Reactivation of Phosphorylated Acetylcholinesterase

  • F. Hobbiger
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 15)


The active centre of acetylcholinesterase (AChE) contains two subsites which are generally called the anionic and esteratic sites. Hydrolysis of acetylcholine (ACh) by AChE involves the following sequence of reactions:

Binding of the ester to the two subsites of the enzyme → hydrolysis of the ester with release of choline into solution and binding of the acetyl group to a basic group of the esteratic site → hydrolysis of the acetylated enzyme.


AChE Activity Hydroxamic Acid Striped Muscle Anionic Site Organophosphate Poisoning 
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© Springer-Verlag Berlin Heidelberg 1963

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  • F. Hobbiger

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