Abstract
The purpose of the present chapter is to review the available data on the structure of the active site of acetylcholinesterase (AChE) and on the way this active site reacts with the substrates and inhibitors of the enzyme. In the present review the term “active site” will refer to those regions of the enzyme surface where the substrate is localized and activated during the enzymic action. No attempt is made to include information on the enzyme, its substrates, or inhibitors which does not directly contribute to an understanding of the structure of the active site or its reactivity. For these many alternative aspects outside the scope of the present paper the reader is referred to excellent articles available in the literature including those by Augustinsson (1948 and 1951 c), Holmstedt (1959), Nachmansohn and Wilson (1951), Whittaker (1951), Zeller (1958) and chapters 4, 8, and 9 of the present handbook
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References
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Cohen, J.A., Oosterbaan, R.A. (1963). The Active Site of Acetylcholinesterase and Related Esterases and its Reactivity towards Substrates and Inhibitors. In: Koelle, G.B. (eds) Cholinesterases and Anticholinesterase Agents. Handbook of Experimental Pharmacology, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-99875-1_7
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