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Pharmaka zur Behandlung von Anämien, zum Blutersatz und zur Verbesserung der Rheologie

  • C. Taube
Chapter
Part of the Springer-Lehrbuch book series (SLB)

Zusammenfassung

Eine Anämie ist gekennzeichnet durch eine Verringerung der Erythrozytenzahl, Hämoglobinmenge und Hämatokritwert (Normwerte s. Tabelle 27.1). Eine Einteilung der verschiedenen Anämieformen und deren Ursachen gibt Tabelle 27.2 wieder. Die Therapie einer Anämie ist nur bei Eisen-, Folsäure- oder Vitamin-B12-Mangel im Sinne einer Substitution möglich, alle anderen Anämieformen können nur symptomatisch behandelt werden.

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Literatur

  1. Aisen P, Brown EB (1977) The iron-binding function of transferrin in iron metabolism. Semin Hematol 1431–53Google Scholar
  2. Beck WS (1991) Diagnosis of megaloblastic anemia. Annu Rev Med 42:311–322PubMedCrossRefGoogle Scholar
  3. Begemann H, Rastetter J (1986) Klinische Hämatologic 3. Aufl. Thieme, Stuttgart New YorkGoogle Scholar
  4. Bothwell TH, Charlton RW, Cool JD, Finch CA (1979) Iron metabolism in man. Blackwell Scientific Publications, OxfordGoogle Scholar
  5. Brizzi MF, Avanzi GC, Pegoraro (1991) Hematopoietic growth factor receptors. Intern J Cell Cloning 9:274–300CrossRefGoogle Scholar
  6. Cook JD (1977) Absorption of food iron. Fed Proc 36:2028–2932PubMedGoogle Scholar
  7. Cook JD, Skikne BS, Baynes RD (1993) Serum transferrin receptor. Annu Rev Med 44:63–74PubMedCrossRefGoogle Scholar
  8. Crosier PS, Clark SC (1992) Basic biology of the hematopoietic growth factors. Semin Oncol 19:349–361PubMedGoogle Scholar
  9. D’Andrea AA (1994) Cytokine receptors in congenital hematopoietic disease. N Engl J Med 330:839–846PubMedCrossRefGoogle Scholar
  10. Demetri GD, Antman KHS (1992) Granulocyte-macrophage colony-stimulating factor (GM-CSF): Preclinical and clinical investigations. Semin Oncol 19:362–385PubMedGoogle Scholar
  11. Eckardt KU, Bauer C (1989) Erythropoietin in health and disease. Eur J Clin Invest 19:117–127PubMedCrossRefGoogle Scholar
  12. Erslev AJ (1991) Erythropoetin. N Engl J Med 324:1339–1344PubMedCrossRefGoogle Scholar
  13. Eschbach JW, Kelly MR, Haley NR, Abels RI, Adamson JW (1989) Treatment of the anemia of progressive renal failure with recombinant human erythropoietin. N Engl J Med 321:158–162PubMedCrossRefGoogle Scholar
  14. Fleischman RA (1993) Southwestern internal medicine conference: Clinical use of hematopoietic growth factors. Am J Med Sci 305:248–273PubMedCrossRefGoogle Scholar
  15. Forth W, Rummel W (1973) Iron absorption. Physiol Rev 53: 724–792Google Scholar
  16. Garcia JF, Ebbe SN, Hollander L, Cutting HO, Miller ME, Cronkite EP (1982) Radioimmunoassay of erythropoietin: Circulatory levels in normal and polycythemic human beings. J Lab Clin Med 99:624–635PubMedGoogle Scholar
  17. Goodnough LT, Anderson KC, Kurtz S, Lane TA (1993) Indications and guidelines for the use of hematopoietic growth factors. Transfusion 33:944–959PubMedCrossRefGoogle Scholar
  18. Groopman JE, Molina J-M, Scadden DT (1989) Hematopoietic growth factors: Biology and clinical applications. N Engl J Med 321:1449–1459PubMedCrossRefGoogle Scholar
  19. Hallberg L (1982) Iron absorption and iron deficiency. Hum Nutr Clin Nutr 36C:259–278Google Scholar
  20. Heinrich HC (1978) Ätiologie, Diagnostik und Dimensionierung der Therapie des Eisenmangels. Löhr GW et al. (Hrsg.): Probleme der Erythropoese, Granulozytopoese und des malignen Lymphoms. Hämatologie und Bluttransfusion. Nd. 21, Springer, Berlin Heidelberg New YorkGoogle Scholar
  21. Hoyer LW (1994) Hemophilia A. N Engl J Med 330:38–47PubMedCrossRefGoogle Scholar
  22. Huebers H, Huebers E, Csiba E, Rummel W (1983) The significance of transferrin for intestinal iron absorption. Blood 61:283–290PubMedGoogle Scholar
  23. Jacobs A (1977) Serum ferritin and iron stores. Fed Proc 36:2024–2027PubMedGoogle Scholar
  24. Jelkmann W (1992) Erythropoietin: Structure, control of production, and function. Physiol Rev 72:449–489PubMedGoogle Scholar
  25. Lieschke GJ, Burgess AW (1992) Granulozyte colony-stimulation factor and granulocyte-macrophage colony-stimulation factor, part I and II. N Engl J Med 327:28–35,PubMedCrossRefGoogle Scholar
  26. Lieschke GJ, Burgess AW (1992) Granulozyte colony-stimulation factor and granulocyte-macrophage colony-stimulation factor, part I and II. N Engl J Med 327: 99–106PubMedCrossRefGoogle Scholar
  27. Metcalf D (1986) The molecular biology and functions of the granulocyte-macrophage colony-stimulating factors. Blood 67:257–267PubMedGoogle Scholar
  28. Munn DH, Cheung NK (1992) Preclinical and clinical studies of macrophage colony-stimulating factor. Semin Oncol 19:395–407PubMedGoogle Scholar
  29. Nicola NA (1989) Hematopoietic cell growth factors and their receptors. Ann Rev Biochem 58:45–78PubMedCrossRefGoogle Scholar
  30. Oski FA (1993) Iron deficiency in infancy and childhood. N Engl J Med 329:190–193PubMedCrossRefGoogle Scholar
  31. Ostendorf PC (Hrsg.) (1991) Hämatologie. Urban & Schwar-zenberg, München Wien BaltimoreGoogle Scholar
  32. Pruthi RK, Tefferi A (1994) Pernicious anemia revisited. Mayo Clin Proc 69:144–150PubMedGoogle Scholar
  33. Sears D (1991) Iron deficiency. In: Rakel RE (ed): Conn’s current therapy. S 299–301. Saunders, PhiladelphiaGoogle Scholar
  34. Spangrude GJ (1994) Biological and clinical aspects of hematopoietic stem cells. Annu Rev Med 45:93–104PubMedCrossRefGoogle Scholar
  35. Spivak JL (1993) Recombinant erythropoietin. Annu Rev Med 44:243–253PubMedCrossRefGoogle Scholar
  36. Suttie JW (1993) Synthesis of vitamin K-dependent proteins. FASEB J 7:445–452PubMedGoogle Scholar
  37. Vadhan-Raj S, Keating M, LeMaistre A, Hiltelman WW, McCudie K, Tryillo JM, Broxmeyer HE, Herney C, Gulterman JU (1987) Effects of recombinant human granulocyte macrophage colony-stimulating factor in patients with my-elodysplastic syndromes. N Engl J Med 317:1545–1552PubMedCrossRefGoogle Scholar
  38. Williams WJ, Beutler E, Erslen AJ, Lichtman MA (1990) Hematology. McGraw-Hill, New YorkGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1999

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  • C. Taube

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