Structure-Activity Relationships of the Organophosphorus Anticholinesterase Agents

  • Bo Holmstedt
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 15)

Abstract

Organic chemists have the habit of tasting new compounds. Useful drugs like local anaesthetics have been discovered in this way. On the other hand, it is amazing that so few scientists have met a premature death as a result. It is remarkable, for example, that the French nobleman and organic chemist Philippe de Clermont did not succumb to tetraethyl pyrophosphate (TEPP) poisoning in 1854. If this had happened, the toxicity of the anticholinesterase (anti-ChE) agents of the organophosphorus type would have been discovered much earlier than it actually was.

Keywords

Diethyl Tetraethyl Phonate Phosphoramide Thiocholine 

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