188.Google Scholar
  940. [860]
    Marois, M.: Sur l’action nocive exercée sur la gestation par certains stéroides. C. R. Soc. Biol. (Paris) 154, 1361 (1960).Google Scholar
  941. [861]
    Marois, M. Action d’un progestatif actif par voie buccale, la dydrogestérone, sur la corne utérine de la lapine. Bull. Acad. nat. Méd. (Paris) 146, 324 (1962).Google Scholar
  942. [862]
    Marois, M. Maintain de la gestation chez la ratte sous l’action d’un progestatif actif par voie buccale: la dydrogestérone. Bull. Acad. nat. Méd. (Paris) 146, 329 (1962).Google Scholar
  943. [863]
    Marois, M. Action d’un progestatif actif par voie buccale, la dydrogestérone sur la symphyse pubienne du cobaye. Bull. Acad. nat. Méd. (Paris) 146, 349 (1962).Google Scholar
  944. [864]
    Marrian, G. F.: The chemistry of oestrin. I. Preparation from urine and separation from an unidentified solid alcohol. Biochem. J. 23, 1090 (1929).PubMedGoogle Scholar
  945. [864a]
    Marshall, C. W., R. E. Ray, I. Laos, and B. Riegel: 7-Keto steroids. II. Steroidal 3β-hydroxy-Δ 5-7-ones and Δ 3,5-7-ones. J. Amer. ehem. Soc. 79, 6308 (1957).Google Scholar
  946. [865]
    Marshall, D. J., and R. Gaudry: 17α-halogenated progesterones: Orally-active pro gestins. Canad. J. Chem. 38, 1495 (1960).Google Scholar
  947. [866]
    Marshall, D. J. P. F. Morand, C. Revesz, and R. Gaudry: 17-substitutes 3β-hydroxy-4-pregnen-20-ones. J. med. Chem. 7, 355 (1964).PubMedGoogle Scholar
  948. [867]
    Marshall, F. H. A., and W. A. Jolly: Contributions to the physiology of mammalian reproduction. Part I: The oestrus cycle in the dog. Part II. The ovary as an organ of internal secretion. Proc. roy. Soc. B 76, 395 (1905).Google Scholar
  949. [868]
    Marshall, F. H. A. W. A. Jolly Contributions to the physiology of mammalian reproduction. Part II. The ovary as an organ of internal secretion. Phil. Trans. B 198, 123 (1905).Google Scholar
  950. [869]
    Marshall, F. H. A., and E. D. Verny: The occurrence of ovulation and pseudopregnancy in the rabbit as a result of central nervous stimulation. J. Physiol. (Lond.) 86, 327 (1936).Google Scholar
  951. [870]
    Martens, S. G. R., and B. Nylén: On the enlarging effect of desoxicorticosterone acetate on the kidneys of female mice. Acta anat. (Basel) 2, 110 (1946).Google Scholar
  952. [871]
    Martin, L.: Interactions between oestradiol and progestogens in the uterus of the mouse. J. Endocr. 26, 31 (1963).Google Scholar
  953. [872]
    Martins, Th., et A. Rocha: La régulation de l’hypophyse par le testicule. C. R. Soc. Biol. (Paris) 106, 510 (1931).Google Scholar
  954. [873]
    Mason, H., C. S. Myers, and E. C. Mendall: The identification of a substance which possesses the qualitative action of cortin; its conversion into a diketone closely related to androstenedione. J. biol. Chem. 116, 267 (1936).Google Scholar
  955. [874]
    Massenbach, W. v.: Über die unzweckmäßige Anwendung von Corpus luteum-Hormon. Dtsch. med. Wschr. 19, 513 (1941).Google Scholar
  956. [875]
    Massenbach, W. v., u. A. Stadtmüller: Die Wirkung des Vitamin E auf die gonadotrope Funktion des Hypophysenvorderlappens. Zbl. Gynäk. 74, 25 (1952).Google Scholar
  957. [876]
    Masson, G.: Deciduoma formation with desoxycorticosterone acetate. Proc. Soc. exp. Biol. (N.Y.) 54, 196 (1943).Google Scholar
  958. [877]
    Masson, G. Spermatogenic activity of various steroids. Amer. J. med. Sei. 209, 324 (1945).Google Scholar
  959. [878]
    Masson, G.: The spermatogenic activity of Δ 5pregnenolone and of its esters. Amer. J. med. Sei. 212, 1 (1946).Google Scholar
  960. [879]
    Masson, G. A. Borduas, and H. Selye: The sex hormone actions of some steroids related to desoxycorticosterone and progesterone. Rev. canad. Biol. 1, 57 (1942).Google Scholar
  961. [880]
    Masson, G. and H. Selye: Additional steroids with luteoid activity. J. Pharmacol, exp. Ther. 84, 46 (1945).Google Scholar
  962. [881]
    Mears, E.: Ovidation inhibitors. Large-scale clinical trials. Int. J. Fertil. 9, 1 (1964).PubMedGoogle Scholar
  963. [882]
    Matsumoto, S., T. Ito, S. Inoue, M. Kuribara u. T. Sato: Norethisteronacetat und Äthinyloestradiol zur Hemmung der Ovulation. Zbl. Gynäk. 88, 1485 (1961).Google Scholar
  964. [883]
    Matsuyama, R.: Experimentelle Untersuchungen mit Rattenparabiosen. III. Teil: Die Veränderungen der Geschlechtsdrüsen und der Organe, die damit in inniger Beziehung stehen. Frankfurt. Z. Path. 25, 436 (1921).Google Scholar
  965. [8841.
    Mayer, G., et A. J. Thevenot-Duluc: Besoins hormonaux de la nidation chez la ratte ovariectomiséele cinquième jour delà gravidité. C. R. Soc. Biol. (Paris) 157,1558 (1964).Google Scholar
  966. [884a]
    McAleer, W. J., T. A. Jacob, L. B. Turnbull, E. F. Schoenewaldt, and T. H. Stoudt: Hydroxylation of progesterone by Bacillus sereus and Bacillus megaterium. Arch. Biochem. 73, 127 (1958).PubMedGoogle Scholar
  967. [885]
    McCann, S. M.: Effect of hypothalamic lesions on the adrenal cortical response to stress in the rat. Amer. J. Physiol. 175, 13 (1953).PubMedGoogle Scholar
  968. [886]
    McCormack, C. E., and R. K. Meyer: Ovulation induced by progesterone in immature rats pretreated with pregnant mare serum gonadotropin. Gen. comp. Endocr. 3, 300 (1963).Google Scholar
  969. [887]
    McCormack, C. E. R. K. Meyer Minimal age for induction of ovulation with progesterone in rats: Evidence for neural control. Endocrinology 74, 793 (1964).PubMedGoogle Scholar
  970. [888]
    McCracken, B. H., and F. M. Parsons: Use (17-ethyl-19-nortestosterone) to suppress protein catabolism in acute renal failure. Lancet 1958 II, 885.Google Scholar
  971. [889]
    McGinty, D. A., L. P. Anderson, and N. B. McCullough: Effect of local application of progesterone on the rabbit uterus. Endocrinology 24, 829 (1939).Google Scholar
  972. [890]
    McGinty, D. A., and C. Djerassi: Some chemical and biological properties of 19-nor-17α-ethynyl- testosterone. Ann. N.Y. Acad. Sei. 71, 500 (1958).Google Scholar
  973. [891]
    McKeown, R., and S. Zuckerman: The suppression of oestrus in the rat during pregnancy and lactation. Proc. roy. Soc. B. 124, 464 (1938).Google Scholar
  974. [892]
    McPhail, M. K.: The assay of progestin. J. Physiol. (Lond.) 83, 10 (1934).Google Scholar
  975. [893]
    McPhail, M. K. The assay of progestin. J. Physiol. (Lond.) 83, 145 (1934).Google Scholar
  976. [894]
    McSwiney, R. R., and F. T. G. Prunty: Metabolic effects of substances allied to testosterone with special reference to 17α-ethyl-19-nortestosterone. Proceedings of the society for endocrinology. J. Endocr. 13, XXV (1956).Google Scholar
  977. [895]
    McSwiney, R. R. F. T. G. Prunty Metabolic effects of three testosterone derivatives including 17 α-ethyl-19-nor-testosterone. J. Endocr. 16, 28 (1957).PubMedGoogle Scholar
  978. [896]
    Mears, E.: Clinical trials of oral contraceptives. Brit. med. J. 1961 II, 1179.Google Scholar
  979. [897]
    Mears, E. A new type of oral contraceptive. Brit. med. J. 1963 I, 1318.Google Scholar
  980. [898]
    Mears, E. Ovulation inhibitors. Family Planning 12, 61 (1963).Google Scholar
  981. [898a]
    Meda, F., B. Camerino, C. G. Alberti u. A. Vercellone: Infrarotabsorptionsspektren von 16,17-Epoxysteroiden. Chem. Zbl. 1957, 6762.Google Scholar
  982. [899]
    Meli, A., A. Wolfe, W. F. Lucker jr., and B. G. Steinmetz: Biological profile of progesterone 3-cyclopentyl enol ether as compared with that of progesterone. Proc. Soc. exp. Biol. (N.Y.) 118, 714 (1965).Google Scholar
  983. [900]
    Metcalf, M. G., and D. W. Beaven: Plasma-corticosteroid levels in women receiving oral contraceptive tablets. Lancet 1963 X, 1095.Google Scholar
  984. [901]
    Mey, R.: Zur Frage einer maskulinisierenden Wirkung von Allyloestrenol. Acta endocr. (Kbh.) 44, 27 (1963).Google Scholar
  985. [902]
    Mey, R. Untersuchungen zur Frage einer intrauterinen Maskulinisierung durch 6-Chlor- 6-dehydro-17α-aeetoxyprogesteron. Arzneimittel-Forsch. 13, 906 (1963).Google Scholar
  986. [902a]
    Mey, R. Zur Frage einer Maskulinisierung des Fetus durch Hydroxy-Nor-Progesteron- Capronat. Arzneimittel-Forsch. 17, 439 (1967).Google Scholar
  987. [903]
    Mey, R., u. H. Scheid: Tierexperimentelle Untersuchungen zur Frage einer androgenen Wirkung von Äthinyl-nortestosteron. Geburtsh. u. Frauenheilk. 19, 783 (1959).Google Scholar
  988. [903a]
    Meyer, A. S., R. W. Jeanloz, and G. Pincus: Chemical transformations of steroids by adrenal perfusion. IV. Dehydroepiandrosterone. J. biol. Chem. 203, 463 (1953).PubMedGoogle Scholar
  989. [904]
    Meystre, C., E. Tschopp u. A. Wettstein: Über 11-Dehydroprogesteron, das wirksamste Gestagen. Helv. chim. Acta 31, 1463 (1948).PubMedGoogle Scholar
  990. [905]
    Meystre, C., ;u A. Wettstein: Einwirkung von N-Brom-succinimid auf Δ 4-3-keto-Steroide. Experientia (Basel) 2, 408 (1946).Google Scholar
  991. [906]
    Meystre, C., A. Wettstein Weitere Steroidhormone mit zusätzlicher Doppelbindung in 11-Stellung. Helv. chim. Acta 32, 1978 (1949).Google Scholar
  992. [906a]
    Meystre, Ch., E. Visoher u. A. Wettstein: Mikrobiologische Hydroxylierung von Steroiden in der 17α- und 21-Stellung. Helv. chim. Acta 37, 1548 (1954).Google Scholar
  993. [907]
    Miescher, K.: On the relation of activity to constitution in the sexogens, with special reference to the doisynolie acids. Recent Progr. Hormone Res. 3, 47 (1948).Google Scholar
  994. [908]
    Miescher, K. W. H. Fischer, and E. Tschopp: Effect of desoxycorticosterone and its esters. Nature (Lond.) 142, 435 (1938).Google Scholar
  995. [909]
    Miescher, K., u. P. Gasche: Über die Wirkung des Jutocyclin in Abhängigkeit von der Applikationsart. Helv. physiol. pharmacol. Acta 1, 287 (1943).Google Scholar
  996. [910]
    Miescher, K. F. Hunziker u. A. Wettstein: Homologe der Keimdrüsenhormone. II. 20-Nor-progesteron. Helv. chim. Acta 23, 400 (1940).Google Scholar
  997. [911]
    Miescher, K. F. Hunziker A. Wettstein Homologe der Keindrüsenhormone. III. 20-Nor-pregnenolon. Helv. chim. Acta 23, 1367 (1940).Google Scholar
  998. [911a]
    Miki, T., K. Morita, Sh. Noguchi, T. Kishi, K. Higara, and H. Nawa: Synthesis of polyhydroxysteroids. II. Syntheses of isomeric 5α-pregnane-3,5,6,16,20-pentols and related compounds. Chem. pharm. Bull. 11, 95 (1963).PubMedGoogle Scholar
  999. [912]
    Miklos, L.: Experimentelle Verlängerung der Schwangerschaft mittels Corpus luteum-Extrakten. Zbl. Gynäk. 54, 1755 (1930).Google Scholar
  1000. [913]
    Meller, M. D., and J. M. Marshall: Response of estrogen, and progesterone-treated uteri to stimulation of the hypogastric nerves. Fed. Proc. 23, 309 (1964).Google Scholar
  1001. [913a]
    Mills, J. S., O. Candiani, and C. Djerassi: Steroids. CXLIV. Synthesis of some 6α,17α-dihaloprogesterones. J. org. Chem. 25, 1056 (1960).Google Scholar
  1002. [914]
    Miramontes, L., G. Rosenkranz, and C. Djerassi: The synthesis of 19-nor-pro-gesterone. J. Amer. chem. Soc. 73, 3540 (1951).Google Scholar
  1003. [915]
    Miura, Y.: Histological studies on the adrenal glands in an experimental hyper-steroid hormon milieu. Exeerpta med. (Amst.), Sect. III, 17, 356 (1963).Google Scholar
  1004. [916]
    Miyake, T.: The use of the carbonic anhydrase method for progestational and anti-progestational activity test. 6th Int. Conf. Planned Parenthood, New-Delhi 1959. Report Proc., IPPF (London) 1959, p. 328—334.Google Scholar
  1005. [917]
    Miyake, T. Inhibitory effect of various steroids on gonadotrophin hypersecretion in parabiotic mice. Endocrinology 69, 534 (1961).PubMedGoogle Scholar
  1006. [918]
    Miyake, T. Progestational substances. In: R. I. Dorfman, Methods in Hormone Research, v. II, p. 127—178. New York and London: Academic Press 1962.Google Scholar
  1007. [919]
    Miyake, T. H. Kakxjshi, and K. Hara: Bioassay of progestational steroids based on the deciduoma formation in spayed mice. Steroids 2, 739 (1963).Google Scholar
  1008. [920]
    Miyake, T. H. Kakxjshi K. Hara Deciduomatogenic and anti-deciduomatogenic activity of steroids. Steroids 2, 749 (1963).Google Scholar
  1009. [921]
    Miyake, T. H. Kakxjshi K. Odaguchi, and M. Kadowaki: Inhibitory effect of various steroids on gonadotrophin hypersecretion in parabiotic mice. Endocrinology 69, 534 (1961).PubMedGoogle Scholar
  1010. [921a]
    Miyake, T. F. Kobayashi, K. Horibe, E. Itoga, H. Kaktjshi, Y. Nomura, M. Kadowaki, K. Odaguchi, K. Hara. T. Furukawa, and M. Ide: Biological activities of Chlormadinone acetate (I), analysis of hormonal activities. Folia endocr. jap. 41,1079 (1965).PubMedGoogle Scholar
  1011. [921b]
    Miyake, T. F. Kobayashi, K. Horibe H. Kakushi, and K. Hara: Biological activities of Chlormadinone acetate (II), effects on the rat pregnancy, fetal development and parturition. Folia endocr. jap. 41, 1154 (1966).PubMedGoogle Scholar
  1012. [922]
    Miyake, T., and T. Minesita: The use of parabiotic mice for the study of pituitary gonadotrophin hypersecretion and its inhibition by certain steroids. Acta endocr. (Kbh.), Suppl. 51, 15 (1960).Google Scholar
  1013. [923]
    Miyake, T., and G. Nagata: The intrauterine assay of progesterone on the rabbit. Shianogi’s Ann. Rept. 10, 185 (1960).Google Scholar
  1014. [924]
    Miyake, T., and G. Pincus: Progestational activity of certain 19-nor-steroids and progesterone derivatives. Endocrinology 63, 816 (1958).PubMedGoogle Scholar
  1015. [925]
    Miyake, T. G. Pincus Anti-progestational activity of estrogens in rabbit endometrium. Proc. Soc. exp. Biol. (N.Y.) 99, 478 (1958).Google Scholar
  1016. [926]
    Miyake, T. G. Pincus Hormonal influences on the carbonic anhydrase concentration in the accessory reproductive tracts of the rat. Endocrinology 65, 64 (1959).PubMedGoogle Scholar
  1017. [927]
    Moffett, R. B., and H. V. Anderson: Acetylation of 17α-hydroxy steroids. J. Amer. chem. Soc. 76, 747 (1954).Google Scholar
  1018. [927a]
    Moffett, R. B., and G. Slomp jr.: Reaction of peracids with Δ 20(21)-steroid enol acetates. J. Amer. chem. Soc. 76, 3678 (1954).Google Scholar
  1019. [927b]
    Moffett, R. B. J.E. Stafford, J. Linsk, and W. M. Hoehn: Degradation of hyodesoxycholic acid. J. Amer. chem. Soc. 68, 1857 (1946).Google Scholar
  1020. [928]
    Moggian, G.: Progestational activity of 17α-methyl-19-nortestosterone. Endocrinology 64, 363 (1959).PubMedGoogle Scholar
  1021. [929]
    Moghissi, K. S., A. Rosenthal, and N. Moss: Provera-ethinyl estradiol for control of conception. Int. J. Fertil. 8, 703 (1963).PubMedGoogle Scholar
  1022. [930]
    Mola, T., and G. Hecht-Lucari: The inability of 17α-ethinyl-19-nortestosterone to maintain pregnancy in ovariectomized rats. Excerpta med. (Amst.) Sect. Ill, 14, 233 (1960).Google Scholar
  1023. [931]
    Moor, P. de, O. Steeno, and R. Deckx: Factors affecting the binding