Advertisement

Die Gestagene pp 264-351 | Cite as

Resorption, Verteilung und Ausscheidung der Gestagene

  • Hedwig Langecker
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 22 / 1)

Zusammenfassung

Die sublinguale Resorption des Progesterons wurde mit der Wirkung nachgewiesen [482], Als lipoidlösliehe Verbindung ist Progesteron per os gut resorbierbar [484], Nach Gaben von 100–1000 mg wurden im Harn (und Galle) eine erhöhte Ausscheidung von Progesteron-Metaboliten festgestellt [1370, 1092, 1091, 1028]. Bis zu 20% Konversion wurde beobachtet [310]. Vergleichsuntersuchungen ergaben sogar höhere Pregnandiolausscheidung nach oraler Gabe als nach intramuskulärer [1245] und keinen Unterschied zwischen intramuskulärer, buccaler und oraler Verabreichung [371]. Die geringe Wirksamkeit des Progesterons bei oraler Verabreichimg [484] ist daher nicht auf mangelnde Resorption zurückzuführen. (Oral verabreicht, gelangten auch (5ß)-Pregnan-3,20-dion und (5β)-Pregnan-3,20-dion zur Resorption [1352].) Untersuchtingen über Dünndarmresorption wäßriger alkoholischer Lösungen von Steroiden mittels Steady state-Perfusion durch eine transintestinale Röhre haben ergeben, daß die Resorption um so besser ist, je weniger Hydroxylgruppen vorhanden sind. Progesteron wurde unter diesen Versuchsbedingungen besonders gut resorbiert [1158].

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. [1]
    Aakvaag, A.: Ovarian metabolism of pregnenolone in vitro. Acta endocr. (Kbh.), Suppl. 119, 72 (1967)Google Scholar
  2. [1a]
    Aakvaag, A.:, and K. B. Eik-Nes: Metabolism in vivo of (7a-3H) pregnenolone by the ovary of dogs treated with follicle stimulating hormone. Biochim. biophys. Acta (Amst.) 86, 380–389 (1964)CrossRefGoogle Scholar
  3. [2]
    Aakvaag, A.: Metabolism in vivo of steroids in the canine ovary. Biochim. biophys. Acta (Amst.) Ill, 273–285 (1965)Google Scholar
  4. [3]
    Aakvaag, A.: Metabolism in vitro of steroids in the canine ovary. Biochim. biophys. Acta (Amst.) Ill, 286–293 (1965)Google Scholar
  5. [3a]
    Aakvaag, A., and P. Fylling: Progesterone and androgens in cyst fluid and vein blood in the human ovary. Acta obstet, gynec. scand. 45, Suppl. 9, 158–159 (1966)Google Scholar
  6. [3b]
    Abrams, C. A. L., M. M. Grumbach, I. Dyranfurth, and H. I. Van de Wiele: Induction of ovulation in hypophysectomized girl using HMG (Pergonal) and HCG. Forty-seventh meeting of Endocrine Society, New York, June 17–19, p. 1900, 1965Google Scholar
  7. [3c]
    Abrams, C. A. L., M. M. Grumbach, I. Dyranfttrth, and H. I. Van de Wiele: Ovarian stimulation with human menopausal and chorionic gonadotropins in a prepubertal hypophysectomized female. J. clin. Endocr. 27, 467–472 (1967)PubMedCrossRefGoogle Scholar
  8. [4]
    Adams, W. C., and J. H. Leathem: Cholesterol metabolism in rats with experimental cystic ovaries. Fed. Proc. 22, 570 (1963)Google Scholar
  9. [5]
    Aitken, E.H., J. R. K. Preedy, B.Eton, and R.V.Short: Oestrogen and progesterone levels in foetal and maternal plasma at parturition. Lancet 1958 II, 1096– 1099Google Scholar
  10. [6]
    Alder, R. M., and V. I. Krieger: Hormonal therapy and the significance of the pregnandiol excretion test in recurrent abortion. Med. J. Aust. 1957 II, 122–131Google Scholar
  11. [6a]
    Alexander, G., and D.Williams: Progesterone and placental development in the sheep. J. Endocr. 34, 241–245 (1966)PubMedCrossRefGoogle Scholar
  12. [6b]
    Allen, E.: Glandular physiology and therapy. Physiology of the ovaries. J. Amer. med. Ass. 116, 405–413 (1941)CrossRefGoogle Scholar
  13. [6c]
    Allen, J. G., G. H. Thomas, and A. A. Wright: Gas chromatographic identification of the urinary oxopregnane derivatives in the pregnant rabbit. J. Endocr. 87, 433–441 (1967)CrossRefGoogle Scholar
  14. [7]
    Allen, W. M.: Physiology of the corpus luteum. V. The preparation and some chemical properties of progestin, a hormone of the corpus luteum which produces progestational proliferation. Amer. J. Physiol. 92, 174–188 (1930)Google Scholar
  15. [8]
    Allen, W. M.Physiology of the corpus luteum. VI. The production of progestational proliferation of the endometrium of the immature rabbit by progestin (an extract of the corpus luteum) after preliminary treatment with oestrin. Amer. J. Physiol. 92,612–618 (1930)Google Scholar
  16. [9]
    Allen, W. M.: Physiology of the corpus luteum. VIII. Interrelationship of oestrin and the corpus luteum as determined by their effects in the adult rabbit. Amer. J. Physiol. 100, 650–663 (1932)Google Scholar
  17. [10]
    Allen, W. M.: The preparation of purified progestin. J. biol. Chem. 98, 591–605 (1932)Google Scholar
  18. [11]
    Allen, W. M.: A simple method for analyzing complicated absorption curves, of use in the colorimetric determination of urinary steroids. J. clin. Endocr. 10, 71–83 (1950)CrossRefGoogle Scholar
  19. [12]
    Allen, W. M.: In: Discussion of A. B. Hunt, and W. M. McConahey: Amer. J. Obstet. Gynec. 66, 970–987 (1953), zit. bei [145]Google Scholar
  20. [13]
    Allen, W. M., and G. W. Corner: Physiology of the corpus luteum. III. Normal growth and implantation of embryos after very early ablation of the ovaries, under the influence of extracts of the corpus luteum. J. Physiol. (Lond.) 88, 340–346 (1929)Google Scholar
  21. [14]
    Allen, W. M., and E. Viergiver: A titrimetric method for the determination of sodium pregnanediol glucuronidate in the urine of pregnant women. J. biol. Chem. 141, 837–852 (1941)Google Scholar
  22. [15]
    Allen, W. M., and O. Wintersteiner: Crystalline progestin. Science 80, 190–191 (1934)PubMedCrossRefGoogle Scholar
  23. [16]
    Allende, I. L. C. de: Blood progesterone during sexual cycle of macaca rhesus; quantitative assay. Proc. Soc. exp. Biol. (N.Y.) 44, 534–538 (1940)Google Scholar
  24. [17]
    Alonzo, R. de, G. Faglia e D. Gelli: Alcune considerazioni su sette casi die sindrome di turner. Atti Accad. med. lombarda 16, 122–127 (1961)Google Scholar
  25. [18]
    Amigi, G., e D. Franzini: Sui metodi di analisi del pregnandiolo e pregnantriolo urinari. Minerva med. 53, 3204–3209 (1962)Google Scholar
  26. [19]
    Amoroso, E. C.: Part. VIII. Structural and functional aspects of the placenta. Comparative anatomy of the placenta. Ann. N.Y. Acad. Sei. 75, 855–872 (1958–59)CrossRefGoogle Scholar
  27. [20]
    Amoroso, E. C.: Corpus luteum in relation to pregnancy and evolution. In: S. Taylor, ed., Intern. Congr. Ser. No. 83, Proceedings of the Second. Intern. Congr. of Endocrinol., part. I, p. 665–668. London: Excerpta med Foundn. 1964Google Scholar
  28. [21]
    Anliker, R., O. Rohr u. L. Ruzicka: Untersuchungen über Organextrakte. 26. Mitt. Über den Nachweis von androgenen Hormonen in einem virilisierenden Ovarialtumor. Justus Liebigs Ann. Chem. 603, 109–114 (1957)Google Scholar
  29. [22]
    Apetov, S. A., and A. A. Popova: Excretion of ovarian hormones in certain disturbances of the menstrual cycle. Ocherki Ginekol. Endokrinol., Moscow, Sb. 1962, 104–108Google Scholar
  30. [22a]
    Apostolaeis, M., H. Becker, and K. D. Voigt: The effect of lynestrenol administration on testosterone, estrogen, pregnanediol and total gonadotrophin excretion during the menstrual cycle. Steroids 7, 146–156 (1966)CrossRefGoogle Scholar
  31. [23]
    Apostolaeis, M., G. Bettendorf u. K. D. Voigt: Klinisch-experimentelle Studien mit menschlichem hypophysärem Gonadotropin. Acta endocr. (Kbh.) 41, 14–30 (1962)Google Scholar
  32. [23a]
    Appleby, J. I., G. Gibson, J. K. Norymberske, and R. D. Sttubbs: Indirect analysis of corticosteroids. 1. The determination of 17-hydroxycorticosteroids. Biochem. J. 60, 453–460 (1955)PubMedGoogle Scholar
  33. [24]
    Appleby, J. I., G. Gibson, J. K. Norymberske, and R. D. Sttjbbs, and J. K. Norymberski: Indirect analysis of corticosteroids. 2. The determination and identification of urinary 17-hydroxy-20-oxosteroids unsubstituted at C21. Biochem. J. 60, 460–467 (1955)PubMedGoogle Scholar
  34. [25]
    Appleby, J. I., G. Gibson, J. K. Norymberske, and R. D. Sttjbbs, and J. K. Norymberski: The urinary excretion of 17-hydroxycorticosteroids in human pregnancy. J. Endocr. 15, 310–319 (1957)PubMedCrossRefGoogle Scholar
  35. [26]
    Arai, K., T. Golab, D. S. Layne, and G. Pincus: Metabolic fate of orally administered H3-norethynodrel in rabbits. Endocrinology 71, 639–648 (1962)PubMedCrossRefGoogle Scholar
  36. [27]
    Arcos, M., E. Gurpide, R. L. van de Wiele, and S. Lieberman: Precursors of urinary pregnanediol and their influence on the determination of the secretory rate of progesterone. J. clin. Endocr. 24, 237–245 (1964)PubMedCrossRefGoogle Scholar
  37. [27]
    Arcos, M.E. Gurpider. L. van de Wiele, and S. Lieberman:S. Lieberman: 5-Pregnene-3ß,20a-diol-3-sulfate-20-(2/-acetamido-2/-deoxy- α-d-glucoside) and 5-pregnene-3ß,20a-diol-3,20-disulfate. Two novel urinary conjugates. Biochemistry 6, 2032–2039 (1967)PubMedCrossRefGoogle Scholar
  38. [28]
    Arias, I. M., and L. M. Gartner: Production of unconjugated hyperbilirubinaemia in full-term new-born infants following administration of pregnane-3 (alpha), 20 (beta)- diol. Nature (Lond.) 203, 1292–1293 (1964)CrossRefGoogle Scholar
  39. [28a]
    Arias, I. M., L. M. Gartner, S. Seifter, and M. Furman: Prolonged neonatal unconjugated hyperbilirubinemia associated with breast feeding and a steroid, pre- gnane-3 (alpha), 20 (beta)-diol, in maternal milk that inhibits glueuronide formation in vitro. J. clin. Invest. 48, 2037–2047 (1964)CrossRefGoogle Scholar
  40. [28b]
    Armstrong, D. T.: Stimulation of glycolytic activity of rat corpus luteum tissue by luteinizing hormone. Endocrinology 72, 908–913 (1963)CrossRefGoogle Scholar
  41. [29]
    Arias, I. M., L. M. Gartner, S. Seifter, and M. Furman: Corpus luteum metabolism and steroid biogenesis. In: S. Taylor, ed., Intern. Congr. Ser. No. 83, Proceedings of the Second Intern. Congr. of Endocrinol., part. I, p. 675– 679. London: Excerpta med. Foundn. 1964Google Scholar
  42. [29a]
    Arias, I. M., L. M. Gartner, S. Seifter, and M. Furman, and D. L. Black: Influence of luteinizing hormone on corpus luteum metabolism and progesterone biosynthesis throughout the bovine estrous cycle. Endocrinology 78, 937–944 (1966)CrossRefGoogle Scholar
  43. [30]
    J. O’brien, and R. O. Greep: Effects of luteinizing hormone on progestin biosynthesis in the luteinized rat ovary. Endocrinology 75, 488–500 (1964)PubMedCrossRefGoogle Scholar
  44. [30a]
    J. O’brien, and R. O. Greep: Effect of gonadotrophs hormones on glucose metabolism by luteinized rat ovaries. Endocrinology 70, 701–710 (1962)CrossRefGoogle Scholar
  45. [30b]
    J. O’brien R. Kilpatrick, and R. O. Greep: In vitro and in vivo stimulation of glycolysis in prepubertal rat ovary by luteinizing hormone. Endocrinology 73, 165–169 (1963)PubMedCrossRefGoogle Scholar
  46. [31]
    Astwood, E. B., and G. E. S. Jones: A simple method for the quantitative determination of pregnanediol in human urine. J. biol. Chem. 137, 397–407 (1941)Google Scholar
  47. [32]
    Atherden, L. M.: Progesterone metabolism: Investigation of the products of metabolism with human liver in vitro. Biochem. J. 71, 411–415 (1959)PubMedGoogle Scholar
  48. [33]
    Atherden, L. M., and J.K. Grant: The metabolism of progesterone in the rat. J. Endocr. 14, 371–375 (1956)CrossRefGoogle Scholar
  49. [34]
    Atkinson, W. B., and Ch. W. Hooker: The day to day level of estrogen and progestin throughout pregnancy and pseudopregnancy in the mouse. Anat. Rec. 98, 75–95 (1945)CrossRefGoogle Scholar
  50. [35]
    Avigan, J., De Witt S. Goodman, and D. Steinberg: Thin-layer chromatography of sterols and steroids. J. Lipid Res. 4, 100–101 (1963)PubMedGoogle Scholar
  51. [36]
    Axelrod, L. R.: Microchemical detection of characteristic functional groups in steroids. Analyt. Chem. 27, 1308–1311 (1955)CrossRefGoogle Scholar
  52. [37]
    Axelrod, L. R., and J. W. Goldzieher: The metabolism of 17a-hydroxyprogesterone and its relation to congenital adrenal hyperplasia. J. clin. Endocr. 20, 238–252 (1960)PubMedCrossRefGoogle Scholar
  53. [38]
    Axelrod, L. R., and J. W. Goldzieher: Enzymic inadequacies of human polycystic ovaries. Arch. Biochem. 95, 547–548 (1961)PubMedCrossRefGoogle Scholar
  54. [39]
    Axelrod, L. R., and J. W. Goldzieher: The polycystic ovary. III. Steroid biosynthesis in normal and polycystic ovariantissue. J. clin. Endocr. 22, 431–440 (1962)PubMedCrossRefGoogle Scholar
  55. [40]
    Axelrod, L. R., and J. W. Goldzieher, and S. D. Ross: Concurrent 3 ß-Hydroxy steroid dehydrogenase deficiency in adrenal and sclerocystic ovary. Acta endocr. (Kbh.) 48, 392–412 (1965)Google Scholar
  56. [41]
    Axelrod, L. R., and J. W. Goldzieher, Ch. Matthijssen, J. W. Goldzieher, and J. E. Pulliam: Definitive identification of microquantities of radioactive steroids by recrystallization to constant specific activity. Acta endocr. (Kbh.) 49, Suppl. 99 (1965)Google Scholar
  57. [42]
    Ayres, P. J., S. A. Simpson, and J. F. Tait: A fluorescence method for the micro analysis of ¿d4–3-oxo steroids on paper ehromatograms. Biochem. J. 65, 647–651 (1957)PubMedGoogle Scholar
  58. [42a]
    Bacchus, H.: A method for measurement of total 17-OH, 21-methyl-steroids in the urine and its application to clinical problems. Metabolism 16, 153–161 (1967)PubMedCrossRefGoogle Scholar
  59. [43]
    Bachman, C.: The excretion of estrogen and pregnanediol preceding normal parturition. Amer. J. Obstet. Gynec. 42, 599–606 (1941)Google Scholar
  60. [44]
    Bachman, C., D. Leekley, and H. Hirschmann: Excretion of sodium pregnanediol glucurenidate in urine of normal human pregnancy. J. clin. Invest. 19, 801–807 (1940)PubMedCrossRefGoogle Scholar
  61. [45]
    Bachman, C., D. Leekley, and H. Hirschmann: Urinary excretion of pregnanediol glucuronidate in the hypertensive disorders of pregnancy. Amer. J. med. Sci. 201, 311–312 (1941)Google Scholar
  62. [46]
    Baer, T., J. Bennet, and S. Neukomm: Investigations on the intermediate metabolism of steroid hormones and carcinogenic compounds. Oncologia (Basel) 18, 289–294 (1960)Google Scholar
  63. [47]
    Baillie, A. H., K. C. Calman, M.M. Ferguson, and D. McK. Hart: Histochemical distribution of hydroxysteroid dehydrogenases in kidney and liver. Histochemie 5, 384–395 (1965)PubMedCrossRefGoogle Scholar
  64. [47a]
    Baillie, A. H., K. C. Calman, M.M. Ferguson, and D. McK. Hart: Histochemical utilization of 3α-, 6ß-, 11α-, 12α-, 16α-, 16ß-, 17α-, 21 and 24-hydroxysteroids. J. Endocr. 84, 1–12 (1966)CrossRefGoogle Scholar
  65. [48]
    Baillie, A. H., K. C. Calman, M.M. Ferguson, and D. McK. Hart: Histochemical demonstration of 20/ß-hydroxysteroid dehydrogenase. J. Endocr. 32, 337–339 (1965)PubMedCrossRefGoogle Scholar
  66. [49]
    Baillie, A.,E. H. D. Cameron, K. Griffiths, and D. McK. Hart: 3β-Hydroxysteroid dehydrogenase in the adrenal gland and placenta. J. Endocr. 81, 227–233 (1965)CrossRefGoogle Scholar
  67. [49a]
    Baillie, A.H., M.M. Ferguson, and D. McK. Hart: Histochemical evidence of steroid metabolism in the human genital ridge. J. elin. Endoer. 26, 738–741 (1966)Google Scholar
  68. [50]
    Balassi, G. P., e C. Ricca: Il metodo di donini e infanti per il dosaggio del pregnandiolo urinario. Minerva ginec. 3, 103–106 (1951)PubMedGoogle Scholar
  69. [51]
    Balassi, G. P., e C. Ricca: Il dosaggio ormonale nell’età prepubere e pubere femminile. Minerva ginee., Suppl. 3, 277–282 (1951)Google Scholar
  70. [52]
    Balfour, W. E., and R. S. Comune: Secretion of progesterone by the adrenal gland. Nature (Lond.) 180, 1480–1481 (1957)CrossRefGoogle Scholar
  71. [52 a]
    Balfour, W. E., and R. S. Comune: Changes in the secretion of 20a-hydroxy-pregn-4-en-3-one by the adrenal gland of young calves. Nature (Lond.) 83, 467–468 (1959)CrossRefGoogle Scholar
  72. [53]
    Ball, J. H., and B. Kadis: Steroid hydroxylations. Biosynthesis of 17,20a-dihydroxypregn-4-ene-3-one by sow ovary. Steroids 4, 533–538 (1964)CrossRefGoogle Scholar
  73. [54]
    Ball, J. H., and B. Kadis: Steroid Hydroxylations. II. Intracellular location of 17a-hydroxylase and its substrate specificity in sow ovary. Arch. Biochem. 110, 427–431 (1965)PubMedCrossRefGoogle Scholar
  74. [55]
    Ball, J. N.: Reproduction in female bony fishes. In: Chester Jones, ed. Hormones in fish-Symposia of the zool. Soc. of London 1960, No 1, p. 105–136Google Scholar
  75. [56]
    Balogh, K.: A histochemical method for the demonstration of 20a-hydroxysteroid dehydrogenase activity in rat ovaries. J. Histoehem. Cytoehem. 12, 670–673 (1964)CrossRefGoogle Scholar
  76. [56a]
    Balogh jr., K., W. R. Kidwell, and W. G. Wiest: Histochemical localization of rat ovarian 20a-hydroxysteroid dehydrogenase activity initiated by gonadotrophie hormone administration. Endocrinology 78, 75–81 (1966)PubMedCrossRefGoogle Scholar
  77. [57]
    Bang, H. O.: A simplified method for the quantitative determination of pregnanediol in urine. J. Chromatogr. 14, 520–523 (1964)CrossRefGoogle Scholar
  78. [58]
    Barker, W. L.: A cytochemieal study of lipids in sows ovaries during the estrous cycle. Endocrinology 48, 772–785 (1951)PubMedCrossRefGoogle Scholar
  79. [59]
    Barnes, A. C., D. Kumar, and J. A. Goodno: Studies in human myometrium during pregnancy. Y. Myometrial tissue progesterone analyses by gas-liquid phase chromatography. Amer. J. Obstet. Gynee. 84, 1207–1212 (1962)Google Scholar
  80. [60]
    Barry, M. C., M. L. Eidinoff, K. Dobriner, and T. F. Gallagher: The rate of C14-testosterone and C14-progesterone in mice and rats. Endocrinology 50, 587–599 (1952)PubMedCrossRefGoogle Scholar
  81. [61]
    Bauld, W. S., and R.*D. H. Heard: Unveröffentlicht. Zit. in R. D. Heabd, YII. Metabolism of the adrenal cortical hormones, p. 602–629. In: G. Pincus and K. V. Thimann, eds., The hormones, vol. 1, p. 620, Tab. XXVI. New York: Academic Press 1948Google Scholar
  82. [62]
    Baulieu, E.-E., and F. DrayConversion of H3-dehydroisoandrosterone (3 ß-hydroxy- Zl5-androsten-17-one) sulfate to H3-estrogens in normal pregnant women. J. clin. Endoer. 23, 1298–1301 (1963)CrossRefGoogle Scholar
  83. [63]
    Baulieu, E.-E., and F. Dray, P. Mauvais- Jarvis, and C. Corpéchot: Steroid studies in a case of Stein-Leventhal syndrome with hirsutism. J. clin. Endoer. 23, 374–382 (1963)CrossRefGoogle Scholar
  84. [63a]
    Baxter, A. D., A. H. Baillie, and M. M. Ferguson: The histochemical localisation of hydroxysteroid dehydrogenase activity in the livers of various species. Histo- chemie 7, 218–223 (1966)Google Scholar
  85. [64]
    Beall, D.: A method for the isolation of pregnandiol from human pregnancy urine. Biochem. J. 31, 35–40 (1937)PubMedGoogle Scholar
  86. [65]
    Bègue, J.-A.: Identification du sulfate de prégnènolone dans le plasma humain normal. C. R. Acad. Sci. (Paris) 260, 3777–3779 (1965)Google Scholar
  87. [65a]
    Beiser, S. M., and B. F. Erlanger: Estimation of steroid hormones by an immunochemical technique. Nature (Lond.) 214, 1044–1045 (1967)CrossRefGoogle Scholar
  88. [66]
    Bell, E. T., and J. A. Loraine: Effect of dydrogesterone on hormone excretion in patients with dysmenorrhoea. Lancet 1965 I, 403–406CrossRefGoogle Scholar
  89. [66a]
    Bell, E. T., and J. A. Loraine: Hormone-excretion patterns in patients with dysmenorrhoea. Lancet 1966 II, 519–521CrossRefGoogle Scholar
  90. [66b]
    Bell, E. T., and J. A. Loraine, H. P. McEwan, and D. Charles: Serial hormone assays in patients with uteroplacental insufficiency. Amer. J. Obstet. Gynee. 97, 562–570 (1967)Google Scholar
  91. [67]
    Bell, E. T., and J. A. Loraine, S. Mukerji, and J. A. Loraine: A new bioassay method for luteinizing hormone depending on the depletion of rat ovarian cholesterol. J. Endocr. 28, 321–328 (1964)PubMedCrossRefGoogle Scholar
  92. [68]
    Bender, S.: The value of the Guterman test in threatened abortion. J. Obstet. Gynaec. Brit. Emp. 54, 783–791 (1947)PubMedCrossRefGoogle Scholar
  93. [69]
    Bengtsson, G., S. Ullberg, N. Wiqvist, and E. Diczfalusy: Autoradiographic studies on previable human foetuses perfused with radioactive steroids. Acta endocr. (Kbh.) 46, 544–551 (1964)Google Scholar
  94. [70]
    Bengtsson, L. Ph.: Beziehungen zwischen Progesteron, Pregnandiol und Erhaltung der menschlichen Schwangerschaft. Bibl. gynaec., Suppl. No 20, 45–51 (1959)Google Scholar
  95. [71]
    Bengtsson, L. Ph.: Recovery of injected progesterone and its relation to the onset of human labour. Nature (Lond.) 183, 405–406 (1959)CrossRefGoogle Scholar
  96. [71a]
    Bengtsson, L. Ph., and P. M. Ejarque: Production rate of progesterone in the last month of human pregnancy. Acta obstet, gynec. scand. 48, 49–57 (1964)CrossRefGoogle Scholar
  97. [72]
    Bengtsson, L. Ph., and P. M. Ejarque, and B. Forsgren: Gas chromatographic determination of urinary oestriol and pregnanediol after foetal death. Acta endocr. (Kbh.), Suppl. 100, 86 (1965)Google Scholar
  98. [72 a]
    Bengtsson, L. Ph., and P. M. Ejarque, and B. Forsgren:The diagnosis of intra-uterine foetal death and elucidation of the aetiology of “missed abortion” by means of semi-quantitative gas chromatographic determination of urinary oestriol and pregnandiol. Acta obstet, gynec. scand. 45,155–175 (1966)CrossRefGoogle Scholar
  99. [73]
    Bennet, Boursnell u. Short: Unveröffentlicht, zit. nach [1203]Google Scholar
  100. [74]
    Bennett, R.D., and E. Heftmann: Biosynthesis of Holarrhena alkaloids from cholesterol. Arch. Biochem. 112, 616–620 (1965)PubMedCrossRefGoogle Scholar
  101. [75]
    Bennett, R.D., and E. Heftmann: Progesterone: Biosynthesis from pregnenolone in Holarrhena floribunda. Science 149, 652–653 (1965)PubMedCrossRefGoogle Scholar
  102. [76]
    Berge, B. S. ten: Pregnanediol excretion in the urine and comparison with estriol values in intrauterine fetal death. Ned. T. Yerlosk. 62, 49–52 (1962)Google Scholar
  103. [77]
    Bergman, P., H. Ekman, B. Hakansson, and B. Sjögren: Adrenalectomy during pregnancy with the appearance of pre-eclampsia at term in a case of Cushing’s syndrome. Acta endocr. (Kbh.) 35, 293–298 (1960)Google Scholar
  104. [78]
    Bergstrand, C. G., and C. A. Gemzell: Pregnandiol excretion in normal children and in children with various endocrine disorders, including congenital adrenal hyperplasia. J. clin. Endocr. 17, 870–877 (1957)PubMedCrossRefGoogle Scholar
  105. [78 a]
    Berliner, D. L., and T. E. Dougherty: Influence of reticuloendothelial and other cells on the metabolic fate of steroids. Ann. N.Y. Acad. Sci. 88, 14–29 (1960)CrossRefGoogle Scholar
  106. [79]
    Berliner, D. L., and H. A. Salhanick: The presence of 6ß-hydroxylase in human placenta. J. clin. Endocr. 16, 903–905 (1956)PubMedCrossRefGoogle Scholar
  107. [80]
    Berliner, D. L., and H. A. Salhanick, and W. G. Wiest: The extrahepatic metabolism of progesterone in rats. J. biol. Chem. 221, 449–459 (1956)PubMedGoogle Scholar
  108. [81]
    Bern, H. A., and J. Nandi: Endocrinology of Poikilothermie vertebrates. In: C. Pincus, K. V. Thimann and E. B. Astwood, eds., The hormones, vol. 4, p. 199–298 (p. 252). New York and London: Academic Press 1964Google Scholar
  109. [82]
    Berthelsen, H. G., and H. O. Bang: The urinary excretion of pregnanediol in healthy women, determined by thin-layer-chromatography. Dan. med. Bull. 12, 29–31 (1965)PubMedGoogle Scholar
  110. [82 a]
    Berthelsen, H. G., and H. O. Bang:The thin-layer chromatographieal determination of urinary pregnanediol excretion in relation to therapeutic abortion and during early pathological pregnancy. Acta obstet, gynec. scand. 45, Suppl. 9, 68–72 (1966)Google Scholar
  111. [83]
    Besch, P. K., R. D. Barry, N. Yorys, V. Stevens, and J. C. Ullery: A review of some aspects of the metabolism of progestational agents. Metabolism 14, 432–443 (1965)PubMedCrossRefGoogle Scholar
  112. [83a]
    Besch, P. K., V. Stevens, E.O. Byron, R.D. Barry, N.J. Teteris, G.J. Hamwi, N. Vorys, and J.C. Ullery: Testosterone synthesis by a Brenner tumor. Amer. J. Obstet. Gynec. 86, 1021–1026 (1963)PubMedGoogle Scholar
  113. [83 b]
    Besch, P. K., V. Stevens, E.O. Byron, N.J. Teteris, G.J. Hamwi, N. Vorys, J. C. Ullery, R. D. Barry, and D. Couri: In vivo metabolism of H3-medroxyprogesterone acetate in pregnant and nonpregnant women and in the fetus. Amer. J. Obstet. Gynec. 95, 228–238 (1966)PubMedGoogle Scholar
  114. [83 c]
    Besch, P. K., V. Stevens, E.O. Byron, R.D. Barry, N.J. Teteris, G.J. Hamwi, N. Vorys, and J.C. Ullery D. J. Watson, N. Vorys, G. J. Hamwi, R. D. Barry, and E. B. Barnett: In vitro biosynthetic studies of endocrine tumors. Amer. J. Obstet. Gynec. 96, 466– 477 (1966)PubMedGoogle Scholar
  115. [84]
    Bethoux, M. R.: Le dosage du pregnandiol urinaire. J. Med. Lyon 33, 63–69 (1952)PubMedGoogle Scholar
  116. [85]
    Beyler, A. L., and C. M. Szego: Correlation of ovarian cholesterol levels with changes in ß-glucuronidase activity of reproductive tract during the estrous cycle and pregnancy. Endocrinology 54, 323–333 (1954)PubMedCrossRefGoogle Scholar
  117. [86]
    Bialy, G., D. S. Layne, and G. Pincus: Some biological properties of a urinary norethynodrel metabolite. Proc. Soc. exp. Biol. (N.Y.) 118, 862–865 (1965)Google Scholar
  118. [87]
    Bigozzi, U.: A simplified method of determination of urinary pregnanediol and pregnanetriol. Riv. crit. Clin. med. 58, 112–119 (1958)Google Scholar
  119. [88]
    Bird, Ch. E., N. Wiqvist, and E. Diczfalusy: Formation of C-21 steroid sulphates and glucosiduronates by previable human foetuses perfused with (4–14C)progesterone. Biochim. biophys. Acta (Amst.) 104, 623–626 (1965)CrossRefGoogle Scholar
  120. [89]
    Bird, Ch. E., N. Wiqvist, and E. Diczfalusy and S. Salomon: Metabolism of progesterone by the perfused breviable human fetus. J. clin. Endocr. 26, 1144 (1966)PubMedCrossRefGoogle Scholar
  121. [90]
    Bishoff, F., and H. Pilhorn: The state and distribution of steroid hormones in biologic systems. III. Solubilities of testosterone, progesterone, and a-estradiol in aqueous salt and protein solution and in serum. J. biol. Chem. 174, 663–682 (1948)Google Scholar
  122. [91]
    Bishop, P. M. F., U. Borell, E. Diczfalusy, and K.-G. Tillinger: Effect of dydrogesterone on human endometrium and ovarian activity. Acta endocr. (Kbh.) 40, 203–216 (1962)Google Scholar
  123. [92]
    Bishop, P.M. F., and S. J. Folley: Absorption of hormone implants in man. Lancet 1951 n, 229–232Google Scholar
  124. [93]
    Bjersing, L., and H. Carstensen: The role of the granulosa cell in the biosynthesis of ovarian steroid hormones. Biochim. biophys. Acta (Amst.) 86, 639–640 (1964)CrossRefGoogle Scholar
  125. [94]
    Blobel, R.: An assay of prolactin based on the excretion of pregnandiol in hypophysectomized, adrenalectomized rats. Acta endocr. (Kbh.), Suppl. 100, 166 (1965)Google Scholar
  126. [95]
    Bloch, E.: Metabolism of 4–14C-progesterone by human fetal testis and ovaries. Endocrinology 74, 833–845 (1964)PubMedCrossRefGoogle Scholar
  127. [96]
    Bloch, E. S. L. Romney, M. Klein, L. Leppiello, P. Cooper, and I. P. Goldring: Steroid ovaries maintained in organ culture. Proc. Soc. exp. Biol. (N.Y.) 119,449–452 (1965)Google Scholar
  128. [97]
    Bloch, H. S., B. Zimmermann, and S. L. Cohen: Paper chromatography of pregnan diol and related compounds. J. clin. Endocr. 18, 1206–1212 (1953)CrossRefGoogle Scholar
  129. [98]
    Bloch, K.: The biological conversion of cholesterol to pregnanediol. J. biol. Chem. 157, 661–666 (1945)Google Scholar
  130. [99]
    Bloch, K.: The biological synthesis of cholesterol. Science 150, 19–28 (1965)PubMedCrossRefGoogle Scholar
  131. [100]
    Bloor, W. R., R. Okey, and G. W. Corner: The relation of the lipids to physiological activity. 1. The changes in the lipid content of the corpus luteum of the sow. J. biol. Chem. 86, 291–306 (1930)Google Scholar
  132. [101]
    Blum, V., and K. Fiedler: Hormonal control of reproductive behavior in some Cichlid fish. Gen. comp. Endocr. 5, 186–196 (1965)CrossRefGoogle Scholar
  133. [102]
    Bompiani, A., G. D. Roversi et C. Aicardi: L’emploi de la Chromatographie en couche mince pour le dosage du prégnandiol urinaire durant le cycle menstrual et pour le prédiagnostic de grossesse. Ann. Endocr. (Paris) 25, 183–187 (1964)Google Scholar
  134. [103]
    Bomskov, Ch., B. Wiesiollek u. W. Doht: Über den Hormongehalt der Walovarien. Erste Mitteilung der Abhandlungsreihe: Vitamin- und Hormongehalt der Walorgane. Klin. Wschr. 19, 392–396 (1940)CrossRefGoogle Scholar
  135. [104]
    Bongiovanni, A. M.: The detection of pregnandiol and pregnandiol in the urine of patients with adrenal hyperplasia. Suppression with cortisone. Bull. Johns Hopk. Hosp. 92, 244–251 (1953)Google Scholar
  136. [105]
    Bongiovanni, A. M.: Urinary pregnanetriol: a practical determination in clinical medicine. Clin. Endocr. 1, 700–704 (1960)Google Scholar
  137. [106]
    Bongiovanni, A. M.: Absorption spectra of zl5-ß-hydroxysteroids in two reagents. Analyt. Biochem. 13, 85–90 (1965)PubMedCrossRefGoogle Scholar
  138. [106.
    a] Bongiovanni, A. M.: Digitonin precipitable steroids in normal human urine. J. clin. Endocr. 26, 1240– 1244 (1966)Google Scholar
  139. [107]
    Bongiovanni, A. M., and G. W. Clayton: A simplified method for the routine determination of pregnanediol and pregnanetriol in urine. Bull. Johns Hopk. Hosp. 94, 180–186 (1954)Google Scholar
  140. [108]
    Bongiovanni, A. M., W. R. Eberlein, and J. Cara: Studies on the metabolism of adrenal steroids in the adrenalgenital syndrome. J. clin. Endocr. 14, 409–422 (1954)PubMedCrossRefGoogle Scholar
  141. [109]
    Bongiovanni, A. M., W. R. Eberlein, and J. Cara: Critical analysis of methods for measurement of pregnane-3-alpha, 17-alpha, 20-alpha-triol in human urine. Analyt. Chem. 30, 388–393 (1958)CrossRefGoogle Scholar
  142. [110]
    Bongiovanni, A. M., and A. J. McPadden: The urinary excretion of three C-21 methylcorticosteroids in the adrenogenital syndrome. J. clin. Endocr. 19, 1608–1618 (1959)PubMedCrossRefGoogle Scholar
  143. [111]
    Bongiovanni, A. M., A. W. Root, and W. R. Eberlein: Measurement of pregnanetriol in plasma. J. clin. Endocr. 24, 1312–1317 (1964)PubMedCrossRefGoogle Scholar
  144. [112]
    Bonnin-Lafeargue, M., et R. Canivenc: Histophysiologie des corps progestatifs et gestatifs chez le blaireau européen (Meies meles L.). Ann. Endocr. (Paris) 23, 165– 174 (1962)Google Scholar
  145. [113]
    Borglin, N. E., and B. Willert: The prognostic value of histaminase and pregnandiol determination in threatening abortion. Acta obstet, gynec. scand. 36,382–397 (1957)CrossRefGoogle Scholar
  146. [114]
    Borth, R., B. Luneneeld, and H. de Watteville: Day-to-day variation in urinary gonadotrophs and steroid levels during the normal menstrual cycle. Fertil. and Steril. 8, 233–254 (1957)Google Scholar
  147. [115]
    Borth, R., u. O. Stamm: Pregnandiol- und Oestriolausscheidung im Urin und Geburtsbeginn. Geburtsh. u. Frauenheilk. 18, 600–604 (1958)Google Scholar
  148. [116]
    Borth, R., and H. de Watteville: Hormone assays in obstetrics and gynecology. Vitam. u. Horm. 10, 141–181 (1952)CrossRefGoogle Scholar
  149. [117]
    Boscott, R. J.: The metabolism of progesterone in goats. Ciba Found. Colloquia Endocr. 2, 327–328 (1952)Google Scholar
  150. [118]
    Boström, H.: Sulfate conjugation and conjugated sulfates. Scand. J. clin. Lab. Invest. 17, Suppl. 86, 33–52 (1965)Google Scholar
  151. [119]
    Boström, H., and B. Wengle: On phenol and steroid sulphokinases in adult human tissues. Acta endocr. (Kbh.), Suppl. 100, 129 (1965)Google Scholar
  152. [120]
    Botte, V.: La loealizzazione della steroide-3 ß-olo-deidrogenasi nel-ovaio di polio. R.C. Ist. Sei. Camerino 4, 205–209 (1963)Google Scholar
  153. [120 a]
    Botte, Y., G. Materazzi, and G. öhieffi: Histochemical distribution of 3ß-hydroxy - steroid dehydrogenase and 17 ß-hydroxysteroid dehydrogenases in the placenta and foetal membranes of the rat. J. Endocr. 34, 179–182 (1966)PubMedCrossRefGoogle Scholar
  154. [121]
    Botticelli, C. R., F. L. Hisaw jr., and W. D. Roth: Estradiol-17 ß, estrone, and progesterone in the ovaries of lamprey. Proc. Soc. exp, Biol. (N.Y.) 114, 255–257Google Scholar
  155. [122]
    Botticelli, C. R. F. L. HisawH. H. WotizEstradiol-17ß and progesterone in ovaries of starfish (Pisaster oehraceous). Proc. Soc. exp. Biol. (N.Y.) 103, 875–877 (1960)Google Scholar
  156. [123]
    Botticelli, C. R. F. L. Hisaw, and H. H. Wotiz: Estrogens and progesterone in the Sea Urchin (Strongyloeentrotus francis-canus)and Pecten (Pecten hericius). Proc. Soc. exp. Biol. 106, 887–889 (1961)Google Scholar
  157. [123a]
    Boucek, R. J., E. Györi, and R. Alvarez: Steroid dehydrogenase reactions in developing chick adrenal and gonadal tissues. Gen. comp. Endocr. 7,292–303 (1966)Google Scholar
  158. [124]
    Bowerman, A. M., and R. M. Melampy: Progesterone and Zl4-pregnen-20/ß-ol-3-one in bovine reproductive organs and body fluids. Proc. Soc. exp. Biol. (N.Y.) 109,45–48 (1962)Google Scholar
  159. [125]
    Boyd, E. M., and C. A. Eld en: The relation of lipids to oestrin and progestin in the corpus luteum of the sow. Endocrinology 19, 599–602 (1935)CrossRefGoogle Scholar
  160. [126]
    Bradbury, J. T., W. E. Brown, and L. A. Gray: Maintenance of the corpus luteum and physiologic actions of progesterone. Recent Progr. Hormone Res.5, 151–194 (1950)Google Scholar
  161. [127]
    Bradlow, H. L., D. K. Fukushima, L. Hellman, and T. F. Gallagher: Transforma tion of epimeric A 5-pregnene-317,20-triols in man. J. clin. Endocr. 24, 359–366Google Scholar
  162. [127a]
    Bradlow, H. L., D. K. Fukushima, D. R. Koerner, L. Hellman, and T. F. Gallagher: Metabolism of pregnene-3a, 17, 20 ß-trio\ in man. Steroids 8, 45–50 (1966)Google Scholar
  163. [128]
    Bradlow, H. L., D. K. Fukushima, D. R. Koerner, L. Hellman, and T. F. Gallagher: Metabolism of progesterone-1-C14 in man. Fed. Proc. 14, 185–186 (1955)Google Scholar
  164. [129]
    Bradshaw, T. E. T., and W. J. E. Jessop: The urinary excretion of oestrogens and pregnanediol at the end of pregnaney, during labour and during the early puer- perium. J. Endocr.9, 427–439 (1952–53)CrossRefGoogle Scholar
  165. [130]
    Bragdon, D. E., E. A. Lazo-Wasem, M. X. Zarrow, and F. L. Hisaw: Progesterone like activity in the plasma of ovo viviparous snakes. Proc. Soc. exp. Biol. (N.Y.) 86, 477–481 (1954)Google Scholar
  166. [131]
    Brambell, F. W. R.: Ovarian changes. In: Marshall’s physiology of reproduction, A. S. Parkes, ed., 3. ed., vol. 1, part. 1, p. 397–542. London-New York-Toronto: Longmans, Green & Co. 1956Google Scholar
  167. [132]
    Brambilla, F.: L’insuffisance lutéale dans les psychopathies. Ann. Endocr. (Paris) 25, 188–191 (1964)Google Scholar
  168. [133]
    Brancaccio, A., B. D’Alessandro, and M. G. Aurilia: Determination of Zl4–3-keto derivatives of progesterone. Progr. med. (Napoli) 16, 630–633 (1960)Google Scholar
  169. [133a]
    Brancaccio, A., B. D’Alessandro, and M. G. Aurilia, M. Rotondi: Escrezione di alcuni cataboliti del progesterone (pregnandiolo, pregnantriolo e Zl4–3-cheto-derivati) in soggetti normali dopo carico di 6-a-metil-17-a-idrossiprogesterone aeetato. Boll. Soc. ital. Biol. sper. 37, 718–720 (1961)Google Scholar
  170. [134]
    Brandau, H., u. W. Lüh: Zur Lokalisation der innersekretorischen Funktion des menschlichen Ovars. Acta endocr. (Kbh.) 46, 580–596 (1964)Google Scholar
  171. [135]
    Braunsberg, H., and V. H. T. James: Studies on the uptake of steroid hormones by human tissues in vitro. Biochem. J. 90, 15 P (1964)Google Scholar
  172. [136]
    Breitenbach, R. P., and R. K. Meyer: Effect of incubation and brooding on fat, visceral weights and body weight of the hen pheasant (Phasianus colchicus). Poultry Sei. 38, 1014–1026 (1959)Google Scholar
  173. [137]
    Breuer, H., U. Dardenne u. W. Nocke: Ausscheidung von 17-Ketosteroiden, 17- ketogenen Steroiden und Oestrogenen beim Menschen nach Gaben von 17-a- Äthynyl-19-nor-testosteron-Estern. Acta endoer. (Kbh.) 33, 10–26 (1960)Google Scholar
  174. [138]
    Breuer, H., U. Dardenne u. W. Nocke, u. B. P. Lisboa: Untersuchungen über den Stoffwechsel von 17-Hydroxy-19-nor-progesteron-capronat beim Menschen in vivo und von 17-Hydroxy-19-nor-progesteron bei der Ratte in vitro. Acta endocr. (Kbh.) 51, 114–130 (1966)Google Scholar
  175. [139]
    Bricaire, H., J. Thoyer-Rozat, R. Tourneur et Ph. Laudat: Tumeur virilisante de l’ovaire chez une enfant de 13 ans. Étude clinique hormonale et anatomique. Ann. Endocr. (Paris) 21, 104–111 (1960)Google Scholar
  176. [140]
    Brinkley, H. J., H. W. Norton, and A. V. Nalbandov: Role of a hypophysial luteotrophic substance in the function of porcine corpora lutea. Endocrinology 74, 9–13 (1964)PubMedCrossRefGoogle Scholar
  177. [140 a]
    Brinkley, H. J., H. W. Norton, and A. V. Nalbandov: Is ovulation alone sufficient to cause formation of corpora lutea ? Endocrinology 74, 14–20 (1964)PubMedCrossRefGoogle Scholar
  178. [141]
    Brinkley, H. J., E. W. Wickersham, N. L. First, and L. E. Casida: Effect of unilateral ovariectomy on the structure and function of the corpora lutea of the pig. Endocrinology 74, 462–467 (1964)PubMedCrossRefGoogle Scholar
  179. [141a]
    Brinkley, H. J., E. W. Wickersham, N. L. First, and L. E. Casida, and E. P. Young: In vivo progesterone secretion by swine ovaries. J. Anim, Sci. 24, 914 (1965)Google Scholar
  180. [142]
    Brit. Med. Res. Council. The use of hormones in the management of pregnancy in diabetics. Lancet 1955II, 833–836Google Scholar
  181. [142 a]
    Brody, S., and L.A. Carlson: Plasma lipid concentrations in the newborn with special reference to the distribution of the different lipid fractions. Clin. chim. Acta 7, 694–699 (1962)Google Scholar
  182. [142b]
    Brooks, C. J. W., E. Chambaz, and E. C. Horning: Thin layer and column chromatographic group separations of steroids as trimethylsilyl ethers. Isolation for GLC analysis of pregnanediol and estriol in pregnancy urine. Analyt. Biochem. 19, 234– 242 (1967)Google Scholar
  183. [143]
    Brooks, R. V., W. Klyne, and E. Miller: Steroids of pregnant mares’ urine. 4. Fractionation of the neutral steroids, Examination of some non-ketonie fractions. Biochem. J. 51, 694–707 (1952)PubMedGoogle Scholar
  184. [144]
    Brooks, R. V., W. Klyne, and E. Miller D. Mattingly, I. H. Mills, and F. T. G. Prunty: Post-pubertal adrenal virilism with biochemical disturbance of the congenital type of adrenal hyperplasia. Brit, med. J. 19601, 1294–1298Google Scholar
  185. [145]
    Brooks, R. V., W. Klyne, and E. Miller D. Mattingly, I. H. Mills, and F. T. G. Prunty: Patterns of steroid excretion in three types of post-pubertal hirsutism. J. Endocr. 21, 263–276 (1960)CrossRefGoogle Scholar
  186. [146]
    Brown, J. B., K. Fotherby, and J. A. Loraine: The effect of 17a-ethinyl-19-nor-testosterone (norethisterone) on the urinary excretion of oestrogens, pregnanediol and gonadotrophins during the menstrual cycle. Proc. roy. Soc. Med. 52, 431–433 (1960)Google Scholar
  187. [146a]
    Brown, J. B., K. Fotherby, and J. A. Loraine: The effect of norethisterone and its acetate on ovarian and pituitary function during the menstrual cycle. J. Endocr. 25, 331–341 (1962/63)PubMedCrossRefGoogle Scholar
  188. [147]
    Brown, J. B., K. Fotherby, and J. A. Loraine A. Klopper, and J. A. Loraine: The urinary excretion of oestrogens, pregnanediol and gonadotrophins during the menstrual cycle. J. Endocr. 17, 401–410 (1958)PubMedCrossRefGoogle Scholar
  189. [148]
    Brown, J. M. M., S. J. van Rensburg, and R. Gray: The urinary excretion of 5/ß- pregnane-3a: 20a-diol and gestational failure in angora goats. Onderstepoort J. vet. Res. 30, 179–190 (1963)Google Scholar
  190. [149]
    Browne, J. S. L., J. S. Henry, and E. M. Venning: The corpus luteum hormone in pregnancy. J. clin. Invest. 16, 678 (1937)Google Scholar
  191. [150]
    Browne, J. S. L., J. S. Henry, and E. M. Venning: The urinary excretion of prolan, estrin and pregnanediol in normal pregnancy and in early and late pregnancy toxemias. J. clin. Invest. 17, 503 (1938)Google Scholar
  192. [151]
    Browne, J. S. L., J. S. Henry, and E. M. Venning: The significance of endocrine assays in threatened and habitual abortion. Amer. J. Obstet. Gynec. 38, 927–955 (1939)Google Scholar
  193. [152]
    Browne, J. S. L., J. S. Henry, and E. M. Venning: Studies in corpus luteum function. J. clin. Endocr. 7, 446 (1947)PubMedCrossRefGoogle Scholar
  194. [153]
    Browne, J. S. L., E. M. Venning, and J.S. Henry: The corpus luteum hormone in gynecology. Progr. Gynec. 1, 174–187 (1946)Google Scholar
  195. [154]
    Brownie, A. C., H. van derMolen, E. F. Nishizawa, and K. B. Eik-Nes: Deter mination of testosterone in human peripheral blood using gasliquid chromatography wiht electron capture detection. J. clin. Endocr. 24, 1091–1102 (1964)PubMedCrossRefGoogle Scholar
  196. [155]
    Bruns, P. D., E. St. Taylor, R. M. Anker, and V. E. Drose: Uterine contractility, circulation, and urinary steroids in premature delivery. Amer. J. Obstet. Gynec. 73, 579–588 (1957)PubMedGoogle Scholar
  197. [156]
    Brush, M. G.: The metabolism of injected progesterone in the ewe. Proc. Intern. Congr. Animal Reprod., 4th., vol. 2, p. 345–347. Den Haag 1961Google Scholar
  198. [157]
    Brush, M. G.: The metabolism of injected progesterone in the ewe. J. Endocr. 26, 65–73 (1962–63)CrossRefGoogle Scholar
  199. [158]
    Bryans, F. E.: Progesterone of the blood in the menstrual cycle of the monkey. Endo crinology 48, 733–740 (1951)Google Scholar
  200. [159]
    Bryson, M. J., O. V. Dominguez, I. H. Kaiser, L. T. Samuels, and M. L. Sweat: Enzymic steroid conversions in a masculinovoblastoma. J. clin. Endocr. 22, 773– 783 (1962)Google Scholar
  201. [159a]
    Bryson, M. J., O. V. Dominguez, I. H. Kaiser, L. T. Samuels, and M. L. Sweat: Endometrial metabolism of progesterone. Fed. Proc. 22, 469 (1963)Google Scholar
  202. [160]
    Burger-Kiel, M.: Der Cholesterinhaushalt beim Menschen. Ergebn. inn. Med. Kinderheilk. 34, 583–701 (1928)CrossRefGoogle Scholar
  203. [161]
    Burger, H. C., and I. F. Sommerville: Further evidence for an ovarian source of urinary pregnanetriol. Acta endocr. (Kbh.) 43, 95–100 (1963)Google Scholar
  204. [162]
    Burstein, S., and R. I. Doreman: Biosynthesis of C19 steroids from 4–14C-cholesterol and 7–3H-pregnenolone in vivo: Consideration of new pathways. Acta endocr. (Kbh.) 40, 182–202 (1962)Google Scholar
  205. [163]
    Burttein, S., and S. Lieberman: Hydrolysis of ketosteroid hydrogen sulfates by solvolysis procedures. J. biol. Chem. 238, 331–335 (1958)Google Scholar
  206. [164]
    Burthiault, R., R. Béthotjx et F. Charyet: Expérimentation clinique d’une nouvelle méthode de dosage du prégnandiol urinaire. Gynéc. et Obstét. 51, 294–297 (1952)Google Scholar
  207. [165]
    Burthiault,et M. Dumont: Etude de l’élimination urinaire du prégnandiol dans les néphropathies gravidiques. J. Méd. Lyon 33, 71–74 (1952)PubMedGoogle Scholar
  208. [166]
    Bush, I. E.: Methods of paper chromatography steroids applicable to the study of steroids in mammalian blood and tissues. Biochem. J. 50, 370–378 (1951/52)Google Scholar
  209. [167]
    Butenandt, A.: Über das Pregnandiol, einen neuen Sterinabkömmling aus Schwangerenharn. Ber. dtsch. chem. Ges. 63, 659–663 (1930)CrossRefGoogle Scholar
  210. [168]
    Butenandt, A.: Neuere Ergebnisse auf dem Gebiet der Sexualhormone. Wien. klin. Wschr. 47, 934–936 (1934).Google Scholar
  211. [169]
    Butenandt, A., u. L. Mamoli: Über allo-Pregnanol-(3)-on-(20), einen Begleitstoff des Corpusluteum-Hormons. Ber. dtsch. chem. Ges. 67, 1897–1901 (1934)CrossRefGoogle Scholar
  212. [170]
    Butenandt, A., u. J. Schmidt: Überführung des Pregnandiols in Corpus luteum-Hormon. Ber. dtsch. chem. Ges. 67, 1901–1904 (1934)CrossRefGoogle Scholar
  213. [171]
    Butenandt, A., u. J. Schmidt: Über Δ 4-Pregnenol-(20)-on-(3); ein Beitrag zur Spezifität der Corpus luteum Wirkung. Ber. dtsch. chem. Ges. 67, 2092–2094 (1934)CrossRefGoogle Scholar
  214. [172]
    Butenandt, A., u. U. Westphal: Zur Isolierung und Charakterisierung des Corpus luteum-Hormons. Ber. dtsch. chem. Ges. 67, 1440–1442 (1934)CrossRefGoogle Scholar
  215. [173]
    Butenandt, A., u. U. Westphal: Über die Darstellung des Corpus luteum-Hormons aus Stigmasterin, die Konstitution des Corpus luteum-Hormons. Ber. dtsch. chem. Ges. 67, 2085–2087 (1934)CrossRefGoogle Scholar
  216. [174]
    Butenandt, A., u. U. Westphalu. W. Hohlweg: Über das Hormon des Corpus luteum. Hoppe-Seylers Z. physiol. Chem. 227, 84–98 (1934)CrossRefGoogle Scholar
  217. [175]
    Butler, G.C., and G. F. Marrian: The isolation of pregnane-3,17,20-triol from the urine of women showing the adrenogenital syndrome. J. biol. Chem. 119, 565–572 (1937)Google Scholar
  218. [176]
    Butler, G.C., and G. F. Marrian: Chemical studies on the adreno-genital syndrome. I. The isolation of 3(α)-hydr- oxyetiocholane-17-one, 3(α)- hydroxyetioaliocholane-17-one (isoandrosterone), and a new triol from the urine of a woman with and adrenal tumor. J. biol. Chem. 124, 237–247 (1938)Google Scholar
  219. [177]
    Butt, W. R., and A. C. Crooke: The disappearance rate of intravenously injected testosterone and progesterone from the human circulation. J. Endocr. 7, XXVIII (1950/51)Google Scholar
  220. [178]
    Butt, W. R., and A. C. CrookeP. Morris, C. J. O. R. Morris, and D. C. Williams: The polarographic estimation of steroid hormones. Biochem. J. 40, 434–438 (1951)Google Scholar
  221. [179]
    Buxton, C. L.: Pregnanediol determination as an aid in clinical diagnosis. Amer. J. Obstet. Gynec. 40, 202–211 (1940)Google Scholar
  222. [180]
    Buxton, C. L. N. Kase, and D. vanOrden: The effect of human FSH and HCG on the anovulatory ovary. Amer. J. Obstet. Gynec. 87, 773–779 (1963)PubMedGoogle Scholar
  223. [181]
    Buxton, C. L. N. Kase, and D. vanOrden, and U. Westphal: Recovery of pregnandiol in urine of men treated with progesterone. Proc. Soc. exp. Biol. (N.Y.) 41, 284–287 (1939)Google Scholar
  224. [182]
    Cagnazzo, G., and F. Misurale: Elimination of pregnane-3α,17α,20α-triol in gestation and normal pregnancy. Monit. ostet.-ginec. 33, 302–316 (1962)Google Scholar
  225. [183]
    Caie, E., and A. Klopper: The urinary excretion of pregnanediol after the administration of an oral gestagen (progesterone cyclopentyl enol ether). J. Endocr. 28, 221– 222 (1964)Google Scholar
  226. [184]
    Callard, G. V., I. P. Callard, and J. H. Leathem: 20α-Hydroxypregn-4-en-3-one, an interfering fluorogen in assay of corticosterone. Proc. Soc. exp. Biol. (N.Y.) 113, 745–747 (1965)Google Scholar
  227. [185]
    Callard, G. V., I. P. Callard, and J. H. Leathem: In vitro synthesis of steroids by experimentally induced cystic ovaries. Proc. Soc. exp. Biol. (N.Y.) 118, 996–999 (1965)Google Scholar
  228. [186]
    Callard, I. P., and J. H. Leathem: In vitro synthesis of progesterone by ovaries and adrenals of snakes. Proc. Soc. exp. Biol. (N.Y.) 115, 567–569 (1964)Google Scholar
  229. [186a]
    Callard, I. P., and J. H. Leathem: In vitro steroid synthesis by the ovaries of elasmobranchs and snakes. Arch. Anat. path. 54, 35–48 (1965)Google Scholar
  230. [186b]
    Callard, I. P., and J. H. Leathem: Steroid synthesis by amphibian ovarian tissue. Gen. comp. Endocr. 7, 80 (1966)Google Scholar
  231. [187]
    Calvin, H. I., and S. Lieberman: Evidence that steroid sulfates serve as biosynthetie intermediates. II. In vitro conversion of pregnenolone-3H sulfate-35 S to 17α-hydroxy- pregnenolone-3H sulfate-35S. Biochemistry 3, 259–264 (1964)Google Scholar
  232. [187a]
    Calvin, H. I., and S. Lieberman: Studies on the metabolism of pregnenolone sulfate. J. clin. Endocr. 26, 402–424 (1966)PubMedCrossRefGoogle Scholar
  233. [187b]
    Calvin, H. I., and S. LiebermanK. D. Roberts, C. Weiss, L. Bandi, J. J. Cos, and S. Lieberman: Column liquid-liquid partition chromatography of steroidal sulfates. Analyt. Biochem. 15, 426–436 (1966)PubMedCrossRefGoogle Scholar
  234. [188]
    Calyin, H. L., R. L. van de Wiele, and S. Lieberman: Evidence that steroid sulfates serve as biosynthetic intermediates: in vivo conversion of pregnenolone-sulfate-S35 to dehydroisoandrosterone sulfate-S35. Biochemistry 2, 648–653 (1963)CrossRefGoogle Scholar
  235. [189]
    Čamacho, A. M., and C. J. Migeon: Studies on the origin of testosterone in the urine of normal adult subjects and patients with various endocrine disorders. J. clin. Invest. 43, 1083–1089 (1964)PubMedCrossRefGoogle Scholar
  236. [189a]
    Canivenc, R., R. V. Short et M. Bonnin-Laeeargfe: Étude histologique et biochimique du corps jaune du blaireau européen (Meles meles L.). Ann. Endocr. (Paris) 27, 401–413 (1966)Google Scholar
  237. [189b]
    Cardeilhac, P. T., M. C. Morrissette, and J. D. Calle: Progesterone biosynthesis in perfused corpora lutea. Proc. Soc. exp. Biol. (N.Y.) 123, 343–346 (1966)Google Scholar
  238. [189c]
    Carlson, I. H., A. J. Blair, and R. K. Meyer: 1964. Abstr. Program 46th Meeting Endocrine Soc. Abstr. No. 113. Zit. nach 338aGoogle Scholar
  239. [190]
    Carstensen, H., G. W. Oertel, and K. B. Eik-Nes: Secretion of 17α-hydroxy-Δ 5-pregnenolone by the canine adrenal gland during stimulation with adreno- cortieotropin. J. biol. Chem. 234, 2570–2577 (1959)PubMedGoogle Scholar
  240. [191]
    Casida, K. E., and E. V. Warwick: The necessity of the corpus luteum for main tenance of pregnancy in the ewe. J. Animal. Sci. 4, 34 (1945)Google Scholar
  241. [191a]
    Caspi, E., and D. O. Lewis: Progesterone: Its possible role in the biosynthesis of cardenolides in digitalis lanata. Science 156, 519–520 (1967)PubMedCrossRefGoogle Scholar
  242. [191b]
    D. M. Piatak, K. V. Thimann, and A. Winter: Biosynthesis of plant sterols. Conversion of cholesterol to pregnenolone in digitalis purpurea. Experientia (Basel) 22, 506–507 (1966)CrossRefGoogle Scholar
  243. [192]
    Cassmer, O.: Hormone production of the isolated human placenta. Acta endocr. (Kbh.) Suppl. 45, 1–82 (1959)Google Scholar
  244. [193]
    Castegnaro, E., and G. Sala: Isolation and identification of 6α,17α,21 -trihydroxy-6α-methyl-Δ 4-pregnene-3,20-dione (21-acetate) from the urine of human subjects treated with 6α-methyl-17α-acetoxyprogesterone. J. Endocr. 24, 445–452 (1962)PubMedCrossRefGoogle Scholar
  245. [194]
    Castrén, O., L. Hirvonen, S. Narvanen, and K. Soiva: On the permeability of the guinea pig placenta to intravenously injected progesterone-4–14C. Acta endocr. (Kbh.) 35, 204–210 (1960)Google Scholar
  246. [195]
    Castrén, O., L. Hirvonen, S. Narvanen, and K. Soiva: Permeability of human placenta to progesterone-4–14C in the middle of pregnancy. Acta endocr. (Kbh.) 39, 506–512 (1962)Google Scholar
  247. [195a]
    Castrén, O., L. Hirvonen, S. Narvanen, and K. Soiva, L. Rauramo, and A. Pekkarinen: Excretion of oestriol and pregnanediol in placental insufficiency. Acta obstet. gynec. scand. 45, Suppl. 9, 66–67 (1966)Google Scholar
  248. [196]
    Cathro, D. M., K. Birchall, F. L. Mitchell, and C. C. Forsyth: The excretion of neutral steroids in the urine of newborn infants. J. Endocr. 27, 53–75 (1963)PubMedCrossRefGoogle Scholar
  249. [196a]
    Cedard, L.: Role du foetus et du placenta dans la biosynthèse et le métabolisme des stéroides au cours de la grossesse humaine. Path, et Biol. 14, 1192–1201 (1966)Google Scholar
  250. [197]
    Chamberlain, J., B. A. Knights, and G. H. Thomas: Analysis of steroid metabolites by gas chromatography. J. Endocr. 26, 367–387 (1962/63)CrossRefGoogle Scholar
  251. [198]
    Chamberlain, J., B. A. Knights, and G. H. Thomas: A system of analysis by gas-chromatography of 17 α- and 17α-pregnane-3,20-diols and their identification as metabolites of progesterone in man, the monkey, rabbit and guineα-pig. J. Endocr. 28, 235–246 (1964)PubMedCrossRefGoogle Scholar
  252. [199]
    Chamberlain, J., B. A. Knights, and G. H. Thomas: Characterization of 20-oxosteroids by gas chromatography. Analyt. Biochem. 8, 104–115 (1964)PubMedCrossRefGoogle Scholar
  253. [200]
    Chaney, A.L., W. E. McKee, R. H. Fischer, and S. P. McColgan: A new and simplified procedure for the determination of free pregnanediol in urine, and its evaluation. J. clin. Endocr. 12, 735–743 (1952)PubMedCrossRefGoogle Scholar
  254. [201]
    Chang, E., W. R. Slatjnwhite jr., and A. A. Sandberg: Biliary and urinary meta bolites of 4-C14-progesterone in human subjects. J. clin. Endocr. 20, 1568–1575 (1960)CrossRefGoogle Scholar
  255. [202]
    Channing, C., and C. Villee: Stimulation by luteinizing hormone of hexose and cholesterol metabolism in luteinized rat ovary. Fed. Proc. 24, 320 (1964)Google Scholar
  256. [202a]
    Channing, C. P.: Progesterone biosynthesis by equine granulosa cells growing in tissue culture. Nature (Lond.) 210, 1266 (1966)CrossRefGoogle Scholar
  257. [202b]
    Channing, C. P., and S. A. Grieves: Effect of gonadotrophins on steroidogenesis by equine granulosa cells grown in tissue culture. J. Endocr. 38, VIII (1967)Google Scholar
  258. [202c]
    Channing, C. P., and C. A. Villee: Stimulation of cholesterol metabolism in the luteinized rat ovary by luteinizing hormone. Biochim. biophys. Acta (Amst.) 127, 1 (1966)CrossRefGoogle Scholar
  259. [203]
    Chatterton jr., R. T., and R. O. Greep: Steroid biosynthesis by the normal rat ovary. Fed. Proc. 24, 384 (1965)Google Scholar
  260. [203a]
    Chattoraj, S. C., and A. Scommegna: A gas chromatographic technique for the simultaneous determination of urinary pregnanediol and pregnanetriol after ammonium sulfate precipitation. Steroids 9, 327–346 (1967)PubMedCrossRefGoogle Scholar
  261. [203b]
    Cheatum, S. G., and J. C. Warren: Purification and properties of 3 ß-hydroxy- steroid dehydrogenase and Δ 5–3-ketosteroid isomerase from bovine corpora lutea. Biochim. biophys. Acta (Amst.) 122, 1–13 (1966)Google Scholar
  262. [204]
    Chen, Ytt Min: The cholesterol and total lipid contents of testes and ovaries and their changes influenced by sex hormone administration in rats. Bull. Ass. Agr. Chem., Nat. Taiwan Univ. 11, 1–3 (1962)Google Scholar
  263. [205]
    Chester, Jones, I.: Hormones in fish. Symposia of the zool. Soe. London, Sympos. No. 1, 1960Google Scholar
  264. [206]
    Chevallier, F.: Transferts et synthèse du cholestérol chez le rat au cours de sa croissance. Biochim. biophys. Acta (Amst.) 84, 316–339 (1964)Google Scholar
  265. [207]
    Chieiït, G.: La luteogensi nei Selaci ovovivipari. Riehereche istologiche e istochimiche in Torpedo marmorate e Torpedo ocellata. Pubbl. Staz. zool. Napoli 32, 145–166 (1961)Google Scholar
  266. [207a]
    Chieiït, G., and H. A. Bern: Report on international roundtable on steroid hormones in fishes at the Stazione Zoologica of Naples. Gen. comp. Endocr. 7, 203 (1966)Google Scholar
  267. [208]
    Chieiït, G., and V. Botte: The distribution of some enzymes involved in the steroidogenesis of hen’s ovary. Experientia (Basel) 21, 16–17 (1965)CrossRefGoogle Scholar
  268. [209]
    Chieiït, G., and V. Botte, and C. Lupo: Indentification of sex hormones in the ovarian extracts of Torpedo marmorata and Bufo vulgaris. Gen. comp. Endocr. 3, 149–152 (1963)Google Scholar
  269. [210]
    Chirkovskaya, K. S.: Some biochemical indices in studies of the placenta during intrauterine death of the fetus. Akush. i Ginek. 39, 42–45 (1963)Google Scholar
  270. [210a]
    Chowaniec, T.: Urinary levels of pregnanediol in pregnancy at term and in prolonged pregnancy. Excerpta med. (Amst.), Sect. XXI, 7, Nr 1241 (1967)Google Scholar
  271. [211]
    Claesson, L., and N.-A. Htllarp: The formation mechanism of oestrogenic hormones. 1. The presence of an oestrogen-precursor in the rabbit ovary. Acta physiol. scand. 13, 115–129 (1946)CrossRefGoogle Scholar
  272. [212]
    Claesson, L., and N.-A. Htllarp: Critical remarks on the histochemical reactions for ketosteroids. Acta anat. (Basel) 3, 109–114 (1947)CrossRefGoogle Scholar
  273. [213]
    Claesson, L., and N.-A. Htllarp: The formation mechanism of oestrogenic hormones. II. The presence of the oestrogen-precursor in the ovaries of rats and guineα-pigs. Acta physiol. scand. 14, 102–119 (1947)PubMedCrossRefGoogle Scholar
  274. [214]
    Clarke, E. G. C., and S. Taylor: Microchemical identification of progesterone. J. Physiol. (Lond.) 151, 14 P–15 P (1960)Google Scholar
  275. [215]
    Clerck, P. de: Contribution à la cytophysiologie du placenta à terme. Les possibilités d’une survie et d’une croissance in vitro du syneytiotrophoblaste. Bull. Soc. roy. belge Gynée. Obstét. 26, 493–503 (1956)Google Scholar
  276. [216]
    Cohen, S. L.: The hydrolysis of steroid glucuronides with calf spleen glucuronidase. J. biol. Chem. 192, 147–160 (1951)PubMedGoogle Scholar
  277. [217]
    Cohen, S. L.: Potentiation of glucuronidase hydrolysis of sodium pregnanediol glueuronidate. Canad. J. Biochem. 42, 127–138 (1964)CrossRefGoogle Scholar
  278. [218]
    Cohen, S. L., M. M. Goldeine, F. Toussaint, K. Friedman, and I. Noma: The hydrolysis of pregnanediol glueuronide by glucuronidase preparations. Endocrinology 54,353–355 (1954)PubMedCrossRefGoogle Scholar
  279. [219]
    Cohn, G. L., and E. Pancake: A standardized technique for the separation of steroids by thin-layer chromatography. Nature (Lond.) 201, 75–76 (1964)CrossRefGoogle Scholar
  280. [220]
    Cole, H. H.: The excretion of steroid hormones concerned with controlling reproduc tive processes in animals. Amer. J. vet. Res. 11, 161–165 (1950)PubMedGoogle Scholar
  281. [221]
    Collins, W. F., and I. F. Sommerville: Quantitative determination of progesterone in human plasma by thin-layer and gas-liquid radiochromatography. Nature (Lond.) 203, 836–839 (1964)CrossRefGoogle Scholar
  282. [222]
    Collins, W. F., and I. F. Sommerville:The in vitro transformation of pregn-5-enolone-4-C14 by human gonadal tissue. Acta endocr. (Kbh.), Suppl. 100, 84 (1965)Google Scholar
  283. [222a]
    Conney, A. H., M. Jacobson, W. Levin, K. Schneidman, and R. Kuntzman: Decreased central depressant effect of progesterone and other steroids in rats pre- treated with drugs and insecticides. J. Pharmacol, exp. Ther. 154, 310–318 (1966)Google Scholar
  284. [222b]
    Conney, A. H., M. Jacobson, W. Levin, and K. Schneidman: Decreased hypnotic action of progesterone and other steroids in rats pretreated with drugs that stimulate steroid metabolism. Fed. Proc. 24 (I), 152, 134 (1965)Google Scholar
  285. [222c]
    Conney, A. H., M. Jacobson, W. Levin, R. M. Welch, R. Kuntzman, and J. J. Burns: Effects of pesticides on drug and steroid metabolism. Clin. Pharmacol. Ther. 8, 2–10 (1967)PubMedGoogle Scholar
  286. [222d]
    Conrad, S. H., R. J. Pion, and J. D. Kitchin: Pregnenolone sulfate in human pregnancy plasma. J. clin. Endocr. 27, 114–119 (1967)PubMedCrossRefGoogle Scholar
  287. [223]
    Constantopoulos, G., and T. T. Tchen: Cleavage of cholesterol side chain by adrenal cortex. J. biol. Chem. 236, 65–67 (1961)PubMedGoogle Scholar
  288. [224]
    Contractor, S. F., and W. H. Pearlman: (16–8H) Progesterone metabolism in advanaced pregnancy and in oophorectomized-hysterectomized women: urinary ketonic metabolites. Biochem. J. 76, 36–41 (1960)PubMedGoogle Scholar
  289. [225]
    Cooke, A. M., A. W. Rogers, and G. H. Thomas: The urinary metabolites of progesterone labelled with tritium and carbon-14 in the rabbit. J. Endocr. 27, 299–315 (1963)PubMedCrossRefGoogle Scholar
  290. [226]
    Cooke, B. A., T. J. McDonald, and D. K. Vallance: Metabolism of 17oc-aeetoxy-6-methyl-pregnα-4,6-diene-3,20-dione in the rat. Biochem. J. 96, 25 P–26 P (1965)Google Scholar
  291. [227]
    Cooke, B. A., T. J. McDonald, and D. K. Vallance, and W. Taylor: Sex differences in metabolism of (4–14C) progesterone by rat liver in vitro. Excerpta med. (Amst.), Internat. Congr. Ser. No. 51, p. 144. Mailand 1962Google Scholar
  292. [228]
    Cooke, B. A., T. J. McDonald, and D. K. Vallance, and W. Taylor: The metabolism of progesterone by animal tissues in vitro. Biochem. J. 86, 365–372 (1963)PubMedGoogle Scholar
  293. [229]
    Cooke, B. A., T. J. McDonald,W. Taylor, and D. K. Vallance: Metabolism of 17α-aeetoxy-6α-methyl-pregnα-4,6-diene- 3,20-dione and related progesterone analogues by liver preparations in vitro. Biochem. J. 91, 31 P (1964)Google Scholar
  294. [230]
    Cooke, B. A., T. J. McDonald,W. Taylor, and D. K. Vallance: Metabolism of megestrol acetate and related progesterone analogues by liver preparations in vitro. Biochem. J. 97, 672–677 (1965)PubMedGoogle Scholar
  295. [230a]
    Cooke, I. D., N. Wiqvist, and E. Diszealusy: Metabolism of pregnanediol in the human foeto-plecental unit at midpregnancy. Acta endocr. (Kbh.) 56, 43–55 (1967)Google Scholar
  296. [231]
    Cooper, J. A., J. P. Abbott, B. K. Rosengreen, and W. R. Claggett: Gas chromato graphy of urinary steroids. I. A preliminary report on the demonstration and identification of pregnanediol in pregnancy urine, by means of gas chromatography. Amer. J. clin. Path. 38, 388–391 (1962)Google Scholar
  297. [232]
    Cooper, J. M., H. E. H. Jones, and A. E. Kellie: The metabolism of megestrol acetate (17α-acetoxy-6-methylpregnα-4,6-diene-3,20-dione) in the rabbit. Steroids 6, 255–275 (1965)PubMedCrossRefGoogle Scholar
  298. [233]
    Cooper, J. M., H. E. H. Jones, and A. E. Kellie: The metabolism of 17α-acetoxy-6-methyl-pregnα-4,6-diene- 3,20-dione in the rabbit. Biochem. J. 91, 31 P (1964)Google Scholar
  299. [233a]
    Cooper, W., M. G. Coyle, V. H. T. James, M. Nicholas, and V. K. Smith: Studies on the determination of pregnanediol in pregnancy urine by gas chromatography. J. Endocr. 35, XXI–XXII (1966)Google Scholar
  300. [234]
    Cope, C. L.: The diagnostic value of pregnandiol excretion in pregnancy disorders. Brit. med. J. 1940, 545–549Google Scholar
  301. [235]
    Corner, G. W.: Physiology of the corpus luteum. I. The effect of very early ablation of the corpus luteum upon embryos and uterus. J. Physiol. (Lond.) 86, 74–81 (1928)Google Scholar
  302. [236]
    Corner, G. W.: The rate of secretion of progestin by the corpus luteum. Cold Spr. Harb. Symp. quant. Biol. 5, 62–65 (1937)CrossRefGoogle Scholar
  303. [237]
    Corner, G. W.: The hormones in human reproduction. Princeton: University Press 1947Google Scholar
  304. [238]
    Corner, G. W.: The reproductive cycle of the rhesus monkey. Amer. Scientist 39, 50–73 (1951)Google Scholar
  305. [239]
    Corner, G. W., and W. M. Allen: Physiology of the corpuus luteum. II. Production of a special uterine reaction (progestational proliferation) by extracts of the corpus luteum. Amer. J. Physiol. 88, 326–339 (1929)Google Scholar
  306. [239a]
    Corral-Gallardo, J., H. A. Acevedo, J. L. Perez de Salazar, M. Loria, and J. W. Goldzieher: The polycystic ovary. VI. A hilus cell tumour of the ovary associated with polycystic ovarian disease: in vivo and in vitro studies. Acta endocr. (Kbh.) 52, 425–442 (1966)Google Scholar
  307. [240]
    Coxjrcy, C. de: A trichloracetic acid reagent for the detection of pregnane-3α,17α,20- triols on paper chromatograms. J. Endocr. 14, 164–170 (1956)CrossRefGoogle Scholar
  308. [241]
    Coxjrcy, C. de, and J. J. Schneider: Enzymatic reduction of the C-20 carbonyl group of tetrα- hydroeortisone and 17-hydroxypregnanolone. J. biol. Chem 223, 865–876 (1956)Google Scholar
  309. [242]
    Courier, R.: Endocrinologie de la Gestation. Paris: Mason & Cie. 1945. Zit. in S.R.M. Reynolds and P. H. Hoeber (eds.), Physiologie of the uterus, p. Ill, Harper and Brother, Inc. 1949Google Scholar
  310. [243]
    Cowie, A. T., and D. S. Flux: The rate of absorption of steroids and synthetic oestrogens from subcutaneously implanted tablets. J. Endocr. 11, 256–260 (1954)CrossRefGoogle Scholar
  311. [244]
    Cox, R. I.: A method for the quantitative determination in urinary extracts of C21 17: 20-dihydroxy-20-methylsteroids. Biochem. J. 52, 339–345 (1952)PubMedGoogle Scholar
  312. [245]
    Cox, R. I.: Separation, detection and estimation of C21 17: 20-dihydroxy-20-methyl-steroids. Nature (Lond.) 181, 638–639 (1958)CrossRefGoogle Scholar
  313. [246]
    Cox, R. I.: The separation and quantitative estimation of pregnane-3oc,17oe,20α-triol, pregnane 3α,17α,20α-triol-ll-one, and other urinary acetaldehydrogenie steroids. J. biol. Chem. 234, 1693–1697 (1959)PubMedGoogle Scholar
  314. [247]
    Cox, R. I.: Pregnane-3α,17α,20α-triol, pregnane-3α,17α,20α-triol-ll-one and related steroids. Acta endocr. (Kbh.) 03, 477–493 (1960)Google Scholar
  315. [248]
    Cox, R. I.: Gas chromatography in the analysis of urinary pregnanediol. J. Chromatogr. 12, 242–245 (1963)PubMedCrossRefGoogle Scholar
  316. [249]
    Cox, R. I., and M. Finkelstein: Pregnane-3α, 17α,20 α-triol and pregnane-3α,17α,20α- triol-ll-one excretion by patients with adrenocortical dysfunction. J. clin. Invest. 36, 1726–1735 (1957)PubMedCrossRefGoogle Scholar
  317. [250]
    Cox, R. I., and M. Finkelstein, and G. F. Marrian: The isolation of pregnane-3α, 17α,20α-triol from the urine of normal men. Biochem. J. 54, 353–356 (1953)PubMedGoogle Scholar
  318. [251]
    Cox, R. I., and M. Finkelstein, and R. P. Shearman: Abnormal excretion of pregnanetriolone and Δ 5-pregnenetriol in the Stein-Leventhal syndrome. J. clin. Endoer. 21, 586–590 (1961)CrossRefGoogle Scholar
  319. [252]
    Coyle, M. G., M. Greig, and J. Walker: Blood-progesterone and urinary pregnanediol and oestrogens in foetal death from severe pre-eclampsia. Lancet 1962 II, 275–277CrossRefGoogle Scholar
  320. [253]
    Cox, R. I., and M. Finkelstein, F. L. Mitchell, C. S. Russell, and O. G. Paine: Errors in the determination of urinary pregnanediol. J. Obstet, Gynaee. Brit. Emp. 62, 291–297 (1955)CrossRefGoogle Scholar
  321. [254]
    Cox, R. I., and M. Finkelstein A report on the chromatographic assay of urinary pregnanediol in pregnancy. J. Obstet. Gynaec. Brit. Emp. 63, 560–566 (1956)CrossRefGoogle Scholar
  322. [255]
    Creech, B. G.: Separation and determination of ketosteroids, pregnandiol and pregnan diol on one column. J. Gaschromatogr. 1, 194–195 (1964)Google Scholar
  323. [256]
    Crepy, O., O. Judas et M. F. Jayle: Métabolisme in vitro des stéroides conjugués. Transformation des sulfates de 5α-pregnane 3/?-yl, 20-one et de 5ß-pregnane 3α-yl, 20-one en présence de coupes de foie de lapin. C.R. Soc. Biol. (Paris) 160, 891–895 (1966)Google Scholar
  324. [256a]
    Crepy, O., O. Judas F. Rulleau-Meslin et M. F. Jayle: Mode de conjugaison des métabolites de la progestérone dans les urines de femmes enceintes. Bull. Soc. Chim. biol. (Paris) 44, 327–336 (1962)Google Scholar
  325. [257]
    Crepy, O., O. Judas, B. Lachèse, J. Fermanian et M. F. Jayle: Etude comparative de quatre méthodes de dosage du pregnandiol urinaire. Clin. chim. Acta 8, 277–282 (1963)PubMedCrossRefGoogle Scholar
  326. [258]
    Crepy, O., O. Judas F. Meslin et M. F. Jayle: Dosage du pregnandiol urinaire. Bull. Soc. Chim. biol. (Paris) 38, 505–534 (1956)Google Scholar
  327. [259]
    Crist, R. D., K. E. Krantz, and J. C. Warren: Placental transfer of synthetic progestins. Obstet, and Gynec. 25, 89–93 (1965)Google Scholar
  328. [259a]
    Cristol, P., et R. Bienfait: Séparation chromatographique en couche mince des stéroides provenant de la 17-hydroxy-progestérone et de la progestérone. Ann. Endoer. (Paris) 27, 199–204 (1966)Google Scholar
  329. [260]
    Cristol, P., et R. Bienfait, et M. F. Jayle: Méthode de dosage des stéroides présentant une chaine 21-des- oxycétol. Bull. Soc. Chim. biol. (Paris) 42, 655–663 (1960)Google Scholar
  330. [261]
    Crooke, A. C., W. R. Butt, R. Palmer, R. Morris, R. E. Edwards, C. W. Taylor, and E.V. Short: Effect of human pituitary-follicle-stimulating hormone and chorionic gonadotrophin in Stein-Leventhal syndrome. Brit. med. J. 1963 I, 1119 bis 1123Google Scholar
  331. [262]
    Czillag, M., and F. Fajtha: Clinical and pathological significance of the simultaneous determination of various steroids excreted in the urine. Orv. Hetil. 103, 2262–2267 (1962)Google Scholar
  332. [262]
    Curtius, H.-Ch.: Gaschromatographische Bestimmung von Pregnandiol, Pregnandiol und Pregnantriolon im Urin. Z. klin. Chem. 4, 114 (1966)Google Scholar
  333. [262b]
    Dässler, C.-G.: Korrelationen zwischen dem Geburtsgewicht des Kindes, dem Placentagewicht und der mütterlichen Oestriol- und Pregnandiolaussch.eid.ung bei Präeklampsie und bei chronischer Hypertonie. Arch. Gynäk. 204, 157 (1967)CrossRefGoogle Scholar
  334. [263]
    Daughaday, W., and I. Kozak: Binding of corticosteroids by plasma proteins. III. The binding of corticosteroid and related hormones by human plasma and plasma protein fractions as measured by equilibrium dialysis. J. clin. Invest. 37, 511–518 (1958)PubMedCrossRefGoogle Scholar
  335. [263a]
    Davenport, G. R., and L. E. Mallette: Some biochemical properties of rabbit ovarian hydroxysteroid dehydrogenases. Endocrinology 78, 672–678 (1966)PubMedCrossRefGoogle Scholar
  336. [263b]
    Davidson, E. T., F. de Venuto, and U. Westphal: The interaction of aldosterone and other steroids with liver and kidney-cell membranes and with subcellular fractions of the kidney. U.S. Army med. Res. Lab., Ft. Knox, Ky., Rept. No 569 (1963)Google Scholar
  337. [263 c]
    Davies, J., G. R. Davenport, J. L. Norris, and P. I. C. Rennte: Histochemical studies of hydroxysteroid dehydrogenase activity in mammalian reproductive tissues. Endocrinology 78, 667–671 (1966)PubMedCrossRefGoogle Scholar
  338. [264]
    Davis, M. E., and N. W. Fugo: A simplified method for the quantitative determina tions on free pregnanediol excretion in pregnancy. Proc. Soc. exp. Biol. (N.Y.) 66, 39–42 (1947)Google Scholar
  339. [265]
    Davis, M. E., and N. W. Fugo, E. J. Plötz, G. V. Le Roy, R. G. Gould, and H. Werbin: Hormones in human reproduction. I. Metabolism of progesterone. Amer. J. Obstet. Gynec. 72, 740–755 (1956)PubMedGoogle Scholar
  340. [266]
    Davis, M. E., and E. J. Plötz: Hormonal interrelationships between maternal adrenal, placental and fetal adrenal functions. Obstet, gynec. Surg. 11, 1–43 (1956)CrossRefGoogle Scholar
  341. [267]
    Davis, M. E., and E. J. Plötz: The excretion of neutral steroids in the urine of normal non-pregnant and pregnant women. Acta endocr. (Kbh.) 21, 245–258 (1956)Google Scholar
  342. [268]
    Davis, M. E., and E. J. Plötz: Progesterone, the pregnancy hormone. Fer til. and Steril. 8, 603–618 (1957)Google Scholar
  343. [269]
    Davis, M. E., and E. J. Plötz: Steroid hormones in human reproduction. Symposium on fetal salvage. Bull. M. Hague matern. Hosp. 10, 53–70 (1957)Google Scholar
  344. [270]
    Davis, M. E., and E. J. Plötz: The metabolism of progesterone and its clinical use in pregnancy. Recent Progr. Hormone Res. 13, 347–388 (1957)Google Scholar
  345. [271]
    Davis, M. E., and E. J. Plötz: Hormones in human reproduction. Part II. Further investigation ofsteroid metabolism in human pregnancy. Amer. J. Obstet. Gynec. 76, 939–954 (1958)PubMedGoogle Scholar
  346. [272]
    Davis, M. E., and E. J. Plötz, C. I. Lupu, and P. M. Ejarque: The metabolism of progesterone and its related compounds in human pregnancy. Fertil. and Steril 11, 18–48 (1960)Google Scholar
  347. [273]
    Davis, M. E., and E. J. Plötz, and G. L. Wied: 17α-Hydroxyprogesterone acetate, an effective progestational substance on oral administration. J. clin. Endocr. 17, 1237–1244 (1957)PubMedCrossRefGoogle Scholar
  348. [274]
    Dean, F. D., and I. Ch. Jones: Sex steroids in the lungfish (Protopterus anneetens owen). J. Endocr. 18, 366–371 (1959)PubMedCrossRefGoogle Scholar
  349. [274 a]
    Deane, H. W., M. F. Hay, R.M. Moor, L. E. A. Rowson, and R.Y. Short: The corpus luteum of the sheep: Relationships between morphology and function during the oestrous cycle. Acta Endocr. (Kbh.) 51, 245–263 (1966)Google Scholar
  350. [275]
    Deane, H. W., M. F. Hay, R.M. Moor, L. E. A. Rowson, and R.Y. Short, B. L. Lobel, E. C. Driks, and B. L. Rubin: Further observations on steroid-3/S-ol dehydrogenase activity in the reproductive system of the female rat. Ann. Histo- chim. 6, 283–291 (1961)Google Scholar
  351. [276]
    Deane, H. W., M. F. Hay, R.M. Moor, L. E. A. Rowson, and R.Y. Short, B. L. Lobel, E. C. Driks, and B. L. Rubin, and S. L. Romney: Enzymie histochemistry of normal human ovaries of the menstrual cycle, pregnancy, and the early puerperium. Amer. J. Obstet. Gynec. 83, 281–294 (1962)PubMedGoogle Scholar
  352. [277]
    Deane, H. W., M. F. Hay, R.M. Moor, L. E. A. Rowson, and R.Y. Short, B. L. Rubin, E. C. Driks, B. L. Lobel, and G. Leipsner: Trophoblastic giant cells in placentas of rats and mice and their probable role in steroid-hormone production. Endocrinology 70, 407–419 (1962)PubMedCrossRefGoogle Scholar
  353. [278]
    Deane, H. W., M. F. Hay, R.M. Moor, L. E. A. Rowson, and R.Y. Short, B. L. Rubin, E. C. Driks, B. L. Lobel, and G. Leipsner: Identification and control of cells that synthesize steroid hormones in the adrenal glands, gonads and placentae of various mammalian species. Arch. Anat. micr. Morph, exp. 54, 49–65 (1965)Google Scholar
  354. [279]
    Deane, H. W., M. F. Hay, R.M. Moor, L. E. A. Rowson, and R.Y. Short, B. L. Rubin, E. C. Driks, B. L. Lobel, and G. Leipsner, and A. M. Seligman: Evaluation of procedures for the cytological localization of ketosteroids. Vitam. u. Horm. 11, 173–204 (1953)CrossRefGoogle Scholar
  355. [280]
    Decourt, J., M. F. Jayle et J.-M. Doumic: Identification du pregnandiol dans les urines de deux sujèts atteints de gynécomastie. Ann. Endocr. (Paris) 9, 305–315 (1948)Google Scholar
  356. [281]
    Deghenghi, R., and C. Revesz: The oral activity of 17α-substituted pregnenolones and their sulphates. J. Endocr. 31, 301–302 (1965)PubMedCrossRefGoogle Scholar
  357. [282]
    Dempsey, E. W., and D. L. Bassett: Observations on the fluorescence, birefringence and histochemistry of the rat ovary during the reproductive cycle. Endocrinology 33, 384–401 (1943)CrossRefGoogle Scholar
  358. [283]
    Dempsey, M. E.: Pathways of enzymie synthesis and conversion to cholesterol of Δ 5 7> 24-cholestatrien-3ß-ol and other naturally occurring sterols. J. biol. Chem. 240, 4176–4188 (1965)PubMedGoogle Scholar
  359. [284]
    Denamur, R., J. Martinet et R. V. Short: Secretion de la progésterone par les corps jaunes de la brebis apres hypophysectomie, section de la tige pituitaire et hystér- ectomie. Acta endocr. (Kbh.) 52, 72–90 (1966)Google Scholar
  360. [285]
    Depaoli, J., and K. B. Eik-Nes Metabolism in vivo of (7oe-3H) pregnenolone by the dog ovary. Biochim. biophys. Acta (Amst.) 78, 457–465 (1963)CrossRefGoogle Scholar
  361. [286]
    Deshpande, G. N., and I. F. Sommerville: Plasma pregnanediol in human pregnancy. Lancet 1958 II, 1046–1047CrossRefGoogle Scholar
  362. [287]
    Deshpande, G. N., and I. F. Sommerville Plasma progesterone and pregnanediol in human pregnancy, during labour and post-partum. J. Obstet. Gynaee. Brit. Emp. 67, 954–961 (1960)CrossRefGoogle Scholar
  363. [287a]
    Detter, F., u. Y. Klingmttller: Untersuchung über die Pregnandiol- und Allo- pregnandiolausscheidung im Cyclus der Frau mit Hilfe der Dünnschichtchromatographie. Clin. chim. Acta 15, 481–487 (1967)PubMedCrossRefGoogle Scholar
  364. [288]
    Devis, R.: Sur l’origine de la prégnandiolurie dans la deuxième moitié de la grossesse. Ann. Endocr. (Paris) 10, 173–179 (1949)Google Scholar
  365. [288 a]
    Devis, R., et R. Noiret: Extraction quantitative et simultanée des conjugués des 17-céto- stéroides, du prégnane 3oc-20α-diol, du prégnane 3oc-17α-20α-triol, des phénol - stéroides naturels et des stéroides α-cétols. Ann. Biol. clin. 24, 1171–1177 (1966)Google Scholar
  366. [289]
    Diczfalusy, E.: Progesterone in human placental tissue. Acta endocr. (Kbh.) 10, 373–389 (1952)Google Scholar
  367. [290]
    Diczfalusy, E.: Experimental verification of the assumption underlying the colour correction equation of Allen. Acta endocr. (Kbh.) 216–229 (1955)Google Scholar
  368. [291]
    Diczfalusy, E.: Endocrinology of the foetus. Acta obstet. gynec. scand. 41, Suppl. 1, 45–79 (1962)CrossRefGoogle Scholar
  369. [292]
    Diczfalusy, E.: Endocrine functions of the human fetoplacental unit. Fed. Proc. 23, 791–798 (1964)PubMedGoogle Scholar
  370. [293]
    Diczfalusy, E.: The functions of biosynthesis of the placenta. (Biochemical, enzymologieal and endocrine aspects.) 4. Congr. Mundial de Ginecologia y Obstetricia Mar del Plata, Argentina, 1964, p. 73–84Google Scholar
  371. [294]
    Diczfalusy, E., u. U. Borell: Influence of oophorectomy on steroid excretion in early pregnancy. J. clin. Endocr. 21, 1119–1226 (1961)PubMedCrossRefGoogle Scholar
  372. [295]
    Diczfalusy, E.: P. Ekwall, L. Sjöblom, and A. Westman: Percutaneous absorption of progesterone in aqueous solutions of association colloide. Acta endocr. (Kbh.) 9, 387–394 (1952)Google Scholar
  373. [296]
    Diczfalusy, E., R. Pion, and J. Schwers: Steroid biogenesis and metabolism in the human foeto-placental unit at midpregnancy. Arch. Anat. (Strasbourg) 54, 67–83 (1965)Google Scholar
  374. [297]
    Diczfalusy, E., and K.-G. Tillinger: Metabolism of some progestationaly active 9/ß,10oc-steroids in man. Nature (Lond.) 200, 79–80 (1963)CrossRefGoogle Scholar
  375. [298]
    Diczfalusy, E. and P. Troen: Endocrine functions of the human placenta. Vitam. and Horm. 19, 229–311 (1961)CrossRefGoogle Scholar
  376. [299]
    Diczfalusy, E.: Dimick, D. P., M. Heron, E.-E. Baulieu, and M. F. Jayle: A comparative study of the metabolic fate of testosterone, 17 α-methyl-testosterone, 19-nor-testosterone, 17α-methyl-19-nor-testosterone and 17α-methyl-estr-5(10)-ene-17/?-ol-3-one in normal males. Clin. chim. Acta 6, 63–71 (1961)CrossRefGoogle Scholar
  377. [300]
    Dingemanse, E., L. C. Huisin’t Veld, and B. M. de Laat: Clinical method for the chromatographic-colorimetrie determination of urinary 17-ketosteroids. J. clin. Endocr. 6, 535–548 (1946)PubMedCrossRefGoogle Scholar
  378. [301]
    Dippelt, L.: Über die Pregnandiolausscheidung im mensuellen Cyclus. Arch. Gynäk. 178, 223–226 (1950)CrossRefGoogle Scholar
  379. [302]
    Dobriner, K.: The normal and pathological physiology of pregnancy, p. 75. Baltimore: Williams & Wilkins Co. 1948Google Scholar
  380. [303]
    Dobriner, K.: Studies in steroid metabolism. XIX. The α-ketosteroid excretion pattern in normal males. J. clin. Invest. 32, 940–949 (1953)PubMedCrossRefGoogle Scholar
  381. [304]
    Dobriner, K., S. Lieberman, and C. P. Rhoads. Studies in steroid metabolism. 1. Methods for the isolation and quantitative estimation of neutral steroids present in human urine. J. biol. Chem. 172, 241–261 (1948)PubMedGoogle Scholar
  382. [305]
    Dobriner, K., S. Lieberman: The metabolism of steroid hormones in humans. Symp. Steroid Hormones 1950, 46–88Google Scholar
  383. [306]
    Dobriner, K., S. Lieberman: The metabolism of steroid hormones in humans. Ciba Foundn. Coll. Endocr. 2, 381–417 (1952)Google Scholar
  384. [306a]
    Döllefeld, E., u. H. Breuer: Vorkommen, Biogenese und Stoffwechsel von Steroid- sulfaten. Z. Vitamin-, Hormon- u. Fermentforsch. 14, 193–298 (1966)Google Scholar
  385. [307]
    Dorfman, R. I.: Steroid hormone metabolism. In: G. Pincus and K. V. Thimann(eds.), The hormones, vol. 3, p. 589–664. Vol. 4: progesterone, p. 601–609. New York: Academic Press 1955Google Scholar
  386. [308]
    Dorfman, R. I.: Evaluation of androgens in humans. Acta endocr.(Kbh.), Suppl.50, 211–212. First Internat. Congr. Endocr. Copenhagen 1960Google Scholar
  387. [309]
    Dorfman, R. I, E. Forchielli, S. Ichil, and J. Kowal: Ovarian steroid biosynthesis. Proc. Second. Internat. Congr. Endocr. 1964, p. 1087–1095Google Scholar
  388. [310]
    Dorfman, R, E. Ross, and R. A. Shipley: Metabolism of the steroid hormones – the metabolism of progesterone and ethynyl testosterone. Endocrinology 42, 77–80 (1948)PubMedCrossRefGoogle Scholar
  389. [310a]
    Dorrington, J. H., and R. Kilpatrick: Stimulation of ovarian progestational steroid synthesis in vitro by cyclie-3’5’-adenosine monophosphate. J. Physiol. (Lond.) 182, 16 P–18 P (1966)Google Scholar
  390. [311]
    Drill, A.: Endocrine properties and long-term safety of oral contraceptives. Meta bolism 14, 295–310 (1965)CrossRefGoogle Scholar
  391. [312]
    Drosdowsky, M. A., A. Dessypris, N. L. McNiyen, R. I. Doreman, and C. Gual: A search for progesteron in human urine. Acta endocr. (Kbh.) 49, 553–557 (1965)Google Scholar
  392. [313]
    Drummond-Robinson, G., and S. A. Asdell: The relation between the corpus luteum and the mammary gland. J. Physiol. (Lond.) 61, 608 (1926)Google Scholar
  393. [314]
    Duboff, G. S., S. J. Behrman, H. Saraiya, and J. Catchick: Pattern of steroid genesis of androgens in the normal human ovary associated with rhythmic processes of the menstrual cycle. Fertil. and Steril. 15, 661–674 (1964)Google Scholar
  394. [315]
    Duboff, G. S, H. Saraiya, and S. J. Behrman: Factors affecting the estimation of pregnanediol in human urine. Clin. Chem. 7, 30–36 (1961)PubMedGoogle Scholar
  395. [316]
    Duboff, G. F., and W. W. Stevenson: Ultramiero method for the estimation of plasma cholesterol. Clin. Chem. 8, 105–112 (1962)PubMedGoogle Scholar
  396. [317]
    Dubreuil, G.: Corps progestatifs et gestatifs. Leurs variétés et leurs modes d’évolution chez les vertébrés vivipares. Ann. Endoer. (Paris) 23, 1–14 (1962)Google Scholar
  397. [318]
    Duncan, G. W., A. M. Bowerman, W. R. Hearn, and R. M. Melampy: In vitro syn thesis of progesterone by swine corpora lutea. Proc. Soc. exp. Biol. (N.Y.) 104, 17–19 (1960)Google Scholar
  398. [319]
    Duncan, G. W., A. M. Bowerman,L. L. Anderson, W. R. Hearn, and K. M. Melampy: Factors influencing in vitro synthesis of progesterone. Endocrinology 68, 199–207 (1961)PubMedCrossRefGoogle Scholar
  399. [320]
    Dutton, G. J.: Uridine diphosphate glucuronic acid as glucuronyl donor in the synthesis of “ester”, aliphatic and steroid glucuronides. Biochem. J. 64, 693–701 (1956)PubMedGoogle Scholar
  400. [321]
    Duyvené de Wit, J. J.: Ein neuer Test zum qualitativen und quantitativen Nachweis des Corpus luteum-Hormons. Klin. Wschr. 17, 660–663 (1938)CrossRefGoogle Scholar
  401. [322]
    Dvorakova, J.:Oseillopolarographic determination of the components of the mixtures equilenin and equilenin-progesterone. Spisy prirodovëdeeké fak. univ. Brno 24, 417–424 (1960)Google Scholar
  402. [323]
    Eales, N. B.: Reproduction of the african elephant. Nature (Lond.) 205, 1269 (1965)Google Scholar
  403. [323a]
    Eastmann, N. J., and L. M. Hellman: Williams obstetrics, ed. 12, p. 144. New York:Appleton-Century-Crofts Inc. 1961 Google Scholar
  404. [324]
    Eberhagen, D.: Über die Lipoide der menschlichen Placenta. Hoppe-Seylers Z. physiol. Chem. 333, 179–189 (1963)Google Scholar
  405. [325]
    Eberlein, W. R.: Progesterone and pregnanediol. Fertil. and Steril 10, 84–90 (1959)Google Scholar
  406. [325a]
    Eberlein, W. R.: Transesterification of urinary steroid sulfates. J. clin. Endoer. 22, 963–969 (1962)CrossRefGoogle Scholar
  407. [326]
    Eberlein, W. R.: Steroids secreted by the fetal adrenal cortex. J. clin. Invest. 43, 1255 (1964)Google Scholar
  408. [327]
    Eberlein, W. R.: A stain for Δ 5–3ß-hydroxysteroids and sterols. J. clin. Endoer. 25, 288–289 (1965)CrossRefGoogle Scholar
  409. [328]
    Eberlein, W. R.: Steroids and sterols in umbilical cord blood. J. clin. Endoer. 25, 1101–1118 (1965)CrossRefGoogle Scholar
  410. [329]
    Eberlein, W. R., and A. M. Bongiovanni: A paper chromatographic method for the measurement of pregnanediol in urine. J. clin. Endoer. 18, 300–309 (1958)CrossRefGoogle Scholar
  411. [330]
    Eddie, D. A. St.: Pregnanediol excretion in pregnant diabetic women. J. Obstet. Gynaec. Brit. Cwlth 70, 847–850 (1963)CrossRefGoogle Scholar
  412. [330a]
    Edgar, D. G.: Progesterone in body fluids. Nature (Lond.) 170, 543–544 (1952)CrossRefGoogle Scholar
  413. [331]
    Edgar, D. G.: The chemical assay of progesterone. Biochem. J. 54, 50–55 (1953)PubMedGoogle Scholar
  414. [332]
    Edgar, D. G.: The progesterone content of body fluids and tissues. J. Endocr. 10,54–64 (1953)PubMedCrossRefGoogle Scholar
  415. [333]
    Edgar, D. G., D. S. Flux, and J. W. Ronaldson: Comparison of chemical and biological estimations of plasma progestin. J. Endocr. 19, 44–51 (1959)PubMedCrossRefGoogle Scholar
  416. [334]
    Edgar, D. G., and J. W. Ronaldson: Blood levels of progesterone in the ewe. J. Endocr. 16, 378–384 (1958)PubMedCrossRefGoogle Scholar
  417. [335]
    Ehrhard, K, u. H. Fischer-Wasels: Untersuchungen über den Gehalt der mensch lichen Placenta an Corpus luteum-Hormon. Mschr. Geburtsh. Gynäk. 102, 80 (1936)Google Scholar
  418. [336]
    Ehrlich, E. N.: A method for measuring urinary pregnanediol by a double isotope derivative dilution technique utilizing thin layer chromatography. J. Lab. clin. Med. 65, 869–882 (1965)PubMedGoogle Scholar
  419. [337]
    Ehrlich, E. N., O. v. Dominguez, L. T. Samuels, D. Lynch, H. Oberhelman jr., and N. E. Warner: Aldosteronism and precocious puberty due to an ovarian androblastoma (Sertoli cell tumor). J. clin. Endocr. 23, 358–367 (1963)CrossRefGoogle Scholar
  420. [338]
    Eik-Nes, K. B.: Effects of gonadotrophins on secretion of steroids by the testis and ovary. Physiol. Rev. 44, 609–630 (1964)PubMedGoogle Scholar
  421. [338a]
    Eik-Nes, K. B., and P. F. Hall: Secretion of steroid hormones in vivo. Yitam. and Horm. 23, 153–208 (1965)Google Scholar
  422. [339]
    Eik-Nes, K., J. A. Schellman, R. Lumry, and L. T. Samuels: The binding of steroid to protein. I. Solubility determinations. J. biol. Chem. 206, 411–419 (1954)PubMedGoogle Scholar
  423. [340]
    Ejarque, P.M., and L. P. Bengtsson: Production rate of progesterone in human midpregnancy. Acta endocr. (Kbh.) 41, 521–530 (1962)Google Scholar
  424. [341]
    Ejarque, P.M., E. J. Plötz, and M. E. Davis: Failure of human placenta tissue homogenates to convert progesterone to estrogens. U.S. Atomic Energy Comm. ACRH-12, 71–75 (1959)Google Scholar
  425. [342]
    Elder, J. H.: Attempt to recover sodium pregnandiol glueuronidate from chimpanzee pregnancy urine. Proc. Soc. exp. Biol. (N.Y.) 46, 57–59 (1941)Google Scholar
  426. [343]
    Elmadhian, F., and E. Forchielli: Hormonal steroids of the chimpanzee; changes observed in simulated and actual space flight. Excerpta med. (Amst.), Intern. Congr. Ser. No. 51, p. 123. Mailand 1962Google Scholar
  427. [344]
    Emerson jr., K., J. Muller, A. deSouza, and G. Loutfi: Paradoxical response of metastatic breast cancer to 17-ethyl-19-nortestosterone. Ann. intern. Med. 55, 742–748 (1961)PubMedGoogle Scholar
  428. [345]
    Emsun, K., and K. Aras: A new ehemieal reaction for some steroids. Acta endocr. (Kbh.) 46, 507–510 (1964)Google Scholar
  429. [346]
    Endröczi, E., J. N. Hayward, J. Hilliard, and C. H. Sawyer: Progestational steroidogenesis in theprepuberal rabbit ovary. Fed. Proc. 23, 109 (1964)Google Scholar
  430. [347]
    Engel, L. L., G. W. Thorn, and R. A. Lewis: The urinary excretion of steroid com pounds. J. biol. Chem. 137, 205–215 (1941)Google Scholar
  431. [348]
    Engel, P.: A study on inactivation of ovarian hormones by the liver. Endocrinology 35, 70–72 (1944)CrossRefGoogle Scholar
  432. [349]
    Erb, H., M. Keller, G. A. Hauseru. R. Wenner: Oestrogen- und Pregnandiol - ausscheidungen bei Blasenmole. Gynaeeologia (Basel) 151, 317–322 (1961)Google Scholar
  433. [350]
    Erb, H., u. K. S. Ludwig: Strukturelle und funktionelle Veränderungen am menschlichen Ovar unter Einwirkung hormonaler Antikonzeptiva. Experientia (Basel) 21, 159– 162 (1965)CrossRefGoogle Scholar
  434. [351]
    Erb, R. E., and F. Stormshak: Progestins in corpora lutea, ovaries and adrenals after estrus and breeding of normal and abnormal cows. J. Dairy Sei. 44, 888–896 (1961)CrossRefGoogle Scholar
  435. [352]
    Ercoli, A., R. Vitali, and R. Gardi: Adsorbents for detection, isolation and evaluation of ethynyl steroids. Steroids 3, 479–485 (1964)CrossRefGoogle Scholar
  436. [353]
    Eto, T., H. Masuda, Y. Suzuki, and T. Hosi: Progesterone and pregn-4-ene-20α-ol-3-one in rat ovarian venous blood at different stages in reproductive cycle. Jap. J. Animal Reprod. 8, 34–40 (1962)CrossRefGoogle Scholar
  437. [354]
    Eton, B., and R. V. Short: Blood progesterone levels in abnormal pregnancies. J.Obstet. Gynaec. Brit. Emp. 67, 785–791 (1960)PubMedCrossRefGoogle Scholar
  438. [355]
    Everett, J. W.: Hormonal factors responsible for deposition of cholesterol in the corpus luteum of the rat. Endocrinology 41, 364–377 (1947)PubMedCrossRefGoogle Scholar
  439. [356]
    Ewald, W., H. Werbin, and I. L. Chaikoee: Partial separation of beef adrenal Δ 5–3-ketosteroid isomerases: androst-5-ene-3,17-dione isomerase and pregn-5-ene- 3,20-dione isomerase. Steroids 4, 759–776 (1964)CrossRefGoogle Scholar
  440. [357]
    Faredin, I., and I. Toth: Steroid studies on florisil adsorbent column. III. Chromatography of steroids on “Nymco” florisil column. Acta med. Acad. Sei. hung. 20, 185–192 (1964)Google Scholar
  441. [358]
    Faredin, I., and I. Toth: Steroid studies on florisil adsorbent column. IV. Pregnanetriol determination in human urine. Acta med. Acad. Sei. hung. 20, 193–207 (1964)Google Scholar
  442. [358a]
    Feder, H.H., R. W. Goy, and J. A. Resko: Progesterone-concentrations in the peripheral plasma of cyclic rats. J. Physiol. (Lond.) 191, 136P (1967)Google Scholar
  443. [359]
    Feher, T.: Application of thin-layer chromatography on purification, separation, and quantitative determination of steroid metabolites. Mikrochim. Acta (1965) No 1, 105–116CrossRefGoogle Scholar
  444. [360]
    Fels, E.: Das rein dargestellte Hormon des Corpus luteum und seine biologischen Wirkungen. Klin. Wschr. 10, 1639 (1931)CrossRefGoogle Scholar
  445. [361]
    Ferguson, M. M.: 3ß-Hydroxysteroid dehydrogenase activity in the mouse ovary.J. Endocr. 32, 365–371 (1965)PubMedCrossRefGoogle Scholar
  446. [362]
    Fernholz, E.: Zur Synthese des Corpus luteum-Hormons. Ber. dtsch. ehem. Ges. 67,1855 (1934)Google Scholar
  447. [363]
    Fevold, H. L., and F. L. Hisaw: Purification of corporin. Proc. Soc. exp. Biol. (N.Y.)29, 620–621 (1932)Google Scholar
  448. [364]
    Fevold, H. L., and F. L. Hisaw and S. L. Leonard: Homones of the corpus luteum. The seperation and purification of three active substances. J. Amer. chem. Soc. 54, 254–262 (1932)CrossRefGoogle Scholar
  449. [365]
    Fienberg, R., and R. B. Cohen: A comparative histochemical study of the ovarian stromal lipid band, stromal theca cell, and normal ovarian follicular apparatus. Amer. J. Obstet. Gynec. 92, 958–969 (1965)PubMedGoogle Scholar
  450. [366]
    Fillios, L. C., R. Kaplan, R.S. Martin, and F. J. Stare: Some aspects of the gonadal regulation of cholesterol metabolism. Amer. J. Physiol. 103, 47–51 (1958)Google Scholar
  451. [366a]
    Findlay, J. K., and R.F. Seamark: The histochemical localization of 20α-hydroxy- steroid-dehydrogenase activity in the human placenta and its significance to the foetal placental circulation of gestagens. Steroids 8, 581–588 (1966)PubMedCrossRefGoogle Scholar
  452. [367]
    Finkelstein, M.: Pregnanetriolone, an abnormal urinary steroid. In: R. I. Doreman(ed.), Methods in hormone research, vol. 1, p. 169–197. New York and London: Academic Press 1962Google Scholar
  453. [368]
    Finkelstein, M., and R. I. Cox: Method for simultaneous estimation of pregnane-3α,17α,20α-triol and pregnane-3α,17α,20α-triol-ll-one in urine. Proc. Soc. exp. Biol. (N.Y.) 95, 297–300 (1957)Google Scholar
  454. [369]
    Fischer, R. H.: Progesterone metabolism. III. Basal body temperature as an index of progesterone production and its relationship to urinary pregnanediol. Obstet, and Gynec. 3, 615–626 (1954)Google Scholar
  455. [370]
    Fischer, R. H., St. P. McColgan, and A. L. Chaney: Progesterone metabolism. I.Pregnanediol excretion in the menstrual cycle. Amer. J. Obstet. Gynec. 63, 613– 619 (1952)Google Scholar
  456. [371]
    Fischer, R. H., St. P. McColganProgesterone metabolism. II. Pregnanediol excretion following oral, sublingual and parenteral administration of progesterone. J. clin. Endocr. 13, 1043–1053 (1953)PubMedCrossRefGoogle Scholar
  457. [372]
    Fischer, R. H., and C. L. Riley: Pregnanediol excretion in a masculinizing syndrome. J. clin.Endocr. 12, 890–900 (1952)PubMedCrossRefGoogle Scholar
  458. [373]
    Fish, W. R., R. I. Doreman, and W. C. Young: Metabolism of the steroid hormones.III. The isolation of pregnandiol-3(α),20(α) from the urine of pregnant chimpanzees. J. biol. Chem. 143, 715–720 (1942).Google Scholar
  459. [373a]
    Floquet, A., et G. Crignon: Etude histologique du follicule post-ovulatoire chez la poule. C. R. Soc. Biol. (Paris) 158, 132–135 (1964)Google Scholar
  460. [374]
    Foote, W. D., R. G. Zimbelman, R. G. Loy, and L. E. Casida: Endocrine activity of corpora lutea from first-service and repeat-breeder dairy heifers. J. Dairy Sci. 42, 1944–1948 (1959)CrossRefGoogle Scholar
  461. [374a]
    Forbes, T. R.: Systemic plasma progesterone levels during the human menstrual cycle. Amer. J. Obstet. Gynec. 60, 180–186 (1950)PubMedGoogle Scholar
  462. [375]
    Forbes, T. R. Systemiclevels of plasma progesterone during pregnancy in women and monkeys.Endocrinology 49, 218–224 (1951)PubMedCrossRefGoogle Scholar
  463. [376]
    Forbes, T. R. Pre-ovulation progesterone in the peripheral blood of the rabbit. Endocrinology 53, 79–87 (1953)PubMedCrossRefGoogle Scholar
  464. [377]
    Forbes, T. R. Apparent secretion of progesterone by human and goat fetuses. Endocrinology 56,699–703 (1955)PubMedCrossRefGoogle Scholar
  465. [377a]
    Forbes, R. Th.: Progesterone, 16α-hydroxyprogesterone, and maintenance of pregnancy in mice. Proc. Soc. exp. Biol. (N.Y.) 125, 438–440 (1967)Google Scholar
  466. [378]
    Forbes, R. Th., A. J. Coulombre, and J. L. Coulombre: Inactivation of progesterone in vitro by cellular fractions of rat liver and kidney. Acta endocr. (Kbh.), Suppl. 51, 715–716 (1960)Google Scholar
  467. [379]
    Forbes, R. Th., A. J. Coulombre and J. L. Coulombre: Inactivation of progesterone by fetal mouse tissues in vitro. Proc. Soc. exp. Biol. (N.Y.) 109, 642–643 (1962)Google Scholar
  468. [380]
    Forbes, R. Th., C. W. Hooker: Plasma levels of progestin during pregnancy in the mouse. Endocrinology 61, 281–286 (1957)PubMedCrossRefGoogle Scholar
  469. [380 a]
    Forbes, R. Th., C. W. Hooker and C. A. Pfeiffer: Plasma progesterone levels and the menstrual cycle of the monkey. Proc. Soc. exp. Biol. (N.Y.) 73, 177–179 (1950)CrossRefGoogle Scholar
  470. [381]
    Forbes, R. Th., C. W. Hooker and C. A. Peeiffer: Decrease in plasma levels of endogenous progesterone during renal passage. Endocrinology 47, 83–88 (1950)PubMedCrossRefGoogle Scholar
  471. [382]
    Forbes, R. Th., S. G. Leibow, E. W. Ray, and L. I. Gardner: Progestin in the blood of newborn infants. J. clin. Endocr. 21, 862–865 (1961)PubMedCrossRefGoogle Scholar
  472. [383]
    Forbes, R. Th., and G. van Wagenen: Progestin in the amniotic fluid of monkeys. Endocrinology 65, 528–529 (1959)PubMedCrossRefGoogle Scholar
  473. [384]
    Forchielli, E., K. Brown-Grant, and R. I. Doreman: Steroid.dehydrogenases of rat liver. Proc. Soc. exp. Biol. (N.Y.) 99, 594–596 (1958)Google Scholar
  474. [385]
    Forleo, R., and W. P. Collins: Some aspects of steroid biosynthesis in human ovarian tissue. Acta endocr. (Kbh.) 46, 265–278 (1964)Google Scholar
  475. [386]
    Forleo, R., e F. Ingrassia: Studio della biosintesi steroidea nell’ovaia umana. Riv. Ostet.Ginec. 18, 597–614 (1963)PubMedGoogle Scholar
  476. [387]
    Foss, G. L.: Implantation of sex hormone tablets in man. J. Endocr. 3, 107–117 (1942)CrossRefGoogle Scholar
  477. [388]
    Fotherby, K.: The isolation of 3β-hydroxy-Δ 5-steroids from the urine of normal men. Biochem. J. 69, 596–600 (1958)PubMedGoogle Scholar
  478. [389]
    Fotherby, K. The isolation of pregn-5-ene-3β,16α,20α-triol from the urine of normal males. Bio-chem. J. 71, 209–210 (1959)Google Scholar
  479. [390]
    Fotherby, K. Excretion of pregnanetriol during the normal menstrual cycle. Brit. med. J. 1960 I,1545–1546CrossRefGoogle Scholar
  480. [391]
    Fotherby, K. The ovarian production of 17α-hydroxyprogesterone. J. Endocr. 22, 11–111 (1960/61)Google Scholar
  481. [392]
    Fotherby, K. The ovarian production of a pregnanetriol precursor. J. Endocr. 25, 19–28 (1962)PubMedCrossRefGoogle Scholar
  482. [393]
    Fotherby, K. The biochemistry of progesterone. Vitam. and Horm. 22, 153–204 (1964)CrossRefGoogle Scholar
  483. [394]
    Fotherby, K., and J. B. Brown: Pregnanetriol, pregnanediol and oestrogen excretion during anovulatory menstrual cycles and in a premenopausal adrenaleetomized woman. J. Endocr. 29, 55–60 (1964)PubMedCrossRefGoogle Scholar
  484. [395]
    Fotherby, K., F. James, and S. Kamyab: The excretion of 6-oxygenated metabolites of progesterone and of pregnane-3α,17α,20α-triol troughout pregnancy. J. Endocr. 31, XXV (1965)Google Scholar
  485. [396]
    Fotherby, K., F. James, and S. Kamyab Excretion of 6-oxygenated metabolites of progesterone and 5β-pregnane-3α,17α,20α-triol during pregnancy. J. Endocr. 33, 133–143 (1965)PubMedCrossRefGoogle Scholar
  486. [396a]
    Fotherby, K., S. Kamyab, Ph. Littleton, and K. J. Dennis: Metabolism of 17α-ethynyl- 19-nortestosterones in humans. Acta endocr. (Kbh.) Suppl. 119, 136 (1967)Google Scholar
  487. [397]
    Fotherby, K., S. Kamyab, Ph. Littleton, and A. Klopfer: Metabolism of synthetic progestational compounds. J.Endocr. 33. XIII–XIV (1965)CrossRefGoogle Scholar
  488. [397a]
    Fotherby, K., S. Kamyab, Ph. Littleton, and A. Klopfer: Metabolism of 17α-ethynyl steroids. Biochem. J. 99, 14 P (1966)Google Scholar
  489. [398]
    Fotherby, K. and D. N. Loye: A modified method for the estimation of pregnanetriol in urine.J. Endocr. 20, 157–162 (1960)PubMedCrossRefGoogle Scholar
  490. [399]
    Fotherby, K. and D. N. Loye: An investigation of the possible precursors of urinary pregnanetriol. J. Endocr.21, 129–135 (1960/61)CrossRefGoogle Scholar
  491. [400]
    Fotherby, K., and J. A. Strong: The hourly excretion of steroids after a short intravenous infusion of ACTH. J. Endocr. 19, 389–397 (1960)CrossRefGoogle Scholar
  492. [401]
    Fraenkel, L., u. F. Cohn: Experimentelle Untersuchungen über den Einfluß des Corpus luteum auf die Insertion des Eies. Anat. Anz. 20, 294 (1902)Google Scholar
  493. [402]
    Franchimont, P.: Variations physiologiques oestrales de la vitamine C et du cholestérol ovariens. Rev. franc. Étud. clin. biol. 7, 289–291 (1962)PubMedGoogle Scholar
  494. [403]
    Franchimont, P.: Modification sous l’action des gonadotrophines des taux de l’acide ascorbique et du cholestérol dans l’ovaire de rattes immatures. Path, et Biol. 10, 1327–1330 (1962)Google Scholar
  495. [404]
    Franchimont, P.: Études de la déplétion de la vitamine C et du cholestérol ovariens. Ann. Endocr. (Paris) 25, 195–198 (1964)Google Scholar
  496. [405]
    Franchimont, P., et H. van Cauwenbebge: Variations de l’acide ascorbique et du cholestérol ovariens sous l’influence des gonadotrophines endo- et exogènes. Ann. Endocr. (Paris) 23, 267–274 (1962)Google Scholar
  497. [406]
    Fbancis, F. E., and R. A. Kinsella jr.: Enteric excretion of metabolites of steroid hormones in the human subject. IV. Isolation of 5ß-pregnane-3α,20 α-diol from meconium. J. clin. Endocr. 26, 128–132 (1966)CrossRefGoogle Scholar
  498. [406a]
    Fbancis, F. E., and R. A. Kinsella jr.: Enteric excretion of metabolites of steroid hormones in the human subject. V. Isolation of 5α-pregnane-3α, 20α-diol from meconium. J. clin. Endocr. 27, 211–213 (1967)CrossRefGoogle Scholar
  499. [407]
    Fbancis, F. E.,N.- H. Ch. Shen, and R. A. Kinsella jr.: Enteric excretion of metabolites of steroid hormones in the human. III. Isolation of 3α-hydroxy-5ß-pregn-16-en-20-one (16-pregnenolone) from meconium. Biochemistry 1, 1184–1186 (1962)CrossRefGoogle Scholar
  500. [408]
    Fbandsen, V. A., and G. Stakemann: The site of production of oestrogenie hormones in human pregnancy. Acta endocr. (Kbh.) 38, 383–391 (1961)Google Scholar
  501. [409]
    Fbandsen, V. A., and G. Stakemann: The site of production of oestrogenie hormones in human pregnancy. III. Acta endocr. (Kbh.) 47, 265–276 (1964)Google Scholar
  502. [410]
    Fbanza, C., e U. Montemagno: Modifiche nel contenuto lipidico dell’ovaio e biosintesi degli estrogeni. Arch. Ostet. Ginec. 66, 738–749 (1960)Google Scholar
  503. [411]
    Fraps, R. M.: Progesterone in blood plasma of the ovulating hen. Science 108, 86–87 (1948)PubMedCrossRefGoogle Scholar
  504. [411a]
    French, A. P., and J. C. Warren: Steroid-3β-sulfatase in fetal and placental tissues. Steroids 6, 865–869 (1965)PubMedCrossRefGoogle Scholar
  505. [411b]
    French, A. P., and J. C. Warren: Sulfatase activity in the human placenta. Steroids 8, 79–85 (1966)PubMedCrossRefGoogle Scholar
  506. [412]
    Fuchs, F.: Endocrine factors in the maintenance of pregnancy. Acta obstet, gynec. scand. 41, Suppl. 1, 1–44 (1962)Google Scholar
  507. [413]
    Fuchs, F., A.-R. Fuchs, and R. V. Short: Progesterone in the uterine venous blood of women during the first half of gestation. J. Endocr. 27, 333–336 (1963)PubMedCrossRefGoogle Scholar
  508. [414]
    Fuchs, F., A.-R. Fuchs, and R. V. Short, and G. Wagner: Uterine motility and concentrations of progesterone in uterine venous blood after intrα-amniotic injection of hypertonic saline. Acta obstet, gynec. scand. 44, 63–70 (1965)CrossRefGoogle Scholar
  509. [415]
    Fuenzalida, F.: Absorption of steroids from subcutaneously implanted tablets of the pure hormone and of the hormone mixed with cholesterol. J. clin. Endocr. 10, 1511–1516 (1950)PubMedCrossRefGoogle Scholar
  510. [416]
    Fuenzalida, F. and A. Lipschütz: Absorption of corticoids and related steroids from subcutaneously implanted pellets in the guinea pig. J. clin. Endocr. 13, 1201–1205 (1953)PubMedCrossRefGoogle Scholar
  511. [417]
    Fuhrmann, K.: Histoehemical proof of 3-ol steroid dehydrogenase activity in endo crine organ tissue. Zbl. Gynäk. 83, 565–572 (1961)Google Scholar
  512. [418]
    Fujii, K., T. Hirano, S. Miyamoto, K. Anan, and Y. Sakagishi: The Zaffaroni method in the paper chromatography of progesterone. Seikagaku 28, 643–649 (1957)Google Scholar
  513. [419]
    Fujii, K., T. Hirano, S. Miyamoto, K. Anan, and Y. Sakagishi: The paper chromatographic properties of mono-keto steroid hormones according to the method of Zaffaroni. Saikagaku 29, 99–103 (1957)Google Scholar
  514. [420]
    Fujil, K., T. Hirano, S. Miyamoto, K. Anan, and Y. Sakagishi: The specility of Zaffaroni’s paper-chromatographic method for the mono-keto steroid hormones. Bull. Tokyo med. deut. Univ. 5, 499–502 (1958)Google Scholar
  515. [421]
    Fukushima, D. K., H. L. Bradlow, L. Hellman, B. Zumoee, and T. F. Gallagher: Study of 17-hydroxyprogesterone-4-C14in man. J. clin. Endocr. 21, 765–778 (1961)PubMedCrossRefGoogle Scholar
  516. [422]
    Fukushima, D. K., H. L. Bradlow, L. Hellman and T. F. Gallagher: Further studies on the origin of pregnanetriol in adrenal carcinoma. J. clin. Endocr. 23, 266–273 (1963)PubMedCrossRefGoogle Scholar
  517. [423]
    Fukushima, D. K., and T. F. Gallagher: Steroid isolation studies in congenital adrenal hyperplasia. J. biol. Chem. 229, 85–92 (1957)PubMedGoogle Scholar
  518. [424]
    Fukushima, D. K., and T. F. Gallagher: Absence of 21-dehydroxylation in congenital adrenal hyperplasia. J. clin.Endocr. 18, 694–698 (1958)PubMedCrossRefGoogle Scholar
  519. [425]
    Fukushima, D. K., A. D. Kemp, R. Schneider, M. B. Stokes, and T. F. Gallagher: Studies in steroid metabolism. XXV. Isolation and characterization of new urinary steroids. J. biol. Chem. 210, 129–137 (1954)PubMedGoogle Scholar
  520. [425a]
    Fukushima, D. K., M. Smulowitz, and K.I.H. Williams: Δ 5-Pregnene-3α, 16α,20α-triol and related steroids in adrenocortical carcinoma. J. biol. Chem. 236, 3147–3150 (1961)Google Scholar
  521. [426]
    Fukushima, M.: Somatotropic hormone secretion in gynecology and obstetrics. Tohoku J. exp. Med. 74, 161–174 (1961)PubMedCrossRefGoogle Scholar
  522. [427]
    Furuhjelm, M.: Pregnandiol excretion in women. Acta endocr. (Kbh.) 14,353–360 (1953)Google Scholar
  523. [428]
    Furuhjelm, M.: The excretion of oestriol and pregnandiol in toxemia of pregnancy and in post maturity. Acta obstet, gynec. scand. 41, 370–381 (1962)CrossRefGoogle Scholar
  524. [429]
    Futterweit, W., N. L. McNiven, and R. I. Doreman: Gas-chromatographic identifica tion of progesterone in human pregnancy plasma. Biochim. biophys. Acta (Amst.) 71, 474–476 (1963)CrossRefGoogle Scholar
  525. [430]
    Gabrilove, J. L.: A biologic concept of adrenocortical function. Acta endocr. (Kbh.) 36, 281–286 (1961)Google Scholar
  526. [431]
    Gagnazzo, G., F. Misurale, A. R. Rose G. Montessori: Analisi chromatografiea degli steroidi pregnane-derivati negli estratti di placenta umana. Excerpta med. (Amst.), Internat. Congr. Ser. No. 51, p. 267. Mailand 1962Google Scholar
  527. [431a]
    Galil, A. K. A.: Utero-ovarian interrelations during gestation – endocrine role of the placenta. Ph. D. thesis, London, University 1965Google Scholar
  528. [431b]
    Galil, A. K. A. and H. Wendler Deane: A 5–3β-Hydroxysteroid dehydrogenase activity in the steroid-hormone producing organs of the ferret (Mustela putorius furo). J. Reprod. Fertil. 11, 333–338 (1966)PubMedCrossRefGoogle Scholar
  529. [432]
    Gallagher, T. F., H. L. Bradlow, D. K. Fukushima, C. T. Beer, T. H. Kritchevsky, M. Stokem, M. L. Eidinoee, L. Hellman, and K. Dobriner: Studies of the metabolites of isotopie steroid hormones in man. Recent Progr. Hormone Res. 9, 411– 434 (1954)Google Scholar
  530. [433]
    Gallagher, T. F., D. K. Fukushima, S. Noguchi, J. Fishman, H. L. Bradlow, J. Cassouto, B. Zumoff, and L. Hellman: Recent studies in steroid hormone metabolism in man. Recent Progr. Hormone Res. 22, 283 (1966)Google Scholar
  531. [434]
    Gallagher, T. F., H. Spencer, H. L. Bradlow, L. Allen, and L. Hellman: Steroid production and metabolism in metastatic arrhenoblastoma. J. clin. Endocr. 22, 970–977 (1962)PubMedCrossRefGoogle Scholar
  532. [434a]
    Ganis, F. M., G. L. Wildasin, and T. B. Connor: In vitro production of dehydro- epiandrosterone in virilising Krukenberg tumor of the ovary. Fed. Proc. 24, 535 (1965)Google Scholar
  533. [434b]
    Gardiner, W. L., C. J. W. Brooks, and E. C. Horning: Urinary steroid pattern of the human newborn infant. Biochim. biophys. Acta (Amst.) 130, 278–280 (1966)CrossRefGoogle Scholar
  534. [434c]
    Gardiner, W. L., and E. C. Horning: Gas-liqued chromatographic separation of C19 and C21 human urinary steroids by a new precedure. Biochim. biophys. Acta (Amst.) 115, 524– 526 (1966)CrossRefGoogle Scholar
  535. [435]
    Gardner, L. I., and A. A. Tice: Cortisol and three less polar substances in adrenal tissue from the human newborn. Helv. paediat. Acta 12, 147–154 (1957)PubMedGoogle Scholar
  536. [436]
    Gassner, F. X., R. P. Martin, and J. W. Algeo: Metabolism of radioactive steroid esters in the bovine male and female. Fertil. and Steril. 11, 49–73 (1960)Google Scholar
  537. [437]
    Gaudry, R., et W. L. Glen: Sur la fraction steroide de l’urine de jument gravide. Ind. Chim. belge, Suppl. 2, 435–439 (1958)Google Scholar
  538. [438]
    Gawienowski, A. M.: The determination of progesterone in ovarian and adrenai tissues by a chemical and chromatographic procedure. Unveröffentlicht. Ph. D. Thesis Univ. of Mo. Library Columbia 1956. Zit. in: R. M. Melampy, W. R. Hearn and J. M. Rakes. J. Animal Sci. 18, 307–313 (1959)Google Scholar
  539. [439]
    Gawienowski, A. M., S.L. Lee, and G. B. Marion: The in vitro metabolism of progesterone-C14to zl1,4-androstadiene-3,17-dione by a cystic bovine ovary. Endocrinology 69, 388– 391 (1961)CrossRefGoogle Scholar
  540. [440]
    Gawienowski, A. M., and D.T. Mayer: Chemical assay of progesterone in ovarian and adrenal tissues. Amer. chem. Soc. Abstr. Papers, 132nd Meet., 6 C–7 C (1957)Google Scholar
  541. [441]
    Gemzell, C. A., E. Diszfalusy, and G. Tillinger: Clinical effect of human pituitary follicle-stimulating hormone (FSH). J. clin. Endocr. 18, 1333–1348 (1958)PubMedCrossRefGoogle Scholar
  542. [442]
    Gemzell, C. A, J. Robbe, and G. Ström: Cortical and medullary adrenal activity in normal labour. Acta endocr. (Kbh.) 23, 158–174 (1956)Google Scholar
  543. [443]
    Genest, J., E. Koiw, W. Nowaczynski, and T. Sandor: Study of a large steroid spectrum in normal subjects and hypertensive patients. Acta endocr. (Kbh.) 55, 413–425 (1960)Google Scholar
  544. [443a]
    Gerhards, E., G. Raspe u. R. Wiechert: Über methyl-substituierte Steroide. VI. Arzneimittel-Forsch. 17, 431–438 (1967)Google Scholar
  545. [444]
    German, E., H. Horowitz, R. van de Wiele, and R. M. Torack: Leydig-cell tumor of the ovary: case report and review. J. clin. Endocr. 21, 91–97 (1961)CrossRefGoogle Scholar
  546. [445]
    Ghilain, A.: In: J. Snoeck et al. (eds.), Le placenta humain, p. 530–560. Paris: Mason & Cie. 1958Google Scholar
  547. [445a]
    Giannopoulos, G., and S. Solomon: Isolation of 15α-hydroxyprogesterone from human pregnancy urine. Fed. Proc. 20, No 485, 342 (1967)Google Scholar
  548. [445b]
    Giannopoulos, G., and S. Solomon Isolation of 15α-hydroxyprogesterone from human pregnancy urine. Biochemistry 6, 1226–1230 (1967)PubMedCrossRefGoogle Scholar
  549. [446]
    Giardinelli, M.: Studio sulla eliminazione del pregnandiolo negli ultimi periodi della gravidanza in rapporto alia durata di questa ed ai caratteri del parto. Ginecologia (Torino) 15, 319–329 (1949)Google Scholar
  550. [446a]
    Giese, A. C.: Lipids in the economy of marine invertebrates, Physiol. Rev. 46, 244– 298 (1966)Google Scholar
  551. [447]
    Giorgi, E. P.: The determination of steroids in cyst fluid from human, polycystic ovaries. J. Endocr. 27, 225–240 (1965)CrossRefGoogle Scholar
  552. [448]
    Giorgi, E. P.:Steroids in cyst fluid from ovaries of normally menstruating women and of women with functional uterine bleeding. J. Reprod. Fertil. 10, 309–319 (1965)PubMedCrossRefGoogle Scholar
  553. [449]
    Girardi, S., D. Jadrijeviö, R. Iglesias, and A. Lipschütz: Behaviour of 19-nor-progesterone and 19-nor-ethinyltestosterone in the liver of the guinea pig. Nature (Lond.) 182, 1450–1451 (1958)CrossRefGoogle Scholar
  554. [450]
    Girardin, R.: Recherches bioehimiques sur la teneur en lipides du follicule et du corps jaune au cours de leur evolution. Gynéc. et Obstét. 22, 110–136 (1930)Google Scholar
  555. [451]
    Glasgow, B. R., and D. T. Mayer: The isolation of two or more metabolites from the urine of the pregnant sow and their relation to factors influencing litter size in swine. J. Animal. Sei. 11, 793 (1952)Google Scholar
  556. [452]
    Glasser, J. W. H.: Early removal of the corpus luteum of pregnancy. Bull. M. Hague matern. Hosp. 5, 112–116 (1952)Google Scholar
  557. [453]
    Glenn, M., S. L. Richardson, and B. J. Bowman: Biologic activity of 6-alphα-methyl compounds corresponding to progesterone, 17-alphα-hydroxy-progesterone acetate and compound S. Metabolism 8, 265–285 (1959)PubMedGoogle Scholar
  558. [454]
    Goddard, W. B.: Hormone determinations in three cases of hydatidiform mole associated with a well-developed fetus. Amer. J. Obstet. Gynec. 79, 956–964 (1960)PubMedGoogle Scholar
  559. [454a]
    Goding, J. R., F. A. Harrison, R. B. Heap, and J. L. Linzell: Ovarian activity in the ewe after autotransplantation of the ovary or uterus to the neck. J. Physiol. (Lond.) 191, 129P (1967)Google Scholar
  560. [455]
    Gold, J. J.: Diskussionsbemerkung in [811], S. 387Google Scholar
  561. [456]
    Gold, J. J., and R. Frank: The broderline andrenogenital syndrome: an intermediate entity. Amer. J. Obstet. Gynec. 75, 1034–1042 (1958)PubMedGoogle Scholar
  562. [457]
    Goldberg, B., G. E. S. Jones, and H. I. Brokowe: A histochemical study of sub strate specificity for the steroid 3β-ol dehydrogenase and isomerase systems in human ovary and testis. J. Histochem. Cytochem. 12, 880–889 (1964)PubMedCrossRefGoogle Scholar
  563. [458]
    Goldberg, B., D. A. Turner, and G. E. S. Jones: Steroid Zß-ol dehydrogenase activity in human endocrine tissues. Amer. J. Obstet. Gynec. 86, 349–359 (1963)PubMedGoogle Scholar
  564. [458a]
    Goldman, A. S., W. C. Yakovac, and A. M. Bongiovanni: Persistent effects of a synthetic androstene derivative on activities of 3β-hydroxysteroid dehydrogenase and glucose-6-phosphate dehydrogenase in rats. Endocrinology 77,1105–1118 (1965)PubMedCrossRefGoogle Scholar
  565. [458b]
    Goldman, A. S., W. C. Yakovac, and A. M. Bongiovanni: Development of activity of 3 ß-hydroxysteroid dehydrogenase in human fetal tissues and in two anencephalic newborns. J. clin. Endocr. 26, 14–22 (1966)PubMedCrossRefGoogle Scholar
  566. [459]
    Goldzieher, J. W.: A new colorimetric method for the determination of pregnandiol. J. Lab. clin. Med. 33, 251–253 (1948)PubMedGoogle Scholar
  567. [460]
    Goldzieher, J. W.: Estrogens and progestins. Progr. Gynec. 4, 201–227 (1963)Google Scholar
  568. [461]
    Goldzieher, J. W., and L. R. Axelrod: Adrenal and ovarian steroidogenesis in the sclerocystic ovary syndrome. Acta endocr. (Kbh.), Suppl. 51, S. 617. First Internat. Congr. Endocr. Kopenhagen 1960Google Scholar
  569. [462]
    Goldzieher, J. W., and L. R. Axelrod: The polycystic ovary. II. Urinary steroid excretion. J. clin. Endocr. 22, 425–430 (1962)PubMedCrossRefGoogle Scholar
  570. [463]
    Goldzieher, J. W., and R. E. Baker: The percutaneous absorption of estradiol-17β and progesterone. J. invest. Derm. 35, 215–218 (1960)PubMedGoogle Scholar
  571. [464]
    Goldzieher, J. W. andB. B. Benigno: The treatment of threatened and recurrent abortion: a critical review. Amer. J. Obstet. Gynec. 75, 1202–1214 (1958)PubMedGoogle Scholar
  572. [464 a]
    Goldzieher, J. W.,Ch. Matthijssen, C. Gual, B. A. Vella, and A. de la Pena: A simplified gas chromatographic method for large numbers of urinary pregnandiol determination. Amer. J. Obstet. Gynec. 98, 759–767 (1967)PubMedGoogle Scholar
  573. [465]
    Goldzieher, J. W., and Y. Nakamtjra: A clinical method for the determination of urinary pregnane-diol and pregnanetriol. Acta endocr. (Kbh.) 41, 371–380 (1962)Google Scholar
  574. [466]
    Gomes, W. R.: Assay of progestins in peripheral and ovarian venous blood from cows.Thesis Washington State University 1962. Zit. in: W. R. Gomes and R. E. Erb, J. Dairy Sci. 48, 314–330 (1965)Google Scholar
  575. [467]
    Goldzieher, J. W. and R. E. Erb: Progesterone in bovine reproduction: a review. J. Dairy Sci. 48, 314–330 (1965)CrossRefGoogle Scholar
  576. [468]
    Goldzieher, J. W., V. L. Estergreen jr., O. L. Frost, and R. E. Erb: Progestin levels in jugular and ovarian venous blood corpora lutea, and ovaries of the nonpregnant bovine. J. Dairy Sci. 46, 553–558 (1963)CrossRefGoogle Scholar
  577. [469]
    Goldzieher, J. W., O. L. Frost, and V. L. Estergreen jr.: Progestins in ovarian and peripheral blood of cows during late pregnancy. J. DairySci. 45, 670 (1962).Zit. in: W. R. Gomes and R. E. Erb. J. Dairy Sci. 48, 314–330 (1965)Google Scholar
  578. [470]
    Goldzieher, J. W., R. C. Herschler, and R. E. Erb: Progesterone levels in ovarian venous effluent of the nonpregnant sow. J. Animal Sci. 24, 722–725 (1965)Google Scholar
  579. [470 a]
    Goldzieher, J. W., D. W. Schomberg, H. Jones, and R. E. Erb: Comparison of ovarian venous plasma progesterone and urinary pregnanolone and pregnanediol levels in the cycling sow. J. Anim. Sci. 24, 919 (1965)Google Scholar
  580. [471]
    Gorski, J., O. V. Dominguez, L.T. Samuels, and R. E. Erb: Progestins of the bovine ovary abstract. Endocrinology 62, 234–235 (1958)PubMedCrossRefGoogle Scholar
  581. [472]
    Gorski, J., R. E. Erb, W. M. Dickson, and H. C. Butler: Sources of progestins in the pregnant cow. J. Dairy Sci. 41, 1380–1386 (1958)CrossRefGoogle Scholar
  582. [472a]
    Gorski, J., R. E. Erb, W. M. Dickson, and H. C. Butler: Sources of progestins in the pregnant cow. Proc. Western Div. Amer. Dairy Sci. Ass. 39, 1 (1958)Google Scholar
  583. [472b]
    Gorski, J., and D. Padnos: Translational control of protein synthesis and the control of steroidogenesis in the rabbit ovary. Arch. Biochem. 113, 100–106 (1966)PubMedCrossRefGoogle Scholar
  584. [472c]
    Gorski, J., and D. Padnos and N. J. Nelson: In vitro effects of luteinizing hormone on rabbit ovaries.Life Sci. 4, 713–720 (1965)PubMedCrossRefGoogle Scholar
  585. [473]
    Gospodarowicz, D.: The action of folMcle stimulating hormone and of human chorionic gonadotropin upon steroid synthesis by rabbit ovarian tissues in vitro. Acta endocr. (Kbh.) 47, 293–305 (1964)Google Scholar
  586. [474]
    Gospodarowicz, D.: The in vitro production of androgens by follicular tissue of rabbits. Acta endocr.(Kbh.) 47, 306–313 (1964)Google Scholar
  587. [475]
    Gospodarowicz, D.: The effect of human chorionic gonadotropin and of follicle - stimulating hormone on the incorporation of (1-14C) acetate into steroids by the rabbit corpus luteum in vitro.Biochim. biophys. Acta (Amst.) 107, 363–373 (1965)CrossRefGoogle Scholar
  588. [476]
    Gospodarowicz, D., et J. Legault-Démare: Etude de l’activité biologique in vitro des hormones gonadotropes. Acta endocr. (Kbh.) 42, 498–508 (1961)Google Scholar
  589. [477]
    Gospodarowicz, D., et J. Legault-Démare: Étude de l’actitivité biologique in vitro des hormones gonadotropes. Acta endocr.(Kbh.) 42, 509–513 (1963)Google Scholar
  590. [478]
    Gosselin, L.: The action of the gonadotrophs hormone on the ovarian cholesterol content of the mature rat. Arch. int. Physiol, et Biochem. 65, 485–496 (1957)Google Scholar
  591. [478a]
    Gottfried, H., and O. Lusis: Steroids of invertebrates: the in vitro production of 11-ketotestosterone and other steroids by the eggs of the slug, Arion ater rufus (L.). Nature (Lond.) 212, 1488–1489 (1966)CrossRefGoogle Scholar
  592. [479]
    Grady, H. J., W.H. Elliott, E. A. Doisy jr., B. C. Bocklage, and E. A. Doisy: Synthesis and metabolic studies of progesterone-21-C14. J. biol. Chem. 195, 755–762 (1952)PubMedGoogle Scholar
  593. [479a]
    Graham, J. M., and C. Green: The role of membrane sterols in hormone binding. Biochem. J. 104, 24P (1967)Google Scholar
  594. [479b]
    Graves, J. M. H., and W. K. Smith: Transformation of pregnenolone and progesterone by cultured plant cells. Nature (Lond.) 214, 1248–1249 (1967)CrossRefGoogle Scholar
  595. [480]
    Gray, Ch. H.: Some endocrine studies in diabetic pregnancy. Ciba Found. Coll.Endocr. 6, 318–329 (1953)Google Scholar
  596. [481]
    Green, J. A., and M. Maqueo: Ultrastructure of the human ovary. 1. The luteal cell during the menstrual cycle. Amer. J. Obstet. Gynec. 92, 946–957 (1965)PubMedGoogle Scholar
  597. [482]
    Greenblatt, R. B.: Sublingual absorption of progesterone and anhydrohydroxyproge-sterone. I. Endometrial studies. J. elm. Endoer. 4, 156 (1944)Google Scholar
  598. [483]
    Greenblatt, R. B.: The physiologic effectiveness of progesterone vaginal suppositories. J. elin. Endoer.14, 1564–1567 (1954)CrossRefGoogle Scholar
  599. [483a]
    The progestational activity of 17α-ethinyl-19-nortestosterone. J. clin. Endocr. 16,869–875 (1956)Google Scholar
  600. [484]
    Greenblatt, R. B., W. E. Bariteld, S. Clark, and N. Brown: Physiologic effectiveness of oral pro gesterone. J. elin. Endoer. 10, 886 (1950)CrossRefGoogle Scholar
  601. [485]
    Greenblatt, R. B., E. C. Jttngck, J. T. Bigger jr., and M. V. Greer: Progestational activity of a new acetoxyprogesterone derivative (6α-methyl-6-dehydro-17 α-acetoxyprogesterone). Fertil. and Steril. 14, 393–401 (1963)Google Scholar
  602. [486]
    Greene jr., J. W., J. L. Duhring, and K. Smith: Placental function tests. Amer. J.Obstet. Gynec. 92, 1030–1058 (1965)PubMedGoogle Scholar
  603. [487]
    Greene, R. R., and S. C. Harris: The percutaneous potency of progesterone. J. Lab.elin. Med. 27, 746–748 (1942)Google Scholar
  604. [488]
    Greig, M., M. G. Coyle, W. Cooper, and J. Walker: Plasma progesterone in mother and foetus in the second half of human pregnancy. J. Obstet. Gynaee. Brit. Cwlth 69, 772–776 (1962)CrossRefGoogle Scholar
  605. [488a]
    Griffiths, K., J.K. Grant, M. C. K. Browning, D. Cunningham, and G. Barr: Steroid biosynthesis in vitro by tissue from a granulosa cell multilocular eyst- adenoma. J. Endoer. 35, 299–309 (1966)CrossRefGoogle Scholar
  606. [488b]
    Griffiths, K., J.K. Grant and T. Symington: Steroid biosynthesis “in vitro“by granulosatheca cell tumour tissue. J. Endocr. 30, 247–254 (1964)CrossRefGoogle Scholar
  607. [489]
    Groot, C. A. de: Spontaneous changes during the day in the ovarian ascorbic acid and progesterone contents in immature pseudopregnant rats. Acta physiol. pharmacol. neerl. 13, 362 (1965)Google Scholar
  608. [489a]
    Groot, C. A., H. G. Kwa, and G. P. van Rees: Progesterone and prolactin blood levels during pseudopregnaney. Acta endoer. (Kbh.) Suppl. 119, 190 (1967)Google Scholar
  609. [489b]
    Grota, L. J., and K. B. Eik-Nes: Plasma progesterone concentration during pregnancy and lactation in the rat. J. Reprod. Fertil. 13, 83–91 (1967)PubMedCrossRefGoogle Scholar
  610. [489c]
    Guraya, S. S., and G. S. Greenwald: A histomical study of the hamster ovary. Amer. J. Anat. 116, 257–267 (1965). Ref. in: Excerpta med. (Amst.), Sect. Ill 19, 595 (1965)PubMedCrossRefGoogle Scholar
  611. [490]
    Guterman, H. S.: A human pregnancy test based upon a color reaction of pregnandiol in the urine. J. elin. Endoer. 4, 262–267 (1944)CrossRefGoogle Scholar
  612. [491]
    Guterman, H. S.: Further observations on the value of the pregnandiol test for pregnancy. J. elin.Endoer. 5, 407–411 (1945)CrossRefGoogle Scholar
  613. [492]
    Guterman, H. S.: Prediction of fate of threatened abortion by pregnandiol. J. Amer. med. Ass. 131,378–382 (1946)CrossRefGoogle Scholar
  614. [493]
    Guterman, H. S.: Clinical applications of pregnandiol determinations. Proc. Third Amer. Congr.Obstetr. Gynecol, 1947, p. 332–336Google Scholar
  615. [494]
    Guterman, H. S.: Relation of the biological activity of progesterone to the extent of its conversion to pregnanediol. Fed. Proc. 9, 54 (1950)Google Scholar
  616. [495]
    Guterman, H. S.: The diagnostic significance of pregnandiol excretion. Progr. elin. Endoer. 1950,366–372Google Scholar
  617. [496]
    Guterman, H. S.: Progesterone metabolism in the human female: Its significance in relation of reproduction. Recent Progr. Hormone Res. 8, 293–331 (1953)Google Scholar
  618. [497]
    Guterman, H. S. and M. S. Schroeder: A simplified technique for the quantitative colorimetric estimation of pregnandiol in urine. J. Lab. elin. Med. 33, 356–366 (1948)Google Scholar
  619. [498]
    Guterman, H. S. and A. S. Tulsky: Observations on the use of progesterone in threatened abortion.With special reference to pregnandiol excretion as a guide to therapy. Amer. J. Obstet. 58, 495–502 (1949)Google Scholar
  620. [499]
    Guttenberg, I.: Plasma levels of “free” progestin during the estrous cycle in the mouse. Endocrinology 68, 1006–1009 (1961)PubMedCrossRefGoogle Scholar
  621. [499a]
    Hack, M. H., and M. Helmy: Correlative lipid histochemistry. Acta histochem. (Jena) 27, 74–84 (1967)Google Scholar
  622. [500]
    Hafez, E. S. E., V. L. Estergreen, and R. J. Foster: Progestin and nucleic acids content of corpora lutea during multiple pregnancy in beef cattle. Acta endoer. (Kbh.) 48, 664–672 (1965)Google Scholar
  623. [501]
    Hafez, E. S. E., Y. Tasutsumi, and M. A. Kahn: Progestin levels in the ovaries and ovarian effluent blood in pregnant rabbits. Proc. Soc. exp. Biol. (NY.) 120, 75–78 (1965)Google Scholar
  624. [502]
    Hagerman, D. D.: Enzymatic capabilities of the placenta. Fed. Proc. 23, 785–790 (1964)PubMedGoogle Scholar
  625. [503]
    Hagerman, D. D., and J. M. Spencer: Thin layer chromatography of some Δ 5–3β-hydroxysteroids. Steroids 4, 547–556 (1964)CrossRefGoogle Scholar
  626. [504]
    Hagopian, M., G. Pincus, J. Carlo, and F B. Romanoff: Isolation of an unknown substance and 6-ketoprogesterone from perfusates of human placentae. Endocrinology 58, 387–388 (1956)PubMedCrossRefGoogle Scholar
  627. [505]
    Hain, A. M.: Further observations on the role of progesterone (pregnanediol) and oestrogen in pregnancy. J. Endocr. 3, 10–63 (1942)CrossRefGoogle Scholar
  628. [506]
    Hain, A. M., and E. M. Robertson: Estimation of luteal activity and early diagnosis of pregnancy. Lancet 1939 I, 1324–1325CrossRefGoogle Scholar
  629. [506a]
    Haksar, A., E.B. Romanoff, N. Hagino, and G. Pincus: In vitro inhibition of cholesterol synthesis by pregnenolone in bovine corpus luteum. Steroids 9, 405–414 (1967)PubMedCrossRefGoogle Scholar
  630. [507a]
    Hall, P. E., and K. Fotherby: Metabolism in vitro of the 6-oxygenated steroids. Acta endocr. (Kbh.) Suppl. 119, 134 (1967), and Biochem. J. 104, 23P (1967)Google Scholar
  631. [507]
    Halkerston, I. D. K., J. Eichhorn, and O. Hechter: A requirement for reduced triphosphopyridine nucleotide for cholesterol side-chain cleavage by mitochondrial fractions of bovine adrenal cortex. J. biol. Chem. 236, 374–380 (1961)PubMedGoogle Scholar
  632. [508]
    Hall, P. F., and S. B. Koritz: The influence of ICSH (LH) and 3’,5’-cyelic AMP on steroidgenesis in the corpus luteum. Fed. Proc. 24, 320 (1964)Google Scholar
  633. [509]
    Hall, P. F., and S. B. Koritz: The conversion of cholesterol and 20 α-hydroxycholesterol to steroids by acetone powder of particles from bovine corpus luteum. Biochemistry 3, 129–134 (1964)PubMedCrossRefGoogle Scholar
  634. [510]
    Hall, P. F., and S. B. Koritz: Influence of interstitial cell-stimulating hormone on the conversion of cholesterol to progesterone by bovine corpus luteum. Biochemistry 4, 1037–1043Google Scholar
  635. [510 a]
    Halperin, G., and M. Finkelstein: Bionysthesis of pregnanetriolone and pregnane- tetrol in congenital adrenal hyperplasia. Acta endocr. (Kbh.) 54, 439–451 (1967)Google Scholar
  636. [511]
    Hamblen, E. C., C. Ashley, and M. Baptist: Sodium pregnanediol glucoronide: the significance of its excretion in the urine. Endocrinology 24, 1–12 (1939)CrossRefGoogle Scholar
  637. [512]
    Hamblen, E. C., W. K. Cuyler, M. Baptist: Pregnanediol determination in gynecology and obstetrics. Amer. J. Obst. Gynec. 44, 442–454 (1942)Google Scholar
  638. [513]
    Hamburger, C.: Administration of progesterone in the form of suppositories. Acta endocr. (Kbh.), Suppl. 100, 101 (1965)Google Scholar
  639. [513a]
    Hamerstein, J.: Diskussionsbemerkung zu den Vorträgen R. Neher u. M. Aposto-lakis. 13. Sympos. Dtsch. Ges. Endokr. 1967Google Scholar
  640. [513b]
    Hammerstein, J., u. J. Nevinny-Stickel: Verminderte Oestrogenausscheidung in der Schwangerschaft nach sub totaler Adrenalektomie. Acta endocr. (Kbh.) 48, 375–382 (1965)Google Scholar
  641. [514]
    Hammerstein, J., B. F. Rice, and K. Savard: Steroid hormone formation in the human ovary. I. Identification of steroids formed in vitro from acetate- 1-14C in the corpus luteum. J. clin. Endocr. 24, 597–605 (1964)PubMedCrossRefGoogle Scholar
  642. [515]
    Hammond, K. B., and H. Leach: The gas chromatography of pregnane series steroids. Clin. chim. Acta 11, 584–585 (1965)PubMedCrossRefGoogle Scholar
  643. [516]
    Hammond, K. B., and H. Leach: The gas chromatography of human steroids as the trimethylsilyl ethers. Clin.chim. Acta 12, 363–364 (1965)CrossRefGoogle Scholar
  644. [516 a]
    Hammond, K. B., and H. Leach:The gas chromatography of pregnenetriol and some pregnanetriol isomers. Clin. chim. Acta 14, 569 (1966)PubMedCrossRefGoogle Scholar
  645. [517]
    Harbert, G. M., H. S. McGaughey, W. A. Scoggin, and N. N. Thorton: Concentration of progesterone in newborn and maternal circulations at delivery. Obstet, and Gynec. 23, 413–426 (1964)Google Scholar
  646. [518]
    Hardonk, M. J.: A new method for the histochemical demonstration of steroid producing cells in human tissues. Histochemie 5, 234–243 (1965)PubMedCrossRefGoogle Scholar
  647. [519]
    Harkness, R. A., and D. Charles: Studies on the biological activity and metabolism of the eyclopentyl-3-enol ether of progesterone. Amer. J. Obstet. Gynec. 93,1005– 1012 (1965)PubMedGoogle Scholar
  648. [520]
    Harkness, R. A., and K. Fotherby: The metabolism of (4-14C) progesterone in humans. Biochem. J. 80, 8 P–9 P (1961)Google Scholar
  649. [520a]
    Harkness, R. A. and K. Fotherby: The metabolism of progesterone in man. Biochem. J. 88, 308–314 (1963)PubMedGoogle Scholar
  650. [521]
    Harkness, R. A., and D. N. Love: Studies on the estimation of urinary pregnanetriol during pregnancy and childhood. Acta endocr. (Kbh.) 51, 526–534 (1966)Google Scholar
  651. [521a]
    Harkness, R. A. E. Menini, D. Charles, F.M. Kenny, and R. Rombaut: Studies of urinary steroid excretion by an adrenaleetomized woman during and after pregnancy. Acta endocr. (Kbh.) 52, 409–415 (1966)Google Scholar
  652. [521 b]
    Hart, D. McK.: Hydroxysteroid dehydrogenase activity in normal human placenta from six weeks to forty-two weeks of gestation. J. Endocr. 35, 255–262Google Scholar
  653. [521c]
    Hart, D. McKay: The histochemical distribution of hydroxysteroid dehydrogenases in the human foetal membranes at term. Histochemie 6, 17–23 (1966)PubMedCrossRefGoogle Scholar
  654. [521d]
    Habt, D. M.: Histochemical demonstration of hydroxysteroid dehydrogenases in hydatidiform mole. Obstet, and Gynee. 27, 766 (1966)Google Scholar
  655. [521e]
    Hart, D. M.,A. H. Baillie, K. C. Calman, and M. M. Febgtison: Hydroxysteroid dehydrogenase development in mouse adrenal and gonads. J. Anat. (Lond.) 100, 801–812 (1966)Google Scholar
  656. [522]
    Hart, G. H., and H. H. Cole: The source of estrin in the pregnant mare. Amer. J. Physiol. 109, 320 (1934)Google Scholar
  657. [523]
    Hartman, C. G.: Noneffect of ovariectomy on the twenty-fifth day of pregnancy in the rhesus monkey. Proc. Soc. exp. Biol. (N.Y.) 48, 221 (1941)Google Scholar
  658. [524]
    Hartmann, M., u. F. Locher: Über Allo-Pregnandiol, einen neuen Alkohol aus Sehwangerenharn. Naturwissenschaften 22, 856 (1934)CrossRefGoogle Scholar
  659. [525]
    Hartmann, M., u. F. Locher: Über Allo-Pregnandiol, einen neuen Alkohol aus dem Sehwangerenharn. Helv. ehim. Acta 18, 160–165 (1935)CrossRefGoogle Scholar
  660. [526]
    Hartmann, M., u. A. Wettstein: Ein kristallisiertes Hormon aus Corpus luteum. Helv. ehim. Acta 17/1, 878–882 (1934); 17/11, 1365–1372 (1934)Google Scholar
  661. [526a]
    Hashimoto, I., and R. M. Melampy: Ovarian progestin secretion in various reproductive states and experimental conditions in the rat. Fed. Proc. 26, No 1270, 485 (1967)Google Scholar
  662. [527]
    Haskins, jr. A. L.: Progestin. Assay of the blood of pregnant women for progestin. J. clin. Endoer. 1, 65–67 (1941)CrossRefGoogle Scholar
  663. [528]
    Haskins jr., A. L.: Assay of circulating progesterone by ultraviolet spectroscopy. Proc. Soc. exp. Biol. (N.Y.) 73, 439–443 (1950)Google Scholar
  664. [529]
    Haskins jr., A. L.: The progesterone content of human placentas before and after the onset of labor.Amer. J. Obstet. Gynee. 67, 330–338 (1954)Google Scholar
  665. [530]
    Haskins jr., A. L., and K. U. Soiva: The placental transfer of progesterone-4-C14 in human term pregnancy. Amer. J. Obstet. Gynee. 79, 674–679 (1960)Google Scholar
  666. [531]
    Haskins jr., A. L., and H. D. Tattbert: Progesterone transportation in blood. Obstet, and Gynee. 21, 395–399 (1963)Google Scholar
  667. [532]
    Haslewood, G. A. D., G. F. Mabblan, and E. R. Smith: A new saturated solid alcohol from the urine of pregnant mares. Biochem. J. 28, 1316–1320 (1934)PubMedGoogle Scholar
  668. [533]
    Hayano, M., M. C. Lindberg, M. Wieneb, H. Rosenkbantz, and R. J. Dobeman: Steroid transformations by corpus luteum tissue. Endocrinology 55, 326–331 (1954)PubMedCrossRefGoogle Scholar
  669. [534]
    Haynes jr., R. C., E. W. Suthebland, and T. W. Rall: The role of cyclic adenylic acid in hormone action. Recent Progr. Hormone Res. 16, 121–138 (1960)PubMedGoogle Scholar
  670. [535]
    Hayward, J. N., J. Hilliard, and C. H. Sawyer: Progestin synthesis and release by the monkey ovary. Fed. Proc. 22, 329 (1963)Google Scholar
  671. [536]
    Hayward, J. N., J. Hilliard, and C. H. Sawyer Preovulatory and post ovulatory progestins in monkey ovary and ovarian vein blood. Proe. Soc. exp. Biol. (N.Y.) 113, 256–259 (1963)Google Scholar
  672. [537]
    Heap, R. B.: A fluorescence assay of progesterone. J. Endocr. 30, 293–305 (1964)PubMedCrossRefGoogle Scholar
  673. [538]
    Heap, R. B., and R. Deanesly: Progesterone levels in intact and ovariectomized pregnant guineα-pigs. J. Endocr. 30, II (1964)Google Scholar
  674. [538 a]
    Heap, R. B., and R. Deanesly: Progesterone in systemic blood and placentae of intact and ovariectomized pregnant guineα-pigs. J. Endocr. 34, 417–423 (1966)PubMedCrossRefGoogle Scholar
  675. [539]
    Heap, R. B.,and J. L. Linzell: Plasma progesterone levels in the goat and mammary uptake during pregnancy. J. Physiol. (Lond.) 180, 10 P–11 P (1965)Google Scholar
  676. [539 a]
    Heap, R. B.,and J. L. Linzell: Metabolism of labelled progesterone by goat mammary tissue in vivo and in vitro. J. Physiol. (Lond.) 186, 62 P (1966)Google Scholar
  677. [539b]
    Heap, R. B.,and J. L. Linzell:Arterial concentration, ovarian secretion and mammary uptake of progesterone in goats during the reproductive cycle. J. Endocr. 36, 389–399 (1966)PubMedCrossRefGoogle Scholar
  678. [540]
    Heap, R. B., J- S. Pebby, and I. W. Rowlands: The effect of hypophysectomy on the corpus luteum of the non-pregnant guineα-pig. Acta endocr. (Kbh.), Suppl. 100, 76 (1965)Google Scholar
  679. [540a]
    Heap, R. B., J. S. Pebby, and I. W. Rowlands: Corpus luteum function in the guineα-pig, arterial and luteal progesterone levels and the effects of hysterectomy and hypophysectomy. J. Reprod. Fertil. 13, 537–553 (1967)PubMedCrossRefGoogle Scholar
  680. [541]
    Heard, R. D. H., W. S. Bauld, and M.M. Hofman: Steroids. Y. ∞-Estradiol and progesterone metabolism. J. biol. Chem. 141, 709–710 (1941)Google Scholar
  681. [542]
    Heard, R. D. H.,E. G. Bligh, M. C. Cann, P. H. Jellinck, V. J. O’Donnell, B. G. Rao, and J. L. Werb: Biogenesis of the sterols and steroid hormones. Recent Progr. Hormone Res. 12, 45–77 (1956)PubMedGoogle Scholar
  682. [543]
    Heard, R. D. H., R- Jacobs, V. O’Donnell, F. G. Pebon, J. C. Saeeban, S. S. Solomon, L. M. Thompson, H. Willoughby, and C. H. Yates: VII. Steroids as tracers. The application of C14 to the study of the metabolism of the sterols and steroid hormones. Recent Progr. Hormone Res. 9, 383–410 (1954)Google Scholar
  683. [544]
    Heard, R. D., and A. F. McKay: Steroids. II. The isolation of a new androstanol- 3(/?)-one and of allopregnanol-3(ß)-one from the urine of pregnant mares. J. biol. Chem. 131, 371–379 (1939)Google Scholar
  684. [545]
    Heard, R. D. H., and V. J. O’Donnell: Biogenesis of the estrogens: the failure of cholesterol-4-C14 to give rise to estrone in the pregnant mare. Endocrinology 54, 209–215 (1954)PubMedCrossRefGoogle Scholar
  685. [546]
    Hechter, O.: Comparison between gravimetric and reduction methods for determination of pregnandiol glucuronidate. Proc. Soc. exp. Biol. (N.Y.) 49, 299–302 (1942)Google Scholar
  686. [546a]
    Heitzman, R. J.: Estimation by gas chromatography of 5ß-pregnane-3α,20α-diol in the urine of normal lactating and ketose cows. J. Dairy Res. 34, 21–25 (1967)CrossRefGoogle Scholar
  687. [546b]
    HeitzmanR.J, and K. G. Hibitt: Evaluation by gas chromatography of the urinary steroids of normal and ketotic dairy cows. J. Endocr. 38, 231–236 (1967)PubMedCrossRefGoogle Scholar
  688. [546c]
    HeitzmanR J, and G. H. Thomas: Evaluation by gas chromatography of the urinary steroids of the pregnant dairy cow. J. Endocr. 33, 455–467 (1965)PubMedCrossRefGoogle Scholar
  689. [547]
    Hellig, H. R., and K. Savard: Sterol synthesis in the bovine corpus luteum in vitro. Fed. Proc. 25, No 178 (1966)Google Scholar
  690. [547 a]
    Hellig, H. R., Biosynthesis of progesterone, sterols, and squalene from acetate-1–14C and mevα- lonate-2–14C by the bovine corpus luteum in vitro. J. biol. Chem. 240, 1957–1961 (1965)PubMedGoogle Scholar
  691. [547b]
    Hellig, H. R., and K. Savard: Sterol biosynthesis in the bovine corpus luteum in vitro. Biochemistry 5, 2944–2956 (1966)PubMedCrossRefGoogle Scholar
  692. [548]
    Helmreich, M. L., and R. A. Huseby: Identification of a 6,21-dihydroxylated metabolite of medroxyprogesterone acetate in human urine. J. clin. Endocr. 22, 1018– 1032 (1962)Google Scholar
  693. [549]
    Helmreich, M. L., and R. A. HusebyFactors influencing the absorption of medroxyprogesterone acetate. Steroids, Suppl. 2, 79–95 (1965)Google Scholar
  694. [550]
    Henderson, J., N. F. Maclagan, V. R. Wheatley, and J. W. Wilkinson: Urinary pregnanediol estimation as a test for pregnancy. J. Endocr. 6, 41–53 (1949)PubMedCrossRefGoogle Scholar
  695. [551]
    Henning, H. D., u. J. Zander: Verwendung von Httbeners 20ß-Hydroxysteroid- dehydrogenase bei mikrochemischer Identifizierung und Trennung von Steroiden. Hoppe-Seylers Z. physiol. Chem. 330, 31–37 (1962)PubMedCrossRefGoogle Scholar
  696. [552]
    Henry, R., et M. Thévenet: Étude d’une méthode de détermination spécifique du prégnanediol, du prégnanetriol, du 20-eéto-prégnanediol. Bull. Soc. Chim. biol. (Paris) 41, 1391–1419 (1959)Google Scholar
  697. [552a]
    Herbst, A. L.: Response of rat ovarian cholesterol to gonadotropins and anterior pituitary hormones. Endocrinology 81, 54–60 (1967)PubMedCrossRefGoogle Scholar
  698. [553]
    Hermstein, A.: Untersuchungen über den Lipoidgehalt des Corpus luteum. Arch. Gynäk. 124, 739 (1925)CrossRefGoogle Scholar
  699. [554]
    Herrmann, W. L.: The differential diagnosis of virilizing disorders. Progr. Gynec. 4, 228–237 (1963)Google Scholar
  700. [555]
    Herrmann, W., F. Buckner, and J. McL. Morris: The problem of “mild” adrenal hyperplasia. Fertil. and Steril. 11, 74–87 (1960)Google Scholar
  701. [556]
    Herrmann, W., and L. Silverman: Excretion of pregnane-3α,17α,20α-triol in pregnancy. J. clin. Endocr. 17, 1482–1484 (1957)PubMedCrossRefGoogle Scholar
  702. [557]
    Herrmann, W., and L. Silverman: Method for determination of urinary pregnane-3-alpha, 17-alpha, 20-alpha triol. Proc. Soc. exp. Biol. (N.Y.) 94, 426–428 (1957)Google Scholar
  703. [557a]
    Hertz, R., W. Tullner, and E. Raefelt: Progestational activity of orally administered 17α-ethinyl-19-nortestosterone. Endocrinology 54, 228–230 (1954)PubMedCrossRefGoogle Scholar
  704. [558]
    Hervé, R., et P. Sergent: Dosage de la progestérone dans le sang: Technique et application à l’exploration du cycle menstruel normal et pathologique. Gynéc. et Obstét. 60, 55–75 (1961)Google Scholar
  705. [559]
    Hervé, R., et P. Sergent: L’élimination urinaire du 5/5 prégnane, 3α, 17α, 20α-triol au cours de la grossesse. (Résultats de 50 chromatographies.) Gynéc. et Obstét. 60, 188–200 (1961)Google Scholar
  706. [560]
    Herzmann, J., Z. K. Stemberau. E. Vrchlabská: Residualpregnandiol. Endokrinologie 38, 67–69 (1959)PubMedGoogle Scholar
  707. [561]
    Hill, D. L., W. E. Petersen, and S. H. Cohen: Assay of cow’s urine for pregnanediol. J. Dairy Sei. 37, 355–359 (1954)CrossRefGoogle Scholar
  708. [562]
    Hilliard, J., D. Archibald, and Ch. H. Sawyer: Gonadotropic activation of preovulatory synthesis and release of progestin in the rabbit. Endocrinology 72, 59–66 (1963)PubMedCrossRefGoogle Scholar
  709. [563]
    Hilliard, J., E. Endröczi, and C. H. Sawyer: Stimulation of progestin release from rabbit ovary in vivo. Proc. Soc. exp. Biol. (N.Y.) 108, 154–156 (1961)Google Scholar
  710. [564]
    Hilliard, J., J. H. Hayward, and Ch. H. Sawyer: Postcoital patterns of secretion of pituitary gonadotropin and ovarian progestin in the rabbit. Endocrinology 75,957–963 (1964)PubMedCrossRefGoogle Scholar
  711. [564a]
    Htlliard, J., B. Penardi, and Ch. H. Sawyer: A functional role for 20oc-hydroxy- pregn-4-en-3-one in the rabbit. Endocrinology 80, 901–909 (1967)CrossRefGoogle Scholar
  712. [565]
    Hinsberg, K., H. Pelzeru. A. Seuken: Bestimmung sehr Heiner Mengen Progesteron im menschlichen Plasma. Biochem. Z. 328, 117–125 (1956)PubMedGoogle Scholar
  713. [566]
    Hiroi, M.: Experimental studies on the relationship between the sexual centre and sex hormones in the rabbit. I. Determination of the urinary excretion of estrogens and pregnanediol in rabbits, and of the weight of the genital organs and adrenals. Acta med. Biol. (Niigata) 11, 105–129 (1963)Google Scholar
  714. [567]
    Hirschmann, H.: Steroids of urine of ovariectomized women. J. biol. Chem. 136, 483–502 (1940)Google Scholar
  715. [568]
    Hirschmann, H. and M. A. Daus: Preparation of pregnane-3α,16a,20α-triol and of two of its stereo isomers. J. Org. Chem. 24, 1114–1119 (1959)CrossRefGoogle Scholar
  716. [569]
    Hirschmann, H., and P. B. Hirschmann: Steroid excretion in a case of adrenocortical carcinoma. II. An examination of the non-ketonie fraction precipitable with digitonin. J. biol. Chem. 157, 601–612 (1945)Google Scholar
  717. [570]
    Hirschmann, H., and P. B. Hirschmann: Steroid excretion in a case of adrenocortical carcinoma. III. The isolation of Δ 5-pregnenediol-3 (ß), 17 (ß)-one-20αnd of 17 α-methyl-∆5-d-homoandrostenediol- 3(£),17(a)-one-17. J. biol. Chem. 167, 7–25 (1947)PubMedGoogle Scholar
  718. [571]
    Hirschmann, H., and P. B. Hirschmann, and M. A. Daus: The configuration of the allopregnanetriol-3–16,20 of the urine of pregnant mares. J. biol. Chem. 178, 751–774 (1949)PubMedGoogle Scholar
  719. [572]
    Hirschmann, H., and P. B. Hirschmann: Steroid excretion in a ease of adrenocortical carcinoma. IY. Δ 5-Pregnene-triol-3£,16 a,20α. J. biol. Chem. 184, 259–282 (1950)PubMedGoogle Scholar
  720. [573]
    Hirschmann, H., and P. B. Hirschmann: Steroid excretion in a case of adrenocortical carcinoma. V. zl 5-Pregnentriol-3,17α,20α. J. biol. Chem. 187, 137–146 (1950)PubMedGoogle Scholar
  721. [574]
    Hirschmann, H., and P. B. Hirschmann, and A. P. Zala: Isolation of two new 16α-hydroxysteroids from human preg nancy urine. J. biol. Chem. 236, 3141–3146 (1961)PubMedGoogle Scholar
  722. [575]
    Hirschmann, H.J. S. Williams The isolation of 5 α-pregnane-3 ß,20 ß-diol 20-sulfate and its hydrolysis to uranediol (17 α-methyl-D-homo-5α-androstane-3ß,17α,ß-diol). J. biol. Chem. 238, 2305–2308 (1963)PubMedGoogle Scholar
  723. [575 a]
    Hirsheield, I. N., and S. B. Koritz: Pregnenolone synthesis stimulation in the large particles from bovine adrenal cortex and bovine corpus luteum. Endocrinology 78, 165–168 (1966)CrossRefGoogle Scholar
  724. [576]
    Hisaw, P. L., and E. B. Astwood: The physiology of reproduction. Ann. Rev. Physiol. 4, 503–560 (1942)CrossRefGoogle Scholar
  725. [577]
    Hisaw jr., F. L., and F. L. Hisaw: Corpora lutea of Elasmobranch fishes. Anat. Ree. 135, 269–273 (1959)CrossRefGoogle Scholar
  726. [576]
    Hoar, W. S.: Comparative physiology: hormones and reproduction in fishes. Ann. Rev. Physiol. 27, 51–70 (1965)CrossRefGoogle Scholar
  727. [578a]
    Höhn, E. O., and S. C. Cheng: Gonadal hormones in Wilson’s phalarope (steganopus tricolor) and other birds in relation to plumage and sex behaviour. Gen. comp. Endoer. 8, 1–11 (1967)CrossRefGoogle Scholar
  728. [579]
    Hoffmann, Fr., u. G. Uhde: Über die Progesteronausscheidung im Neugeborenen-harn. Zbl. Gynäk. 76, 2196–2199 (1954)Google Scholar
  729. [580]
    Hoffmann, Fr., u. G. Uhde: Über den Progesterongehalt des Blutes im uterinen und im fetalen Kreislauf bei der schwangeren Frau. Arch. Gynäk. 185, 469–475 (1955)CrossRefGoogle Scholar
  730. [581]
    Hoffmann, M. M.: Studies in the metabolism of progesterone. Canad. med. Ass. J. 41, 424–432 (1942)Google Scholar
  731. [582]
    Hoffmann, M. M., G. Masson, and M. L. Desbarats: The role of bile in the absorption of steroid hormones from gastro-intestinal tract. Endocrinology 42, 279–284 (1948)CrossRefGoogle Scholar
  732. [582a]
    Hofmann, P., K. Kuschinsky, E. Mutschleru. U. Wollert: Die Verteilung von Progesteron- und Dodecandion-2,ll-bisguanylhydrazon im Meerschweinchenorganismus. Vortr. Frühjahrstagg Dtsch. Pharmak. Ges. 1967Google Scholar
  733. [583]
    Hollander, N., and V. P. Hollander: The effect of follicle-stimulating hormone on the biosynthesis in vitro of estradiol-17 £ from acetate-1-C14 and testosterone-4-C14. J. biol. Chem. 233, 1097–1099 (1958)Google Scholar
  734. [584]
    Holm, L. W., and R. V. Short: Progesterone in the peripheral blood of Guernsey and Friesian cows during prolonged gestation. J. Reprod. Fertil. 4, 137–141Google Scholar
  735. [585]
    Holton, J. B., and G. H. Lathe: Inhibitors of bilirubin conjugation in new-born infant serum and male urine. Clin. Sei. 25, 499–509 (1963)Google Scholar
  736. [586]
    Horning, E. C., T. Luukkainen, E. O. A. Haahti, B. G. Creech, and W. J. A. van-den Heuvel: Studies of human steroidal hormones by gaschromatographie techniques. Recent Progr. Hormone Res. 19, 57–106 (1963)PubMedGoogle Scholar
  737. [587]
    Hoshino, S.: Progesterone metabolism. Acta med. biol. (Niigata) 10, 303–321 (1963)Google Scholar
  738. [588]
    Huang, W. Y., and W. H. Pearlman: The corpus luteum and steroid hormone formation. I. Studies of luteinized rat ovarian tissue in vitro. J. biol. Chem. 237, 1060– 1065 (1962)Google Scholar
  739. [589]
    Huang, W. Y., and W. H. Pearlman: The corpus luteum and steroid hormone formation. II. Studies on the human corpus luteum in vitro. J. biol. Chem. 238, 1308–1315 (1963)PubMedGoogle Scholar
  740. [590]
    Huber, D.: Determination of pregnanediol in urine for diagnostic purposes. Biochem. J. 41, 609–611 (1947)Google Scholar
  741. [591]
    Hübener, H. J., u. C. O. Lehmann: Die enzymatische 20-keto-Reduktion durch Extrakte aus Streptomyces hydrogenans. Hoppe-Seylers Z. physiol. Chem. 313, 124–129 (1958)PubMedCrossRefGoogle Scholar
  742. [592]
    Hübener, H. J., P. G. Sahrholz, J. Schmidt-Thomé, G. Nesemannu. R. Junk: 20-Hydroxy-steroid-Dehydrogenase, ein neues kristallines Enzym. Biochim. biophys. Acta (Amst). 35, 270–272 (1959)CrossRefGoogle Scholar
  743. [593]
    Hughes, E. C., C. W. Lloyd, D. Jones, J. Lobotsky, J. S. Rienzo, and G. M. Avery: Some recent observations concerning the toxemias of pregnancy. Amer. J. Obstet. Gynec. 67, 782–809 (1964)Google Scholar
  744. [593a]
    Hughes, H. E., J. A. Loraine, E. T. Bell, and R. Layton: Cytological observations, cervical mucus “fering” and hormone assay in early pregnancy. Amer. J. Obstet. Gynec. 90, 1297–1303 (1964)PubMedGoogle Scholar
  745. [594]
    Huis in’t Veld, L. G.: L’excrétion des 17-eétostéroides au cours de la grossesse. Gynéc. et Obstét. 53, 42–56 (1954)Google Scholar
  746. [595]
    Huis in’t Veld, The neutral 17-ketosteroid excretion during the menstrual cycle. Acta endocr. (Kbh.) 33, 494–500 (1960)Google Scholar
  747. [596]
    Huis in’t Veld, The method of Klopper et al. for the determination of urinary pregnanediol. Bull. Soc. roy. belge Gynéc. Obstét. 30, 286–292 (1960)Google Scholar
  748. [597]
    Huis in’t Veld, u. G. J. Kloosterman: Bull. Rijks Instituut voor de Volksgezondheid, Utrecht 1964. Zit. bei [145]Google Scholar
  749. [598]
    Hurlock, B., and P. Talalay: Principles of the enzymatic measurement of steroids. J. biol. Chem. 227, 37–52 (1957)PubMedGoogle Scholar
  750. [599]
    Ichu, S.: Effect of ACTH in vivo on the cholesterol side-chain cleaving enzyme and on steroid hormone precursor cholesterol in rat adrenal gland. Steroids 5, 663–676 (1965)CrossRefGoogle Scholar
  751. [600]
    Ichu, S., E. Eorchielli and R. I. Dorfmann: In vitro effect of gonadotrophins on the soluble cholesterol side chain cleaving enzyme system of bovine corpus luteum. Steroids 2, 631–656 (1963)CrossRefGoogle Scholar
  752. [601]
    Idler, D. R., U. H. M. Fagerlund, and A. P. Ronald: Isolation of pregn-4-ene-17α,20ß-diol-3-one from the plasma of pacific salmon (Oncorhynchus nerica). Biochem. biophys. Res. Commun. 2, 133–137 (1960)CrossRefGoogle Scholar
  753. [602]
    Idler, D. R., A. P. Ronald, and P. J. Schmidt: Biochemical studies on sockeye salmon during spawning migration. Canad. J. Biochem. 27, 1227–1238 (1959)Google Scholar
  754. [603]
    Idler, D. R., and B. Truscott: In vivo metabolism of steroid hormones by sockeye salmon. Impaired hormone clearance in mature and spawned pacific salmon (O. nerka). Precursors of 11-ketotestosterone. Canad. J. Biochem. 41, 875–887 (1963)PubMedCrossRefGoogle Scholar
  755. [604]
    Ikonen, M., M. Niemi, S. Pesonen, and S. Timonen: Histochemical localization of four dehydrogenase systems in human ovary during the menstrual cycle. Acta endocr. (Kbh.) 38, 293–302 (1961)Google Scholar
  756. [605]
    Ismail, A. A. A., and R. A. Harkness: The isolation of progesterone from human pregnancy urine. Biochem. J. 98, 15 P (1966)Google Scholar
  757. [606]
    Isselbacher, K. J.: Enzymatic mechanisms of hormone metabolism. II. Mechanism of hormonal glucuronide formation. Recent Progr. Hormone Res. 12, 134–151 (1956)PubMedGoogle Scholar
  758. [607]
    Isselbacher, K. J., and G. Tomkins: Metabolism of cortisone, hydrocortisone and other α-ft un saturated steroids by a cell-free preparation of rat liver. Fed. Proc. 13, (54), 236 (1954)Google Scholar
  759. [607a]
    Iwamiya, M., F. J. Tweedi, and S. Solomon: Unverôffentlicht. Zit. nach 1228aGoogle Scholar
  760. [608]
    Iwata, R.: II. Incubation of human placental villi with pregnenolone and progesterone. Tokyo Jikeikai Ikadaigaku Zasshi 74, 936–941 (1959)Google Scholar
  761. [608a]
    Jaakomaki, P. I., K. A. Yarger, and E. C. Horning: Gas-liquid chromatographic separation of human urinary steroid glucuronides. Biochim. biophys. Acta (Amst. 137, 216–219 (1967)Google Scholar
  762. [608b]
    Jackanicz, T. M., and D. T. Armstrong: Progesterone biosynthesis in rabbit ovarian interstitial tissue mitochondria. Fed. Proc. 26, No 946, 425 (1967)Google Scholar
  763. [609]
    Jacobsohn, G. M.: Quantitation of estrone, estradiol, and estriol on thin layer chro- matograms by a photogrammetric procedure. Analyt. Chem. 36, 275–279, 2030– 2032 (1964)CrossRefGoogle Scholar
  764. [610]
    Jaffe, R., G. Eriksson, and E. Diczfalusy: In situ perfusion of the midterm humanplacenta with cholesterol. Excerpta med. (Amst.), Int. Congr. Ser. 99, E182 1965). New MexicoGoogle Scholar
  765. [610 a]
    Jaffe, R., R. Pion, G. Eriksson, N. Wiqvist, and E. Diczfalusy: Studies on the aromati- sation of neutral steroids in pregnant women. Acta endocr. (Kbh.) 48, 413–422Google Scholar
  766. [610b]
    Jaeee, R. B., and W. J. Ledger: In vivo steroid biogenesis and metabolism in the human term placenta. 1. Insitu placental perfusion with isotopic pregnenolone. Steroids 8, 61–78 (1966)CrossRefGoogle Scholar
  767. [610c]
    Jaffe, R. B., and E. P. Peterson: In vivo steroid biogenesis and metabolism in the human term placenta. 2. In situ placental perfusion with cholesterol-7α-3H. Steroids 8, 695–718Google Scholar
  768. [611]
    Jailer, J. W., J. J. Gold, R. V. Wiele, and S. Lieberman: 17α-Hydroxyprogesterone and 21-desoxyhydrocortisone; their metabolism and possible role in congenital adrenal virilism. J. clin. Invest. 34, 1639–1646 (1955)PubMedCrossRefGoogle Scholar
  769. [612]
    Jailer, J., and A. I. Knowlton: Simulated adreno-cortical activity during pregnancy in an Addisonian patient. J. elin. Invest. 29, 1430–1436 (1950)CrossRefGoogle Scholar
  770. [613]
    James, P., and K. Fotherby: Estimation of 6-oxygenated metabolites of progesterone in urine. J. Endocr. 30, 1 (1964)CrossRefGoogle Scholar
  771. [614]
    James, P., and K. Fotherby: A method for the estimation of 6-oxygenated metabolites of progesterone in urine. Biochem. J. 95, 459–465 (1965)PubMedGoogle Scholar
  772. [615]
    James, P., and K. Fotherby, and M. C. McNaughton: Metabolites of progesterone in the urine of pregnant women. Biochem. J. 99, 13 P–14 P (1966)Google Scholar
  773. [616]
    Jansen, A. P.: Determination of pregnanediol in urinary extracts by gas-liquid chro matography. Clin. chim. Acta 8, 785–787 (1963)PubMedCrossRefGoogle Scholar
  774. [617]
    Jayle, M. F.: Exploration de la fonction endocrinienne de la gestation. Gynéc. Et Obstét. 49, 336–342 (1950)Google Scholar
  775. [618]
    Jayle, M. F.: Elimination des stéroides urinaires au cours des grossesses normales et pathologiques. Sem. Hôp. Paris 29, 1790–1795 (1953)Google Scholar
  776. [619]
    Jayle, M. F.: Exploration biochimique de l’ovaire. Bull. Soc. roy. belge Gynéc. Obstét. 27, 59–69 (1957)Google Scholar
  777. [620]
    Jayle, M. F., et J. Bret: Elimination des stéroides urinaires dans l’hypertension au cours du cycle menstruel de la grossesse et de l’aménorrhée. Ann. Endocr. (Paris) 9, 390–395 (1948)Google Scholar
  778. [620a]
    Jayle, M. F., G. A. Chaillot et J. de Brux: Étude clinique, biochimique, eytohormonale et anatomopathologique d’un cas d’arrhénoblastome. Ann. Endocr. (Paris) 20, 625– 635 (1959)Google Scholar
  779. [621]
    Jayle, M. F., and O. Crépy: Technique for determination of pregnanediol glucuronide and total butanol-soluble glucuronides (in urine). Bull. Soc. Chim. biol. (Paris) 34, 435–443 (1952)Google Scholar
  780. [622]
    Jayle, M. F., and O. Crépy: Elimination des stéroides neutres et phéonliques au cours de la grossesse. Gynéc.; et Obstét. 53, 1–26 (1964)Google Scholar
  781. [623]
    Jayle, M. F., J. Guéguen, Y. Yallin et F. Veyrin-Forrer: Exploration dynamique du corps jaune. Presse méd. 64, 1965–1968 (1956)PubMedGoogle Scholar
  782. [624]
    Jayle, M. F., O. Judas et O. Crépy: Méthode de dosage du pregnandiol urinaire. Bull. Soc. Chim. biol. (Paris) 41, 1441–1453 (1959)Google Scholar
  783. [625]
    Jayle, M. F., et O. Libert: Étude technique et clinique des stéroides urinaires. Ann. Biol. clin. 2, 93–124 (1947)Google Scholar
  784. [626]
    Jayle, M. F., et G. Plantureux: Intérêt du dosage des 3α-stéroides totaux, du pregnandiol et de la folliculine dans les avortements endocriniens. Bull. Féd. Soc. Gynéc. Obstét. franc. 5, 551–557 (1953)Google Scholar
  785. [627]
    Jayle, M. F., G. Roussange, E. Veyrin-Forrer et F. Mège: Intérêt clinique des dosages du pregnandiol et des phénolstéroides au début de la grossesse. Gynéc. et Obstét. 59, 47–56 (1960)Google Scholar
  786. [628]
    Jayle, M. F., R. Scholler et J. Begue: Relations entre la croissance du placenta et du foetus et les taux des oestrogenes et de steroides neutres dans les urines. Excerpta med. (Amst.), Internat. Congr. Ser. No 51, p. 276, Mailand 1962Google Scholar
  787. [629]
    Jayle, M. F., R. Scholler et J. Begue, and L. Hanns: Oestrogens, progesterone and their metabolites in the blood and urine or normal pregnancies. Europ. Rev. Endocr. 1, 45–85 (1964)Google Scholar
  788. [630]
    Jayle, M. F., F. Veyrin-Forrer, S. Geller et F. Mège: Classification biochimique des in suffisances lutéales à l’aide d’une nouvelle épreuve d’exploration dynamique du corps jaune. Gynéc. et Obstét. 60, 381–389 (1961)Google Scholar
  789. [631]
    Jefecoate, T. N. A., J. R. H. Fliegner, S. H. Russell, J. C. Davis, and A. P. Wade: Diagnosis of the adrenogenital syndrome before birth. Lancet 1965 II, 553–555CrossRefGoogle Scholar
  790. [632]
    Jeffery, J. D. A.: Metabolism of progesterone in the pig-tail monkey (Maeaca neme-strina). J. Endocr. 34, 387–392 (1966)PubMedCrossRefGoogle Scholar
  791. [632 a]
    Jeffery, J. Shortcommunications on a polar progesterone metabolite in the pig-tail monkey. J. Endocr. 36, 93–94 (1966)PubMedCrossRefGoogle Scholar
  792. [632 b]
    Jellinck, P. H., and I. Lucieer: Sex differences in the metabolism of oestrogens by rat liver microsomes. J. Endocr. 32, 91–98 (1965)PubMedCrossRefGoogle Scholar
  793. [633]
    Jensen, C. C.: Improved procedure for quantitative determination of urinary pregnane-diol. Acta endocr. (Kbh.) 28, 37–38 (1958)Google Scholar
  794. [634]
    Johnson, G. E., and J. S. Challans: Ovariectomy and corpus luteum extract experiments in pregnant rats. Anat. Ree. 47, 300 (1930)Google Scholar
  795. [635]
    Johnson, K. R.: Maintenance of pregnancy in ovariectomized cattle with progestin compounds and their effect on progestin levels in the corpus luteum. J. Dairy Sei. 45, 633–639 (1962)CrossRefGoogle Scholar
  796. [635a]
    Johnson, K. R., and R. E. Erb: Maintenance of pregnancy in ovariectomiued cattle with progestin compounds and their effect on progestin levels in the corpus luteum. J. Dairy Sei. 45, 633–639 (1962)CrossRefGoogle Scholar
  797. [636]
    Jonck, J. Chromatographic detection of steroid hormones in the interstitial cells of the ovary. Ginek. pol. 30, 671–676 (1959)Google Scholar
  798. [637]
    Jones, G. E., and H.M. Stran: The of effect of alphα-tocopherol administration on pregnanediol excretion. J. clin. Endocr. 9, 743–748 (1949)PubMedCrossRefGoogle Scholar
  799. [638]
    Jones, G. E. S., E. Delfs, and H. M. Stran: Chorionic gonadotropin and pregnanediol values in normal pregnancy. Bull. Johns Hopk. Hosp. 75, 359–376 (1944)Google Scholar
  800. [639]
    Jones, G. E. S., and R. W. Telinde: The metabolism of progesterone in the hysterectomized woman. Amer. J. Obstet. Gynec. 41, 682–687 (1941)Google Scholar
  801. [640]
    Jones, G. E. S., D. Turner, I. J. Sarlos, A. C. Barnes, and R. Cohen: The determination of urinary pregnanediol by gas liquid chromatography. Fertil. and Steril. 13, 544–549 (1962)Google Scholar
  802. [641]
    Jones, H. W., and P. G. Weil: The corpus luteum hormone in early pregnancy. J. Amer. med. Ass. Ill, 519–521 (1938)Google Scholar
  803. [642]
    Jones, J. E.: Isolation of polar steroids from placenta and pregnancy plasma. Fed. Proc. 14, 82 (1955)Google Scholar
  804. [643]
    Jull, J. W., and J. A. Dossett: Hormone excretion studies of gynaeeomastia of puberty. Brit. med. J. 1964 II, 795–797CrossRefGoogle Scholar
  805. [644]
    Jull, J. W., G. M. Bonser, and J. A. Dossett: Hormone excretion studies of males with gynaeeomastia. Brit. med. J. 1964 H, 797–799Google Scholar
  806. [644a]
    Jungmann, R. A., E. Calvary, and J. S. Schweppe: Quantitative analysis of urinary ll-deoxy-17-ketosteroids and pregnanediol by gas-liquid chromatography. J. clin. Endocr. 27, 355–364 (1967)PubMedCrossRefGoogle Scholar
  807. [644b]
    Jungmann, R. A., and J. S. Schweppe: Biosynthesis and metabolism of neutral steroids by human midterm placenta and fetal liver. J. clin. Endocr. 27, 1151 (1967)PubMedCrossRefGoogle Scholar
  808. [645]
    Junkmann, K.: Über protrahiert wirksame Gestagene. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 223, 244–253 (1954)Google Scholar
  809. [645]
    Junkmann, K.: Long-acting steroids in reproduction. Recent Progr. Hormone Res. 13,389–428 (1957)PubMedGoogle Scholar
  810. [646a]
    Kadis, B.: Conversion of 16α-hydroxyprogesterone to estriol by sow ovary. Biochim. biophys. Acta (Amst.) 82, 649–651 (1964)CrossRefGoogle Scholar
  811. [646b]
    Kadis, B.: Steroid hydroxylations. V. Intracellular location of 16α-hydroxylase and its substrate specificity in sow ovary. Biochemistry 5, 3604–3608 (1966)PubMedCrossRefGoogle Scholar
  812. [647]
    Käser, O., u. E. Eichelberger: Hormonbestimmungen bei drohenden Aborten. Gynaecologia (Basel) 127, 115–125 (1949)Google Scholar
  813. [648]
    Kattnt, F. W., R. Neher, K. Schmidu. A. Wettstein: Bildung von 17α-Hydroxy-Δ 5-pregnenolon und 3 ß-Hy droxy-17-keto-zl 5-androsten (DHA) in Nebennieren- und Testesgewebe. Experientia (Basel) 17, 19–21 (1961)CrossRefGoogle Scholar
  814. [648a]
    Kahri, A.: Ovarian steroid cells in tissue culture of pregnant rat ovaries. Acta endocr. (Kbh.) Suppl. 119, 197 (1967)Google Scholar
  815. [649]
    Kaiser, E., W. Rindt u. G. W. Oertel: Steroidmetaboliten bei Lebererkrankung. 17-Ketosteroid- und 17-ketogene Corticoidausscheidung bei Lebercirrhose. Acta hepatosplenoi. (Stuttg.) 12, 12–20 (1965)Google Scholar
  816. [650]
    Kaiser, R.: Die Pregnandiolausscheidung im Harn vor der Geburt. Arch. Gynäk. 179, 115–122 (1951)CrossRefGoogle Scholar
  817. [651]
    Kaiser, R.: Ergebnisse der klinischen Auswertung von Pregnandiolbestimmungen im Cyclus und ihre Bedeutung für die Hormontherapie. Geburtsh. u. Frauenheilk. 12, 1006–1014 (1952)Google Scholar
  818. [652]
    Kaiser, R.: Zur Frage der Corpus luteum-Insuffizienz beim habituellen und drohenden Abortus. Arch. Gynäk. 181, 586–606 (1952)CrossRefGoogle Scholar
  819. [653]
    Kaiser, R.: Vergleichende Untersuchungen über den Abbau von Progesteron und Desoxy-corticosteron in Pregnandiol. Klin. Wsehr. 33, 264–269 (1955)CrossRefGoogle Scholar
  820. [654]
    Kaiser, R. Über die Zunahme an Harnoestrogenen hei Verwendung von 19-Nortesto-steron. Dtsch. med. Wsehr. 85, 1457–1460 (1960)CrossRefGoogle Scholar
  821. [655]
    Kaiser, R., u. A. Eichstädter: Das Ausscheidungsverhältnis Oestriol zu Pregnandiol in Cyelus und Schwangerschaft. Arch. Gynäk. 185, 726–738 (1955)CrossRefGoogle Scholar
  822. [656]
    Kaiser, R., u. H. Stecher: Die Beeinflussung der Oestrogenausscheidung durch unveresterte und veresterte 19-Nortestosteronverbindungen. Arch. Gynäk. 194, 146–157Google Scholar
  823. [657]
    Kaiser, R., u. I. Will: Das Verhalten der Ovarialhormone bei der Übertragung. Arch. Gynäk. 184, 159–180 (1953)CrossRefGoogle Scholar
  824. [657a]
    Kämpen, E. J. van, and W. Hoeck: Urinary steroid spectrum by gas chromatography. Clin. chim. Acta 16, 442–444 (1967)PubMedCrossRefGoogle Scholar
  825. [657b]
    Kamyab, S., K. Fotherby, and G. Wilson: Metabolism of lynesterenal in humans. Biochem. J. 103, 14 P (1967)Google Scholar
  826. [658]
    Kaneda, M.: The excretion of pregnanediol in the urine of normal nonpregnant womenafter the administration of estrogen, androgen, and deoxycorticosterone acetate (Doca). Rinsho Fujinka Sanka 9, 356–359 (1957)Google Scholar
  827. [659]
    Kankaanrinta, T.: On the pregnanediol excretion in the urine during the last tri mester of normal and toxemic pregnancy. Scand. J. clin. Lab. Invest., Suppl. 74, 1–104 (1963)Google Scholar
  828. [660]
    Kaplan, N. M.: Successful pregnancy following hypophysectomy during the twelfth week of gestation. J. clin. Endocr. 21, 1139–1145 (1961)PubMedCrossRefGoogle Scholar
  829. [661]
    Kapri, A., and H. Aratei: The biochemistry of the follicular fluid. Rev. roum. Biochim. 2, 243–248 (1965)Google Scholar
  830. [662]
    Kase, N.: Diskussionsbemerkung zu R. V. Short: Ovarian steroid synthesis and secretion in vivo. Recent Progr. Hormone Res. 20, 303–340 (1964), S. 338Google Scholar
  831. [663]
    Kase, N.: Steroid synthesis in abnormal ovaries. II. Granulosa cell tumor. Amer. J. Obstet. Gynec. 90, 1262–1267 (1964)PubMedGoogle Scholar
  832. [664]
    Kase, N.: Steroid synthesis in abnormal ovaries. III. Polycystic ovaries. Amer. J. Obstet. Gynec. 90, 1268–1273 (1964)PubMedGoogle Scholar
  833. [665]
    Kase, N., and S. H. Conrad: Steroid synthesis in abnormal ovaries. I. Arrhenoblastoma. Amer. J. Obstet. Gynee. 90, 1251–1261 (1964)Google Scholar
  834. [666]
    Kase, N. F. Forchielli, and R. I. Doreman: In vitro production of testosterone and androst-4-ene-3,17-dione in a human ovarian homogenate. Acta endocr. (Kbh.) 37, 19–23 1961Google Scholar
  835. [667]
    Kase, N. J. Kowal, and L. J. Soeeer: In vitro production of testosterone and androstene-dione in normal and Stein-Leventhal ovaries. Acta Endocr. 44, 8–14 (1963)PubMedGoogle Scholar
  836. [668]
    Kaufmann, C.: Progesteron, sein Schicksal im Organismus und seine Anwendimg in der Therapie. Klin. Wschr. 33, 345–347 (1955)PubMedCrossRefGoogle Scholar
  837. [669]
    Kaufmann, C.: Über Sexualhormone der Frau. Klin. Wschr. 36, 1145–1152 (1958)PubMedCrossRefGoogle Scholar
  838. [670]
    Kaufmann, C., u. U. Westphal: Über die Ausscheidung des Pregnandiols im mensuellen Cyclus. Klin. Wschr. 24, 910–913 (1947)PubMedCrossRefGoogle Scholar
  839. [671]
    Kaufmann, C. Ulrich Westphal u. J. Zander: Untersuchungen über die biologische Bedeutung der Ausscheidungsprodukte des Gelbkörperhormons. Arch. Gynäk. 179, 247–299 (1951)CrossRefGoogle Scholar
  840. [672]
    Kaufmann, C., u. J. Zander: Progesteron und Chorionepitheliom. Acta endocr. (Kbh.) 17, 216–225 (1954)Google Scholar
  841. [673]
    Kaufmann, C., u. J. Zander: Progesteron in menschlichem Blut und Gewebe. II. Mitt. Progesteron im Fett gewebe. Klin. Wschr. 34, 7–9 (1956)PubMedCrossRefGoogle Scholar
  842. [674]
    Keltz, B. F., E. C. Keaty, and A. A. Hellbaum: Hormonal studies in diabetic preg nancies. Sth. med. J. (Bgham, Ala.) 43, 803–813 (1950)CrossRefGoogle Scholar
  843. [674a]
    Kidwell, W. R., K. Balogh jr., and W. G. Wiest: Effects of luteinizing hormones on glucose-6-phosphate and 20 α-hydroxysteroid dehydrogenase activities in super- ovulated rat ovaries. Endocrinology 79, 352–361 (1966)PubMedCrossRefGoogle Scholar
  844. [674b]
    Kidwell, W. R. and W. G. Wiest 20α–Hydroxysteroid dehydrogenase (20-SDH), progesterone (P), and 20α-hydroxypregn-4-en-3-one (20α-OH) in rats during pregnancy. Fed. Proc. 26, No 1271, 485 (1967)Google Scholar
  845. [675]
    Kilinichenko, T. Ya.: Urinary levels of pregnanediol in women with dystocia. Pediat. Akush. Ginec. 2, 46–48 (1957)Google Scholar
  846. [676]
    Kilpatrick, R., D.T. Armstrong, and R. O. Greep: Release of steroid hormones into ovarian venous blood following LH in intact and hypophysectomized rabbits. Excerpta med. (Amst.), Internat. Congr. Ser. No. 51, p. 144. Mailand 1962Google Scholar
  847. [677]
    Kimbel, K. H., J. Willenbrinku. K. Junkmann: Verteilung und Ausscheidung von 17α-Hydroxyprogesteroneapronat an der Ratte. Acta endocr. (Kbh.) 28, 502–506 (1958)Google Scholar
  848. [678]
    Kimbel, K. H., J. Willenbrink, P. E. Schulze, H. Langecker, and K. Junkmann: Studies on the fate of testosterone enanthate and 17α-progesterone eaproate in man and rat. Acta endocr. (Kbh.), Suppl. 51, 737 (1960)Google Scholar
  849. [678 a]
    Kinoshita, K., K. Isurugi, Y. Kumamoto, and H. Takayasu: Gas chromatographic estimation of urinary pregnanetriol, pregnanetriolone, and pregnanetetrol in congenital adrenal hyperplasia. J. clin. Endocr. 26, 1219–1226 (1966)PubMedCrossRefGoogle Scholar
  850. [679]
    Kirschner, M. A., and M. B. Lipsett: The analysis of urinary steroids using gas-liquid chromatography. Steroids 3, 277–294 (1964)CrossRefGoogle Scholar
  851. [679a]
    Kitchin, J. D., R. J. Peon, and S. H. Conrad: Metabolism of progesterone by the term human placenta perfused in situ. Steroids 9, 263–274 (1967)PubMedCrossRefGoogle Scholar
  852. [680]
    Kleeberg, J., and W. Z. Polishuk: Lipid determinations in maternal and foetal blood. J. Obstet. Gynaec. 70, 701–704 (1963)Google Scholar
  853. [681]
    Klein, I., u. X. G. Ober: Progesteronbestimmungen im Blut mit dem Hooker-Forbes-Test in der Schwangerschaft. Klin. Wsehr. 32, 464–468 (1954)CrossRefGoogle Scholar
  854. [681a]
    Kloek, J.Die sexuelle Bedeutung des Geruches, eine experimentelle Studie (in Holländisch). Ned. T. Geneesk. 106, 2204–2208 (1961)Google Scholar
  855. [682]
    Klopper, A. I.: Some observations on the sulphuric acid colour reaction for the estima tion of pregnandiol. J. Endocr. 13, 291–295 (1956)PubMedCrossRefGoogle Scholar
  856. [683]
    Klopper, A. I.: The excretion of urinary pregnanediol during the normal menstrual cycle. J. Endocr. 14, XXXII (1956)Google Scholar
  857. [684]
    Klopper, A. I.: The excretion of pregnanediol during the normal menstrual cycle. J. Obstet. Gynaee. Brit. Emp. 64, 504–511 (1957)CrossRefGoogle Scholar
  858. [685]
    Klopper, A. I.: A comparison of the clinical effects of various progestational compounds. Folia endocr. (Roma) 14 (Suppl. to No. 6), p. 288–293 (1961)Google Scholar
  859. [686]
    Klopper, A. I.: Pregnanediol and pregnanetriol In: I. Dreman(ed.), Methods in hormone research, vol. 1, p. 139–168. New York u. London: Academic Press 1962Google Scholar
  860. [687]
    Klopper, A. I., and W. Billewicz: Urinary excretion of oestriol and pregnanediol during normal pregnancy. J. Obstet. Gynaee. Brit. Cwlth 70, 1024–1033 (1963)CrossRefGoogle Scholar
  861. [688]
    Klopper, A. I., and M. C. MacNaughton: The identification of pregnanediol in liquor amnii, bile and faeces. J. Endocr. 18, 319–325 (1959)PubMedCrossRefGoogle Scholar
  862. [689]
    Klopper, A. I., and E. A. Michie: Oestriol and pregnanediol excretion during pregnancy and at the onset of labour. J. Endocr. 22, XIV–XV (1961)Google Scholar
  863. [690]
    Klopper, A. I. F. A. Michie, and J. B. Brown: A method for the determination of urinary preg nanediol. J. Endocr. 12, 209–219 (1955)PubMedCrossRefGoogle Scholar
  864. [691]
    Klopper, A. I. The excretion of urinary pregnanediol after the administration of progesterone. J. Endocr. 13, 360–364 (1956)PubMedCrossRefGoogle Scholar
  865. [692]
    Klopper, A. I. J. A. Strong, and L. H. Cook: The excretion of pregnanediol and adrenocortical activity. J. Endocr. 15, 180–189 (1957)PubMedCrossRefGoogle Scholar
  866. [693]
    Klyne, W., and G. F. Marrian: The isolation of a new sulphuric acid ester from the urine of pregnant mares. Biochem. J. 39, XIV–XVI (1945)Google Scholar
  867. [694]
    Klyne, W., B. Schachter, and G. F. Marrian: The steroids of pregnant mares’ urine. I. Amethod for the extraction of steroid sulphates and the isolation of alio pregn- 16-en-3(ß)-ol-20-one sulphate. Biochem. J. 43, 231–234 (1948)Google Scholar
  868. [695]
    Klyne, W., and A. A. Wright: Steroids of pregnant cows’ urine. J. Endocr. 14, XXXIII–XXXIV (1956)PubMedGoogle Scholar
  869. [696]
    Klyne, W., and A. A. Wright: Steroids and other lipids of pregnant goat’s urine. Biochem. J. 66, 92–101 (1957)PubMedGoogle Scholar
  870. [697]
    Klyne, W., and A. A. Wright: Steroids and other lipids of pregnant cow’s urine. J. Endocr. 18, 32–45 (1959)PubMedCrossRefGoogle Scholar
  871. [697a]
    Knights, B. A.: Application of retention indices to steroid gas chromatography. J. Gas Chromatography 4, 329 (1966)Google Scholar
  872. [698]
    Knights, B. A., A. W. Rogers, and G.H.Thomas: 5α-Pregnane-3α,6a,20α-triol, a metabolite of progesterone in the rabbit. Biochem. biophys. Res. Commun. 8, 253–258 (1962)Google Scholar
  873. [699]
    Knoppers, A. Th.: Pregnanediol estimations in the urine of laboratory animals. Proc. ned. Akad. Med. 43, 1127–1132 (1940)Google Scholar
  874. [700]
    Knowlton, A. I., G. H. Madge, and J. W. Jaller: Pregnancy in Addison’s disease. J. clin. Endocr. 9, 514–528 (1949)PubMedCrossRefGoogle Scholar
  875. [701]
    Kochakian, C. D., A. L. Haskins, and R. A. Bruce: The site of metabolism of progesterone in the rabbit. Amer. J. Physiol. 142, 326–327 (1944)Google Scholar
  876. [702]
    Kochakian, C. D., and G. Stidworthy: Paper chromatography of C19 steroids. J. biol. Chem. 199, 607–612 (1952)PubMedGoogle Scholar
  877. [703]
    König, P. A.: Über Enzymlokalisation in den endokrinaktiven Formationen des menschlichen Ovariuins. Geburtsh. u. Frauenheilk. 24, 816 (1964)Google Scholar
  878. [704]
    König, P. A.: In: G. Jungu. P. A. König (Hrsg.), Enzyme des Ovariums, S. 77. Basel u. New York: S. Karger 1965Google Scholar
  879. [704]
    Koee, A. K., and A. S. Tulsky: Threatened abortion. An evaluation of the prognosis based on pregnanediol determinations and of treatment with progesterone. Surg. Clin. N. Amer. 33, 3–15 (1953)Google Scholar
  880. [705]
    Koide, S. S., and S. M. Mitsttdo: Histochemieal study of 3ß- and 17 ß-hydroxy steroid dehydrogenases in human term placenta. Endocrinology 76, 403–407 (1965)PubMedCrossRefGoogle Scholar
  881. [706]
    Koide, S. S., and M. T. Torres: Distribution of 3/3-hydroxysteroid dehydrogenase and ¿J5–3-oxo-steroid isomerase in homogenate fractions of human term placenta. Bioehim. bio- phys. Acta (Amst.) 105, 115–120 (1965)Google Scholar
  882. [707a]
    Koide, S. S., and M. T. TorresIsolation of 3-oxosteroid zJ4-Δ 5-isomerase of human term placenta. Bioehim. biophys. Acta (Amst.) 122, 151–153 (1966)Google Scholar
  883. [707 b]
    Kolb, K. H.: Resorption, Verteilung und Ausscheidung von Norgestrel. UnveröffentlichtGoogle Scholar
  884. [708]
    Koritz, S. B.: A spectrophotometric determination for zJ4–3-hydroxy steroids. Analyt. Biochem. 7, 495–497 (1964)PubMedCrossRefGoogle Scholar
  885. [709]
    Koritz, B., and P. F. Hall: Further studies on the locus of action of interstitial cell-stimulating hormone on the biosynthesis of progesterone by bovine corpus luteum. Biochemistry 4, 2740–2747 (1965)PubMedCrossRefGoogle Scholar
  886. [710]
    Kowal, J., E. Forchielli, and R. I. Doreman: The Δ 5–3ß-hydroxysteroid dehydro genase of bovine corpus luteum and adrenal. I. Properties, substrate specificity and Co-factor requirements. Steroids 3, 531–549 (1964)CrossRefGoogle Scholar
  887. [711]
    Kowal, J., E. Forchielli, and R. I. DoremanThe Δ 5–3 ß-hydroxysteroid dehydrogenase of corpus luteum and adrenal. II. Interaction of C19 and C21 substrates and products. Steroids 4, 77–100Google Scholar
  888. [712]
    Krieger, V. I.: Pregnanediol excretion in pregnancy. A comparison of the reported findings of several workers using various modifications of the Sommerville, Gough and Marrian method. Aust. N. Z. J. Obstet. Gynaec. 3, 136–139 (1962)CrossRefGoogle Scholar
  889. [713]
    Kristofeersen, J.: Gestagens in corpus luteum of cattle. Acta endocr. (Kbh.) 33, 417–427 (1960)Google Scholar
  890. [714]
    Kristofeersen, J., T. Lunaas, and W. Velle: Idendif ication of 20 ß-hydr oxy pregn-4-ene - 3 - one in luteal tissues from pregnant whales. Nature 190, 1009–1010 (1961)CrossRefGoogle Scholar
  891. [715]
    Kritchevsky, D., and M. R. Kirk: Detection of steroids in paper chromatography. Arch. Biochem. 35, 346–351 (1952)PubMedCrossRefGoogle Scholar
  892. [716]
    Kroc, R. L., B. G. Steinetz, and V. L. Beach: The effects of estrogens, progestagens, and relaxin in pregnant and nonpregnant laboratory rodents. Ann. N.Y. Acad. Sei. 75, 942–980 (1958/59)CrossRefGoogle Scholar
  893. [717]
    Kulenda, Z. u. E. Horakova: Eine einfache Methode der semiquantitativen Pregnan-diolbestimmung unter Anwendung der Dünnschichtchromatographie. Z. med. Labortechnik 4, 173–176 (1963)Google Scholar
  894. [717a]
    Kumar, D.: Tissue progesterone concentrations of placentas in pre-eclamptic patients. Amer. J. Obstet. Gynec. 95, 594–595 (1966)PubMedGoogle Scholar
  895. [718]
    Kulenda, Z., R. S. Azoury, and A. C. Barnes: Studies on human premature births I. Placental progesterone concentrations. Amer. J. Obstet. Gynec. 87, 126–129 (1963)Google Scholar
  896. [719]
    Kulenda, Z., and A. C. Barnes: Studies in human myometrium during pregnancy. VI. Tissue progesterone profile of the various compartments in the same individual. Amer. J. Obstet. Gynec. 92, 717–719 (1965)Google Scholar
  897. [720]
    Kulenda, Z., J. A. Goodno, and A. C. Barnes: Isolation of progesterone from human pregnant myometrium. Nature (Lond.) 195, 1204 (1962)Google Scholar
  898. [721]
    Kulenda, Z., E.F. Ward, and A.C. Barnes: Serial plasma progesterone levels and onset of labor. Amer. J. Obstet. Gynec. 90, 1360–1362 (1964)Google Scholar
  899. [721a]
    Kumari, L., and J. W. Goldzieher: In vitro steroid-ogenesis in normal human ovarian tissue. Acta endocr. (Kbh.) 52, 455–464 (1966)Google Scholar
  900. [722]
    Kuntzman, R., and M. Jacobson: Effect of drugs on the metabolism of progesterone by liver microsomal enzymes from various animal species. Fed. Proc. 24, 152Google Scholar
  901. [723]
    Kuntzman, R., D. Lawrence, and A. H. Conney: Michaelis constants for the hydroxylation of steroid hormones and drugs by rat liver microsomes. Molec. Pharmacol. 1, 163–167 (1965)Google Scholar
  902. [724]
    Kyle, T. I., and G. F. Marrian: Allo-pregnane-3α,20α-diol in the urine of pregnant women. Biochem. J. 49, 80–83 (1951)PubMedGoogle Scholar
  903. [725]
    Kyle, T. I., and G. F. Marrian:The metabolic reduction of progesterone to allo-pregnane-3α,20α-diol in human subjects. Biochem. J. 49, 162–164 (1951)PubMedGoogle Scholar
  904. [726]
    Lachese, B., O. Crepy et M. F. Jayle: Seperation chromatographique et dosage de la pregnanolone. Clin. chim. Acta 8, 538–546 (1963)PubMedCrossRefGoogle Scholar
  905. [727]
    Laitinen, O., and S. Pesonen: Some aspects of the funcrion of ovaries in secondaryamenorrhoea. Acta endocr. (Kbh.) 50, 254–260 (1965)Google Scholar
  906. [728]
    Lakhsmanan, T. K., and S. Lieberman: An improved method of gradient elution chromatography and its application t