Control of Corticotrophin Secretion

  • J. R. Hodges
  • M. T. Jones
  • M. A. Stockham
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 14 / 3)


It is now forty years since Smith (1927) showed that removal of the pituitary gland from various animal species results in atrophy of their adrenal cortices which can be prevented by the daily injection of anterior pituitary extracts or by transplants of adenohypophysial tissue. Thus, the existence of a trophic hormone responsible for the maintenance of the adrenal cortices was clearly shown. This hormone is called adrenocorticotrophic hormone, corticotrophin or ACTH. It is a comparatively simple polypeptide which varies slightly according to the species from which it is obtained. The chemical structures are known and some have been synthesised.


Pituitary Gland Adrenal Cortex Corticotrophin Release Factor Median Eminence ACTH Secretion 
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© Springer-Verlag Berlin · Heidelberg 1968

Authors and Affiliations

  • J. R. Hodges
  • M. T. Jones
  • M. A. Stockham

There are no affiliations available

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