Abstract
Despite considerable controversy, the identities of the major mechanisms regulating aldosterone secretion are known and the broad outlines if not the details of how they operate are established. The release of this hormone from the zona glomerulosa of the adrenal cortex is increased by ACTH and by angiotensin II. The latter is formed in the blood stream by the action of renin from the kidney on a protein in the plasma. In addition to the hypothalamo-pituitary system and the renin-angiotensin system, a rise in plasma potassium or a fall in plasma sodium acts directly on the zona glomerulosa to increase aldosterone secretion. Additional stimulating and inhibiting factors from the posterior diencephalon and pineal gland may exist, but it now appears that, if they do, their physiological roles are minor.
The literature reviewed in this chapter includes for the most part only that available through March 1, 1964. The chapter includes previously unpublished results of experiments supported by United States Public Health Service Grants A-5437 and AM-06704.
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Ganong, W.F., Van Brunt, E.E. (1968). Control of Aldosterone Secretion. In: Deane, H.W., Rubin, B.L. (eds) The Adrenocortical Hormones. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 14 / 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-99938-3_2
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