Manifestations of Hypersecretion of Adrenal Sex Steroids in Man

  • Patricia Zeis Thomas
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 14 / 3)


The adrenal cortex is believed to secrete steroids with androgenic and estrogenic activity or precursors which are transformed to androgenic or estrogenic substances outside the adrenal cortex. Howard and Migeon (1962) in Chapter 5 of Part 1 of this Volume have reviewed the evidence for the secretion of sex hormones by the normal adrenal cortex. Excessive secretion of androgens and estrogens, regardless of origin, results in precocious and exaggerated isosexual or heterosexual physical changes in the organism. This chapter is confined to the consideration of certain clinical syndromes in the human being which are attributed to adrenocortical disease and in which manifestations of feminization or masculinization occur. These manifestations may be isosexual, i.e. feminization of the female and masculinization of the male, or heterosexual, i.e. masculinization of the female and feminization of the male. As will become apparent, abnormalities of the adrenocortical secretion of a quantitative and, possibly, of a qualitative nature may be caused by disease of the adrenal gland itself or may be a secondary consequence of disease of other endocrine glands such as the pituitary or gonads.


Adrenal Cortex Congenital Adrenal Hyperplasia Adrenal Tumor Electrolyte Imbalance External Genitalia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin · Heidelberg 1968

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  • Patricia Zeis Thomas

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