Control of Aldosterone Secretion

  • William F. Ganong
  • Edmund E. Van Brunt
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 14 / 3)


Despite considerable controversy, the identities of the major mechanisms regulating aldosterone secretion are known and the broad outlines if not the details of how they operate are established. The release of this hormone from the zona glomerulosa of the adrenal cortex is increased by ACTH and by angiotensin II. The latter is formed in the blood stream by the action of renin from the kidney on a protein in the plasma. In addition to the hypothalamo-pituitary system and the renin-angiotensin system, a rise in plasma potassium or a fall in plasma sodium acts directly on the zona glomerulosa to increase aldosterone secretion. Additional stimulating and inhibiting factors from the posterior diencephalon and pineal gland may exist, but it now appears that, if they do, their physiological roles are minor.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Abdul-Karim, R., and N. D. Assali: Pressor response to angiotonin in pregnant and nonpregnant women. Amer. J. Obstet. Gynec. 82, 246–251 (1961).PubMedGoogle Scholar
  2. Allen, J. M.: A chemical and histochemical study of aliesterase in the adrenal gland of the developing mouse. Anat. Rec. 132, 195–205 (1958).PubMedGoogle Scholar
  3. Amador, E., and G. C. Gil: Experimental production of acute sodium and water retention by the intact white rat. Metabolism 12, 653–658 (1963).PubMedGoogle Scholar
  4. Anderson, C. H., M. McCally, and G. L. Farrell: The effects of atrial stretch on aldoster-one secretion. Endocrinology 64, 202–207 (1959).PubMedGoogle Scholar
  5. Anderson, F. G., J. C. Johnson, and J. R. Derrick: A study of the dog’s blood pressure after unilateral renal vein constriction. Clin. Res. 10, 42 (1962).Google Scholar
  6. Ando, T.: Adrenal structure and function with special reference to the relationship between zona glomerulosa and zona fasciculata. Endocr. jap. 4, 35–56 (1957).PubMedGoogle Scholar
  7. Arndt, J. O., H. Reineck U. O. H. Gauer: Ausscheidungsfunktion und Hämodynamik der Nieren bei Dehnung des linken Vorhofes am narkotisierten Hund. Pflügers Arch. ges. Physiol. 277, 1–15 (1963).Google Scholar
  8. Astarabadi, T.: Some experimental evidence for the dependence of the kidney on the pituitary gland. Acta endocr. (Kbh.), Suppl. 67, 169 (1962).Google Scholar
  9. — The effect of growth and lactogenic hormones on renal compensatory hypertrophy in rats. Quart. J. exp Physiol. 48, 85–92 (1963).PubMedGoogle Scholar
  10. Atkins, E. L., and J. W. Pearce: Mechanisms of the renal response to plasma volume expansion. Canad. J. Biochem. 37, 91–102 (1959).PubMedGoogle Scholar
  11. August, J. T., and D.H. Nelson: Adjustment to aldosterone or desoxycorticosterone acetate induced sodium retention in patients with Addison’s disease. J. Clin. Invest. 38, 1964–1971 (1959).PubMedGoogle Scholar
  12. — —, and G. W. Thorn: Reponse of normal subjects to large amounts of aldosterone. J. Clin. Invest. 37, 1549–1555 (1958a).PubMedGoogle Scholar
  13. — —— Aldosterone. New Engl. J. Med. 259, 917–923, 967–971 (1958b).PubMedGoogle Scholar
  14. Axelrad, B. J., and J. A. Luetscher, Jr.: Adrenal cortical activity in normal men on diets of low sodium content. J. clin. Invest. 33, 916 (1954).Google Scholar
  15. Ayres, C. R., J. O. Davis, F. Lieberman, C. C. J. Carpenter, and M. Berman: The effects of chronic hepatic venous congestion on the metabolism of d,l-aldosterone and d-aldosterone. J. clin. Invest. 41, 884–895 (1962).Google Scholar
  16. Ayres, P. J., O. Garrod, S. A. Tart, J. F. Tait, G. Walker, and W. H. Pearlman: The use of 16-3H-aldosterone in studies on human peripheral blood. Ciba Found. Coll. Endocr. 11, 309–326 (1957).Google Scholar
  17. — R.C. Hurter, and E.S. Williams: Aldosterone excretion and potassium retention in subjects living at high altitude. Nature (Lond.) 191, 78–80 (1961).Google Scholar
  18. Bacchus, H.: Cytochemical study of the adrenal cortex of the rat under salt stresses. Amer. J. Physiol. 163, 326–331 (1950).PubMedGoogle Scholar
  19. Bachrach, D., E. B. Szabo, G. Y. Baradnay, and B. Korpassy: Histophysiological changes of the adrenal cortex of rat in dehydration and rehydration. J. Endocr. 23, 1–8 (1961).PubMedGoogle Scholar
  20. Badinez, O., and H. Croxatto: Histological modifications of the adrenal cortex in the rat treated with potassium chloride and sodium chloride [Spanish]. Bol. Soc. Biol. Santiago 5, 40–43 (1948).Google Scholar
  21. Bahn, R. C., H. E. Storino, and R. W. Schmit: The mass of the zona glomerulosa following complete anterior and posterior hypophysectomy and subtotal removal of the pars tuberalis in the dog. Endocrinology 66, 403–408 (1960).PubMedGoogle Scholar
  22. Baïsset, A., L. Douste-Blazy, et P. Montastruc: Réduction de la sécrétion de l’aldostérone sous l’effet d’une distention auriculaire. J. Physiol. (Paris) 51, 393–394 (1959).Google Scholar
  23. — — — et P. Valdigine: Recherches sur la régulation volumetrique de la sécrétion de l’aldostérone. Ann. Endocr. (Paris) 23, 419–424 (1962).Google Scholar
  24. — — H. Planel et P. Montastruc: Cortex surrénal et diabéte insipide expérimental. C. R. Soc. Biol. (Paris) 148, 1867–1870 (1954).Google Scholar
  25. Baldus, W. P., W. H. J. Summerskill, J. C. Hunt, and F. T. Maher: The renal circulation in cirrhosis: studies based on catheterization of the renal vein. J. clin. Invest. 42, 915 (1963).Google Scholar
  26. Baldwin, D., H. D. Landahl, and T. B. Schwartz: The role of fluctuations of sodium balance in the regulation of body sodium stores. Metabolism 12, 1032–1050 (1963).PubMedGoogle Scholar
  27. Bálint, P., and G. Pethes: Isosmotic hypervolemia and “water diuresis” in the dog. Acta med. scand. 163, 21–29 (1959).PubMedGoogle Scholar
  28. Ball, W. D., and J. O. Davis: Failure of chronic adrenal venous congestion to produce sodium retention and increase aldosterone excretion in the dog. Amer. J. Physiol. 191, 339–341 (1957).PubMedGoogle Scholar
  29. Barajas, L., and H. Latta: Juxtaglomerular apparatus in rats. Lab. Invest. 12, 1046–1059 (1963).PubMedGoogle Scholar
  30. Baratz, R. A., and R. C. Ingraham: Renal hemodynamics and antidiuretic hormone release associated with volume regulation. Amer. J. Physiol. 198, 565–570 (1960).PubMedGoogle Scholar
  31. Barbour, B. H.: Influence of salt on central nervous system control of steroidogenesis. Circulation 28, 687 (1963a).Google Scholar
  32. —, and F. C. Bartter: Angiotensin labelled with I131 and with tritium. J. clin. Endocr. 23, 313–314 (1963).PubMedGoogle Scholar
  33. — A. G. T. Casper, and F. C. Bartter: The role of salt in the interaction of steroidogenesis and angiotensin. Clin. Res. 10, 398 (1962a).Google Scholar
  34. — — — The role of lymph in the control of steroidogenesis. Fed. Proc. 22, 210 (1963b).Google Scholar
  35. Barbour, B. H. J. R. Gill, Jr., and F. C. Bartter: The effect of angiotensin II on sodium transport in the toad skin. Clin. Res. 10, 92 (1962b).Google Scholar
  36. — — — J.D.H. Slater, and F.C. Bartter: An explanation for the antidiuresis produced by angiotensin II in man. Clin. Res. 10, 245 (1962c).Google Scholar
  37. — J.D. H. Slater, A. G. T. Casper, and F. C. Bartter: Role of the kidney in the control of aldosterone secretion by dietary sodium. Circulation 26, 683–684 (1962d).Google Scholar
  38. — D. Testerman, A. G. T. Casper, and F. C. Bartter: On the role of the central nervous system in control of adrenal cortical steroid production. Clin. Res. 11, 213 (1963c).Google Scholar
  39. Barger, A. C., R. D. Berlin, and J. F. Tulenko: Infusion of aldosterone, 9-α-fluorohydrocortisone and antidiuretic hormone into the renal artery of normal and adrenalectomized dogs: effect on electrolyte and water excretion. Endocrinology 62, 804–815 (1958).PubMedGoogle Scholar
  40. — F. E. Yates, and A. M. Rudolph: Renal hemodynamics and sodium excretion in dogs with graded valvular damage and in congestive failure. Amer. J. Physiol. 200, 601–608 (1961).PubMedGoogle Scholar
  41. Barnes, A. C., and E. J. Quilligan: Measurements of aldosterone in eclamptogenic toxemias of pregnancy. Amer. J. Obstet. Gynec. 71, 670–682 (1956).PubMedGoogle Scholar
  42. Baronofsky, I., J. Caravaca, and M. D. May: Urinary aldosterone output in dogs with renal hypertension. Clin. Res. 11, 42 (1963).Google Scholar
  43. Barraclough, M. A., and N. F. Jones: Effect of fluid retention following vasopressin on sodium excretion by hypertensive subjects. Clin. Sci. 23, 433–440 (1962).PubMedGoogle Scholar
  44. Barrett, A. M., and G. Sayers: Loss of ACTH activity following incubation of pituitary tissue: inhibition by glucagon and by pitressin. Endocrinology 68, 637–645 (1958).Google Scholar
  45. Bartter, F. C.: The role of aldosterone in normal homeostasis and in certain disease states. Metabolism 5, 369–383 (1956).PubMedGoogle Scholar
  46. — Regulation of the volume and composition of extracellular and intracellular fluid. Ann. N. Y. Acad. Sci. 110, 682–703 (1963).PubMedGoogle Scholar
  47. — B. H. Barbour, A. A. Carr, and C. S. Delea: On the role of potassium in the regulation of aldosterone secretion. In: E. E. Baulieu and P. Robel (eds.), Aldosterone. Oxford: Blackwell 1964a.Google Scholar
  48. Bartter, F. C, B. H. Barbour, A. A. Carr, and D. H. Suter: Control of adrenocortical steroid secretion dependent upon and independent of pituitary and kidneys. Canad. med. Ass. J. 90, 240–242 (1964b).PubMedGoogle Scholar
  49. — E. G. Biglieri, P. Pronove, and C. S. Delea: Effect of changes in intravascular volume on aldosterone secretion in man. In: A. F. Müller and C. M. O’Connor (eds.), An Int. Symposium on Aldosterone, p. 100–110. London: J. & A. Churchill 1958.Google Scholar
  50. Bartter, F. C, A. G. T. Casper, C. S. Delea, and J. D. H. Slater: On the role of the kidney in the control of adrenal steroid production. Metabolism 10, 1006–1020 (1961).Google Scholar
  51. Bartter, F. C., and D. S. Gann: On the hemodynamic regulation of the secretion of aldosterone. Circulation 21, 1016–1023 (1960).PubMedGoogle Scholar
  52. — G. W. Liddle, L. E. Dunoan, J. K. Barber, and C. Delea: The regulation of aldosterone secretion in man: the role of fluid volume. J. clin. Invest. 35, 1306–1316 (1956).PubMedGoogle Scholar
  53. Bartter, F. C., I. H. Mills, E. G. Biglirri, and C. Delea: Studies on the control and physiologic action of aldosterone. Recent Progr. Hormone Res. 15, 311–344 (1959).Google Scholar
  54. — —, and D. S. Gann: Increase in aldosterone secretion by carotid artery constriction in the dog and its prevention by thyrocarotid arterial junction denervation. J. clin. Invest. 39, 1330–1336 (1960).PubMedGoogle Scholar
  55. — P. Pronove, J.R. Gill, Jr., and R. C. Maocardle: Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. Arner. J. Med. 33, 811–828 (1962).Google Scholar
  56. Bean, J. W.: Specificity of the renin-hypertensinogen reaction. Amer. J. Physiol. 136, 731–742 (1942a).Google Scholar
  57. — On the specificity of renin and some related phenomena. Fed. Proc. 1, 6–7 (1942b).Google Scholar
  58. Beck, J. C., C. J. P. Giroud, I. Dyrenfurth, and E. H. Venning: Observations on the regulatory mechanisms of aldosterone secretion in man. Arch. intern. Med. 96, 463–469 (1955).Google Scholar
  59. — E. E. Mcgarry, I. Dyrenfurth, and E. H. Venning: Metabolic effects of human and monkey growth hormone in man. Science 125, 884–885 (1957).PubMedGoogle Scholar
  60. — — — — The metabolic effects of human and monkey growth hormone in man. Ann. intern. Med. 49, 1090–1105 (1958).PubMedGoogle Scholar
  61. Bentley, P. J.: The adrenal cortex and renal sodium and potassium excretion in the newborn rat. J. Endocr. 26, 361–365 (1963).PubMedGoogle Scholar
  62. Berliner, R. W.: The regulation of water balance and plasma sodium concentration. Arch. intern. Med. 102, 986–989 (1958).Google Scholar
  63. Bernardis, L. L., and S. Kamura: Blood pressure and dietary sodium as regulators of juxtaglomerular cell function. Fed. Proc. 23, 445 (1964).Google Scholar
  64. Berry, W. B., W. G. Austen, and W. D. Clark: Studies of the mechanism of action of angiotensin. Surg. Forum 14, 294–296 (1963).PubMedGoogle Scholar
  65. Besch, P. K., K. A. Brownell, F. A. Hartman, and D. J. Watson: Adrenocortical steroid profile in the hypertensive dog. Acta endocr. (Kbh.) 39, 355–370 (1962).Google Scholar
  66. Bianchi, A., A. F. de Sohaepdryver, G. R. de Vleesohouer, and P. Preziosi: On the pharmacology of synthetic hypertensine. Arch. int. Pharmacodyn. 124, 21–44 (1960).PubMedGoogle Scholar
  67. Bickerton, R. K., and J. P. Buckley: Evidence for a central mechanism in angiotensin induced hypertension. Proc. Soc. exp. Biol. (N. Y.) 106, 843–836 (1961).Google Scholar
  68. Biglieri, E. G., and W. F. Ganong: Effect of hypophysectomy on the adrenocortical response to bilateral carotid constriction. Proc. Soc. exp. Biol. (N. Y.) 106, 806–809 (1961).Google Scholar
  69. — — Failure of aldosterone infusions to inhibit aldosterone secretion in hypophysectomized dogs. Excerpta Med. (Arnst.), Series 111 15, 223 (1962).Google Scholar
  70. — S. Hane, P. E. Slaton Jr., and P. H. Forsham: In vivo and in vitro studies of adrenal secretion in Cushing’s syndrome and primary aldosteronism. J. clin. Invest. 42, 516–522 (1963).PubMedGoogle Scholar
  71. — M. B. McIlroy, A. Naimark, and P. H. Forsham: Altered autonomic nervous system and renal response in primary aldosteronism. J. clin. Invest. 41, 1345 (1962).Google Scholar
  72. — and P.E. Slaton, Jr.: Adrenal function in autonomic insufficiency. Clin. Res. 12, 88 (1964).Google Scholar
  73. — C. O. Watlington, and P. H. Forsham: Sodium retention with human growth hormone and its subfractions. J. clin. Endocr. 21, 361–370 (1961).Google Scholar
  74. Bilsel, Y. C., J. E. Wood, and R. D. Lange: Angiotensin II and erythropoiesis. Proc. Soc. exp. Biol. (N. Y.) 114, 475–479 (1963).Google Scholar
  75. Bing, J.: Renal hypertension in rennin-depleted rats. Acta path. microbiol. scand. 56, 362–376 (1962a).PubMedGoogle Scholar
  76. — Angiotensinase content of kidneys of normal and hypertensive rats. Acta path. microbiol. scand. 56, 385–387 (1962b).PubMedGoogle Scholar
  77. —, and J. Kazimierczak: Renin content of different parts of the periglomerular circumference. Acta path. microbiol. scand. 50, 1–11 (1960).Google Scholar
  78. — — Renin content of different parts of the juxtaglomerular apparatus. Acta path. Micro-biol. scand. 54, 80–84 (1962).Google Scholar
  79. Birchard, W. H., J. D. Rosenbaum, and M. B. Strauss: Diuretic response to water ingestion in the presence of elevated serum electrolyte levels and expanded extracellular fluid volume. Amer. J. Med. 14, 496 (1953).Google Scholar
  80. Biron, P., H. Chretien, E. Kiow, and J. Genest: Effects of angiotensin infusion on aldosterone and electrolyte excretion in normal subjects and patients with hypertension and adrenal cortical disorders. Brit. med. J. 1962 I, 1569–1575.Google Scholar
  81. Biron, P., E. Kiow, F. O. Nowaczynski, J. Brouillet, and J. Genest: The effects of intravenous infusions of valine-5 angiotensin II and other pressor agents on urinary electrolytes and corticosteroids, including aldosterone. J. clin. Invest. 40, 338–347 (1961).PubMedGoogle Scholar
  82. Black, D. A. K.: Renal factors in volume control. In: G. E. W. Wolstenholme and J. Etherington (eds.), Ciba Symposium on the Kidney, p.309–320. Boston: Little, Brown & Co. 1954.Google Scholar
  83. Blair-West, J. R., J. P. Cogelan, and D. A. Denton: Evidence against an aldosterone feedback mechanism within the adrenal gland. Acta endocr. (Kbh.) 41, 61–66 (1962a).Google Scholar
  84. — — — J. R. Goding, J. A. Munroe, R. E. Peterson, and M. Wintour: Humoral stimulation of adrenal cortical secretion. J. clin. Invest. 41, 1606–1627 (1962b).PubMedGoogle Scholar
  85. — — — — — M. Wintour, and R. D. Wright: A useful method for collection of adrenal venous blood in conscious sheep. Endocrinology 71, 990–992 (1962c).PubMedGoogle Scholar
  86. — — — — —, and R. D. Wright: The effect of neuraxial ablations upon the secretion of electrolyte-active steroid. J. Physiol. (Lond.) 153, 50P (1960).Google Scholar
  87. — — — — — — The reduction of the pressor action of angiotensin II in sodium deficient conscious sheep. Aust. J. exp. Biol. med. Sci. 41, 369–376 (1963a).PubMedGoogle Scholar
  88. — — — — M. Wintour, and R. D. Wright: The control of aldosterone secretion. Recent Progr. Hormone Res. 19, 311–383 (1963b).PubMedGoogle Scholar
  89. — — — —, and R. D. Wright: The effect of aldosterone, cortisol and corticosterone upon the sodium and potassium content of sheep’s parotid saliva. J. clin. Invest. 42, 484–496 (1963c).PubMedGoogle Scholar
  90. —, and J. R. Goding: Effect of temporary thoracic caval constriction on aldosterone secretion in conscious and in anesthetized sheep. Endocrinology 70, 822–836 (1962).PubMedGoogle Scholar
  91. Blake, W. D., R. Wegria, H. P. Ward, and C. W. Frank: Effect of renal arterial constriction on excretion of sodium and water. Amer. J. Physiol. 163, 422–429 (1950).PubMedGoogle Scholar
  92. Blaquier, P., D. F. Bohr, and S. W. Hoobler: Evidence against an increase in circulating pressor material in renal hypertensive rats. Amer. J. Physiol. 198, 1148–1152 (1960).PubMedGoogle Scholar
  93. — — A. C. Taquini, Jr., and S. W. Hoobler: Renin and angiotensinase content of the kidney of normal and renal hypertensive rats. Proc. Soc. exp. Biol. (N. Y.) 108, 711–715 (1963).Google Scholar
  94. — S. W. Hoobler, J. Schroeder, A. Gomez, and T. Kreulen: Effect of bilateral nephrectomy on the pressor response to renin. Amer. J. Physiol. 203, 339–343 (1962).PubMedGoogle Scholar
  95. Bledsoe, T., D. P. Island, A. Riondel, and G. Liddle: Modification of aldosterone biosynthesis in man by a chemical inhibitor of 18-oxidation. Clin. Res. 11, 214 (1963).Google Scholar
  96. Block, M. A., K. G. Wakim, and F. C. Mann: Renal function during stimulation of renal nerves. Amer. J. Physiol. 169, 670–677 (1952).PubMedGoogle Scholar
  97. Blythe, W. B., and L. G. Welt: Dissociation between filtered load of sodium and its rate of excretion in the urine. J. clin. Invest. 42, 1491–1496 (1963).PubMedGoogle Scholar
  98. Bock, K. D., and F. Gross: Renin and angiotensin tachyphylaxis. Circulat. Res. 9, 1044–1050 (1961).PubMedGoogle Scholar
  99. Bohler, C. S., L. C. Chesley, F. P. Zuspan, E. Talledo, and P. Dow: Cardiovascular responsiveness to norepinephrine and angiotensin in pregnant women. Fed. Proc. 23, 357 (1964).Google Scholar
  100. Bojesen, E.: Aldosterone in peripheral plasma of normal man. In: E. E. Baulieu and P. Robel (eds.), Aldosterone. Oxford: Blackwell 1964.Google Scholar
  101. —, and H. Degn: A double isotope derivative method for the determination of aldosterone in peripheral plasma. Acta endocr. (Kbh.) 37, 541–558 (1961a).Google Scholar
  102. — — Influence of changes of blood volume on the concentration of aldosterone in peripheral plasma of intact unanesthetized dogs. Nature (Lond.) 190, 352–353 (1961b).Google Scholar
  103. Booth, E., J. W. Hinman, E. G. Daniels, M. Kosinski, and E. E. Muirhead: Antihypertensive renal factor. J. clin. Invest. 42, 918 (1963).Google Scholar
  104. Boucher, R., P. Biron, and J. Genest: Procedure for isolation and determination of human blood angiotensin. Canad. J. Biochem. 39, 581–590 (1961).Google Scholar
  105. — M. Launay, J. de Champlain, R. Veyrat, and J. Genest: A shorter method for isolation of human angiotensin. J. clin. Invest. 42, 919 (1963).Google Scholar
  106. — R. Veyrat, J. de Champlain, and J. Genest: New procedures for measurement of human angiotensin and renin activity levels. Canad. med. Ass. J. 90, 194–201 (1964).PubMedGoogle Scholar
  107. Bougas, J., C. Flood, B. Little, J. F. Tait, S. A. S. Tait, and R. Underwood: Dynamic aspects of aldosterone metabolism. In: E. E. Baulieu and P. robel (eds.), Aldosterone, p. 25–50. Oxford: Blackwell 1964.Google Scholar
  108. Braun-Menéndez, E.: Pharmacology of renin and hypertensin. Pharmacol. Rev. 8, 25–55 (1956).PubMedGoogle Scholar
  109. B raun-Menéndez, E., J. C. Fasciolo, L. F. Leloir, M. M. Munoz, and A. C. Taquini: Renal hypertension (Translated by L. Dexter.) Springfield (Ill.): Ch. C. Thomas 1946.Google Scholar
  110. Bricker, N.S., R.A. Stratton, E.P. Mahoney, and J.P. Merrill: The functional capacity of the kidney denervated by autotransplantation in the dog. J. clin. Invest. 37, 185–193 (1958).PubMedGoogle Scholar
  111. Brogi, M. P., and C. Pellegrino: The secretion of corticosterone and aldosterone by the rat adrenal cortex regenerating after enucleation. J. Physiol. (Lond.) 146, 165–178 (1959).Google Scholar
  112. Brooks, F. P., and M. Pickford: Conditions under which the posterior pituitary hormones increase sodium and potassium excretion by the kidney. In: H. Heller (eds.), The neurophypophysis, p. 141–156. London: Butterworths 1957.Google Scholar
  113. — — The effect of posterior pituitary hormones on the excretion of electrolytes in dogs. J. Physiol. (Lond.) 142, 468–493 (1958).Google Scholar
  114. Brotchner, R. J.: Hypertension from obstruction of the aorta. Proc. Soc. exp. Biol. (N. Y.) 40, 264–265 (1939).Google Scholar
  115. B rown, E., J. Hopper, Jr., and R. Wennesland: Blood volume and its regulation. Ann. Rev. Physiol. 19, 231–254 (1957).Google Scholar
  116. Brown, J. J., D. L. Davies, P. B. Doak, A. F. Lever, and J. I. S. Robertson: Plasmarenin in normal pregnancy. Lancet 1963a II, 900–901.Google Scholar
  117. — — A. F. Lever, R. A. Parker, and J. I. S. Robertson: Assay of renin in single glomerulirenin distribution in the normal rabbit kidney. Lancet 1963b II, 668–669.Google Scholar
  118. — — —, and J. I. S. Robertson: Influence of sodium loading and sodium depletion on plasma renin in man. Lancet 1963c II, 278–279.Google Scholar
  119. — — — — Variations in plasma renin concentration in several physiological and pathological states. Canad. med. Ass. J. 90, 201–206 (1964).PubMedGoogle Scholar
  120. —, and W. S. Peart: The effect of angiotensin on urine flow and electrolyte excretion in hypertensive patients. Clin. Sci. 22, 1–17 (1962).PubMedGoogle Scholar
  121. Brownell, K. A., F. A. Hartman, and R. W. Relman: Effect of adrenal enucleation on serum sodium. Endocrinology 47, 326–330 (1950).PubMedGoogle Scholar
  122. Brunner, H., P. A. Desaulles, D. Regoli, and F. Gross: Renin content and excretory function of the kidney in rats with experimental hypertension. Amer. J. Physiol. 202, 795–799 (1962).PubMedGoogle Scholar
  123. Bugnon, C., N. Moreau et R. Lenys: Recherches histophysiologiques sur les relations entre l’épiphyse et la zone glomerulaire du cortex surrenalien chez le rat blanc. Ann. Endocr. (Paris) 24, 348–355 (1963).Google Scholar
  124. Bumpus, F. M., H. Schwarz, and I. H. Page: Synthesis and pharmacology of the octapeptide angiotonin. Science 125, 886–887 (1957).PubMedGoogle Scholar
  125. — R. R. Smeby, and I. H. Page: Angiotensin, the renal pressor hormone. Circulat. Res. 9, 762–767 (1961).Google Scholar
  126. — — —, and P. A. Khairallah: Distribution and metabolic fate of angiotensin II and various derivatives. Canad. med. Ass. J. 90, 190–193 (1964).PubMedGoogle Scholar
  127. B uñag, R. D., S. L. Skinner, and J. W. McCubbin: Further observations on the release of renin by the kidney. Fed. Proc. 23, 467 (1964).Google Scholar
  128. Burger, J. S., and W. N. Hess: Function of the rectal gland of the spiny dogfish. Science 131, 670–671 (1960).PubMedGoogle Scholar
  129. Butterfield, J. L., and J. A. Richardson: Comparison of the effect of synthetic angiotensin (hypertensin) and I-norepinephrine on blood acid-base parameters. Pharmacologist 5, 259 (1963).Google Scholar
  130. C ade, J. R., and T. Perenich: Aldosterone production by rats. Clin. Res. 12, 47 (1964).Google Scholar
  131. — R. J. Shalhoub, M. Canessa-Fischer, and R. F. Pitts: Effect of strophanthidin on the renal tubules of dogs. Amer. J. Physiol. 200, 373–379 (1961).PubMedGoogle Scholar
  132. Camargo, C. H., E. W. Hancock, A. J. Dowdy, and J. A. Luetscher, Jr.: Impaired metabolism of aldosterone in patients with congestive heart failure. Clin. Res. 12, 114 (1964).Google Scholar
  133. C amp III, J. L.: Effect of posture on salt and water retention. II. Appearance of a circulating vasoconstrictor substance in the blood on assuming erect posture. J. Lab. clin. Med. 52, 202–205 (1958).PubMedGoogle Scholar
  134. — F. Tate, P. B. Lowrance, and J. E. Wood, Jr.: Effects of posture on sodium and water retention. J. Lab. clin. Med. 52, 193–201 (1958).PubMedGoogle Scholar
  135. Cara, J., and L. I. Gardner: Histopathology of adrenal hyperplasia. Pediatrics 32, 825–840 (1963).PubMedGoogle Scholar
  136. C argill, W. H., W. B. Fackle, R. L. McWhorter, and J. V. Warren: Effect of abdominal compression on chloride excretion following administration of hypertonic saline solution. Amer. J. Med. 7, 413–414 (1949).Google Scholar
  137. C arpenter, C. C. J., J. O. Davis, and C. R. Ayers: Concerning the role of arterial baroreceptors in the control of aldosterone secretion. J. clin. Invest. 40, 1160–1171 (1961b).PubMedGoogle Scholar
  138. — — — Relation of renin, angiotensin II and experimental renal hypertension to aldosterone secretion. J. clin. Invest. 40, 2026–2042 (1961c).PubMedGoogle Scholar
  139. Carpenter, C. C. J., J. O. Davis, J. E. Holman, C. R. Ayers, and R. C. Barn: Studies on the response of the transplant of kidneys and the transplant of adrenal gland to thoracic inferior vena cava constriction. J. clin. Invest. 40, 196–204 (1961a).PubMedGoogle Scholar
  140. — — C. R. Wallace, and W. F. Hamilton: Acute effects of cardiac glycosides on aldosterone secretion in dogs with hyperaldosteronism secondary to chronic right heart failure. Circulat. Res. 10, 178–187 (1962).PubMedGoogle Scholar
  141. Carr, A. A., B. H. Barbour, and F. C. Bartter: Effect of angiotensin on blood pressure. Lancet 1963 I, 1376–1377.Google Scholar
  142. —, and F. C. Bartter: Effect of angiotensin II on adrenal ascorbic acid. Proc. Soc. exp. Biol. (N. Y.) 111, 210–212 (1962).Google Scholar
  143. Carstensen, H., A. C. J. Burgers, and C. H. Li: Demonstration of aldosterone and corticosterone as the principal steroids formed in incubates of adrenals of the American bullfrog (Rana catesbeiana) and stimulation of their production by mammalian corticotrophin. Gen. compo Endocr. 1, 37–50 (1961).Google Scholar
  144. Carter, W. T.: Effect of tilting on sodium excretion during salt loading in essential hypertension. Clin. Res. 11, 303 (1963).Google Scholar
  145. C asey, J. H., E. Y. Bickel, and B. Zimmerman: The pattern and significance of aldosterone excretion by the postoperative surgical patient. Surg. Gynec. Obstet. 57, 179–183 (1957).Google Scholar
  146. C astagnoli, N., Jr., A. Goldfien, and W. F. Ganong: Release of adrenal steroids during asphyxia. Fed. Proc. 20, 178 (1961).Google Scholar
  147. Cater, D. B., and M. P. Stack-Dunne: The histological changes in the adrenal of the hypophysectomized rat after treatment with pituitary preparations. J. Path. Bact. 56, 119–133 (1953).Google Scholar
  148. Cejka, V., L. A. de Vries, J. J. van Daatsebar, and J. G. G. Borst: The effect of aldosterone on aldosterone antagonism in patients with hypoaldosteronism produced by heparinoid (in Dutch). Ned. T. Geneesk. 106, 617–620 (1962).PubMedGoogle Scholar
  149. — — M. E. Smorenberg-Schoorl, J. J. van Daatsebar, J. G. G. Borst, and C. L. H. Majoor: Effect of heparinoid and spirolactones on the renal excretion of sodium and aldosterone. Lancet 1960 I, 317–319.Google Scholar
  150. Celander, O.: The range of control exercized by the sympathico-adrenal system. Acta physiol. scand. 32, Suppl. 116 (1954).Google Scholar
  151. Champlain, J. de, R. Boucher, and J. Genest: Arterial angiotensin levels in edematous patients. Proc. Soc. exp. Biol. (N. Y.) 113, 932–937 (1963).Google Scholar
  152. Chan, W. Y., and W. H. Sawyer: Saluretic actions of neurohypophysial peptides in conscious dogs. Amer. J. Physiol. 201, 799–803 (1961).PubMedGoogle Scholar
  153. Chart, J. J., and H. Sheppard: Pharmacology and biochemistry of some amphenone analogues and other adrenocortical inhibitors. J. med. pharm. Chem. 1, 407–441 (1959).PubMedGoogle Scholar
  154. — E. G. Shipley, and E. S. Gordon: Evidence for a sodium retaining factor in toxemia of pregnancy. Proc. Soc. exp. Biol. (N. Y.) 78, 244–246 (1951).Google Scholar
  155. Cheek, D. B., and C. D. West: Natriuretic response and the distribution of body water during enforced hydration. Effect of renal denervation and desoxycorticosterone. Amer. J. Physiol. 179, 626 (1954).Google Scholar
  156. Chesley, L. C., R. M. Wynn, and N.I. Silverman: Renal effects of angiotensin II infusion in normotensive pregnant and non-pregnant women. Circulat. Res. 13, 232–238 (1963).PubMedGoogle Scholar
  157. Chester-Jones, I., J. G. Phillips, and D. Bellamy: Studies on water and electrolytes in cyclostomes and teleosts. Gen. comp Endocr., Suppl. 1, 36–47 (1962).Google Scholar
  158. Chiandussi, L., A. Vaccarino, A. Greco, F. Muratori, L. Cesano, and D. Indovina: Effect of drug infusion on the splanchnic circulation. I. Angiotensin infusion in normal and cirrhotic Subjects. Proc. Soc. exp. Biol. (N. Y.) 112, 324–326 (1963).Google Scholar
  159. Chien, S., B. Peric, and S. Usami: The reflex nature of release of antidiuretic hormone upon common carotid occlusion in vagotomized dogs. Proc. Soc. exp. Biol. (N. Y.) 111, 193–196 (1962).Google Scholar
  160. Chimoskey, J. E., P. C. Blaquier, A. C. Taquini, and D. F. Bohr: Effects of angiotensin on pulmonary and systemic hemodynamics. Amer. J. Physiol. 202, 690–694 (1962).PubMedGoogle Scholar
  161. Clementi, F., F. Fraschini, E. Mmuller, and A. Zambori: Pineal gland control of adrenal secretion; functional and morphological observations. Abstract Papers, Int. Roundtable Conference on the Epiphysis Cerebri, July 1963, p. 10–13.Google Scholar
  162. Coghlan, J. P., D. A. Denton, J. R. Goding, and R. D. Wright: The control of aldosterone secretion. Postgrad. med. J. 36, 76–102 (1960).PubMedGoogle Scholar
  163. Cohen, R. B., and J. D. Crawford: Glucose-6-phosphate dehydrogenase activity in the adrenal cortex of the sodium-depleted rat: a histochemical study. Endocrinology 70, 288–290 (1962a).PubMedGoogle Scholar
  164. — — Distribution of glycogen, lipid and glucose-6-phosphate dehydrogenase activity in the adrenal cortex of the sodium-depleted rat: a histochemical study. Endocrinology 71, 847–852 (1962b).PubMedGoogle Scholar
  165. Cohen, R. B., and J. D. Crawford: Glycogen in the adrenal cortex of sodium depleted rat. Proc. Soc. exp. Biol. (N.Y.) 109, 211–213 (1962c).Google Scholar
  166. Collins, K. J.: Endocrine control of salt and water in hot conditions. Fed. Proc. 22, 716–720 (1963).PubMedGoogle Scholar
  167. Conn, J. W.: Aldosteronism in man. Some clinical and climatological aspects. J. Amer. med. Ass. 183, 775–781, 871–878 (1963).Google Scholar
  168. Cook, W., D. B. Gordon, and W. S. Peart: The location of renin in the rabbit kidney. J. Physiol. (Lond.) 135, 46P (1957).Google Scholar
  169. —, and G. W. Pickering: Location of renin within kidney. J. Physiol. (Lond.) 135, 46P (1957).Google Scholar
  170. — — A rapid method for separating glomeruli from rabbit kidney. Nature (Lond.) 182, 1103–1104 (1958b).Google Scholar
  171. — — The location of renin in the rabbit kidney. In: M. Schachter (ed.), Polypeptides that affect smooth museles and blood vessels, p. 155–157. London: Pergamon 1960.Google Scholar
  172. Cooper, G. W., and M. R. Nocenti: Unilateral renal ischemia and erythropoietin. Proc. Soc. exp. Biol. (N. Y.) 108, 546–549 (1961).Google Scholar
  173. Cope, C. L., and E. Black: The hydrocortisone production in late pregnancy. J. Obstet. Gynaec. Brit. Emp. 66, 404–408 (1959).PubMedGoogle Scholar
  174. — H. Hharwood, and J. Pearson: Aldosterone secretion in hypertensive diseases. Brit. med. J. 1962 I, 569–665.Google Scholar
  175. —, and J. Pearson: Aldosterone secretion in severe renal failure. Clin. Sci. 25, 331–341 (1963).PubMedGoogle Scholar
  176. Coppage, W. S., Jr., and A. E. Cooner: The effects of thyroid disease on aldosterone metabolism. Clin. Res. 11, 216 (1963).Google Scholar
  177. — D. P. Island, A. E. Cooner, and G. W. Liddle: The metabolism of aldosterone in normal subjects and in patients with hepatic cirrhosis. J. clin. Invest. 41, 1672–1680 (1962).PubMedGoogle Scholar
  178. Corbascio, A. N.: Action of long chain polymers in kidney juxtaglomerular cells and connective tissue mast cells. Circulat. Res. 8, 390–398 (1960).PubMedGoogle Scholar
  179. Cox, J. R., G. A. B. Davies-Jones, P. J. Leonard, and B. Singer: The effect of positive pressure respiration on urinary aldosterone excretion. Clin. Sci. 24, 1–5 (1963).PubMedGoogle Scholar
  180. — P. J. Leonard, and B. Singer: Effect of vasopressin on the volume of body fluid compartments and its relation to aldosterone excretion. Clin. Sci. 21, 205–219 (1961).PubMedGoogle Scholar
  181. — — — Changes in sodium distribution in body fluid compartments and urinary aldosterone excretion. Clin. Sci. 23, 13–26 (1962).PubMedGoogle Scholar
  182. Crabbé, J., W. J. Reddy, E. J. Ross, and G. W. Thorn: The role of the adrenal cortex in the normal adaptation to dietary sodium deprivation J. clin. Endocr. 18, 1147–1158 (1958a).PubMedGoogle Scholar
  183. — — — — The stimulation of aldosterone secretion by adrenocorticotropic hormone (ACTH). J. clin. Endocr. 19, 1185–1191 (1959).PubMedGoogle Scholar
  184. — E. J. Ross, and G. W. Thorn: The significance of the secretion of aldosterone during dietary sodium deprivation in normal subjects. J. clin. Endocr. 18, 1159–1177 (1958b).PubMedGoogle Scholar
  185. Craig, R. L., N. Wetzel, and R. G. Bianchi: Renal function studies in the dog hypophysectomized for ascites. Amer. J. Physiol. 200, 890–892 (1961).PubMedGoogle Scholar
  186. Cranston, W. I., and W. Brown: Diurnal variation in plasma volume in normal and hypertensive subjects. Clin. Sci. 25, 107–114 (1963).PubMedGoogle Scholar
  187. Cressman, R. D., and A. Blalock: Experimental hypertension. Effects of Kieselguhr injection and splanchnic stimulation. Proc. Soc. exp. Biol. (N.Y.) 40, 258–260 (1939).Google Scholar
  188. Crocker, D. W., R. A. Newton, E. M. Mahoney, and J. H. Harrison: Hypertension due to primary renal ischemia. New Engl. J. Med. 267, 794–800 (1962).PubMedGoogle Scholar
  189. Dahl, L. K.: Salt intake and salt need. New Engl. J. Med. 258, 1152–1159 (1958).PubMedGoogle Scholar
  190. — L. Sslver, S. Sparagen, and M. Smilay: Effect of chronic high and low salt intake on adrenocortical function. Nature (Lond.) 190, 348–349 (1961).Google Scholar
  191. Dailey, R.E., E. R. Karickhoff, L. Swell, H. Field, Jr., and C. R. Treadwell: Metabolism of cortisol by the liver of sodium deficient rats. Proc. Soc. exp. Biol. (N. Y.) 105, 326–328 (1960).Google Scholar
  192. Daily, W. J. R., and W. F. Ganong: The effect of ventral hypothalamic lesions on sodium and potassium metabolism in the dog. Endocrinology 62, 442–454 (1958).PubMedGoogle Scholar
  193. Das Gupta, D., N. Kalant, and C. J. P. Gmoud: Experimental aminonucleoside nephrosis (II); effect of adrenalectomy on fluid retention of aminonucleoside nephrosis. Proc. Soc. exp. Biol. (N. Y.) 100, 602–604 (1959).Google Scholar
  194. Daughaday, W. H.: Steroid protein interactions. Physiol. Rev. 39, 885–902 (1959).PubMedGoogle Scholar
  195. — J. Holloszy, and I. K. Martz: Binding of corticosterone by plasma protein. J. clin. Endocr. 21, 53–61 (1961).PubMedGoogle Scholar
  196. Davidson, E. T., F. de Venuto, and V. Westphal: Steroid-protein interactions IX: Interactions of aldosterone with human serum proteins in conjunction with spirolactones and other steroids. Endocrinology 71, 893–900 (1962).PubMedGoogle Scholar
  197. Davis, J. O.: Some aspects of the physiology of aldosterone. J. nat. med. Ass. (N.Y.) 49, 42–50 (1957).Google Scholar
  198. — Mechanisms of salt and water retention in congestive heart failure. Amer. J. Med. 29, 486–507 (1960a).PubMedGoogle Scholar
  199. — Hormonal control of aldosterone secretion. In: J. H. Moyer and M. Fuchs (eds.), Edema, p. 113–120. Philadelphia: Saunders 1960b.Google Scholar
  200. — A critical evaluation of the role of receptors in the control of aldosterone secretion and sodium excretion. Progr. cardiovasc. Dis. 4, 27–46 (1961a).Google Scholar
  201. — Mechanisms regulating the secretion and metabolism of aldosterone in experimental secondary hyperaldosteronism. Recent Progr. Hormone Res. 17, 293–331 (1961b).PubMedGoogle Scholar
  202. — Adrenocorticoid and renal hormonal function in experimental cardiac failure. Circulation 25, 1002–1014 (1962a).PubMedGoogle Scholar
  203. — The control of aldosterone secretion. Physiologist 5, 65–86 (1962b).PubMedGoogle Scholar
  204. — The regulation of aldosterone secretion. Physiol. Physicians 1, No 5 (1963a).Google Scholar
  205. — The role of the adrenal cortex and the kidney in the pathogenesis of cardiac edema. Yale J. Biol. Med. 35, 402–428 (1963b).PubMedGoogle Scholar
  206. — E. Anderson, C. C. J. Carpenter, C. R. Ayers, W. Haymaker, and W. T. Spence: Aldosterone and corticosterone secretion following midbrain transection. Amer. J. Physiol. 200, 437–443 (1961a).PubMedGoogle Scholar
  207. — C. R. Ayers, and C. C. J. Carpenter: Renal origin of aldosterone stimulating hormone in dogs with thoracic caval constriction and in sodium depleted dogs. J. clin. Invest. 40, 1466–1474 (1961b).PubMedGoogle Scholar
  208. — The renin-angiotensin system in the control of aldosterone secretion. Physiologist 4, 27 (1961c).Google Scholar
  209. — R. C. Bahn, and W. C. Ball: Subacute and chronic effects of hypothalamic lesions on aldosterone and sodium excretion. Amer. J. Physiol. 197, 387–390 (1959a).PubMedGoogle Scholar
  210. — — M. J. Goodkind, and W. C. Ball, Jr.: Aldosterone excretion in urine from hypophys. ectomized dogs with thoracic inferior vena cava constriction. Amer. J. Physiol. 191, 329–338 (1957).PubMedGoogle Scholar
  211. — — N. A. Yankopoulos, B. Kliman, and R. E. Peterson: Acute effects of hypophys. ectomy and diencephalic lesions on aldosterone secretion. Amer. J. Physiol. 197, 380–386 (1959b).PubMedGoogle Scholar
  212. —, and W. C. Ball, Jr.: Effects of a body cast on aldosterone and sodium excretion in dogs with experimental ascites. Amer. J. Physiol. 192, 536–542 (1958).Google Scholar
  213. — — R. C. Bahn, and M. J. Goodking: Relationship of adrenocortical and anterior pitui. tary function to fecal excretion of sodium and potassium. Amer. J. Physiol. 196, 149–152 (1959c)PubMedGoogle Scholar
  214. — C. C. J. Carpenter, and C. R. Ayers: Relation of renin and angiotensin II to the control of aldosterone secretion. Circulat. Res. 11, 171–184 (1962a).PubMedGoogle Scholar
  215. —, and R. C. Bahn: Relation of anteroir pituitary function to aldosterone and corticosterone secretion in conscious dogs. Amer. J. Physiol. 199, 212–216 (1960a).PubMedGoogle Scholar
  216. — — — J. E. Holman, and R. C. Bahn: Evidence for secretion of an aldosterone-stimulating hormone by the kidney. J. clin. Invest. 40, 684–696 (1961d).PubMedGoogle Scholar
  217. — P. H. Hartroft, E. O. Titus, C. C. J. Carpenter, C. R. Ayers, and M. E. Spiegel: The role of the renin-angiotensin system in the control of aldosterone secretion. J. clin. Invest. 41, 378–389 (1962b).PubMedGoogle Scholar
  218. — J. E. Holman, C. C. J. Carpenter, J. Urquhart, and J. T. Higgins, Jr.: The extra-adrenal factor essential for chronic renal sodium retention in the presence of increased sodium.retaining hormone. Circulat. Res. 14, 17–31 (1964a).PubMedGoogle Scholar
  219. — D. S. Howell, and R. E. Hyatt: Effect of chronic pitressin administration on electrolyte excretion in normal dogs and in dogs with experimental ascites. Endocrinology 55, 409–416 (1954).PubMedGoogle Scholar
  220. — B. Kliman, N. A. Yankopoulos, and R. E. Peterson: Increased aldosterone secretion following acute constriction of the inferior vena cava. J. clin. Invest. 27, 1783–1790 (1958).Google Scholar
  221. — J. Urquhart, and J. T. Higgins, Jr.: The effects of alterations of plasma sodium and potassium concentration on aldosterone secretion. J. clin. Invest. 42, 597–609 (1963).PubMedGoogle Scholar
  222. — — — Renin, angiotensin and aldosterone in experimental secondary hyperaldosteronism. Canad. med. Ass. J. 90, 245–248 (1964b).PubMedGoogle Scholar
  223. — — — E. Rubin, and P. M. Hartroft: Hypersecretion of aldosterone in dogs with a chronic-caval fistula and high output heart failure. Circulat. Res. 14, 471–485 (1964c).PubMedGoogle Scholar
  224. — N. A. Yankopoulos, and J. Holman: Chronic effects of carotid sinus denervation, cervical vagotomy and aortic depressor nerve section on aldosterone and sodium excretion. Amer. J. Physiol. 197, 207–210 (1959d).PubMedGoogle Scholar
  225. Davis, J.O., N. A. Yankopoulos, F. Lieberman, J. Holman, and R. C. Bahn: The role of the anterior pituitary in the control of aldosterone secretion in experimental secondary hyperaldosteronism. J. clin. Invest. 39, 765–775 (1960b).PubMedGoogle Scholar
  226. Davis, L., E. Fischer, R. Brechner, and A. S. Biddle: Effect of hypotensive drugs and hypophysectomy upon the adrenal cortex of normal and hypertensive dogs. Ann. Surg. 153, 877–886 (1961).PubMedGoogle Scholar
  227. Deane, H. W.: Physiological regulation of the zona glomerulosa of the rat’s adrenal cortex, as revealed by cytochemical observations. In: R. C. christman (ed.), Pituitary-adrenal function, p. 31–38. Washington: Amer. Ass. Advanc. Sci. 1951.Google Scholar
  228. —, and A. C. Barger: Histophysiology of the adrenal cortex in dogs with mild and severe cardiac damage. Endocrinology 61,758–764 (1957).PubMedGoogle Scholar
  229. —, and R. O. Greep: A morphological and histochemical study of the rat’s adrenal cortex after hypophysectomy, with comments on the liver. Amer. J. Anat. 19, 112–146 (1946).Google Scholar
  230. — — A cytochemical study of the adrenal cortex in hypo- and hyperthyroidism. Endocrinology 41, 243–257 (1947).PubMedGoogle Scholar
  231. — F. G. Hofmann, A. K. Solomon, and G. B. Wislocki: Selective uptake of silver by the adrenal zona glomerulosa. Anat. Rec. 121, 283 (1955).Google Scholar
  232. —, and G. M. C. Masson: Adrenal cortical changes in rats with various types of experimental hypertension. J. clin. Endocr. 11, 193–208 (1951).PubMedGoogle Scholar
  233. — R. H. Schneiweiss, and L. I. Gidez: Response of rat zona glomerulosa in experimental nephrosis. Proc. Soc. exp. Biol. (N. Y.) 104, 417–419 (1960).Google Scholar
  234. — J. H. Shaw, and R. O. Greep: The effect of altered sodium or potassium intake on the width and cytochemistry of the zona glomerulosa of the rat’s adrenal cortex. Endocrinology 43, 133–153 (1948).PubMedGoogle Scholar
  235. Del Greco, F.: Effects of valine-5 angiotensin II on excretion of water and salt in primary and secondary hypertension. Proc. Soc. exp. Biol. (N. Y.) 107, 943–946 (1961).Google Scholar
  236. — Comparative effect of valine-5 angiotensin II amide and pitressin on renal excretory function in diabetes insipidus. Proc. Soc. exp. Biol. (N. Y.) 109, 105–110 (1962).Google Scholar
  237. —, and I. H. Page: Effects of intrarenal infusion of angiotensin in the dog. Circulation 24, 917 (1961).Google Scholar
  238. Delost, P., H. Delost et T. Terroine: Involution de la zone glomerulée surrénalienne dans la carence en B1 J. Physiol. (Paris) 51, 445–446 (1959).Google Scholar
  239. Deming, Q. B., and J. A. Leutscher, Jr.: Bioassay of desoxycorticosteronelike material in urine. Proc. Soc. exp. Biol. (N.Y.) 73, 171–175 (1950).Google Scholar
  240. Ddemopoulos, H. B., and G. Kaley: The role of renal juxtaglomerular cells in the elaboration of erythropoietin. Fed. Proc. 23, 183 (1964).Google Scholar
  241. Denton, D. A., J. R. Goding, and R. D. Wright: Control of adrenal secretion of electrolyteactive steroids. Brit. med. J. 1959 II, 447–456, 522–530.Google Scholar
  242. — — — The control of aldosterone secretion. In: E. B. astwood (ed.), Clinical endocrinology, I, p. 373–396. New York: Grune & Stratton 1960.Google Scholar
  243. Deodhar, S. D.: Immunological production of anti-angiotensin. I. Preparation of angiotensin-protein complex antigen. J. exp Med. 111, 419–427 (1960a).PubMedGoogle Scholar
  244. — Immunological production of anti-angiotensin. II. Production and detection of antiangiotensin. J. exp Med. 111, 429–439 (1960b).PubMedGoogle Scholar
  245. Dexter, L.: Mechanism of human hypertension. Amer. J. Med. 4, 279–284 (1948).PubMedGoogle Scholar
  246. Doe, R. P., E. B. Flink, and M. G. Goodsell: Relation of diurnal variation in 17-OH-corticosteroid levels in blood and urine to eosinophils and electrolyte excretion. J. clin. Endocr. 16, 196–206 (1956).PubMedGoogle Scholar
  247. Ddougherty, T. F.: Relation of adrenal cortical stimulation to histological alterations in the kidneys and cardiovascular tissues of mice. Macy Conference on factors regulating blood pressure 2, 17–40 (1948).Google Scholar
  248. Driscol, T. E., M. M. Maultsby, G. L. Farrell, and R. M. Berne: Aldosterone secretion in experimental congestive heart failure. Amer. J. Physiol. 191, 140–144 (1957).PubMedGoogle Scholar
  249. Dumont, A. E., and J. H. Mulholland: Effect of thoracic duct to esophagus shunt in dogs with vena cava constriction. Amer. J. Physiol. 204, 289–290 (1963).Google Scholar
  250. Duncan, L. E., G. W. Liddle, and F. C. Bartter: The effect of changes in body sodium on extracellular fluid volume and aldosterone and sodium excretion by normal and edematous men. J. clin. Invest. 35, 1299–1305 (1956).PubMedGoogle Scholar
  251. Dunihue, F. W., M. Bloomfield, and B. Machanic: Effect of mineralocorticoids and of adrenocorticotrophin on the granularity of juxtaglomerular cells. Endocrinology 72, 963–965 (1963a).Google Scholar
  252. — — and W. van B. Robertson: Effect of reserpine and catecholamines on juxtaglomerular cells in rats fed normal and low sodium diets. Endocrinology 69, 934–938 (1961).PubMedGoogle Scholar
  253. Dunihue, F. W., W. van B. Robertson, and B. Macranic: Effects of adrenal enucleation and of the spirolactone SC 8109 on granularity of rat juxtaglomerular cells. Endocrinology 72, 859–864 (1963b).Google Scholar
  254. Dustan, H. P., I. H. Page, E. F. Poutasse, and L. Wilson: An evaluation of treatment of hypertension associated with occlusive renal arterial disease. Circulation 27, 1018–1027 (1963).Google Scholar
  255. Dyrenfurth, I., A. J. Blair, J. C. Beck, and E. H. Venning: Studies in patients with adrenal cortical hyperfunction. J. clin. Endocr. 20, 735–750 (1960).PubMedGoogle Scholar
  256. — C. H. Stacey, J. C. Beck, and E. H. Venning: Aldosterone excretion in patients with cirrhosis of the liver. Metabolism 6, 544–555 (1957).PubMedGoogle Scholar
  257. —, and E. H. Venning: Studies on the assay of aldosterone: chromatography and chemical determination. Endocrinology 64, 648–663 (1959).PubMedGoogle Scholar
  258. Earle, D. P., R. C. de Bodo, I. L. Schwartz, S. J. Farber, M. Kurtz, and J. Green-Berg: Effect of hypertension on electrolyte and water metabolism in the dog. Proc. Soc. exp. Biol. (N. Y.) 76, 608–612 (1951).Google Scholar
  259. Edelman, R., and P. M. Hartroft: Localization of renin in juxtaglomerular cells of rabbit and dog through the use of fluorescent-antibody technique. Circulat. Res. 9, 1069–1077 (1961).Google Scholar
  260. Egdahl, R. H.: Corticosterone secretion following caval constriction in dogs with isolated pituitaries. Endocrinology 68, 226–231 (1961).PubMedGoogle Scholar
  261. Eilers, E. A., and R. E. Peterson: Control of aldosterone secretion in the rat. Endocrine Society, Abstracts of the 46th Meeting 1964, p. 62.Google Scholar
  262. Eisenstein, A. B.: Effect of sodium chloride feeding on adrenocortical hormone secretion of salt deprived rats. Proc. Soc. exp. Biol. (N. Y.) 101, 850–852 (1959).Google Scholar
  263. —, and I. Strack: Effect of sodium deficiency on secretion of hormones by the rat adrenal cortex. Endocrinology 68, 121–124 (1961).PubMedGoogle Scholar
  264. EndröCZI, E., K. LissáK, and M. Terkeres: Hormonal “feedback” regulation of pituitaryadrenal cortex activity. Acta physiol. Acad. Sci. hung. 18, 291–299 (1961).PubMedGoogle Scholar
  265. Epstein, F. H.: Acute tubular necrosis-acute renal failure. In: T. R. Harrison, R. D. Adams, I. L. Bennett, Jr., W. H. Resnik, G. W. Thorn and M. M. Wintrobe (eds.), Principles of internal medicine, 4th ed. p. 1493–1498. New York: McGraw-Hill 1962.Google Scholar
  266. Erankö, O.: Short term effects of potassium, sodium and ACTH on the histochemistry of the adrenal gland of rats. Acta endocr. (Kbh.) 18, 189–200 (1955).Google Scholar
  267. Fachet, J., E. Stark, K. Vallent, and M. Palkovits: Some observations on the functional interrelation between the thymus and the adrenal cortex. Acta med. Acad. Sci. hung. 18, 461–471 (1962).Google Scholar
  268. FäNGE, R., K. Schmidt-Nielsen, and M. Robinson: Control of secretion from the avian salt gland. Amer. J. Physiol. 195, 321–326 (1958).PubMedGoogle Scholar
  269. Falbriard, A., A. F. Muller, R. Neher et R. S. Mach: Etude des variations de l’aldostér-onurie sous l’effect de surcharges en potassium et de déperditions renales et extrarénales de sel et d’eau. Schweiz. med. Wschr. 85, 1218–1220 (1955).PubMedGoogle Scholar
  270. Falkheden, T.: Renal function following hypophysectomy in man. Acta endocr. (Kbh.) 42, 571–590 (1963).Google Scholar
  271. Farrell, G.: Regulation of aldosterone secretion. Physiol. Rev. 38, 709–728 (1958).PubMedGoogle Scholar
  272. — Steroidogenic properties of extracts of beef diencephalon. Endocrinology 65, 29–33 (1959a).PubMedGoogle Scholar
  273. — The physiological factors which influence the secretion of aldosterone. Recent Progr. Hormone Res. 15, 275–298 (1959b).Google Scholar
  274. — Adrenoglomerulotropin. Circulation 21, 1009–1015 (1960a).PubMedGoogle Scholar
  275. — Epiphysis cerebri in the control of steroid secretion. Fed. Proc. 19, 601–604 (1960b).PubMedGoogle Scholar
  276. — Recent contributions to the study of the role the central nervous system in aldosterone secretion. In: E. E. Baulieu and P. Robel (eds.), Aldosterone. Oxford: Blackwell 1964.Google Scholar
  277. — R. C. Banks, and S. Koletsky: The effect of corticosteroid injection on aldosterone secretion. Endocrinology 58, 104–108 (1956a).PubMedGoogle Scholar
  278. —, and W. M. McIsaac: Adrenoglomerulotropin. Arch. Biochem. 94, 543–544 (1961).PubMedGoogle Scholar
  279. —, and E. W. Rauschkolb: Neural control of endocrine function. Ann. Rev. Med. 12, 323–334 (1961).PubMedGoogle Scholar
  280. — R. S. Rosnagle, and E. W. Rauschkolb: Increased aldosterone secretion in response to blood loss. Circulat. Res. 4, 606–611 (1956b).PubMedGoogle Scholar
  281. —, and P. C. Royce: Secretion of aldosterone by the adrenal of the dog. Effects of hypophy-sectomy and ACTH. Amer. J. Physiol. 182, 269–272 (1955).PubMedGoogle Scholar
  282. — P. C. Royce, E. W. Rauschkolb, and H. Hirschmann: Isolation and identification of aldosterone from adrenal venous blood. Proc. Soc. exp. Biol. (N.Y.) 87, 141–143 (1954).Google Scholar
  283. —, and A. N. Taylor: Neuroendocrine aspects of blood volume regulation. Ann. Rev. Physiol. 24, 471–490 (1962).Google Scholar
  284. Fasoiolo, J. C., and A. C. Taquini: Action of partial ischemia on the renin content of kidneys (in Spanish). Medicina (B. Aires). 10, 452–457 (1950).Google Scholar
  285. —, E. De Vito, and I. Gómez: Renin, hormone of the kidney. Acta physiol. lat.-amer. 12, 348–349 (1962).Google Scholar
  286. —, —, J. C. Romero, and J. M. Cucchi: The renin content of the blood of humans and dogs under several conditions. Canad. med. Ass. J. 90, 206–209 (1964).Google Scholar
  287. Fasola, A. F., and D. M. Helmer: Effect of exercise on renin content of plasma of normotensive and hypertensive subjects. Physiologist 6, 178 (1963).Google Scholar
  288. Fejfar, Z.: Water and electrolyte metabolism in congestive heart failure. Ciba Foundation Colloquium on Aging 4, 271–298 (1958).Google Scholar
  289. Feldberg, W., and G. P. Lewis: Release of adrenaline from cat’s suprarenals by bradykinin and angiotensin. J. Physiol. (Lond.) 167, 46P–47P (1963).Google Scholar
  290. Finkel, M. J.: Human growth hormone. Amer. J. Med. 32, 588–598 (1962).Google Scholar
  291. Finnerty, F. A., G. D. Massero, V. Chupkovich, and J. Tuckman: Evaluation of the pressor, cardiac and renal hemodynamic properties of angiotensin II in man. Circulation 9, 256–263 (1961).Google Scholar
  292. Fisher, E. R., and H. Z. Klein: Effect of renal hypertension in sodium deficient rats on juxtaglomerular index and zona glomerulosa. Proc. Soc. exp. Biol. (N.Y.) 113, 37–39 (1963).Google Scholar
  293. —, —: Effect of sodium on juxtaglomerular index and zona glomerulosa in experimental nephrosis. Proc. Soc. exp. Biol. (N.Y.) 114, 541–544 (1963).Google Scholar
  294. —, E. R, and G. M. C. Masson: Renal lesions in renin proteinuria. Arch. Path. 71, 480–484 (1961).PubMedGoogle Scholar
  295. Fisher, J. W., and J. J. Crook: Influence of several hormones on erythropoiesis and oxygen consumption in the hypophysectomized rat. Blood 19, 557–565 (1962).PubMedGoogle Scholar
  296. Fishman, R. A.: The failure of intracranial pressure-volume changes to influence renal function. J. clin. Invest. 32, 847–851 (1953).PubMedGoogle Scholar
  297. Fitz, A. E., and M. L. Armstrong: Plasma vasoconstrictor activity in patients with renal, malignant, and primary hypertension. Clin. Res. 10, 288 (1962).Google Scholar
  298. Fitzhugh, F. W., R. Huie, and A. J. merrill: Endocrine factors in congestive heart failure. Amer. J. Med. 33, 644 (1952).Google Scholar
  299. Fleming, R., and G. L. Farrell: Aldosterone and hydrocortisone secretion by the denervated adrenal. Endocrinology 59, 360–363 (1958).Google Scholar
  300. Floyer, M. A.: The role of the kidney in the mechanism of experimental hypertension. In: G. E. W. Wolstenholme and M. P. Cameron (eds.), Ciba Symposium on Hypertension, p. 155–171. Boston: Little, Brown & Co. 1954.Google Scholar
  301. Földvári, I. P., E. Czeizel, G. Simon, M. Palkóvits, and P. Kortai: The influence of the sub commissural organ on the resorption of water and electrolytes from the small intestine. Acta physiol. Acad. Sci. hung. 21, 43–50 (1962).Google Scholar
  302. Foglia, V.G., and J.L. Moglia: Action of hypertension on the plasma glucose and potassium (in Spanish). Rev. Soc. argent. Biol. 16, 529–536 (1940).Google Scholar
  303. Fordham, C. C., III, and M. Newton: Response of salt-loaded rats to abrupt withdrawal of salt. Amer. J. Physiol. 205, 467–470 (1963).PubMedGoogle Scholar
  304. Forsham, P. H., V. C. Di Raimondo, F. G. Biglieri, and C. H. Li: Adrenocorticotropic activity of a synthetic nonadecapeptide (NDP) in man. Metabolism 10, 335–338 (1961).PubMedGoogle Scholar
  305. Fortier, C.: Adenohypophysis and adrenal cortex. Ann. Rev. Physiol. 24, 223–258 (1962).Google Scholar
  306. Fourman, P.: The adrenal cortex and the kidney. In: D. A. K. Black (ed.), Renal diseases, p. 213–241. Philadelphia: Davis 1962.Google Scholar
  307. Franken, F. H., u. H. Zimmerman: Aldosterone, cortisol und cortison im Harn und in operativ entfernten Nebennieren bei Patienten mit Cushing-Syndrom. Acta endocr. (Kbh.) 41, 531–545 (1962).Google Scholar
  308. Fredrickson, D. S., R. E. Peterson, and D. Steinberg: Inhibition of adrenocortical steroid secretion by delta-4-cholestenone. Science 127, 704–705 (1958).PubMedGoogle Scholar
  309. Freed, S. C., and S. St. GEORGE: Adrenal cortex in the maintenance of hypertension. Endocrinology 71, 422–424 (1962).PubMedGoogle Scholar
  310. Fregly, M. J., R. L. Brimhall, and O. J. Galindo: Effect of the antithyroid drug, propylthiouracil, on the sodium balance of rats. Endocrinology 71, 693–700 (1962).PubMedGoogle Scholar
  311. Friedman, M., and A. Kaplan: Studies concerning the site of renin formation in the kidney. I. The absence of renin in the aglomerular kidney of the midshipman fish. J. exp Med. 75, 127–134 (1942).PubMedGoogle Scholar
  312. Gabelman, E. H., and P. A. Rondell: Mechanisms effecting the protracted pressor response to angiotensin in nephrectomized rats. Fed. Proc. 23, 514 (1964).Google Scholar
  313. Gann, D. S., and F. C. Bartter: Buffer function of the nerves arising at the thyrocarotid arterial junction in the dog. Amer. J. Physiol. 197, 1229–1232 (1959).PubMedGoogle Scholar
  314. —, —: Increase in aldosterone secretion by acute denervation of the thyrocarotid arterial junction. Amer. J. Physiol. 199, 193–194 (1960).PubMedGoogle Scholar
  315. Gann, D. S., J.F. Cruz, A. G. T. Casper, and F. C. Bartter: Mechanism by which potassium increases aldosterone secretion in the dog. Amer. J. Physiol. 202, 991–996 (1962a).PubMedGoogle Scholar
  316. —, K. L. Gould, and J. V. Mumma: On the role of vagal and carotid receptors in the control of adrenal corticoid secretion in the dog. Clin. Res. 10, 296 (1962b).Google Scholar
  317. —, B. Kingsbury, W. R. Drucker, and R. H. Travis: Diminished adrenal corticoid response to burn and ACTH in the nephrectomized dog. Proc. Soc. exp. Biol. (N.Y.) 108, 99–103 (1961).Google Scholar
  318. —, I. H. Mills, J. F. Cruz, A. G. T. Casper, and F. C. Bartter: On the mechanisms of decrease of aldosterone secretion in the dog. Proc. Soc. exp. Biol. (N.Y.) 105, 158–161 (1960).Google Scholar
  319. —, and E. S. Redgate: Failure of angiotensin to deplete adrenal ascorbic acid. Physiologist 4, 39 (1961).Google Scholar
  320. —, and R. H. Travis: Dissociation of response of aldosterone and hydrocortisone secretion to carotid constriction in the dog. Endocr. Soc. Abstracts, p. 2 (1963).Google Scholar
  321. —, and H. K. Wright: Effects of hemorrhage and extracellular fluid volume depletion on sodium metabolism and urinary concentrating ability. Fed. Proc. 23, 463 (1964).Google Scholar
  322. Ganong, W. F.: The effect of ACTH on adrenal size in hypophysectomized rats after removal of one adrenal. Endocrinology 55, 117–120 (1954).PubMedGoogle Scholar
  323. —: Review of medical physiology. Los Altos, California: Lange Med. Publ. 1963a.Google Scholar
  324. —: The central nervous system and the synthesis and release of adrenocorticotropic hormone. In: A. V. Nalbandov (ed.), Advances in neuroendocrinology, p. 92–148. Urbana: U. Illinois Press 1963b.Google Scholar
  325. —, W. F. Bernhard, and J. D. Mcmurray: The effect of hypothermia on the output of 17–hydroxycorticoids from the adrenal vein in the dog. Surgery 38, 506–512 (1955).PubMedGoogle Scholar
  326. —, A. Boryczka, R. Shackleford, R. N. Clark, and R. P. Converse: Effect of dietary salt restriction on the adrenocortical response to ACTH. Proc. Soc. exp. Biol. (N.Y.) 118, 792–794 (1965b).Google Scholar
  327. —, E. E. van Brunt, T. C. Lee, and E. G. Biglieri: Inhibition of aldosterone-stimulating activity of hog and dog renin by plasma of dogs treated with hog renin. Fed. Proc. 22, 631 (1963a).Google Scholar
  328. —, —, —, and P. J. Mulrow: Inhibition of aldosterone-stimulating activity of hog and dog renin by the plasma of dogs immunized with hog renin. Proc. Soc. exp. Biol. (N.Y.) 112, 1062–1064 (1963b).Google Scholar
  329. —, and P. H. Forsham: Adenohypophysis and adrenal cortex. Ann. Rev. Physiol. 22, 579–614 (1960).Google Scholar
  330. —, T. C. Lee, E. E. van Brunt, and E. G. Biglieri: Aldosterone secretion in dogs immunized with hog renin. Endocrinology 76, 1141 (1965a).PubMedGoogle Scholar
  331. —, A. H. Lieberman, W. J. R. Daily, Y. S. Yuen, P. J. Mulrow, J. A. Luetscher, Jr., and R. E. Bailey: Aldosterone secretion in dogs with hypothalamic lesions. Endocrinology 65, 18–28 (1959).PubMedGoogle Scholar
  332. —, and P. J. Mulrow: Rate of change in sodium and potassium excretion after injection of aldosterone into the aorta and renal artery of the dog. Amer. J. Physiol. 195, 337–342 (1958).PubMedGoogle Scholar
  333. —, and —: Evidence of secretion of an aldosterone-stimulating substance by the kidney. Nature (Lond.) 190, 1115–1116 (1961).Google Scholar
  334. —, and —: The role of the kidney in the adrenocortical response to hemorrhage in hypophysectomized dogs. Endocrinology 70, 182–188 (1962a).PubMedGoogle Scholar
  335. —, and —: The effect of aortic constriction on aldosterone secretion in hypophysectomized dogs. J. clin. Invest. 41, 1503–1508 (1962b).PubMedGoogle Scholar
  336. —, —, A. Boryczka and G. Cera: Evidence for a direct effect of angiotensin II on the adrenal cortex of the dog. Proc. Soc. exp. Biol. (N.Y.) 109, 381–384 (1962).Google Scholar
  337. —, A. M. Nolan, A. Dowdy, and J.A. Luetscher, Jr.: The effect of hypothalamic lesions on adrenal secretion of cortisol, corticosterone, 11-desoxy-cortisol and aldosterone. Endocrinology 68, 169–171 (1961a).PubMedGoogle Scholar
  338. —, Y. S. Yuen, R. S. Stevenson, W. J. R. Daily, and J. M. Davidson: The effect of diencephalic and frontal lobe lesions on sodium metabolism in dogs. Arch. Neurol. 4, 182–189 (1961b).PubMedGoogle Scholar
  339. Garber, B. S., F. W. Mccoy, E. R. Hayes, and B. H. Marks: Pharmacological studies on the renal juxtaglomerular apparatus. Arch. into Pharmacodyn. 121, 275–286 (1959).Google Scholar
  340. Garcia, J. F., and J. C. Schooley: Immunological neutralization of various erythropoietins. Proc. Soc. exp. Biol. (N.Y.) 112, 712–714 (1963).Google Scholar
  341. Gardner, L. I., H. Berman, and H. W. Deane: Metabolic competition between desoxy corticosterone acetate and strophanthin-G in the rat. Endocrinology 55, 417–425 (1954).PubMedGoogle Scholar
  342. Gaskell, J. R., R. K. Jones, and A. P. Shapiro: Hyper-responsiveness of renal hypertensive rats to intravenous angiotensin II. Proc. Soc. exp. Biol. (N.Y.) 115, 179–182 (1964).Google Scholar
  343. Gauer, O. H., and J. P. Henry: Circulatory basis of fluid volume control. Physiol. Rev. 43, 423–481 (1963).PubMedGoogle Scholar
  344. Gault, C. L., and R. E. Ecklund: Significance of aldosterone antagonists in the treatment of edema and ascites. Amer. J. Med. 33, 490–500 (1962).Google Scholar
  345. Gaunt, R., J. J. Chart, and A. A. Renzi: Endocrine pharmacology. Science 133, 613–621 (1961).PubMedGoogle Scholar
  346. Genest, J.: Clinical states associated with abnormal aldosterone excretion. Canad. med. Ass. J. 77, 780–785 (1957).PubMedGoogle Scholar
  347. —, P. Biron, M. Chrétien, R. Boucher, and E. Kiow: Blood angiotensin levels in normal subjects and hypertensive patients. J. clin. Invest. 41, 1360–1361 (1962).Google Scholar
  348. —, —, M. E. Kiow, W. Nowaczynsri, R. Boucher, and M. Chrétien: Studies of the pathogenesis of human hypertension. The adrenal cortex and renal pressor mechanism. Ann. intern. Med. 55, 12–28 (1961a).PubMedGoogle Scholar
  349. —, —, —, —, M. Chrétien, and R. Boucher: Adrenocortical hormones in human hypertension and their relation to angiotensin. Circulat. Res. 9, 775–791 (1961b).PubMedGoogle Scholar
  350. —, R. Boucher, J. De Champlain, R. Veyrat, M. Chrétien, P. Biron, G. Tremblay, P. Roy, and P. Cartier: Studies on the rennin-angiotensin system in hypertensive patients. Canad. med. Ass. J. 90, 263–268 (1964a).PubMedGoogle Scholar
  351. —, —, W. Nowaczynsri, E. Kiow, J. CDe hamplain, P. Biron, M. Chrétien, and J. Marcaurele: Studies on the relation of aldosterone and angiotensin to human hypertensive disease. In: E. E. Baulieu and P. Robel (eds.): Aldosterone. Oxford: Blackwell 1964b.Google Scholar
  352. Gennari, F. J., and P. J. Mulrow: A mechanism for the reversal of experimental hypertension by hypothyroidism. Clin. Res. 10, 400 (1962).Google Scholar
  353. Giacomelli, F.: Über Veränderungen der Nebennierenrinde nach Pinalektomie. Endokrinologie 42, 144–150 (1962).PubMedGoogle Scholar
  354. Gilbert, G. J.: Subcommissural organic secretion in the dehydrated rat. Anat. Rec. 132, 563–568 (1958).PubMedGoogle Scholar
  355. —: The subcommissural organ. Neurology (Minneap.) 10, 138–142 (1960).Google Scholar
  356. Gill, J. R., Jr., D. T. Mason, and F. C. Bartter: Adrenergic nervous system in sodium metabolism: Effects of guanethidine and sodium retaining steroids in normal man. J. clin. Invest. 43, 177–184 (1964).PubMedGoogle Scholar
  357. Gillenwater, J. Y., J. B. Scott, E. D. Frohlich, and F. J. Haddy: Acute chlorthiazide attenuation of the pressor responses to epinephrine, levarterenol and angiotensin in the perfused peripheral vascular bed. Clin. Res. 9, 233 (1961).Google Scholar
  358. Ginn, H. E., and R. Cade: Aldosterone secretion in magnesium deficient rats. Physiologist 4, 40 (1961).Google Scholar
  359. Giordano, G., and R. Balesteri: La glande épiphysaire dans la régulation de la biosyn-thése de l’aldostérone. Ann. Endocr. (Paris) 24, 331–347 (1963).Google Scholar
  360. —, H. A. Samiy, J. Bloom, F. W. Haynes, and J. P. Merrill: Activity of some exzymes in experimental hypertension in the rabbit. Experientia (Basel) 17, 558–560 (1961).Google Scholar
  361. Girerd, R. J., and C. L. Rassaert: Effect of various hormones upon the responsiveness of the hypophysectomized rat to DOCA implantation. Acta endocr. (Kbh.) 42, 337–347 (1963).Google Scholar
  362. Giroud, C. J. P., M. Saffran, A. V. Schally, J. Stachenko, and E. H. Venning: Production of aldosterone by rat adrenal glands in vitro. Proc. Soc. exp. Biol. (N.Y.) 92, 855–859 (1956b).Google Scholar
  363. —, J. Stachenko, and E. H. Venning: Secretion of aldosterone by the zona glomerulosa of rat adrenal glands incubated in vitro. Proc. Soc. exp. Biol. (N.Y.) 92, 154–158 (1956a).Google Scholar
  364. Gláz, E., and K. Sugár: The effect of synthetic angiotensin II on synthesis of aldosterone by the adrenals. J. Endocr. 24, 299–302 (1962).PubMedGoogle Scholar
  365. —, and —: Effect of heparin and heparinoids on the synthesis of aldosterone and corticosteroids by the rat adrenal gland. Endocrinology 74, 159–164 (1964).PubMedGoogle Scholar
  366. Goding, J. R., and D. A. Denton: The responsiveness to sodium depletion in adrenalectomized sheep with parotid fistulae. Aust. J. exp. Biol. med. Sci. 37, 211–238 (1959).PubMedGoogle Scholar
  367. Goeverts, P.: Experiments on the role of vasoconstrictor substances in the mechanism of renal hypertension in dogs. In: G. E. W. Wolstenholme and M. P. Cameron (eds.), Ciba Colloquium on Hypertension, p. 136–147. Boston: Little, Brown 1954.Google Scholar
  368. —. and A. verniory: Vasoconstrictor properties of vena cava blood of dogs with acute and chronic renal hypertension. Acta med. scand., Suppl. 266, 419–428 (1952).Google Scholar
  369. Gold, E. M., E. E. van Brunt, A. D. Daily, A. T. Boryczka, and W. F. Ganong: ACTH content of dog kidneys. Proc. Soc. exp. Biol. (N.Y.) 112, 626–629 (1963).Google Scholar
  370. Goldberg, A. H., and L. S. Lilienfield: Evidence for the existence of a renal vasodilating factor. Circulation 28, 727–728 (1963).Google Scholar
  371. Goldberg, L.I., R.H. Mcdonald Jr., and A.M. Zimmerman: Sodium diuresis produced by dopamine in patients with congestive heart failure. New Engl. J. Med. 269, 1060–1064 (1963).PubMedGoogle Scholar
  372. Goldberg, M., and D. K. Mccurdy: Hyperaldosteronism and hypergranulation of the juxtaglomerular cells in renal hypertension: Metabolic studies. Ann. intern. Med. 59, 24–36 (1963).PubMedGoogle Scholar
  373. Goldblatt, H., Y. J. Katz, H. A. Lewis, and E. Richardson: Studies on experimental hypertension. XX. The bioassay of renin. J. exp Med. 17, 309–313 (1943).Google Scholar
  374. —, H. Lamfrom, and E. Haas: Physiological properties of renin and hypertensin. Amer. J. Physiol. 175, 75–83 (1953).PubMedGoogle Scholar
  375. Goldfarb, B., and L. Ttobian: The inter-relation of hypoxia erythropoietin and the renal juxtaglomerular cell. Proc. Soc. exp. Biol. (N.Y.) 111, 510–511 (1962).Google Scholar
  376. —, —: Effect of high oxygen concentration on erythropoietin and the renal juxtaglomerular cell. Proc. Soc. exp. Biol. (N.Y.) 113, 35–36 (1963).Google Scholar
  377. Goldman, M. D., E. Ronzoni, and H. A. Schroeder: The response of the adrenal cortex of the rat to dietary salt restriction and replacement. Endocrinology 58, 57–61 (1956).PubMedGoogle Scholar
  378. Gollan, F., E. Richardson, and H. Goldblatt: Hypertensin in the systemic blood of animals with experimental renal hypertension. J. exp Med. 88, 389–400 (1948).PubMedGoogle Scholar
  379. Gombos, E. A., W. H. Hulet, P. Bopp, W. Goldring, D. S. Baldwin, and H. Chasis: Reactivity of renal and systemic circulation to vasoconstrictor agents in normotensive and hypertensive subjects. J. clin. Invest. 41, 203–217 (1962).PubMedGoogle Scholar
  380. Gomez, A., S. W. Hoobler, and P. Blaquler: Effect of renal transplantation on adrenocortical hypertension. Physiologist 1, 28 (1958).Google Scholar
  381. Ggomoll, A. W., and H. E. Schmid, Jr.: Urinary excretion of aldosterone in dogs with elevated plasma antirenin titers. Fed. Proc. 23, 301 (1964).Google Scholar
  382. —, and T. R. Sherrod: Inhibitory action of acetyl strophanthidin on the secretion of aldosterone. Fed. Proc. 19, 152 (1960).Google Scholar
  383. Goodkind, M. J., W.C. Ball, Jr., and J. O. Davis: Effect of chronic hemorrhage on urinary aldosterone-like activity and sodium excretion. Amer. J. Physiol. 189, 181–184 (1957).PubMedGoogle Scholar
  384. Goodyer, A. V. N., A. S. Relman, F. D. Lawrason, and F. H. Epstein: Salt retention in cirrhosis of the liver. J. clin. Invest. 29, 973–981 (1950).PubMedGoogle Scholar
  385. Goormaghtigh, N.: La fonction endocrine des arterioles rénales: Son role dans la pathogénie de l’hypertension artérielle. Louvain: Librairie R. Fonteyn 1944.Google Scholar
  386. —: The renal arteriolar changes in the anuric crush syndrome. Amer. J. Path. 23, 513–529 (1947).PubMedGoogle Scholar
  387. Gordon, D. B., and A. Nogueira: Increased vascular reactivity in experimental hypertension. Circulat. Res. 10, 269–273 (1962).PubMedGoogle Scholar
  388. Gordon, E. S., J. J. Chart, D. Hagedorn, and E. G. Shipley: Mechanism of sodium retention in pre-eclamptic toxemia. Obstet. and Gynec. 4, 39–50 (1954).Google Scholar
  389. Gornall, A. G., and C. Guilliam: Aldosterone I. Isolation from adrenocortical extract and a test for its identity. Canad. J. Biochem. 35, 71–78 (1957).PubMedGoogle Scholar
  390. —, —, and A. E. D. Hall: Aldosterone secretion in various clinical states. J. clin. Endocr. 16, 950 (1956).Google Scholar
  391. Gornel, D. L., R. C. Lancestremere, S. Papper, and L. M. Lowenstein: Acute changes in renal excretion of water and solute in patients with Laennec’s cirrhosis induced by the administration of the pressor amine metaraminol. J. clin. Invest. 41, 594–603 (1962).PubMedGoogle Scholar
  392. Gowenlock, A. H., J. N. Mills, and S. Homas: Acute postural changes in aldosterone and electrolyte excretion in man. J. Physiol. (Lond.) 146, 133–141 (1959).Google Scholar
  393. —, and O. Wrong: Hyperaldosteronism secondary to renal ischemia. Quart. J. Med. 31, 323–344 (1962).PubMedGoogle Scholar
  394. Greene, M. A., A. J. Bolfax, M. Niv, and E. S. Soherr: Effects of vasoactive drugs on serum electrolytes in hypertensive and normotensive humans. Proc. Soc. exp. Biol. (N.Y.) 111, 423–427 (1962).Google Scholar
  395. Greenough, W. B. III, E. H. Sonnenblick, V. Januszewicz, and J. H. Laragh: Correction of hyperaldosteronism and of massive fluid retention of unknown cause by sympathicomimetic agents. Amer. J. Med. 33, 603–614 (1962).PubMedGoogle Scholar
  396. Greenway, C. V., and E. B. Verney: The effect of adrenocorticotrophic hormone on the secretion of corticosteroids by the isolated perfused adrenal gland of the dog. J. Physiol. (Lond.) 162, 183–192 (1962).Google Scholar
  397. Greep, R. O., and H. W. Deane: Cytochemical evidence for the cessation of hormone production in the zona glomerulosa of the rat’s adrenal cortex after prolonged treatment with desoxycorticosterone acetate. Endocrinology 40, 417–425 (1947).PubMedGoogle Scholar
  398. Grimson, K. S.: Role of the sympathetic nervous system in experimental neurogenic hypertension. Proc. Soc. exp. Biol. (N.Y.) 44, 219–221 (1940).Google Scholar
  399. —: The sympathetic nervous system in neurogenic renal hypertension: experimental correlation and clinical consideration. Arch. Surg. 43, 284–305 (1941).Google Scholar
  400. Grollman, A.: Antihypertensive and pressor agents of renal origin. Canad. med. Ass. J. 90, 299–302 (1964).PubMedGoogle Scholar
  401. Grollman, A., and C. Rule: Experimentally induced hypertension in parabiotic rats. Amer. J. Physiol. 138, 587–592 (1943).Google Scholar
  402. Gross, F.: Renin und Hypertensin; Physiologische oder pathologische Wirkstoffe. Klin. Wschr. 36, 693–706 (1958).PubMedGoogle Scholar
  403. —: Adrenocortical function and renal pressor mechanism in experimental hypertension. In: K. D. Beck and P. T. Cottier (eds.), Essential hypertension, p. 92–111. Berlin-Göttingen-Heidelberg: Springer 1960.Google Scholar
  404. —: Differentiation of effects mediated by aldosterone and rennin-angiotensin in experimental hypertension. In: E. E. Baulieu and P. Robel (eds.), Aldosterone. Oxford: Blackwell 1964.Google Scholar
  405. —, O. Buschor, and H. Zeugin: Reduction of increased sensitivity to renin by cross circulation. Amer. J. Physiol. 202, 1095–1097 (1962).PubMedGoogle Scholar
  406. —, O. Buschor, and P. Zeugin: Renin in the kidney of rats with aminonucleoside nephrosis. Amer. J. Physiol. 199, 1–4 (1960).PubMedGoogle Scholar
  407. —, and W. D. Dettbarn: Water and salt loading in adrenalectomized dogs treated with cortexone, aldosterone and 9-α-fluorocortisol. Acta endocr. (Kbh.) 22, 335–370 (1956).Google Scholar
  408. —, and P. Lichtlen: Experimental renal hypertension: Renin content of kidneys in intact and adrenalectomized rats given cortexone. Amer. J. Physiol. 195,543–548 (1958a).PubMedGoogle Scholar
  409. —, and —: Pressor substance in kidneys of renal hypertensive rats with and without adrenals. Proc. Soc. exp. Biol. (N.Y.) 98, 431–345 (1958b).Google Scholar
  410. —, P. Loustalot u. F. Susler: Die Bedeutung von Kochsalz für den Cortexon-Hochdruck der Ratte und den Gehalt der Nieren und presserischen Substanzen. Naunyn-Schmiedebergs Arch. exp Path. Pharmak. 229, 381–388 (1956).Google Scholar
  411. —, G. Schaechtclin, H. Brunner, and G. Peter: The role of the renin angiotensin system in blood pressure regulation and kidney function. Canad. med. Ass. J. 90, 258–262 (1964).PubMedGoogle Scholar
  412. —, u. F. Susler: Pressurische Substanzen in den Nieren experimentell hypertonischer Ratten. Naunyn-Schmiedebergs Arch. exp Path. Pharmak. 229, 374–380 (1956).Google Scholar
  413. —, u. —: Der Einfiuß der Nebennieren auf die blutdrucksteigernde Wirkung von Renin und auf pressorische Substanzen in den Nieren. Naunyn-Schmiedebergs Arch. exp Path. Pharmak. 203, 274–283 (1957).Google Scholar
  414. —, and H. Turrian: Pharmacology of hypertensin and synthetic analogues. In: M. Schachter (ed.), Polypeptides which affect smooth muscles, p. 137–151. London: Pergamon 1960.Google Scholar
  415. Haas, E., and H. Goldblatt: Renin content of kidneys in experimental renal and human hypertension. Amer. J. Physiol. 197, 1103–1106 (1959).PubMedGoogle Scholar
  416. —, — and E. C.G ipson: A study of enzymatic and antigenic properties of renin. J. Immunol. 91, 170–178 (1963).PubMedGoogle Scholar
  417. —, H. Lamfrom, and H. Goldblatt: A simple method for the extraction and partial purification of renin. Arch. Biochem. 48, 256–260 (1954).PubMedGoogle Scholar
  418. Halasz, B.: Der zeitliche Ablauf von Veränderungen des Kernvolumens in der Nebennierenrinde. Acta morph. Acad. Sci. hung. 7, 193–198 (1958).Google Scholar
  419. Hamilton, A. S., and D. A. Collins: Role of the kidney in the maintenance of arterial blood pressure in hemorrhage. Amer. J. med. Sci. 202, 914 (1941).Google Scholar
  420. Hamilton, J. G., and A. Grollman: The preparation of renal extracts effective in reducing blood pressure in experimental hypertension. J. Biol. Chem. 233, 528–529 (1958).PubMedGoogle Scholar
  421. Hartroft, P. M.: Juxtaglomerular cells. Circulat. Res. 12, 525–533 (1963).Google Scholar
  422. —, and R. Edelman: Renal juxtaglomerular cells in sodium deficiency. In.: J. Moyer and M. Fuchs (eds.), Edema: Mechanisms and management, p. 63–68. Philadelphia: Saunders 1960.Google Scholar
  423. —., and W. S. Hartroft: Studies on renal juxtaglomerular cells. I. Variations produced by sodium chloride and desoxycorticosterone acetate. J. exp Med. 97, 415–428 (1953).PubMedGoogle Scholar
  424. —., and —: Studies on renal juxtaglomerular cells. II. Correlation of the degree of granulation of juxtaglomerular cells with width of the zona glomerulosa of the adrenal cortex. J. exp Med. 102, 205–212 (1955).PubMedGoogle Scholar
  425. —., and S. D. Hathaway: Effect of pitressin on juxtaglomerular cells and zona glomerulosa of sodium deficient rats. Fed. Proc. 23, 445 (1964).Google Scholar
  426. Hartroft, W. S., and P. M. Hartroft: New approaches in the study of cardiovascular disease: aldosterone, renin, hypertension and juxtaglomerular cells. Fed. Proc. 20, 845–854 (1961).PubMedGoogle Scholar
  427. Hatt, P. Y., Y. Allalre, P. Berjál, J. Chauveau, M. Dvojakovic, H. Kernec, J. Grossetête et H. Guillemot: L’appareil juxtaglomérulaire dans l’hypertension arterielle expérimentale. J. Urol. Nephrol. 68, 544–549 (1962).Google Scholar
  428. Hawthorne, E. W., and M. Gaspar: Antihypertensive effect of hypophysectomy in dogs with hypertension following bilateral carotid sinus constriction. Circulat. Res. 7, 705–708 (1959).PubMedGoogle Scholar
  429. Hawthorne, E. W., S. L. C. Perry, and W. G. Pogue: Development of experimental renal hypertension in the dog following reduction of renal arterial pulse pressure without reducing mean pressure, Amer. J. Physiol. 174, 393–396 (1953).PubMedGoogle Scholar
  430. Hayes, M. A., and I. S. Goldenberg: Renal effects of anesthesia and operation mediated by endocrines. Anesthesiology 24, 487–499 (1963).PubMedGoogle Scholar
  431. Haynes, F. W., L. Dexter, and R. S. Seibel: Renin content of renal venous blood of normal and hypertensive patients at rest. Amer. J. Physiol. 150, 198–201 (1947).PubMedGoogle Scholar
  432. — P. H. Forsham, and D. M. Hume: Effects of ACTH, cortisone, desoxycorticosterone and epinephrine plasma hypertensinogen and renin concentration of dogs. Amer. J. Physiol. 172, 265–275 (1953).PubMedGoogle Scholar
  433. Haynes, R. C., Jr.: The activation of adrenal phosphorylase by the adrenocorticotrophic hormone. J. Biol. Chem. 233, 1220–1222 (1958).PubMedGoogle Scholar
  434. Hebb, C., and R. H. Nimmo-Smith: Partition of potassium between the isolated lung of dog and its perfusate with particular reference to the action of epinephrine. J. Physiol. (Lond.) 105, 1–15 (1946).Google Scholar
  435. Helmer, O. M.: Studies on renin antibodies. Circulation 17, 648–652 (1958).PubMedGoogle Scholar
  436. — Presence of renin in plasma of patients with arterial hypertension. Circulation 25, 169–173 (1962).PubMedGoogle Scholar
  437. — Renin activity in blood from patients with hypertension. Canad. med. Ass. J. 90, 221–225 (1964).PubMedGoogle Scholar
  438. — and W. E. Judson: The quantitative determinations of renin in the plasma of patients with arterial hypertension. Circulation 27, 1050–1060 (1963).PubMedGoogle Scholar
  439. Heni, F., P. Gruner, u. H. Mast: Untersuchungen über Eigenleistung der Nebennierenrinde hypophysektomierter Ratten. Acta endocr. (Kbh.) 11, 229–244 (1952).Google Scholar
  440. Hess, R., and F. Gross: Glucose-6-phosphate dehydrogenase and renin in kidney of hypertensive and adrenalectomized rats. Amer. J. Physiol. 197, 869–872 (1959).Google Scholar
  441. — and A. G. E. Pearse: The significance of renal glucose-6-phosphate dehydrogenase in experimental hypertension in the rat (a histochemical study). Brit. J. exp. Path. 40, 243–249 (1959).PubMedGoogle Scholar
  442. — — Mitochondrial α-glycerophosphate dehydrogenase activity of juxtaglomerular cells in experimental hypertension and adrenal insufficiency. Proc. Soc. exp. Biol. (N.Y.) 106, 895–898 (1961).Google Scholar
  443. Hickler, R. B., D. P. Lauler, C. A. Saravis, A. I. Vagnucci, G. Steiner, and G. W. Thorn: Vasodepressor lipid from the renal medullar. Canad. med. Ass. J. 90, 280–287 (1964).PubMedGoogle Scholar
  444. — —, and G. W. Thorn: Plasma angiotensin activity in patients with hypertension and edema. J. clin. Invest. 42, 635–648 (1963a).PubMedGoogle Scholar
  445. — C. H. Saravis, S. F. Mowbray, D. P. Lauler, A. I. Vagnucci, and G. W. Thorn: Renal medullary vasopressor factor. J. clin. Invest. 42, 942 (1963b).Google Scholar
  446. Higginbotham, R. D., and T. F. Dougherty: Potentiation of polymyxin-B toxicity by ACTH. Proc. Soc. exp. Biol. (N.Y.) 96, 464–470 (1957).Google Scholar
  447. Higgins, J. T., Jr., and J. O. Davis: Hypersecretion of aldosterone in dogs with chronic aortic caval fistula and heart failure. Fed. Proc. 22, 210 (1963).Google Scholar
  448. — and J. Urquhart: Demonstration by pressor and steroidogenic assays of increased renin in lymph of dogs with secondary hyperaldosteronism. Circulat. Res. 14, 218–227 (1964).PubMedGoogle Scholar
  449. Hill, M., M. Pospišil, and K. Dvořák: On the participation of the zona glomerulosa in the adrenal response to stress. Experientia (Basel) 14, 419–421 (1958).Google Scholar
  450. Hill, S.R., Jr., W. G. Hood, Jr., T. A. Farmer, Jr., and J. F. Burnum: Ideopathic edema. New EngI. J. Med. 263, 1342–1345 (1960).Google Scholar
  451. — J. F. Nickerson, S. B. Chenault, J. H. Macneil, W. R. Starnes, and M. C. Gautney: Studies in man on hyper- and hypo-aldosteronism. Arch. intern. Med. 104, 982–994 (1959).PubMedGoogle Scholar
  452. Hirashima, K., and F. Takaku: Experimental studies on erythropoietin: II. The relation between juxtaglomerular cells and erythropoietin. Blood 20, 1–8 (1962).PubMedGoogle Scholar
  453. Hökfelt, B., and B. Sranse: Effect of aldosterone in a case of hypoaldosteronism. Acta endocr. (Kbh.) 33, 511–519 (1960).Google Scholar
  454. Hoff, E. C., J. F. Kell, Jr., and M. N. Carroll, Jr.: Effects of cortical stimulation and lesions on cardiovascular function. Physiol. Rev. 43, 68–114 (1963).PubMedGoogle Scholar
  455. — — N. Hastings, D. M. Sholes, and E. H. Gray: Vasomotor cellular and functional changes produced in kidney by brain stimulation. J. Neurophysiol. 14, 317–332 (1951).PubMedGoogle Scholar
  456. Holmes, W. N., J. G. Phillips, and D. G. Butler: The effect of adrenocortical steroids on the renal and extrarenal responses of the domestic duck (Anas platyrhynchus) after hypertonic saline loading. Endocrinology 69, 483–495 (1961).PubMedGoogle Scholar
  457. Holzbauer, M.: Aldosterone secretion during operative stress in relation to release of ACTH. J. Physiol. (Lond.) 168, 40P (1963).Google Scholar
  458. Holzbauer, M., and M. Vogt: Rapid changes in aldosterone secretion by the adrenal of the dog. 21st Int. Physiology Congress 1959a, p. 128.Google Scholar
  459. — — Observations on the control of the secretion of aldosterone. J. Physiol. (Lond.) 148, 13P–14P (1959b).Google Scholar
  460. — — The effect of anoxia produced by removal of red cells on aldosterone secretion from the dog adrenal. J. Physiol. (Lond.) 153, 55P (1960a).Google Scholar
  461. — — Corticosteroids in plasma and cells of adrenal venous blood. J. Physiol. (Lond.) 157, 137–156 (1960b).Google Scholar
  462. — — Splanchnotomy and aldosterone secretion. J. Physiol. (Lond.) 165, 21P (1963).Google Scholar
  463. Hoobler, S., J. Schroeder, P. Blaqmer, and V. Demerjian: Further studies on the mechanism whereby nephrectomy augments the pressor response to renin. Canad. med. Ass. J. 90, 227–231 (1964).PubMedGoogle Scholar
  464. Houck, C. R.: Alterations in renal hemodynamics and function during the intravenous injection of epinephrine in the dog. Amer. J. Physiol. 166, 649–657 (1951a).Google Scholar
  465. — Alterations in renal hemodynamics and function in separate kidneys during stimulation of renal artery nerves in dogs. Amer. J. Physiol. 167, 523–530 (1951b).PubMedGoogle Scholar
  466. Houdas, Y., et J. C. Favarel-Garrigues: La régulation physiologique de la sécrétion de l’aldostérone: problémes actuels. Path. et Biol. 11, 779–788 (1963).Google Scholar
  467. Howard, J. E.: Hypertension as related to renal ischemia. George Brown Memorial Lecture. Circulation 24, 657–665 (1964).Google Scholar
  468. Howell, D. S., J. O. Davis, and G. L. Lacquer: Effect of hypophysectomy on electrolyte excretion in dogs with ascites produced by thoracic inferior vena cava constriction. Circulat. Res. 3, 264–273 (1955).PubMedGoogle Scholar
  469. Hudson, J. B., A. V. Chabanian, and A. S. Relman: Hypoaldosteronism: a clinical study of a patient with an isolated adrenal mineralocorticoid deficiency, resulting in hyperkalemia and Stokes-Adams attacks. New Engl. J. Med. 257, 529–536 (1957).PubMedGoogle Scholar
  470. Huidobro, F., and E. Braun-Menéndez: The secretion of renin by the intact kidney. Amer. J. Physiol. 127, 47–55 (1942).Google Scholar
  471. Huidobro, H. V., and A. C. Paladini: Potentiation of angiotensin action on smooth muscle by alkaline pH. Experientia (Basel) 19, 572–573 (1963).Google Scholar
  472. Hume, D. M.: Hypothalamic localization of the control of various endocrine secretions. In: H. H. Jasper, L. D. Procter, R. S. Knighton, W. C. Noshay, and R. T. Castello (eds.), Reticular formation of the brain, p. 111–142. Boston: Little, Brown 1958a.Google Scholar
  473. — The method of hypothalamic regulation of pituitary and adrenal secretion in response to trauma. In: S. Curri and L. Martini (eds.), Pathophysiologica diencephalica, p. 217–228. Wien: Springer 1958b.Google Scholar
  474. — C. C. Bell, and F. Bartter: Direct measurement of adrenal secretion during operative trauma and convalescence. Surgery 52, 174–187 (1962).PubMedGoogle Scholar
  475. —, and D. H. Nelson: Adrenocortical function in surgical shock. Surg. Forum 5, 568–575 (1955).PubMedGoogle Scholar
  476. Hungerford, G. F.: The effect of age in determining the adrenal response to a low sodium diet. Anat. Rec. 133, 394–395 (1959).Google Scholar
  477. —, and H. M. Panagiotis: Response of pineal lipid to hormone imbalances. Endocrinology 71, 936–942 (1962).PubMedGoogle Scholar
  478. Ikos, D., R. Luft, and C. A. Gemzell: The effect of human growth hormone in man. Acta endocr. (Kbh.) 32, 341–361 (1959).Google Scholar
  479. Ingle, D. J., G. M. Higgins, and E. C. Kendall: Atrophy of the adrenal cortex in the rat produced by administration of large amounts of cortin. Anat. Rec. 71, 363–372 (1938).Google Scholar
  480. Itskovitz, H. D., E. A. Hildreth, A. M. Sellers, and W. S. Blakemore: The granularity of the juxtaglomerular cells in human hypertension. Ann. intern. Med. 59, 8–22 (1963).PubMedGoogle Scholar
  481. Jablons, B., M. Kolak, A. H. W. Wolfson, and M. Lion: Inhibitory effect of kidney derived vasodilator, tubulin, on pressor response to aldosterone in humans. Circulation 26, 736–737 (1962).Google Scholar
  482. Jacobs, D. R., J. van der Poll, L. Gabrilove, and L. J. Soffer: 17.Hydroxyprogesterone-a salt-losing steroid: relation to congenital adrenal hyperplasia. J. clin. Endocr. 21, 909–922 (1961).PubMedGoogle Scholar
  483. — and J. B. Posner: Isolated hypoaldosteronism manifested by periodic paralysis, hyper. kalemia and salt-losing tendency. Clin. Res. 10, 250 (1962).Google Scholar
  484. Jaoobson, L. O.: Erythropoietin and the regulation of the red blood cell formation. Physiol. Physicians 1, No 8 (1963).Google Scholar
  485. —, and M. Doyle: Erythropoiesis. New York: Grune & Stratton 1963.Google Scholar
  486. Jessiliman, A. G., D. D. Matson, and F. D. Moore: Hypophysectomy in the treatment of breast cancer. New Engl. J. Med. 261, 1199–1207 (1959).PubMedGoogle Scholar
  487. Johnson, B. B.: Bioassay of adrenal cortical steroids on the basis of electrolyte excretion by rats: effects of 11-desoxy- and 11-oxy-steroids. Endocrinology 54, 196–208 (1954).PubMedGoogle Scholar
  488. Johnson, B. B., A. H. Lieberman, and P. J. Mulrow: Aldosterone excretion in normal subjects depleted of sodium and potassium. J. clin. Invest. 36, 757–766 (1957).PubMedGoogle Scholar
  489. Johnson, H. C., and K. M. Browne: Cerebral cortical ablations in dogs with chronic renal hypertension. J. Neurophysiol. 17, 183–188 (1954).PubMedGoogle Scholar
  490. Johnston, C. I., and A. D. Jose: Reduced vascular response to angiotensin II in secondary hyperaldosteronism. J. clin. Invest. 42, 1411–1420 (1963).PubMedGoogle Scholar
  491. Jones, F. M., R. Lloyd-Jones, A. Riondel, J. F. Tait, S. A. S. TAit, R. D. Bulbrook, and F. C. Greenwood: Aldosterone secretion and metabolism in normal men and women and in pregnancy. Acta endocr. (Kbh.) 30, 321–342 (1959).Google Scholar
  492. Jones, N. F., and M. A. Barraclough: Angiotensin. Response of the kidneys in unilateral renal artery stenosis. Lancet 1962 I, 454–457.Google Scholar
  493. — —, and I. H. Mills: The mechanism of increased sodium excretion during water loading with 2.5% dextrose and vasopressin. Clin. Sci. 25, 449–457 (1963).PubMedGoogle Scholar
  494. Jouan, P.: Action de l’épiphyse sur la sécrétion in vitro de l’aldostérone par les surrénales du rat. C. R. Acad. Sci. (Paris) 204, 2680–2682 (1962a).Google Scholar
  495. — Action de l’adrénoglomérulotrophine sur la corticoidegenése in vitro chez le rat. C. R. Soc. Biol. (Paris) 156, 1567–1569 (1962b).Google Scholar
  496. — Epiphyse, 5-hydroxytryptamine et corticoidogenése in vitro. Ann. Endocr. (Paris) 24, 365–370 (1963).Google Scholar
  497. Judson, W. E.: Pressor activity of dialyzed plasma of patients with primary and secondary (renal) hypertension. Amer. J. Cardiol. 9, 710–715 (1962).PubMedGoogle Scholar
  498. Jungmann, P., u. E. Meyer: Experimentelle Untersuchungen über die Abhängigkeit der Nierenfunktion vom Nervensystem. Naunyn-Schmiedebergs. Arch. exp. Path. Pharmak. 73, 49–80 (1913).Google Scholar
  499. Kahn, J.R., L. T. Skeggs, Jr., N. P. Shumway, and P. E. Wisenbaugh: The assay of hypertensin from the arterial blood of normotensive and hypertensive human beings. J. exp. Med. 95, 523–529 (1952).PubMedGoogle Scholar
  500. Kalant, N., D. das Gupta, R. Despointes, and C. J. P. Giroud: Mechanism of edema in experimental nephrosis. Amer. J. Physiol. 202, 91–96 (1962).PubMedGoogle Scholar
  501. Kaplan, N. M.: Comparison of aldosterone secretion and excretion measurements. Clin. Res. 11, 221 (1963).Google Scholar
  502. — and F. C. Bartter: The effect of ACTH, renin, angiotensin II and various precursors on biosynthesis of aldosterone by adrenal slices. J. clin. Invest. 41, 715–724 (1962).PubMedGoogle Scholar
  503. — and J. G. Silah: The effect of angiotensin II on the blood pressure in humans with hypertensive disease. J. clin. Invest. 43, 659–669 (1964).PubMedGoogle Scholar
  504. Katz, Y. J.: Angiotensin and the kidney. Lancet 1961 I, 1006.Google Scholar
  505. — S. Bernick, P. R. Patek, R. de Hoyos, and R. S. Moore: The inter-relation of angiotensin and aldosterone on kidney renin. Physiologist 5, 165 (1962a).Google Scholar
  506. —, and A. T. K. Cockett: Elevation of inferior vena cava pressure and thoracic lymph and urine flow. Circulat. Res. 7, 118–122 (1959).PubMedGoogle Scholar
  507. — R. S. Moore, A. M. Velasquez, and I. T. Tamersaltis: Angiotensin pressor inhibition by aldosterone in the rabbit. Science 141, 725–726 (1963).PubMedGoogle Scholar
  508. — P. R. Patek, and S. Bernick: Effect of angiotensin on juxtaglomerular cells and vessels of the kidney. Circulat. Res. 11, 955–960 (1962b).PubMedGoogle Scholar
  509. Keeler, R., and H. Schnieden: Investigation of the mechanism of diuresis produced in the rat by an intravenous infusion of isotonic solution of sodium chloride. Amer. J. Physiol. 195, 137–141 (1958).PubMedGoogle Scholar
  510. Keller, A., L. E. Piotti et J. D. Romani: Nouvelles preuves de l’activité adréno-glomérulotrope de l’extrait epiphysaire. Ann. Endocr. (Paris) 22, 82–86 (1961).Google Scholar
  511. Kelly, D. E.: Pineal organs: photoreception, secretion and development. Amer. Scientist 50, 597–625 (1962).Google Scholar
  512. Kempner, W.: Treatment of hypertensive vascular disease with rice diet. Amer. J. Med. 4, 545–554 (1948).PubMedGoogle Scholar
  513. Kennedy, A., D. Kilshaw, N. C. R. W. Reid, and W. H. Taylor: Pineal enlargement with hypernatremia, hypokalemic alkalosis and thyrotoxicosis. Brit. med. J. 1962 II, 641–644.Google Scholar
  514. Khairallah, P. A., F. M. Bumpus, I. H. Page, and R. R. Smeby: Unitage and suggested designation of angiotensin activity. Nature (Lond.) 196, 1059–1061 (1962).Google Scholar
  515. — — — — Angiotensinase with a high degree of specificity in plasma and red cells. Science 140, 672–674 (1963a).PubMedGoogle Scholar
  516. — I. H. Page, F. M. Bumpus, and R. R. Smeby: Angiotensin II: Its metabolic fate. Science 138, 523–525 (1963b).Google Scholar
  517. Kilburn, K. H., and H. O. Sieker: Effect of continuous positive and negative pressure breathing on intrathoracic hemodynamics in man. Circulation 18, 741 (1958).Google Scholar
  518. Kitay, J. I., and M. D. Altschule: The pineal gland. Cambridge (Mass.): Harvard University Press 1954.Google Scholar
  519. Kittinger, G. W., B. C. Wexler, and B. F. Miller: Effect of aldosterone antagonism on in vitro production of aldosterone and corticosterone in rats. Proc. Soc. exp. Biol. (N.Y.) 105, 394–395 (1960).Google Scholar
  520. Klein, R., P. Taylor, C. Papadatos, Z. Laron, D. Keele, J. Fortunato, C. Byers, and C. Billings: Sodium losing material in human urine. Proc. Soc. exp. Biol. (N.Y.) 98, 863–866 (1958).Google Scholar
  521. Kliman, B., and R. E. Peterson: Double isotope derivative assay of aldosterone in biological extracts. J. Biol. Chem. 235, 1639–1648 (1960).PubMedGoogle Scholar
  522. — J. Rahill, and F. C. Bartter: Alterations in aldosterone secretion during sustained, maximal ACTH treatment. Endocr. Soc. Abstract 74 (1961).Google Scholar
  523. Knigge, K. M.: Response of the hamster’s adrenal cortex to desoxycorticosterone acetate, with observations on the kidney, thyroid and hypophysis. Endocrinology 55, 731–744 (1954).Google Scholar
  524. Knobil, E., and R. O. Greep: Serum electrolytes in the hypophysectomized rhesus monkey. Endocrinology 62, 61–63 (1958).PubMedGoogle Scholar
  525. — and J. Hotchkiss: Growth hormone. Ann. Rev. Physiol. 26, 47–74 (1964).Google Scholar
  526. — A. Morse, F. G. Hofmann, and R. O. Greep: A histologic and histochemical study of hypophyseal-adrenocortical relationships in the rhesus monkey. Acta endocr. (Kbh.) 17, 229–238 (1954).Google Scholar
  527. Kohlstaedt, K. G., and I. H. Page: The liberation of renin by perfusion of kidneys following reduction in pulse pressure. J. exp Med. 72, 201–216 (1940).PubMedGoogle Scholar
  528. Koletsky, S., and W. H. Prichard: Vasopressor material in experimental hypertension. Circulat. Res. 13, 552–556 (1963).PubMedGoogle Scholar
  529. Kolff, W. J.: Discussion in Circulation 17, 676–679 (1958).Google Scholar
  530. Kolman, S. N.: Improvement of hypertensive and uremic states in dogs when subjected to chronic lymphatic shunts. Physiologist 5, 169 (1962).Google Scholar
  531. Kornel, L.: Kidney, adrenal cortex and hypertension. Arch. intern. Med. 103, 820–831 (1959).Google Scholar
  532. Korner, P. I.: Effects of low oxygen and of carbon monoxide on the renal circulation in unanesthetized rabbits. Circulat. Res. 12, 361–374 (1963).PubMedGoogle Scholar
  533. Kottke, F. J., W. G. Kubicek, and M. B. Visscher: The production of arterial hypertension by chronic renal artery nerve stimulation. Amer. J. Physiol. 145, 38–47 (1945).PubMedGoogle Scholar
  534. Kovách, A. G. B., M. Földi, N. Papp, D. S. Róheim, and E. Koltay: Cerebral regulation of sodium excretion. Lancet 1959 I, 338–339.Google Scholar
  535. Kovács, K., M. A. Dávid, and P. Weisz: Aldosteronotrophic and corticosteronotrophic substances in normal human brain. Med. exp. 3, 113–116 (1960).PubMedGoogle Scholar
  536. Kramer, A. A., and Y. A. Serebrovskaya: Renin activity in the kidneys in vascular hypertension and in symptomatic renal hypertension [in Russian]. Ter. Arkh. 34, 14–17 (1962).PubMedGoogle Scholar
  537. Kremen, S. H., and G. E. Wakerlin: Renin and antirenin in the treatment of long-term experimental renal hypertension in the dog. Proc. Soc. exp. Biol. (N.Y.) 90, 99–101 (1955).Google Scholar
  538. Krieger, D. T., A. Saite, and H. P. Krieger: Aldosterone excretion in disease of the pretectum. Lancet 1961 II, 567–570.Google Scholar
  539. Kubicek, W. G., F. J. Kottke, D. J. Laker, and M. B. Visscher: Renal function during arterial hypertension produced by chronic splanchnic nerve stimulation in the dog. Amer. J. Physiol. 174, 397–400 (1953).PubMedGoogle Scholar
  540. —, and A. P. Thal: Diverting renal and adrenal vein blood into liver and renal hypertension in dogs. Amer. J. Physiol. 205, 1275–1278 (1963).PubMedGoogle Scholar
  541. Kukuchi, S.: Hypertension and aldosterone. II. Urinary aldosterone in human arterial hypertension [in Japanese]. Folia endocr. jap. 36, 1371–1378 (1960).Google Scholar
  542. Kumar, D., L. A. W. Feltram, and A. G. Gornall: Aldosterone excretion and tissue electrolytes in normal pregnancy and pre-eclampsia. Lancet 1959 I, 541–545.Google Scholar
  543. Laidlaw, J. C., J. L. Ruse, and A. G. Gornall: The influence of estrogen and progesterone on aldosterone excretion. J. clin. Endocr. 22, 161–171 (1962).PubMedGoogle Scholar
  544. — E. R. Yendt, C. E. Bird, and A. G. Gornall: Hypertension due to renal artery occlusion simulating primary aldosteronism. Canad. med. Ass. J. 90, 321–325 (1964).PubMedGoogle Scholar
  545. —, and A. G. Gornall: Hypertension caused by renal artery occlusion simulating primary aldosteronism. Metabolism 9, 612–623 (1960).PubMedGoogle Scholar
  546. Lambrew, C. T., S. T. Carver, R. E. Peterson, and M. Horwith: Hypoaldosteronism as a cause of hyperkalemia and syncopal attacks in a patient with complete heart block. Amer. J. Med. 31, 81–85 (1961).PubMedGoogle Scholar
  547. Lamfrom, H., E. Haas, and H. Goldblatt: Studies on antirenin. Amer. J. Physiol. 177, 55–64 (1959).Google Scholar
  548. Lamson, E. T., F. Elmadjian, J. M. Hope, G. Pincus, and D. Jorjorian: Aldosterone excretion in normal, schizophrenic and psychoneurotic subjects. J. clin. Endocr. 16, 954 (1956).Google Scholar
  549. Landau, R. L., and K. Lugibihl: Inhibition of the sodium retaining influence of aldosterone by progesterone. J. clin. Endocr. 18, 1237–1245 (1958).PubMedGoogle Scholar
  550. Lane, N., and R. C. de Bodo: Generalized adrenal cortical atrophy in hypophysectomized dogs and correlated functional studies. Amer. J. Physiol. 168, 1–19 (1952).PubMedGoogle Scholar
  551. Langford, H. G.: Tubular action of angiotensin. Canad. med. Ass. J. 90, 332–333 (1964).PubMedGoogle Scholar
  552. —, and F. Allison, Jr.: Arteriolar changes in renin tachyphylaxis. Amer. J. Physiol. 200, 130–132 (1961).PubMedGoogle Scholar
  553. — L. H. Day, T. Conner, and J. E. Howard: A pressor substance, probably angiotensin, found in renal venous blood. Clin. Res. 9, 57 (1961).Google Scholar
  554. — and M. E. Fallis: Tubular effect of angiotensin. Circulation 28, 754 (1963).Google Scholar
  555. — J. Mayfield, and O. Irby: Direct pressor role of ischemic kidney in renal hypertension. Clin. Res. 10, 251 (1962).Google Scholar
  556. — and G. W. Pickering: The diuretic action of angiotensin. Clin. Res. 11, 68 (1963).Google Scholar
  557. Lanthier, A., and C. E. Grignon: Clinical studies on the control of sodium and water metabolism in panhypopituitarism. Amer. J. med. Sci. 236, 353–361 (1958).PubMedGoogle Scholar
  558. Laragh, J. H.: The role of aldosterone in man. J. Amer. med. Ass. 174, 293–295 (1960).Google Scholar
  559. — Relation of aldosterone secretion to hypertensive vascular disease. Circulat. Res. 9, 792–802 (1961).PubMedGoogle Scholar
  560. — Interrelationship between angiotensin, norepinephrine, epinephrine, aldosterone secretion and electrolyte metabolism in man. Circulation 25, 203–211 (1962a).PubMedGoogle Scholar
  561. — Hormones and the pathogenesis of congestive heart failure: vasopressin, aldosterone and angiotensin II. Circulation 24, 1015–1032 (1962b).Google Scholar
  562. — M. Angers, W. G. Kelly, and S. Lieberman: Hypotensive agents and pressor substances. J. Amer. med. Ass. 174, 234–240 (1960a).Google Scholar
  563. — P. J. Cannon, and R. P. Ames: Aldosterone secretion and various forms of hypertensive vascular disease. Ann. intern. Med. 59, 117–119 (1963a).PubMedGoogle Scholar
  564. — —, and R. P. Ames: Aldosteronism: Factors controlling secretion of the hormone. In: E. E. Baulieu and P. Robel (eds.), Aldosterone. Oxford: Blackwell 1964a.Google Scholar
  565. — — — Interaction between aldosterone secretion, sodium and potassium balance and angiotensin activity in man: studies in hypertension and cirrhosis. Canad. med. Ass. J. 90.248–256 (1964b).PubMedGoogle Scholar
  566. — — C. J. Bentzel, A. M. Sicinski, and J. I. Meltzer: Angiotensin II, norepinephrine and renal transport of electrolytes and water in normal man and in cirrhosis with ascites. J. clin. Invest. 42, 1179–1192 (1963b).PubMedGoogle Scholar
  567. —, and H. C. Stoerk: A study of the mechanism of secretion of the sodium-retaining hormone (Aldosterone). J. clin. Invest. 36, 383–392 (1957).PubMedGoogle Scholar
  568. — S. Ulick, B. Januszewicz, Q. B. Deming, W. G. Kelly, and S. Lieberman: Aldosterone secretion and primary and malignant hypertension J. clin. Invest. 39, 1091–1106 (1960b).PubMedGoogle Scholar
  569. — — — W. G. Kelly, and S. Lieberman: Electrolyte metabolism and aldosterone secretion in benign and malignant hypertension. Ann. intern. Med. 53, 259–272 (1960c).PubMedGoogle Scholar
  570. — —, and S. Lieberman: Rate of secretion of aldosterone by the adrenal cortex in normal man and in patients with heart failure, nephrosis and cirrhosis. Circulation 28, 745–746 (1958).Google Scholar
  571. Lauler, D. P., and R. B. Hickler: Angiotensin II influence in adrenalectomized dogs. Clin. Res. 10, 251 (1962).Google Scholar
  572. — A. I. Vagnucci, R. B. Hickler, and G. W. Thorn: Clinical features of sodium retention induced by antihypertensive therapy. Circulation 28, 754–755 (1963).Google Scholar
  573. Laumas, K. R., J. F. Tait, and S. A. S. Tait: The validity of the calculation of secretion rates from the specific activity of a urinary metabolite. Acta endocr. (Kbh.) 36, 265–280 (1961a).Google Scholar
  574. — — — Further considerations on the calculations of secretion rates. A correction. Acta endocr. (Kbh.) 36, 265–280 (1961a).Google Scholar
  575. Laverty, R.: A nervously-mediated action of angiotensin in anesthetized rats. J. Pharm. Pharmacol. 15, 63–68 (1963).Google Scholar
  576. — and F. H. Smirk: Observations on the pathogenesis of spontaneous inherited hypertension and constricted renal artery hypertension in rats. Circulat. Res. 9, 455––463 (1961).PubMedGoogle Scholar
  577. Leaf, A.: The clinical and physiological significance of the serum sodium concentration. New Engl. J. Med. 267, 24–30, 77–83 (1962).PubMedGoogle Scholar
  578. Le Brie, S. J., and H. S. Mayerson: Influence of elevated venous pressure on flow and composition of renal lymph. Amer. J. Physiol. 198, 1037–1040 (1960).Google Scholar
  579. Ledsome, J. R., R. J. Linden, and W. J. O’Conner: The mechanisms by which distension of the left atrium produces diuresis in anesthetized dogs. J. Physiol. (Lond.) 159, 87–100 (1961).Google Scholar
  580. Lee, J. B., R. B. Hickler, C. A. Saravis, and G. W. Thorn: Sustained depressor effect of renal medullary extract in the normotensive rat. Circulat. Res. 13, 359–366 (1963).PubMedGoogle Scholar
  581. Lee, J. B., D. H. Nelson, and G. W. Thorn: The cyclical pattern of renal excretion during the adaptation of normal subjects to desoxycorticosterone induced sodium retention. J. clin. Endocr. 21, 1426–1439 (1961).PubMedGoogle Scholar
  582. Lee, T. C., E. E. Van Brunt, E. G. Biglieri, and W. F. Ganong: Aldosterone secretion in dogs treated with hog renin. Fed. Proc. 23, 301 (1964).Google Scholar
  583. Lemaire, R., et A. Mazer: Influence du séjour en climat désertique sur le taux de l’aldostérone urinaire. C. R. Soc. Biol. (Paris) 115, 583–584 (1961).Google Scholar
  584. Lentz, K. E., L. T. Skeggs, K. R. Woods, J. R. Kahn, and N. P. Shumway: The amino acid composition of hypertensin II and its biochemical relation to hypertensin I. J. exp Med. 104, 183–192 (1956).PubMedGoogle Scholar
  585. Lever, A. F., and W. S. Peart: Renin and angiotensin-like activity in renal lymph. J. Physiol. (Lond.) 160,548–563 (1962).Google Scholar
  586. — and M. Tree: The estimation of renin in rabbit plasma. J. Physiol. (Lond.) 166, 26P–27P (1963).Google Scholar
  587. Levinsky, N. G., and R. C. Lalone: The mechanism of sodium diuresis after saline infusion in the dog. J. clin. Invest. 42, 1261–1276 (1963).PubMedGoogle Scholar
  588. Levitin, H., W. B. Lehmann, G. Pigeon, Y. Warren, and I. S. Goldenberg: The effect of anesthesia and adrenalectomy on the renal response to angiotensin. J. clin. Invest. 42, 951 (1963).Google Scholar
  589. Lewy, F. H., and F. K. Gassmann: Experiments on the hypothalamic nuclei in the regulation of chloride and sugar metabolism. Amer. J. Physiol. 112, 504–510 (1935).Google Scholar
  590. Liddle, G. W., F. C. Bartter, L. E. Duncan, J. K. Barber, and C. Delea: Mechanisms regulating aldosterone production in man. J. clin. Invest. 34, 949–950 (1955b).Google Scholar
  591. — J. Cornfield, A. G. T. Casper, and F. C. Bartter: The physiological basis for a method of assaying aldosterone in extracts of human urine. J. clin. Invest. 34, 1410–1416 (1955a).PubMedGoogle Scholar
  592. — D. Island, E. M. Lance, and A. P. Harris: Alteration of adrenal steroid patterns in man resulting from treatment with a chemical inhibitor of 11-hydroxylation. J. clin. Endocr. 18, 906–912 (1958).PubMedGoogle Scholar
  593. — —, and C. Meader: Normal and abnormal regulation of corticotropin secretion in man. Recent Progr. Hormone Res. 18, 125–166 (1962).Google Scholar
  594. Lieberman, A. H.: Current status of aldosterone in the etiology of edema. Arch. intern. Med. 102, 990–997 (1958).Google Scholar
  595. —, and J. A. Leutscher, Jr.: Stimulation of adrenocortical secretions after air encephalography. J. clin. Invest. 36, 911 (1957).Google Scholar
  596. —, —, Some effects of abnormalities of pituitary, adrenal or thyroid function on excretion of aldosterone and the response to corticotropin or sodium deprivation. J. clin. Endocr. 20, 1004–1016 (1960).PubMedGoogle Scholar
  597. Little, B., J. Bougas, J. F. Tait, and S. A. S. Tait: The hepatic extraction of aldosterone 7-H3 and progesterone 7-H3. Endocr. Soc. Abstracts, 2–3 (1963).Google Scholar
  598. Llaurado, J. G.: Increased secretion of aldosterone immediately after operation. Lancet 1955 I 1295–1298.Google Scholar
  599. — Aldosterone secretion following hypophysectomy in man: relation to urinary sodium/potassium ratio. Metabolism 6, 556–563 (1957).PubMedGoogle Scholar
  600. Lostroh, A. J.: Synergistic effect of somatotrophin with corticotrophin on the adrenal of hypophysectomized rats. Proc. Soc. exp. Biol. (N.Y.) 97, 828–832 (1958).Google Scholar
  601. —, and C. H. Li: Effects of growth hormone and thyroxine on body weight of hypophysectomized C3H mice. Endocrinology 62, 484–492 (1958).PubMedGoogle Scholar
  602. —, and P. Woodward: Changes in the adrenal of the hypophysectomized C3H mouse with α-corticotrophin and growth hormone. Endocrinology 62, 484–492 (1958).PubMedGoogle Scholar
  603. Loyke, H.: Angiotensinogen effect in CCI4-treated experimental hypertension. Clin. Res. 11, 170 (1963).Google Scholar
  604. Lucis, O. J., I. Dyrenfurth, J. C. Beck, and E. H. Venning: In vitro secretion of corticosteroids by rat adrenal. Fed. Proc. 18, 277 (1959).Google Scholar
  605. — —, and E. H. Venning: Effect of various preparations of pituitary and diencephalon on the in vitro secretion of aldosterone and corticosterone by the rat adrenal. Canad. J. Biochem. 39, 901–903 (1961).PubMedGoogle Scholar
  606. —, and E. H. Venning: In vitro and in vivo effect of growth hormone on aldosterone secretion. Canad. J. Biochem. 38, 1069–1075 (1960).PubMedGoogle Scholar
  607. Luetscher, J. A., Jr.: Aldosterone. Advanc. intern. Med. 8, 155–203 (1956a).Google Scholar
  608. — Studies of aldosterone in relation to water and electrolyte balance in man. Recent Progr. Hormone Res. 12, 175–184 (1956b).PubMedGoogle Scholar
  609. — Idiopathic edema with hyperaldosteronuria. In: E. E. Baulieu and P. Robel (eds.), Aldosterone. Oxford: Blackwell 1964.Google Scholar
  610. — C. A. Camargo, A. P. Cohn, A. J. Dowdy, and A. M. Callaghan: Observations on metabolism of aldosterone in man. Ann. intern. Med. 59, 1–7 (1963a).PubMedGoogle Scholar
  611. Luetscher, J.A., Jr., A. P. Cohn, C. A. Camargo, A. J. Dowdy, and A. M. Callaghan: Aldosterone secretion and metabolism in hyperthyroidism and myxedema. J. clin. Endocr. 23, 873–880 (1963b).PubMedGoogle Scholar
  612. — A. J. Dowdy, A. M. Callaghan, and A. P. Cohn: Studies of secretion and metabolism of aldosterone and cortisol. Trans. Ass. Amer. Phycns 75, 293–300 (1962).Google Scholar
  613. — B. B. Johnson, A. Dowdy, J. Hanery, W. Lew, and L. J. Poo: Observations on the sodium-retaining corticoid (aldosterone) in the urine of children and adults in relation to sodium balance and edema. J. clin. Invest. 33, 1441–1446 (1954).PubMedGoogle Scholar
  614. —, and A. H. Lieberman: Aldosterone. Arch. intern. Med. 102, 314–330 (1958).Google Scholar
  615. Lurie, A. O., and W. P. U. Jackson: Aldosteronuria and the edema of kwashiorkor. Amer. J. clin. Nutr. 11, 115–126 (1962).PubMedGoogle Scholar
  616. Maccmi, I A.: In vitro action of mammalian adrenocorticotropin and 5-hydroxytryptamine on adrenocortical secretion in the turtle, snake and bullfrog. Amer. Zool. 3, 548–556 (1963).Google Scholar
  617. Mach, R. S., J. Fabre, A. F. MüLLER, and R. Neher: Oedemes par rétention de chlorure de sodium avec hyperaldosteronurie. Schweiz. med. Wschr. 85, 1229–1234 (1955).PubMedGoogle Scholar
  618. Machado, A. B. M., and C. R. da Silva: Pineal body and urinary sodium excretion in the rat. Experientia (Basel) 19, 264–265 (1963).Google Scholar
  619. MacLean, J. P., M. B. Lipsett, M. C. Li, C. D. West, and O. H. Pearson: Regulation of salt metabolism after hypophysectomy in man. J. clin. Endocr. 17, 346–355 (1957).PubMedGoogle Scholar
  620. Mandel, M. J., and L. A. Sapirstein: Effect of angiotensin infusion on regional blood flow and regional vascular resistance in the rat. Circulat. Res. 10, 807–816 (1962).PubMedGoogle Scholar
  621. Marieb, N. J., and P. J. Mulrow: The response of aldosterone secretion to angiotensin in the rat. Fed. Proc. 23, 300 (1964).Google Scholar
  622. Markley, K., M. Bocanegra, G. Morales, and M. Chiapport: Oral sodium loading in normal individuals. J. clin. Invest. 36, 303–308 (1957).PubMedGoogle Scholar
  623. Marks, B. H., B. G. Garber, and F. W. Mc coy: The juxtaglomerular apparatus as an extra-adrenal site of ACTH action. Proc. Soc. exp. Biol. (N.Y.) 105, 593–595 (1960).Google Scholar
  624. Marks, L. J., R. Chute, J. V. I. O’Sullivan, and T. J. Giovanniello: Observations on the role of the adrenal in the electrolyte response to surgery. Metabolism 10, 610–620 (1961).PubMedGoogle Scholar
  625. Martz, B. L., H. A. Kneubuhler, and O. M. Helmer: Constrictor activity of peripheral blood after renal artery clamping in dogs. Circulation 26, 757 (1962).Google Scholar
  626. Marx, A. J., and H. W. Deane: Histophysiologic changes in the kidney and adrenal cortex in rats on a low sodium diet. Endocrinology 73, 317–328 (1963).PubMedGoogle Scholar
  627. — — T. F. Mowles, and H. Sheppard: Chronic administration of angiotensin in rats; changes in blood pressure, renal and adrenal histophysiology and aldosterone production. Endocrinology 73, 329–337 (1963).PubMedGoogle Scholar
  628. Masson, G. M. C., C. Kashii, and J. C. Panisset: Experimental vascular disease elicited by aldosterone and renin. Endocrinology 71, 505–512 (1962a).PubMedGoogle Scholar
  629. — — — Transfer of experimental hypertension and vascular disease. Circulation 28, 764 (1963).Google Scholar
  630. — — —, and I. H. Page: Relationship of renin content and secretion following treatment with corticosteroids. Circulation 26, 758 (1962b).Google Scholar
  631. — A. Mikasa, and H. Yasuda: Transfer of experimental renal hypertension and vascular disease. Canad. med. Ass. J. 90, 231–235 (1964).PubMedGoogle Scholar
  632. McCaa, C. S., T. Q. Richardson, R. B. Mccaa, L. L. Sulya, and A. C. Guyton: Decreased aldosterone secretion in Goldblatt hypertension. Circulation 28, 765 (1963).Google Scholar
  633. McCall, M. F., and B. Singer: Studies in nephrosis: chemical corticoids, salt-retaining factor and effect of ACTH. J. clin. Endocr. 13, 1157–1168 (1953).PubMedGoogle Scholar
  634. Mccubbin, J. W., and I. H. Page: Renal pressor system and neurogenic control of arterial pressure. Circulat. Res. 12, 553–559 (1963a).Google Scholar
  635. — — Neurogenic component of chronic renal hypertension. Science 139, 210–215 (1963b).PubMedGoogle Scholar
  636. McDonald, I. R., J. R. Goding, and R. D. Wright: Transplantation of the adrenal gland of the sheep to provide access to its blood supply. Aust. J. exp. Biol. med. Sci. 36, 83–96 (1958).PubMedGoogle Scholar
  637. McDonald, R., and M. Reich: Corticosteroid secretion by the autotransplanted adrenal gland of the conscious sheep. J. Physiol. (Lond.) 147, 33–50 (1959).Google Scholar
  638. McGiff, J. C.: Allocation of cardiac output to limb and kidney during hypotensive procedures. Amer. J. Physiol. 205, 541–548 (1963).PubMedGoogle Scholar
  639. —, and H. D. Itskovltz: Reversal of angiotensin vasoconstrictor activity. Circulation 28, 767–768 (1963a).Google Scholar
  640. — — Reversal of angiotensin vasoconstrictor activity during renal ischemia. Clin. Res. 11, 410 (1963b).Google Scholar
  641. McGonigle, D. J., R. S. Seipel, and E. J. Wylie: Renal effect of temporary extensive infrarenal arterial occlusion: an experimental study. Surgery 49, 235–241 (1961).PubMedGoogle Scholar
  642. McQueen, E. G.: The effect of control of blood pressure on vascular reactivity in experimental renal hypertension. Clin. Sci. 21, 133–140 (1961).PubMedGoogle Scholar
  643. —, and R. B. I. Morrison: The effects of synthetic angiotensin and noradrenalin on blood pressure and renal function. Brit. Heart J. 23, 1–6 (1961).PubMedGoogle Scholar
  644. Meakin, J. W., J. Bethune, R. H. Despointes, and D. H. Nelson: The rate of disappearance of ACTH activity from the blood of humans. J. clin. Endocr. 19, 1491–1494 (1959).Google Scholar
  645. Mendlowitz, M., N. E. Naffchi, E. B. Bobrow, R. L. Wolf, and S. E. Gitlow: Effect of aldosterone on digital vascular reactivity to l.norepinephrine, in normotensive, hypertensive and hypotensive patients. Circulation 26, 761 (1962).Google Scholar
  646. Merrill, A. J., J. L. Morrison, and E. S. Brannon: Concentration of renin in renal venous blood in patients with chronic heart failure. Amer. J. Med. 1, 468–472 (1946).PubMedGoogle Scholar
  647. Merrill, J. P.: Diagnosis and treatment of renal hypertension of humoral origin. Anesthesiology 24, 479––486 (1963).PubMedGoogle Scholar
  648. Metaxas, P., and G. M. Bull: The relation between right auricular pulsation and the excretion of water and salt. Clin. Sci. 23, 571–574 (1962).PubMedGoogle Scholar
  649. Meyer, C. J., D. S. Layne, J. F. Tait, and G. Pincus: The binding of aldosterone to plasma proteins in normal, pregnant and steroidtreated women. J. clin. Invest 40, 1663–1671 (1961).PubMedGoogle Scholar
  650. Mialhe-Voloss, C.: Posthypophyse et activité corticotrope. Acta endocr. (Kbh.) 28, Suppi. 35 (1958).Google Scholar
  651. —, et E. E. Baulieu: Étude qualitative des corticostéroides libérés par la surrénale du Rat in vitro sous l’influence des hormones corticotropes antihypophysaire et posthypophysaire. C. R. Acad. Sci. (Paris) 246, 639–642 (1958).Google Scholar
  652. Mikasa, A., and G. M. C. Masson: Effects of renal pressor system during hemorrhagic hypotension. Proc. Soc. exp. Biol. (N. Y.) 106, 315–316 (1961).Google Scholar
  653. Millar, F. K., J. N. Toal, R. H. Brooks, J. O. Davis, and J. White: Increased aldosterone secretion by tumor-bearing rats. Amer. J. Physiol. 205, 189–194 (1963).Google Scholar
  654. Miller, R. A.: Cytological phenomena associated with experimental activity in the adrenal cortex of mice. Amer. J. Anat. 86, 405–437 (1950).PubMedGoogle Scholar
  655. — Hypophyseal and extra-hypophyseal factors affecting glomerular, nucleolar, and nuclear hypertrophy, following enucleation of the adrenal in the rat. Amer. J. Anat. 103, 187–199 (1958).PubMedGoogle Scholar
  656. Miller, T. R., II., W. W. Faloon, and C. W. Lloyd: Divergence in magnesium sodium and potassium excretion during stimulation of endogenous aldosterone production. J. clin. Endocr. 18, 1178–1185 (1958).PubMedGoogle Scholar
  657. Mills, I. H.: Sodium retaining steroids in non-oedematous patients; production of oedema and heart failure. Lancet 1962 I, 1264–1267.Google Scholar
  658. — A. Casper, and F. C. Bartter: On the role of the vagus in the control of aldosterone secretion. Science 128, 1140–1141 (1958).PubMedGoogle Scholar
  659. — H. E. de Wardener, C. J. Harper, and W. F. Clapham: Studies on the afferent mechanism of the sodium chloride diuresis which follows intravenous saline in the dog. Clin. Sci. 21, 259–264 (1961).PubMedGoogle Scholar
  660. Mills, J. N., S. Thomas, and K. S. Williamson: The extent of the adrenal influence upon renal electrolyte excretion in the healthy man on a normal diet, and its contribution to the renal changes on standing. J. Endocr. 23, 365–373 (1962).PubMedGoogle Scholar
  661. Miyabo, S.: The urinary excretion of aldosterone in hypertensive patients (in Japanese). Folia endocr. jap. 36, 1654–1676 (1961).PubMedGoogle Scholar
  662. Moore, F. D.: Common patterns of water and electrolyte change in injury, surgery and disease. New Engl. J. Med. 268, 277–285, 325–333, 377–384, 427–432 (1958).Google Scholar
  663. Moran, W. H., Jr., A. Martinson, and B. Zimmerman: Estimation of aldosterone in small human peripheral venous samples. Surg. Forum 12, 21–22 (1961).PubMedGoogle Scholar
  664. Morris, R. E., Jr., P. A. Ransom, and J. E. Howard: Studies on the relation of angiotensin to hypertension of renal origin. J. clin. Invest. 41, 1386–1387 (1962).Google Scholar
  665. —, and P. R. Robinson: A method for determination of angiotensin II in human blood. Bull. Johns Hopk. Hosp. 114, 127–145 (1964).Google Scholar
  666. — —, and G. A. Schule: The relation of angiotensin to renal hypertension. Canad. med. Ass. J. 90, 272–276 (1964).PubMedGoogle Scholar
  667. MüLLER, A. F.: Wasserhaushalt bei Herzinsuffizienz. Schweiz. med. Wschr. 92, 836–842 (1962a).PubMedGoogle Scholar
  668. — Regulation der aldosterone secretion. Verh. Dtsch. Ges. inn. Med. 281, 529–544 (1962b).Google Scholar
  669. — E. L. Manning, and A. Riondel: Diurnal variation of aldosterone. In: A. F. MüLLER and C. M. O’Connor (eds.), An Int. Symposium on Aldosterone, p. 111–127. London: J. & A. Churchill 1958.Google Scholar
  670. MüLLER, A. F., A. M. Riondel et E. L. Manning: Influence de l’ACTH sur la sécrétion de l’aldosMrone. Helv. med. Acta 23, 572–577 (1956a).PubMedGoogle Scholar
  671. — — — Mechanisms régulateurs de l’aldostérone chez l’homme. Helv. med. Acta 23, 610–618 (1956b).PubMedGoogle Scholar
  672. Muirhead, E. E., E. G. Daniels, E. Booth, W. A. Freyburger, and J. W. Hinman: Medullorenal vasodepressor effect and the antihypertensive function of the kidney. Fed. Proc. 23, 515 (1964).Google Scholar
  673. —, and M. Kosinski: Renal medulla and renoprival hypertension. Relationship between corticorenal (renin) and medullorenal extracts. Circulat. Res. 11, 674–680 (1962).Google Scholar
  674. Muldowney, F. P., and P. Banks: Kaliuretic effect of heparin. Lancet 1960 I, 548–549.Google Scholar
  675. Mulrow, P. J.: The role of the rennin-angiotensin system in the hypertension associated with renal vascular disease. Canad. med. Ass. J. 90, 277–280 (1964).PubMedGoogle Scholar
  676. —, and W. F. Ganong: The effect of hemorrhage upon aldosterone secretion in normal and hypophysectomized dogs. J. clin. Invest. 40, 579–585 (1961a).PubMedGoogle Scholar
  677. — — Stimulation of aldosterone secretion by angiotensin II. Yale J. Biol. Med. 33, 386–395 (1961b).Google Scholar
  678. — — Role of the kidney and the rennin-angiotensin system in the response of aldosterone secretion to hemorrhage. Circulation 25, 213–220 (1962).PubMedGoogle Scholar
  679. — — The role of the rennin-angiotensin system in the regulation of aldosterone secretion in the dog and man. In: E. E. Baulieu and P. Robel (eds.), Aldosterone, p.265–278. Oxford: Blackwell 1964.Google Scholar
  680. — — Effect of simultaneous infusions of ACTH and angiotensin II upon aldosterone secretion of hypophysectomized nephrectomized dogs. Proc. Soc. exp. Biol. (N. Y.) 118, 195–197 (1965).Google Scholar
  681. — —, and A. BORYCZKA: Further evidence for a role of the rennin-angiotensin system in the regulation of aldosterone secretion. Proc. Soc. exp. Biol. (N. Y.) 112, 7–10 (1963a).Google Scholar
  682. — —, G. Cera, and A. Kuljian: The nature of the aldosterone-stimulating factor in dog kidney. J. clin. Invest. 41, 505–518 (1962).PubMedGoogle Scholar
  683. — N. A. Powell, and R. L. Kahler: Angiotensin concentration in plasma of sodium-depleted humans. J. clin. Invest. 42, 959 (1963b).Google Scholar
  684. — G. L. Schmagranoff, A. H. Lieberman, C. I. Slade, and J. A. Luetscher, Jr.: Stimulation of rat adrenocortical secretion by a factor present in human urine. Endocrinology 64, 631–637 (1959).PubMedGoogle Scholar
  685. Murakawa, S.: Effects of splanchnic nerve stimulation on aldosterone secretion (in Japanese). Folia endocr. jap. 38, 1085–1097 (1963).Google Scholar
  686. Murphy, R. J. F.: The effect of “rice diet” on plasma volume and extracellular fluid space in hypertensive subjects. J. clin. Invest. 29, 912–917 (1950).PubMedGoogle Scholar
  687. Myers, R. M., W. R. Bishop, and B. T. Scheer: Anterior pituitary control of active sodium transport across frog skin. Amer. J. Physiol. 200, 444–450 (1961).PubMedGoogle Scholar
  688. Mylon, E., and L. R. Freedman: On the occurrence of renin in the blood of hypertensive patients. Amer. Heart J. 38, 509–516 (1949).PubMedGoogle Scholar
  689. NáDASDI, M.: Pituitary and adrenal influence on the “endocrine kidney” syndrome. J. Endocr. 22, 1–6 (1961).PubMedGoogle Scholar
  690. Nairn, R. C., C. S. Chadwick, and K. B. Fraser: Purification of renin by electrophoresis, absorption and immunologic methods. Brit. J. exp Path. 41, 214–221 (1960).PubMedGoogle Scholar
  691. Neher, R., P. Desaulles, I. E. Vischer, P. Wieland u. A. Wettstein: Isolierung, Konstitution und Synthese eines neuen Steroides aus Nebennieren. Helv. chim. Acta 41, 1667–1692 (1958).Google Scholar
  692. — C. Meystre u. A. Wettstein: Neue 16α-Hydroxysteroide aus menschlichen Urin und aus Schweine-Nebennieren. Helv. chim. Acta 42, 132–152 (1959).Google Scholar
  693. —, and A. Wettstein: Physiochemical detection and measurement of aldosterone in body fluids and tissues. Acta endocr. (Kbh.) 18, 386–395 (1955).Google Scholar
  694. Nelson, D. H., and J. T. August: Abnormal response of oedematous patients to aldosterone or deoxycortone. Lancet 1909 II, 883–885.Google Scholar
  695. Newman, A. F., E. S. Redgate, and G. Farrell: The effect of diencephalons-mesencephalon lesions on aldosterone and hydrocortisone secretion. Endocrinology 63, 723–736 (1958).PubMedGoogle Scholar
  696. Nichols, J.: Effects of electrolyte imbalance on the adrenal glands. Arch. Path. 45, 717–721 (1948).PubMedGoogle Scholar
  697. — The adrenal cortex of patients dying in hyponatremia. Inter. Physiol. Congr. 20, 678 (1956).Google Scholar
  698. Nickerson, M., and M. C. Sutter: Angiotensin in shock. Canad. med. Ass. J. 90, 325–327 (1964).PubMedGoogle Scholar
  699. Norman, N.: The influence of the concentration of sodium and potassium in the cerebrospinal fluid on the secretion of steroids, including aldosterone, from the adrenal cortex. Acta endocr. (Kbh.) 37, 559–564 (1961).Google Scholar
  700. Olson, R. E., and H. W. Deane: A physiological and cytochemical study of the kidney and the adrenal cortex during acute choline deficiency in weanling rats. J. Nutr. 39, 31–55 (1949).PubMedGoogle Scholar
  701. Omae, T., G. M. C. Masson, and I. H. Page: Release of renin in hypertensive rats. Amer. J. Physiol. 199, 637–643 (1960).PubMedGoogle Scholar
  702. Orti, E., and E. P. Ralli: Purification and mode of action of a sodium-retention stimulating factor. Amer. J. Physiol. 199, 43–48 (1960).PubMedGoogle Scholar
  703. Ostrovsky, D., and A. G. Gornall: Effects of aldosterone and other adrenal hormones on the blood pressure responses to renin and angiotensin. Canad. med. Ass. J. 90, 180–184 (1964).PubMedGoogle Scholar
  704. Page, I. H.: The changing outlook for the hypertensive patient. Ann. intern. Med. 57, 96–109 (1962).PubMedGoogle Scholar
  705. —, and F. M. Bumpus: Angiotensin. Physiol. Rev. 41, 331–390 (1961).PubMedGoogle Scholar
  706. — — Angiotensin – a renal hormone. Recent Progr. Hormone Res. 18, 167–186 (1962).Google Scholar
  707. —, and F. Olmstead: Hemodynamic effects of angiotensin, norepinephrine and bradykinin continuously measured in unanesthetized dogs. Amer. J. Physiol. 201, 92–96 (1961).PubMedGoogle Scholar
  708. Paladini, A. C., E. Braun-MenéNDEZ, I. S. Del Frane, and Z. M. Massani: The estimation of angiotensin in blood. J. Lab. clin. Med. 53, 264–271 (1959).PubMedGoogle Scholar
  709. —, and O. A. Scornik: Angiotensin blood levels in dogs during blood pressure depression. Excerpta med. (Amst.), Int. Congr. Ser. 48, Abstract No 190 (1962).Google Scholar
  710. — —, and Z. M. Massani: The role of angiotensin in experimental hypertension (in Spanish). Acta physiol. lat.-amer. 12, 188–194 (1962).PubMedGoogle Scholar
  711. PalkóVLTS, M., and P. I. FöLDVáRI: Effect of the subcommissural organ and the pineal body on the adrenal cortex. Endocrinology 72, 28–32 (1963).Google Scholar
  712. Panagiotis, N. M., and G. F. Hungerford: Response of the pineal and adrenal glands to sodium restriction. Endocrinology 69, 217–224 (1961).PubMedGoogle Scholar
  713. Pasqualino, A., and G. H. Bourne: Histochemical change in kidneys and adrenal of rats made hypertensive by the Goldblatt method. Nature (Lond.) 182, 1426–1427 (1958).Google Scholar
  714. — — Comparative histochemical effects of a loose, non-compressive clip on one renal artery and a tight hypertension-producing clip. Acta anat. (Basel) 46, 311–342 (1961).Google Scholar
  715. Pearce, J. W.: The effect of vagotomy and denervation of the carotid sinus on diuresis following plasma volume expansion. Canad. J. Biochem. 37, 81–90 (1959).PubMedGoogle Scholar
  716. Peart, W. S.: Renin and hypertensin. Ergebn. Physiol. 50, 409–432 (1959).PubMedGoogle Scholar
  717. — Possible relation between salt metabolism and the angiotensin system. In: K. D. Beok and P. T. Cottier (eds.), Essential hypertension, p.112–120. Berlin-Göttingen-Heidelberg: Springer 1960.Google Scholar
  718. — Estimation of renin in body fluids. In: E. E. Baulieu and P. Robel (eds.), Aldosterone. Oxford: Blackwell 1964.Google Scholar
  719. — J. J. Brown, D. D. Davies, A. F. Lever, and J. I. S. Robertson: The influence of sodium loading and sodium depletion on plasma renin in man. In: E. E. Baulieu and P. Robel (eds.), Aldosterone. Oxford: Blackwell 1964.Google Scholar
  720. — J. I., S. Robertson, and D. G. Grarame-Smith: Examination of the relation of renin release to hypertension produced in the rabbit by renal-artery constriction. Circulat. Res. 9, 1171–1184 (1961).PubMedGoogle Scholar
  721. Pechet, M.: Studies of secretion of aldosterone. Proc. 20th Int. Physiological Congr. 1956, p.714.Google Scholar
  722. — R. H. Hesse, and H. Kohler: The metabolism of d-aldosterone: isolation and chemical identity of metabolites; distribution of free aldosterone and metabolism in tissues and fluids under physiological conditions. J. clin. Invest. 41, 1391 (1962).Google Scholar
  723. Perloff, D., M. Sokolow, E. J. Wylie, D. R. Smith, and A. J. Palabinskas: Hypertension secondary to renal arterial occlusive disease. Circulation 24, 1286–1304 (1961).PubMedGoogle Scholar
  724. Peters, G.: Renal tubular effect of val-5-angiotensin II amide in rats. Proc. Soc. exp. Biol. (N.Y.) 112, 771–775 (1963).Google Scholar
  725. Peterson, R. E.: Metabolism of adrenocorticosteroids in man. Ann. N.Y. Acad. Sci. 82, 846–853 (1959a).PubMedGoogle Scholar
  726. — The miscible pool and turnover rate of adrenocortical steroids in man. Recent Progr. Hormone Res. 15, 231–261 (1959b).Google Scholar
  727. Peterson, R. E. and B. Miller: Determination of peripheral plasma aldosterone. Endocr. Soc. Abstract, 46th Annual Meeting 1964, p. 63.Google Scholar
  728. —, and J. Miller: Aldosterone-stimulating material in urine. Endocrinology 71, 174–175 (1962).PubMedGoogle Scholar
  729. Petronio, L., and G. Casirola: Some aspects of the exchange of the electrolytes and phosphates of plasma in response to treatment with pituitary extract (in Italian). Arch. Sci. med. 103, 99–105 (1957).Google Scholar
  730. Pickering, G. W.: Introduction. In: M. Schacter (eds.), Polypeptides that affect smooth muscle and blood vessels, p. 97–98. London: Pergamon 1960.Google Scholar
  731. — Discussion. Canad. med. Ass. J. 90, 166 (1964).Google Scholar
  732. Pitcock, J. A., P. M. Hartroft, and L. N. Newmark: Increased renal pressor activity (renin) in sodium deficient rats and correlation with juxtaglomerular cell granulation. Proc. Soc. exp. Biol. (N.Y.) 100, 868–869 (1958).Google Scholar
  733. Poll, M., M. W. Switchik, J. W. Canter, R. L. Segal, and I. D. Baronofsky: The effect of thyroidectomy on experimental ascites. Surgery 49, 636–640 (1961).PubMedGoogle Scholar
  734. Proceedings of conference on hypertension. Circulation 17, No 4, part 2 (1958).Google Scholar
  735. Prunty, F. T. G., P. H. Forsham, and G. W. Thorn: Desoxycorticosterone like activity induced by ACTH in man. Clin. Sci. 7, 109–120 (1948).PubMedGoogle Scholar
  736. Purjesz, I., and G. Urbán: To the problem of control of aldosterone secretion. Excerpta med. (Amst.), Int. Congr. Ser. 51, 222 (1962).Google Scholar
  737. Raab, W., J. J. Humphreys, N. Makons, R. de Grandpre, and W. Gigee: Pressor effects of epinephrine, norepinephrine and desoxycorticoacetate (DCA) weakened by sodium withdrawal. Circulation 6, 373–377 (1952).PubMedGoogle Scholar
  738. Race, G. J., W. M. Nickey, P. S. Wolf, and E. J. Jordan: Studies on functional zonation of the adrenal cortex. Arch. Path. 64, 312–323 (1957).Google Scholar
  739. — and H. M. Wu: Adrenal cortex functional zonation in the whale (Physeter catadon). Endocrinology 68, 156–158 (1960).Google Scholar
  740. Randall, R. E., Jr., and S. Papper: Mechanism of postoperative limitation on sodium excretion: the role of extracellular fluid volume and adrenal cortex activity. J. clin. Invest. 37, 1628–1641 (1958).PubMedGoogle Scholar
  741. Rapaport, A.,and A. G. Gornall: Secondary hyperaldosteronism in constrictive pericarditis. Canad. med. Ass. J. 85, 83–85 (1961).Google Scholar
  742. Rapp, J. P.: Electrolyte and juxtaglomerular changes in adrenal regeneration hypertension. Amer. J. Physiol. 206, 93–104 (1964).PubMedGoogle Scholar
  743. Rausohkolb, E. W., and G. L. Farrell: Evidence for diencephalic regulation of aldosterone secretion. Endocrinology 59, 526–531 (1956).Google Scholar
  744. — —, and S. Koletsky: Aldosterone secretion after hypophysectomy. Amer. J. Physiol. 184, 55–58 (1956).Google Scholar
  745. Reale, E., and O. Bucher: Sur l’ultrastructure d’appareil juxtaglomérulaire du rein. Experientia (Basel) 9, 430–431 (1961).Google Scholar
  746. Rector, F. C., Jr., G. van Giesen, F. Kill, and D. W. Seldin: Influence of expansion of extracellular volume on tubular reabsorption of sodium independent of changes in glomerular filtrate rate and aldosterone activity. J. clin. Invest. 43, 341–348 (1964).PubMedGoogle Scholar
  747. Regoli, D., H. Brunner, G. Peters, and F. Gross: Changes in renin content in kidneys of renal hypertensive rats. Proc. Soc. exp. Biol. (N.Y.) 109, 142–145 (1962).Google Scholar
  748. Relman, A. S., and W. B. Schwarz: The effect of desoxycorticosterone acetate on electrolyte balance in normal man and its relation to sodium chloride intake. Yale J. Biol. Med. 24, 540–558 (1952).PubMedGoogle Scholar
  749. Rennels, E. G., and R. E. Dill: Effect of pinealectomy on the histology and lipid content of the rat adrenal gland. Tex. Rep. Biol. Med. 19, 843–850 (1961).PubMedGoogle Scholar
  750. Renold, A. E., J. Crabbé, L. Hernando-Avendano, D. H. Nelson, E. J. Ross, K. Emerson Jr., and G. W. Thorn: Inhibition of aldosterone secretion by amphenone in man. New Engl. J. Med. 256, 16–21 (1957).PubMedGoogle Scholar
  751. Rick, W., G. Winkler, E. Koch, and H. Bohn: Clinical observations in hypoaldosteronism. Acta endocr. (Kbh.), Suppl. 67, 103 (1962).Google Scholar
  752. Robertson, J. I. S.: Renin in plasma of normal and hypertensive rabbits. J. Physiol. (Lond.) 166, 27P (1963).Google Scholar
  753. Roels, H.: Deoxyribonucleic acid content of the nuclei of the adrenal cortex of the white rat. Nature (Lond.) 182, 873–874 (1958).Google Scholar
  754. Romani, J. D., et A. Keller: Le rôle du rein et de l’angiotensine dans la stimulation de la fonction minérale de la surrénale. Aun. Endocr. (Paris) 23, 344–348 (1962).Google Scholar
  755. — — et L. E. Piotti: Action d’un extrait épiphysaire sur la distribution des lipides et des phosphates alcalines du cortex surrénal. Ann. Endocr. (Paris) 21, 79–85 (1961).Google Scholar
  756. Roos, R. de, and C. C. de Roos: Angiotensin II: Its effects on corticoid production by chicken adrenals in vitro. Science 141, 1284–1285 (1963).Google Scholar
  757. Rosas, R., A. Gomez, D. Montague, M. Gross, and S. W. Hoobler: Hemodynamic effects of renal transplants in hypertensive and control rats. Proc. Soc. exp. Biol. (N.Y.) 115, 4–8 (1964).Google Scholar
  758. Rosemberg, E., M. Demany, E. Budnitz, R. Underwood, and R. S. Leard: Effects of administration of large amounts of d-aldosterone in normal subjects and in a patient with Sheehan’s syndrome. J. clin. Endocr. 22, 465–480 (1962).PubMedGoogle Scholar
  759. Rosenfeld, G., E. Roselmberg, F. Ungar, and R. I. Dorfman: Regulation of the secretion of aldosterone-like material. Endocrinology 58, 255–261 (1956).PubMedGoogle Scholar
  760. Rosnagle, R. S., and G. L. Farrell: Alterations in electrolyte intake and adrenal cortical secretion. Amer. J. Physiol. 187, 7–10 (1956).PubMedGoogle Scholar
  761. Ross, E. J.: Aldosterone in clinical and experimental medicine. Oxford: Blackwell 1959.Google Scholar
  762. — and E. K. McClean: The excretion of an aldosterone-stimulating hormone in the urine of sodium-deprived adrenalectomized rats. Clin. Sci. 22, 401–408 (1962).PubMedGoogle Scholar
  763. — W. van’t Hoff, J. Crabbé, and G. W. Thorn: Aldosterone excretion in hypopituitarism and after hypophysectomy in man. Amer. J. Med. 28, 229–238 (1960).PubMedGoogle Scholar
  764. — and W. W. Winternitz: The effect of an aldosterone antagonist on the renal response to sodium restriction. Clin. Sci. 20, 143–148 (1961).PubMedGoogle Scholar
  765. Rosse, W. F., R. J. Berry, and T. A. Waldmann: Some molecular characteristics of erythropoietin from different sources determined by inactivation by ionizing radiation. J. clin. Invest. 42, 124–129 (1963).PubMedGoogle Scholar
  766. Salya, L. L., C. S. McCaa, V. H. Read, and D. Bomer: Uptake of tritiated aldosterone by rat tissues. Nature (Lond.) 200, 788–789 (1963).Google Scholar
  767. Sambhi, M. P., J. C. Beck, and E. H. Venning: Malignant hypertension and aldosterone secretion. Amer. J. Med. 35, 251–256 (1963).PubMedGoogle Scholar
  768. Sanders, L. L., and J. C. Melby: Aldosterone excretion in congestive heart failure. Clin. Res. 11, 173 (1963).Google Scholar
  769. Sapirstein, L. A., E. Ogden, and F. D. Southard, Jr.: Renin-like substance in blood after hemorrhage. Proc. Soc. exp. Biol. (N.Y.) 48, 505–508 (1941).Google Scholar
  770. — F. D. Southard Jr., and E. Ogden: Restoration of blood pressure by renin activator after hemorrhage. Proc. Soc. exp. Biol. (N.Y.) 50, 320–324 (1942).Google Scholar
  771. Sarason, F. L.: Morphologic changes in the rat’s adrenal cortex under various experimental conditions. Arch. Path. 35, 373–390 (1943).Google Scholar
  772. Schaechtelin, G., D. Regoli, and F. Gross: Bio-assay of circulatory rennin-like pressor material by isovolemic cross circulation. Amer. J. Physiol. 205, 303–306 (1963).PubMedGoogle Scholar
  773. Schaffenburg, C. A., E. Haas, and H. Goldblatt: Concentration of renin in kidneys and angiotensinogen in serum of various species. Amer. J. Physiol. 199, 788–792 (1960).PubMedGoogle Scholar
  774. — G. M. C. Masson, and A. C. Corcoran: Renin inhibition of compensatory renal hypertrophy. Proc. Soc. exp. Biol. (N.Y.) 87, 469––473 (1954).Google Scholar
  775. Scheele, G. A., P. A. Ransom, and R. E. Morris, Jr.: Studies on the site of action and destruction of angiotensin II. Clin. Res. 10, 391 (1962).Google Scholar
  776. Scheer, B. T., K. Matsumoto, and G. Shane: Histological changes in the diencephalon of frogs in relation to osmo-regulatory control. Amer. Zoologist 2, 444 (1962).Google Scholar
  777. Scheifley, C. H.: A new clinical syndrome producing hypertension-arterio-venous fistula of the kidney. J. Amer. med. Ass. 174, 1625–1627 (1960).Google Scholar
  778. Scherrer, H.: Hypothalamic influences on electrical activity in the renal nerve of the rat. Acta neuroveg. (Wien) 23, 499–522 (1962).Google Scholar
  779. Schlatmann, R. J. A. F. M., A. P. Jansen, H. Prenen, J. K. Vanderkarst, and C. L. H. Majoor: The natriuretic and aldosterone suppressive action of heparin and some related polysulfated polysaccharides. J. clin. Endocr. 24, 35–47 (1964).PubMedGoogle Scholar
  780. — H. Prenen, A. P. Jansen, and C. L. H. Majoor: The natriuretic action of heparin and some related substances. Lancet 1960 I, 314–317.Google Scholar
  781. Schlegel, J. V.: Renal hypertension. J. Amer. med. Ass. 183, 92–96 (1960).Google Scholar
  782. Schmid, H. E., Jr.: Renin, a physiologic regulator of renal hemodynamics. Circulat. Res. 11, 185–190 (1962).PubMedGoogle Scholar
  783. — Effect of antirenin formation on renal hemodynamics and electrolyte excretion in dogs. Fed. Proc. 22, 630 (1963).Google Scholar
  784. —, and L. A. Graham: Juxtaglomerular cell changes in dogs with antirenin titers. Circulat. Res. 11, 853–856 (1962).PubMedGoogle Scholar
  785. — — B. B. Brennan, and G. E. Wakerlin: Renin concentration of normotensive and hypertensive dog kidney. Circulat. Res. 10, 696–703 (1962).PubMedGoogle Scholar
  786. Schwartz, J., R. Bloch, and J. Velly: Relation between renin, aldosterone and experimental hypertension in rats. Canad. med. Ass. J. 90, 243–244 (1964).PubMedGoogle Scholar
  787. Schwartz, W. B., W. Bennett, S. Curelop, and F. C. Bartter: Syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone. Amer. J. Med. 23, 529–542 (1957).PubMedGoogle Scholar
  788. Schwyzer, R., and H. Turrian: The chemistry and pharmacology of angiotensin. Vitam. and Horm. 18, 237–288 (1960).Google Scholar
  789. Scian, L. F., C. D. Westermann, O. R. Kruesi, and J. G. Hilton: Effect of ACTH and vasopressin on aldosterone secretion. Fed. Proc. 18, 545 (1959).Google Scholar
  790. Scornik, O. A., and A. C. Paladini: Angiotensin blood levels in dogs with experimental renal hypertension. Amer. J. Physiol. 201, 526–530 (1961).PubMedGoogle Scholar
  791. Scornik, O. A., and A. C. Paladini: Significance of blood angiotensin levels in different experimental conditions. Canad. med. Ass. J. 90, 269–271 (1964).PubMedGoogle Scholar
  792. — — and E. Braun-MenéNDEZ: Further improvements in a method for the estimation of angiotensin in blood. Acta physiol. lat.-amer. 10, 64–67 (1960).PubMedGoogle Scholar
  793. Selkurt, E. E.: Effect of pulse pressure and mean arterial pressure modification on renal hemodynamics and electrolyte and water excretion. Circulation 4, 541–546 (1951).PubMedGoogle Scholar
  794. — Sodium excretion by the mammalian kidney. Physiol. Rev. 34, 287–333 (1954).PubMedGoogle Scholar
  795. Seller, R., M. Fuchs, C. Swartz, and O. Ramirez: Spirolactone effect on postoperative electrolytes and adrenal activity. Clin. Res. 10, 403 (1962).Google Scholar
  796. Selye, H.: Adrenal changes produced by parenteral administration of highly hypertonic solutions. Acta neuroveg. (Wien) 6, 212–219 (1953).Google Scholar
  797. — E. M. Rowley, and C. E. Hall: Changes in the adrenals following prolonged treatment with methyl-testosterone. Froc. Soc. exp. Biol. (N.Y.) 54, 140–143 (1943).Google Scholar
  798. Sevy, R. W., and E. A. Ohler: Effect of renin on adrenal ascorbic acid concentration in rats. Amer. J. Physiol. 174, 471–474 (1953).PubMedGoogle Scholar
  799. — and G. E. Wakerlin: Endocrine factors in experimental renal hypertension. Amer. J. Physiol. 172, 129–140 (1953).PubMedGoogle Scholar
  800. Sheppard, H., R. Swenson, and T. F. Mowles: Steroid biosynthesis by rat adrenal: functional zonation. Endocrinology 73, 819–824 (1963).PubMedGoogle Scholar
  801. Shoemaker, W. C., and A. G. Finder: Relation of potassium and glucose release from the liver in the unanesthetized dog. Proc. Soc. exp. Biol. (N.Y.) 108, 248–252 (1961).Google Scholar
  802. Siegenthaler, W. E., A. Dowdy, and J. A. Luetscher, Jr.: Determination of the secretion rate of aldosterone in normal man by use of 7-H3-d-aldosterone and acid hydrolysis of urine. J. clin. Endocr. 22, 172–177 (1962).PubMedGoogle Scholar
  803. Simkin, B., H. C. Bergman, H. Silver, and A. M. Prinzmetal: Renal arteriovenous anastamoses in rabbits, dogs and human Subjects. Arch. intern. Med. 81, 115–125 (1948).Google Scholar
  804. Simonson, E., and J. BrožEK: Russian research on arterial hypertension. Ann. intern. Med. 50, 129–193 (1959).PubMedGoogle Scholar
  805. Simpson, S. A., J. F. Tait, A. Wettstein, R. Neher, J. von Euw, O. Schindler. u. T. Reichstein: Aldosteron-Isolierung und Eigenschaften über Bestandteile der Nebennierenrinde und verwandte Stoffe. Helv. chim. Acta 37, 1163–1200 (1954).Google Scholar
  806. Singer, B.: Effect of aldosterone-antagonist, SC 8109, on the secretion of aldosterone in normal rats. Endocrinology 65, 512–514 (1959).PubMedGoogle Scholar
  807. — Further studies on the secretion of aldosterone by the rat adrenal gland. J. Endocr. 19, 310–324 (1960).Google Scholar
  808. — C. Losito, and S. Salmon: Aldosterone and corticosterone secretion rates in rats with experimental renal hypertension. Acta endocr. (Kbh.) 44, 505–518 (1963).Google Scholar
  809. — — — Studies on the effect of angiotensin II on adrenal cortical secretion in hypophysectomized rats. Endocrinology 74, 325–332 (1964).PubMedGoogle Scholar
  810. —, and M. P. Stack-Dunne: The secretion of aldosterone and corticosterone by the rat adrenal. Nature (Lond.) 174, 790–791 (1954).Google Scholar
  811. — — The secretion of aldosterone and corticosterone by the rat adrenal. J. Endocr. 12, 130–145 (1955).PubMedGoogle Scholar
  812. —, and E. H. Venning: Method of assay of sodium-retaining factor in human urine. Endocrinology 52, 623–633 (1953).PubMedGoogle Scholar
  813. —, and J. Wener: Excretion of sodium-retaining substances in patients with congestive heart failure. Amer. Heart J. 45, 795–801 (1953).PubMedGoogle Scholar
  814. Sirotina, M. F.: Renin content of kidneys in experimental hypertension. Fed. Proc. 22, T1126–T1128 (1963).Google Scholar
  815. Skeggs, L. T., Jr.: Polypeptides of the renal pressor system. In: M. Schachter (ed.), Polypeptides that affect smooth muscle and blood vessels, p.106–121. London: Pergamon 1960.Google Scholar
  816. — J. R. Kahn, K. E. Lentz, and N. P. Shumway: Preparation, purification and amino-acid sequence of a polypeptide renin substrate. J. exp. Med. 106, 439–453 (1957).PubMedGoogle Scholar
  817. — —, and N. P. Shumway: The isolation and assay of hypertensin from blood. J. exp. Med. 95, 241–246 (1952).PubMedGoogle Scholar
  818. — K. E. Lentz, H. Hochstrasser, and J. R. Kahn: The chemistry of renin substrate. Canad. med. Ass. J. 90, 185–189 (1964).PubMedGoogle Scholar
  819. — — J. R. Kahn, N. P. Shumway, and K. R. Woods: The amino-acid sequence of hypertensin II. J. exp. Med. 104, 193–197 (1956).PubMedGoogle Scholar
  820. Skelton, F. R.: Adrenal regeneration and adrenal regeneration hypertension. Physiol. Rev. 39, 162–182 (1959).PubMedGoogle Scholar
  821. Skinner, S. L., J. W. McCubbin, and I. H. Page: Angiotensin in blood and lymph following reduction in renal arterial perfusion pressure in dogs. Circulat. Res. 13, 336–345 (1963a).PubMedGoogle Scholar
  822. — — — Renal baroceptor control of renin secretion. Science 141, 814–816 (1963b).PubMedGoogle Scholar
  823. Slater, J. D. H., B. H. Barbour, H. H. Henderson, A. G. T. Casper, and F. C. Bartter: Influence of the pituitary and the rennin-angiotensin system on the secretion of aldosterone, cortisol and corticosterone. J. clin. Invest. 42, 1504–1520 (1963).PubMedGoogle Scholar
  824. — H. H. Henderson, A. G. T. Casper, B. H. Barbour, and F. C. Bartter: Control of adrenal cortical activity by the rennin-angiotensin system with changes in renal blood flow. Clin. Res. 10, 256 (1962).Google Scholar
  825. Slaton, P.E. Jr., and E. G. Biglieri: Hypertension and hyperaldosteronism of renal origin. Circulation 28, 826 (1963).Google Scholar
  826. Smeby, R. R., F. M. Bumpus, P. A. Khairallah, I. H. Page, and P. J. Cheriathundam: Determination of angiotensin in blood. Circulation 28, 807 (1963).Google Scholar
  827. Smith, H. W.: Salt and water volume receptors. Amer. J. Med. 23, 623–652 (1957).PubMedGoogle Scholar
  828. Sokabe, H., and A. Grollman: Localization of blood pressure regulating and erythropoietic functions in rat kidney. Amer. J. Physiol. 203, 991–994 (1962).PubMedGoogle Scholar
  829. — — Pressor activity of renal venous effluent of normal and hypertensive rats. Amer. J. Physiol. 205, 264–266 (1963).PubMedGoogle Scholar
  830. — A. MIkasa, H. Yasude, and G. M. C. Masson: Adrenal cortex and renal pressor function. Circulat. Res. 12, 94–100 (1963).PubMedGoogle Scholar
  831. Solyom, J., J. Sturcz, S. Kotra, and A. Salamon: Renin angiotensin and aldosterone secretion. Lancet 1963 I, 1376–1378.Google Scholar
  832. Sonnenberg, H., and J. W. Pearce: Renal response to measured blood volume expansion in differently hydrated dogs. Amer. J. Physiol. 203, 344–352 (1962).PubMedGoogle Scholar
  833. Spiller, P. J., and D. H. P. Streeten: Mechanism of the natriuretic action of D-amphetamine. Clin. Res. 11, 252 (1963).Google Scholar
  834. Spink, W. W., J. A. Vick, J. C. Melby, and J. Finstad: Influence of aldosterone and angiotensin II on endotoxin shock in the primate. Proc. Soc. exp. Biol. (N.Y.) 112, 795–799 (1963).Google Scholar
  835. Stachenko, J., and C. J. P. Giroud: Functional zonation of the adrenal cortex; pathways of corticosteroid biogenesis. Endocrinology 64, 730–742 (1959a).PubMedGoogle Scholar
  836. — — Functional zonation of the adrenal cortex; site of ACTH action. Endocrinology 64, 743–752 (1959b).PubMedGoogle Scholar
  837. Stamler, J., L. Dreifus, L. N. Katz, and I. J. Lichton: Response to rapid water, sodium and dextran loads of intact Ringer’s-infused unanesthetized dogs. Amer. J. Physiol. 195, 362–368 (1958a).PubMedGoogle Scholar
  838. — — I. J. Lichton, E. Marcus, E. E. Hasbrouck, and S. Wong: Effects of ascites formation on response to rapid water, sodium and dextran loads in intact and diabetes insipidus Ringer’s-infused dogs. Amer. J. Physiol. 195, 369–372 (1958b).PubMedGoogle Scholar
  839. Stark, G., u. H. Kossmann: Die Ausscheidung von Aldosteron, Natrium und Kalium nach fortlaufender hoher Progesterongabe. Acta endocr. (Kbh.). 42, 537–551 (1963).Google Scholar
  840. —, u. U. Pfeifer: Die Wirkung hoher Oestrogen-Gaben auf die Ausscheidung von Aldosteron, Cortisol sowie Natrium und Kalium. Acta endocr. (Kbh.) 44, 216–224 (1963).Google Scholar
  841. Stein, J. D., L. L. Bennett, A. A. Batts, and C. H. Li: Sodium, potassium, and chloride retention produced by growth hormone in the absence of the adrenals. Amer. J. Physiol. 171, 587–591 (1952).PubMedGoogle Scholar
  842. Stein, R. M., B. H. Levitt, M. H. Goldstein, J. G. Porush, G. M. Eisner, and M. F. Levitt: The effects of salt restriction on the renal concentration operation in normal, hydropenic man. J. clin. Invest. 41, 2101–2111 (1962).PubMedGoogle Scholar
  843. Stoerk, H. C., A. I. Knowlton, and E. N. Loeb: Correlation between serum potassium and the weight of the adrenal glomerulosa in rats. J. clin. Invest. 34, 965 (1955).Google Scholar
  844. Strauss, M. B., R. K. Davis, J. D. Rosenbaum, and E. C. Rossmeisl: Production of increased renal sodium excretion by the hypotonic expansion of extra-adrenal fluid volume in recumbent subjects. J. clin. Invest. 31, 80–88 (1951).Google Scholar
  845. Strauss, M. D., and L. E. Early: An inquiry into the role of “sodium-retaining” steroids in the homeostasis of body sodium in man. Trans. Ass. Amer. Phycns. 72, 200 (1959).Google Scholar
  846. — E. Lamdin, W. P. Smith, and D. J. Bliefer: Surfeit and deficit of sodium. Arch. intern. Med. 102, 527–536 (1958).Google Scholar
  847. Streeten, D. H. P., J. W. Conn, L. H. Lewis, S. S. Fajans, H. S. Seltzer, R. D. Johnson, R. D. Gittler, and A. H. Dube: The metabolic and adrenocortical responses of normal men to high environmental temperatures. J. Lab. clin. Med. 46, 957–958 (1955).Google Scholar
  848. Strom, E. A., and J. D. Coffman: Aspirin and peripheral circulatory response to catacholamines and angiotensin. Clin. Res. 11, 174 (1963).Google Scholar
  849. Suki, W., and A. Grollman: Role of the kidney in erythropoiesis. Amer. J. Physiol. 199, 629–632 (1960).Google Scholar
  850. Swann, H. G.: The pituitary-adrenocortical relationship. Physiol. Rev. 20, 493–521 (1940).Google Scholar
  851. — J. M. Prine, U. Moore, and R. D. Rice: The intrarenal pressure during experimental renal hypertension. J. exp. Med. 96, 282–291 (1952).Google Scholar
  852. Sweeney, R.D., G.N. French, and W.O. O’Sullivan: The role of the liver in renal hypertension. Physiologist 5, 219 (1962).Google Scholar
  853. Swingle, W.W., and A.J. Swingle: Effect of sodium pentobarbital anesthesia on plasma volume of adrenalectomized dogs. Amer. J. Physiol. 205, 555–559 (1963).PubMedGoogle Scholar
  854. Tait, J.F.: The use of isotopic steroids for the measurement of production rates in vivo. J. clin. Endocr. 23, 1285–1297 (1963).PubMedGoogle Scholar
  855. — B. Little, S.A.S. Tait, and C. Flood: The metabolic clearance rate of aldosterone in pregnant and nonpregnant subjects, estimated by both single injections and constant infusion methods. J. clin. Invest. 41, 2093–2100 (1962).PubMedGoogle Scholar
  856. — S.A.S. Tait, B. Little, and R.R. Laumas: The disappearance of 7H3-d-aldosterone in the plasma of normal subjects. J. clin. Invest. 40, 72–80 (1961).PubMedGoogle Scholar
  857. Takeuchi, J., S. Yagi, S. Nakayama, T. Ikeda, E. Uchida, G. Inoui, F. Shintani, and H. Ueda: Experimental studies on the nervous control of the renal circulation-effect of the electrical stimulation of the diencephalon on the renal circulation. Jap. Heart J. 1, 288–299 (1960).Google Scholar
  858. Talanti, S., and A. Eisalo: The hypothalamo-hypophysial neurosecretory system in experimental hypertension in the rat. J. Endocr. 26, 107–111 (1963).PubMedGoogle Scholar
  859. Tanner, W.D., and G.E. Hungerford: Sodium and potassium excretion in pinealectomized and adrenalectomized rats. Proc. Soc. exp. Biol. (N.Y.) 109, 388–390 (1962).Google Scholar
  860. Taquini, A.C.: Neurogenic control of peripheral resistance in renal hypertension. Circulat. Res. 12, 562–567 (1963).PubMedGoogle Scholar
  861. — P. Blaquier, and A.C. Taquini, Jr.: On the production and role of renin. Canad. med. Ass. J. 90, 210–213 (1964).PubMedGoogle Scholar
  862. Taquini, A.C., Jr., P.C. Blaquier, and D.F. Bohr: Neurogenic factors and angiotension in etiology of hypertension. Amer. J. Physiol. 201, 1173–1175 (1961).PubMedGoogle Scholar
  863. —, and A.C. Taquini: The rennin-angiotensin system in hypertension. Amer. Heart. J. 62, 558–564 (1961).PubMedGoogle Scholar
  864. — — Angiotensin tachyphylaxis in the rat. Acta physiol. lat.-amer. 13, 159–164 (1963).PubMedGoogle Scholar
  865. Taylor, A.N., and G. Farrell: Effect of brain stem lesions on aldosterone and cortisol secretion. Endocrinology 70, 556–566 (1962).PubMedGoogle Scholar
  866. — — Facteur glomérulotrope. Ann. Endocr. (Paris) 24, 228–232 (1963).Google Scholar
  867. — W.M. Mcisaac, and G. Farrell: Steroidogenic properties of l-methyl-6-methoxy-tetrahydro carboline. Fed. Proc. 21, 186 (1962).Google Scholar
  868. Taylor, R.E., Jr., and M.J. Fregly: Renal response of propylthiouracil-treated rats to injected mineralocorticoids. Fed. Proc. 22, 210 (1963).Google Scholar
  869. Thal, A.P., T.B. Grage, and R.L. Vernier: Function of the contralateral kidney in renal hypertension due to renal artery stenosis. Circulation 27, 36–43 (1963).PubMedGoogle Scholar
  870. Thorn, G.W., J. Crabbé, L. Hernando-Avendano, F. J. Ross, D. H. Nelson, J. Hoet et A. E. Renold: Etudes sur la signification de la sécrétion de l’aldostérone chez l’homme. Bruxe.-méd. 37, 415–428, 459–469 (1957b).Google Scholar
  871. — E.J. Ross, J. Crabbé, and W. vant Hoff: Studies on aldosterone secretion in man. Brit. med. J. 1957a II, 955–966.Google Scholar
  872. Tobian, L.: Physiology of the juxtaglomerular cells. Ann. intern. Med. 52, 395–410 (1960a).PubMedGoogle Scholar
  873. — Interrelation of electrolytes, juxtaglomerular cells and hypertension. Physiol. Rev. 40, 280–312 (1960b).PubMedGoogle Scholar
  874. — Relation of juxtaglomerular apparatus to renin and angiotensin. Circulation 25, 189–192 (1962).PubMedGoogle Scholar
  875. — Sodium, renal artery distension and the juxtaglomerular apparatus. Canad. med. Ass. J. 90, 160–162 (1964).PubMedGoogle Scholar
  876. —, and K. Coffee: Effect of thiazide drugs on renovascular hypertension in contrast to their effect on essential hypertension. Proc. Soc. exp. Biol. (N. Y.) 115, 196–198 (1964).Google Scholar
  877. — — D. Ferreira, and J. Meuli: The effect of renal perfusion pressure on the net transport of sodium out of distal tubular urine as studied with the stop-flow technique. J. clin. Invest. 43, 118–128 (1964).PubMedGoogle Scholar
  878. — J. Janecek, J. Coker, and D. Ferreira: Effect of chlorothiazide on renal juxtaglomerular cells and tissue electrolytes. Amer. J. Physiol. 202, 905–908 (1962a).PubMedGoogle Scholar
  879. — —, and A. Tomboulian: Correlation between granulation of juxtaglomerular cells and extractable renin in rats with experimental hypertension. Proc. Soc. exp. Biol. (N. Y.) 100, 94–96 (1959).Google Scholar
  880. — S. Perry, and J. Mark: The relation of the juxtaglomerular apparatus to sodium retention in experimental nephrosis. Ann. intern. Med. 57, 382–388 (1962b).PubMedGoogle Scholar
  881. — J. Thompson, R. Tuedt, and J.J. Janecek: The granulation of juxtaglomerular cells in renal hypertension, adrenal regeneration hypertension and adrenal insufficiency. J. clin. Invest. 37, 660–671 (1958).PubMedGoogle Scholar
  882. TUrgeon, C., and S. C. SOmmers: Juxtaglomerular cell counts and human hypertension. Amer. J. Path. 38, 227–241 (1961).PubMedGoogle Scholar
  883. Ulick, S., J. H. Laragh, and S. Lieberman: The isolation of a urinary metabolite of aldosterone and its use to measure the rate of secretion of aldosterone by the adrenal cortex of man. Trans. Ass. Amer. Physcns 71, 225–235 (1958).Google Scholar
  884. —, and K. K. Vetter: The secretion of aldosterone and 18-hydroxycorticosterone in man. In: E. E. Baulieu and P. Robel (eds.), Aldosterone. Oxford: Blackwell 1964.Google Scholar
  885. Upton, P. D., F. W. Dunihue, and W. F. Chambers: Subcommissural organ and water metabolism. Amer. J. Physiol. 201, 711–713 (1961).PubMedGoogle Scholar
  886. Urquhart, J., and J. O. Davis: Role of the kidney and the adrenal cortex in congestive heart failure. Mod. Conc. cardiov. Dis. 32, 781–787 (1963).PubMedGoogle Scholar
  887. —., —, and J. T. Higgins, Jr.: Effects of prolonged infusion of angiotensin II in normal dogs. Amer. J. Physiol. 205, 1241–1246 (1963a).PubMedGoogle Scholar
  888. —., —, and —. Independence of glomerular filtration rate and the abnormal sustained renal response to the sodium retaining action of electrolyte-active steroids. Physiologist 6, 290 (1963b).Google Scholar
  889. Usami, S., B. Peric, and S. Chien: Release of antidiuretic hormone due to common carotid occlusion and its relation with vagus nerve. Proc. Soc. exp. Biol. (N. Y.) 111, 189–193 (1962).Google Scholar
  890. Vaamonde, C. A., I. N. Sporn, R. G. Lancestremere, J. L. Belsky, and S. Papper: Augmented natriuretic response to acute sodium infusion after blood pressure elevation with metaraminol in normotensive subjects. J. clin. Invest. 34,496–502 (1964).Google Scholar
  891. Vander, A. J.: Inhibition of distal tubular sodium reabsorption with angiotensin II. Amer. J. Physiol. 205, 133–138 (1963).PubMedGoogle Scholar
  892. Venning, E. H., and O. J. Lucis: Effect of growth hormone on the biosynthesis of aldosterone in the rat. Endocrinology 70, 486–491 (1962).PubMedGoogle Scholar
  893. —., —, and —: Effect of corticotrophin and prednisone on the excretion of aldosterone in man. J. clin. Endocr. 16, 1541–1553 (1956a).PubMedGoogle Scholar
  894. —, —, and —: The effect of anxiety upon aldosterone excretion in man. J. clin. Endocr. 17, 1005–1008 (1957 a).PubMedGoogle Scholar
  895. —., —, J. B. Dosseter, and J. C. Beck: Influence of alterations in sodium intake on urinary aldosterone response to corticotropin in normal individuals and patients with essential hypertension. Metabolism 11, 254–264 (1962).PubMedGoogle Scholar
  896. —., — C. J. P. Giroud, and J. C. Beck: Effect of growth hormone on aldosterone excretion. Metabolism 5, 697–702 (1956b).PubMedGoogle Scholar
  897. —, —, —, and —: Factors affecting aldosterone excretion. Canad. med. Ass. J. 77, 773–777 (1957b).PubMedGoogle Scholar
  898. —., —, L. Lowenstein, and J. Beck: Metabolic studies in pregnancy and the puerperium. J. clin. Endocr. 19, 403–424 (1959).PubMedGoogle Scholar
  899. —., J. R. McCorriston, I. Dyrenfurth, and J. Beck: Aldosterone excretion following trauma. Metabolism 7, 293–300 (1958).PubMedGoogle Scholar
  900. Verdesca, A. S., C. D. Westermann, R. S. Crampton, W. C. Black, R. I. Nedeljkovic, and J. G. Hilton: Direct adrenocortical stimulatory effect of serotonin. Amer. J. Physiol. 201, 1065–1067 (1961).PubMedGoogle Scholar
  901. Verniory, A., and P. Potvliege: Effects of cortexone and salt on renin content, juxtaglomerular index and renal hypertension in rabbits. Proc. Soc. exp. Biol. (N. Y.) 115, 18–21 (1964).Google Scholar
  902. Vertes, V., J. A. Granel, and H. Goldblatt: Renal arteriography, separate renal function studies and renal biopsy in human hypertension. New Engl. J. Med. 270, 656–659 (1964).PubMedGoogle Scholar
  903. Veyrat, R., J. de Champlain, R. Boucher, and O. Genest: Measurement of human arterial renin activity in some physiological and pathological states. Canad. med. Ass. J. 90, 215–220 (1964).PubMedGoogle Scholar
  904. Viar, W., and T. Lombardo: Effects of posture and of compression of the neck on glomerular filtration. Amer. J. Med. 9, 407 (1950).Google Scholar
  905. Vito, E. de, I. Gómez, and J.C. Fasciolo: The angiotensin content of the renal blood in normal dogs. Acta physiol. lat.-amer. 13, 49–53 (1963).Google Scholar
  906. Vogel, J. H. K.: Aldosterone in cerebral salt wasting. Circulation 27, 44–50 (1963).PubMedGoogle Scholar
  907. Voth, D., M. Kohlhardt. u. K. W. Tietze: Zur Frage der renalen Steuerung der Zona glomerulosa der NNR. Klin. Wschr. 41, 443–439 (1963).Google Scholar
  908. Wagner, H.N., Jr.: The influence of autonomic vasoregulatory reflexes on the rate of sodium and water excretion in man. J. clin. Invest. 36, 1319–1327 (1957).PubMedGoogle Scholar
  909. —., Orthostatic hypotension. Bull. Johns Hopk. Hosp. 105, 322–359 (1959).Google Scholar
  910. Wakerlin, G. E.: Endocrine factors in renal hypertension. Physiol. Rev. 35, 555–582 (1955).PubMedGoogle Scholar
  911. —.: Antibody to renin as proof of the pathogenesis of sustained renal hypertension. Circulation 17, 653–657 (1958).PubMedGoogle Scholar
  912. Wakerlin, G. E., and G. R. Chobot: Does renin play a role in the maintenance of of normal blood pressure? Proc. Soc. exp. Biol. (N. Y.) 40, 331–334 (1939).Google Scholar
  913. Wal, B. van der, J. Moll, and D. de Wied: The effect of pinealectomy and of lesions in the subcommissural body on the rate of aldosterone secretion by rat adrenals in vitro. Abstracts of Papers, Int. Round-Table Conf. on the Epiphysis Cerebri. Amsterdam July 10–13, 1963.Google Scholar
  914. —, and D. de Wied: Aldosterone secretion in vitro. Acta physiol. pharmacol. neer. 12, 181–182 (1963).Google Scholar
  915. Walthard, B.: Funktionen der Nebennierenrinde, insbesondere der Zona glomerulosa. Acta endocr. (Kbh.) 5, 61–85 (1950).Google Scholar
  916. Wardener, H. E. de, I. H. Mills, W. F. Clapham, and C. J. Hayter: Studies on the efferent mechanism of the sodium diuresis which follows the administration of intravenous saline in the dog. Clin. Sci. 21, 249–258 (1961).Google Scholar
  917. Wardlaw, J. M., and R. L. Pike: Some effects of high and low sodium intake during pregnancy in the rat. IV. Granulation of renal juxtaglomerular cells and zona glomerulosa width. J. Nutr. 80, 355–364 (1963).PubMedGoogle Scholar
  918. Warzynski, R., Y. Demirjian, and S. Hoobler: A method for the determination of “renin” in blood and some preliminary findings. Canad. med. Ass. J. 90, 225–226 (1964).PubMedGoogle Scholar
  919. Watanabe, M., O. V. Dominguez, C. I. Meeker, E. A. H. Sims, M. J. Gray, and S. Solomon: Aldosterone and progesterone secretion in pregnancy. J. clin. Invest. 41, 1408–1409 (1962).Google Scholar
  920. —., C. I. Meeker, M. J. Gray, E. A. H. Sims, and S. Solomon: Secretion rate of aldosterone in normal pregnancy. J. clin. Invest. 42, 1619–1631 (1963).PubMedGoogle Scholar
  921. Wathen, R. L., W. S. Kingsbury, D. A. Strouder, and H. H. Rosterfer: Renin release during catacholamine infusion into the renal artery of the dog. Fed. Proc. 23, 437 (1964).Google Scholar
  922. Weber, A. F., W. R. Pritchard, and A. F. Sellers: The production of lipid accumulation and other histological and cytological changes in the zona glomerulosa of calves. Amer. J. vet. Res. 17, 402–409 (1956).PubMedGoogle Scholar
  923. Weisz, P., and V. Kemény: Aldosterone production of compensated hypertrophic adrenals. Experientia (Basel) 19, 540–541 (1963).Google Scholar
  924. Welt, L.G. (ed.): Essays in metabolism. J. P. Peters Memorial Issue of Yale J. Biol. Med., vol. 29, 1956. Boston: Little, Brown & Co. 1957.Google Scholar
  925. Wesson, L.G., Jr., and D.P. Lauler: Diurnal cycle of glomerular filtration rate and sodium chloride excretion during responses to altered salt and water balance in man. J. clin. Invest. 40, 1967–1977 (1961).PubMedGoogle Scholar
  926. Wexler, B. C.: Lipid depletion of the zona glomerulosa of the rat adrenal cortex after administration of 9α-fluorohydrocortisone. Endocrinology 64, 300–304 (1959).PubMedGoogle Scholar
  927. —.: Histological alterations in the adrenal cortex of intact and hyposectomized rats following ACTH, pitressin and adrenal steroids. Endocrinology 72, 149–158 (1963).PubMedGoogle Scholar
  928. —, and A. P. Rinfret: Histological observations on the zona glomerulosa of the rat adrenal cortex following administration of corticotrophin preparations. Endocrinology 57, 608–620 (1955).PubMedGoogle Scholar
  929. —, —, A. C. Griffin, and H. L. Richardson: Evidence for pituitary control of the lipid content of the zona glomerulosa of the rat adrenal cortex. Endocrinology 56, 120–123 (1955).PubMedGoogle Scholar
  930. Wiedman, M. L., F. W. Dunihue, and W. van B. Robertson: Effect of sodium chloride intake and mineralocorticoid level on the granularity of the juxtaglomerular cells. J. Endocr. 17, 261–264 (1958).PubMedGoogle Scholar
  931. Williams, H. E., P. L. Johnson, and J. B. Field: In vitro studies on the effect of ACTH in rat and bovine adrenal glands. Endocrinology 71, 293–297 (1962).PubMedGoogle Scholar
  932. Williams, J. R., Jr., J. T. Diaz, J. C. Burch, and T. R. Harrison: The relation of the adrenal glands to the action of renal pressor substances. Amer. J. med. Sci. 198,212–219 (1939).Google Scholar
  933. Wilson, I. D., and F. C. Goetz: Selective hypoaldosteronism after prolonged heparin administration. Amer. J. Med. 36, 635–640 (1964).PubMedGoogle Scholar
  934. Winer, B. M.: Humoral vasoconstrictor effect of diuretics. Circulation 26, 805 (1962).Google Scholar
  935. —., A vasoconstrictor effect of plasma during salt depletion. J. clin. Invest. 42, 994 (1963).Google Scholar
  936. Winkler, G., W. Rick, B.v. Kügelgen u. E. Koch: Klinische Beobachtungen bei Hypoaldosteronismus. Verh. dtsch. Ges. inn. Med. 68, 671–677 (1962).Google Scholar
  937. Wise, B.L., and W.F. Ganong: The effect of ablation of the area postrema on water and electrolyte metabolism in dogs. Acta neuroveg. (Wien) 22, 14–32 (1960a).Google Scholar
  938. —., and —: Effect of brain stem stimulation on renal function. Amer. J. Physiol. 198, 1291–1295 (1960b).PubMedGoogle Scholar
  939. Wislocki, G.B., and E.H. Leduc: The cytology and histochemistry of the subcommissural organ, and Reissner’s fiber in rodents. J. comp. Neurol. 97, 515–544 (1952).PubMedGoogle Scholar
  940. Wolf, R.L., M. Mendolowitz, S. Gitlow, and N. Naftchi: In vitro degradation of angiotensin II131 in normotensive and hypertensive human subjects. Circulation 24, 1074 (1961).Google Scholar
  941. —., —, —, and — The metabolism of angiotensin II. Circulat. Res. 11, 195–205 (1962).PubMedGoogle Scholar
  942. —., —, —, J. Roboz, and N. Naftchi: Angiotensin II degradation by human Cohn plasma fractions. Proc. Soc. exp. Biol. (N.Y.) 112, 209–212 (1963).Google Scholar
  943. —., — J. Roboz, N.E. Naftchi, and S.E. Gitlow: Recent studies on I131-labelled angiotensin II and analogues. Canad. med. Ass. J. 90, 295–298 (1964).PubMedGoogle Scholar
  944. Wolff, H.P., K.R. Koczorek, and E. Buchborn: Aldosteronuria in oedema. In: A.F. Müller and C.M. O’Connor (eds.), An Int. Symposium on Aldosterone, p. 193–206. London: Churchill 1958.Google Scholar
  945. —., — W. Jesch, and E. Buchborn: Untersuchungen über die Aldosteronausscheidung bei Leberkranken. Klin. Wschr. 34, 366–371 (1956).PubMedGoogle Scholar
  946. —., and M. Torbica: Detection of plasma-aldosterone. Lancet 1963 I, 1346–1347.Google Scholar
  947. Wright, R.D.: Control of secretion of aldosterone. Brit. med. Bull. 18, 159–163 (1962).PubMedGoogle Scholar
  948. Wrong, O.M.: Hyperaldosteronism secondary to renal ischemia. In: E.E. Baulieu and P. Robel (eds.), Aldosterone. Oxford: Blackwell 1964.Google Scholar
  949. Wurtman, R.J., M.D. Altschule, and U. Holmgran: Effects of pinealectomy and of a bovine pineal extract in rats. Amer. J. Physiol. 197, 108–110 (1959).PubMedGoogle Scholar
  950. —., —, R.O. Greep, J.L. Falk, and G. Grave: The pineal gland and aldosterone. Amer. J. Physiol. 199, 1109–1111 (1960).PubMedGoogle Scholar
  951. —, W. Roth, M.D. Altschule, and J.J. Wurtman: Interactions of the pineal and exposure to continuous light on organ weights of female rats. Acta endocr. (Kbh.) 36, 617–624 (1961).Google Scholar
  952. Yamada, T.: The effect of electrical ablation of the nuclei habenulae, pineal body and sub-commissural organ on endocrine function, with special reference to thyroid function. Endocrinology 69, 706–711 (1961).PubMedGoogle Scholar
  953. Yamauchi, H., and J. Hopper, Jr.: Pure nephrosis in an adult patient. Ann. intern. Med 55, 464–471 (1961).PubMedGoogle Scholar
  954. Yankopoulos, N.A., J.O. Davis, B. Kliman, and R.E. Peterson: Evidence that a humoral agent stimulates the adrenal cortex to secrete aldosterone in experimental secondary hyperaldosteronism. J. clin. Invest. 38, 1278–1289 (1959).PubMedGoogle Scholar
  955. Yates, F.E.: Effects of central venous congestion on sodium, potassium and water metabolism in the rat: response to desoxycorticosterone. Amer. J. Physiol. 194, 57–64 (1958).PubMedGoogle Scholar
  956. —, J. Urquhart, and A.L. Herbst: Impairment of the enzymatic inactivation of adrenal cortical hormones following passive venous congestion of the liver. Amer. J. Physiol. 194, 65–71 (1958).PubMedGoogle Scholar
  957. Yoshinaga, K., M. Aida, M. Maebashi, T. Sato, K. Abe, and I. Miwa: Assay of renin in peripheral blood. Tohoku J. exp. Med. 80, 32–41 (1963).PubMedGoogle Scholar
  958. Zaugheri, E.O., H. Campana, F. Ponce, J.C. Silva, F.O. Fernandez, and J.R.E. Suarez: Production of erythropoietin by anoxic perfusion of the isolated kidney of a dog. Nature (Lond.) 199, 572–573 (1963).Google Scholar
  959. Zimmerman, B.G.: Effect of acute sympathectomy on responses to angiotensin and nor-epinephrine. Circulat. Res. 11, 780–787 (1962).PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1968

Authors and Affiliations

  • William F. Ganong
  • Edmund E. Van Brunt

There are no affiliations available

Personalised recommendations