Skip to main content
SpringerLink
Log in

Pharmaka mit Wirkung auf den glatten Muskel

  • Chapter
Book cover Pharmakologie und Toxikologie

Part of the book series: Springer-Lehrbuch ((SLB))

  • 124 Accesses

Zusammenfassung

Von der Elektrophysiologie, der Rezeptorausstattung und der Wirkung von Pharmaka her lassen sich 2 Gruppen der glatten Muskulatur differenzieren: intestinaler und vaskulärer Typ, Die glatte Muskulatur des Bronchialsystems nimmt eine Mittelstellung ein.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Ahlner J, Andersson RGG, Torfgard K, Axelsson KL (1991) Organic nitrate esters: Clinical use and mechanisms of actions. Pharmacol Rev 43:351–423

    PubMed  CAS  Google Scholar 

  • Anggard E (1994) Nitric oxide: Mediator, murderer, and medicine. Lancet 343:1199–1206

    Article  PubMed  CAS  Google Scholar 

  • Atwal KS (1992) Modulation of potassium channels by organic molecules. Med Res Rev 12:569–591

    Article  PubMed  CAS  Google Scholar 

  • Beavo JA (1995) Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms. Physiol Rev 75:725–748

    PubMed  CAS  Google Scholar 

  • Berridge MJ (1993) Inositol trisphosphate and calcium signalling. Nature 361:315–325

    CAS  Google Scholar 

  • Bootman MD, Berridge MJ (1995) The elemental principles of calcium signaling. Cell 83:675–678

    Article  PubMed  CAS  Google Scholar 

  • Callewaert G (1992) Excitation-contraction coupling in mammalian cardiac cells. Cardiovasc Res 26:923–932

    Article  PubMed  CAS  Google Scholar 

  • Cantin M, Genest J (1985) The heart and the atrial natriuretic factor. Endocr Rev 6:107–127

    Article  PubMed  CAS  Google Scholar 

  • Catterall WA (1995) Structure and function of voltage-gated ion channels. Annu Rev Biochem 64:493–531

    Article  PubMed  CAS  Google Scholar 

  • Catterall WA, Striessnig J (1992) Receptor sites for Ca2+ channel antagonists. Trends Pharmacol Sci 13:256–262

    Article  PubMed  CAS  Google Scholar 

  • Conti M, Jin S-LC, Monaco L, Repaske DR, Swinnen JV (1991) Hormonal regulation of cyclic nucleotide phosphodiesterases. Endocr Rev 12:218–234

    Article  PubMed  CAS  Google Scholar 

  • Davies NM, Standen NB, Stanfield PR (1991) ATP-dependent potassium channels of muscle cells: Their properties, regulation, and possible functions. J Bioenerg Biomembr 23:509–535

    Article  CAS  Google Scholar 

  • De Weille JR (1992) Modulation of ATP sensitive potassium channels. Cardiovasc Res 26:1017–1020

    Article  PubMed  Google Scholar 

  • De Zeeuw D, Janssen WMT, De Jong PE (1992) Atrial natriuretic factor: Its (patho)physiological significance in humans. Kidney Int 41:1115–1133

    Article  PubMed  Google Scholar 

  • Dolphin AC (1991) Regulation of calcium channel activity by GTP binding proteins and second messengers. Biochim Biophys Acta 1091:68–80

    Article  PubMed  CAS  Google Scholar 

  • Elkayam U (1991) Tolerance to organic nitrates: Evidence, mechanisms, clinical relevance, and strategies for prevention. Ann Intern Med 114:667–677

    PubMed  CAS  Google Scholar 

  • Fasolato C, Innocenti B, Pozzan T (1994) Receptor-activated Ca2+ influx: How many mechanisms for how many channels. Trends Pharmacol Sci 15:77–83

    Article  PubMed  CAS  Google Scholar 

  • Ferro CJ, Webb DJ (1996) The clinical potential of endothelin receptor antagonists in cardiovascular medicine. Drugs 51:12–27

    Article  PubMed  CAS  Google Scholar 

  • Fleckenstein A (1983) History of calcium antagonists. Circ Res 52 [Suppl I]:3–16

    CAS  Google Scholar 

  • Galen PJM van, Stiles GL, Michaels G, Jacobson KA (1992) Adenosin A1 and A2 receptors: Structure-function relationships. Med Res Rev 12:423–471

    Article  PubMed  Google Scholar 

  • Garbers DL, Koesling D, Schultz G (1994) Guanylyl cyclase receptors. Mol Biol Cell 5:1–5

    PubMed  CAS  Google Scholar 

  • Gerzer R (1985) Das Herz, ein endokrines Organ: Die Entdeckung eines neuen Hormons. Klin Wochenschr 63:529–536

    Article  PubMed  CAS  Google Scholar 

  • Glossmann H, Striessnig J (1990) Molecular properties of calcium channels. Rev Physiol Biochem Pharmacol 114:1–105

    Article  PubMed  CAS  Google Scholar 

  • Goldmann B, Stoltefuss J (1991) 1,4-dihydropyridines: Effects of chirality and conformation on the calcium antagonist and calcium agonist activities. Angew Chem (Int Ed Engl) 30:1559–1578

    Article  Google Scholar 

  • Grobecker H (1994) Calciumantagonisten. Med Monatsschr Pharm 17:130–139

    PubMed  CAS  Google Scholar 

  • Hellwig B (1994) Kaliumagonisten. Med Monatsschr Pharm 17:164–167

    PubMed  CAS  Google Scholar 

  • Hess P (1990) Calcium channels in vertebrate cells. Annu Rev Neurosci 13:337–356.

    Article  PubMed  CAS  Google Scholar 

  • Hofmann F, Biel M, Flockerzi V (1994) Molecular basis for Ca2+ channel diversity. Annu Rev Neurosci 17:399–418

    Article  PubMed  CAS  Google Scholar 

  • Hollenberg MD (1994) Tyrosine kinase pathways and the regulation of smooth muscle contractility. Trends Pharmacol Sci 15:108–114

    Article  PubMed  CAS  Google Scholar 

  • Kam PCA, Govendeer G (1994) Nitric oxide: Basic science and clinical applications. Anaesthesia 49:515–521

    Article  PubMed  CAS  Google Scholar 

  • Kamm KE, Stull JT (1985) The function of myosin and myosin light chain kinase phosphorylation in smooth muscle. Annu Rev Pharmacol Toxicol 25:593–620

    Article  PubMed  CAS  Google Scholar 

  • Levin ER (1995) Endothelins. N Engl J Med 333:356–363

    Article  PubMed  CAS  Google Scholar 

  • Masaki T (1995) Possible role of endothelin in endothelial regulation of vascular tone. Annu Rev Pharmacol Toxicol 35:235–255

    Article  PubMed  CAS  Google Scholar 

  • Masaki T, Yanagisawa M (1992) Physiology and pharmacology of endothelins. Med Res Rev 12:391–421

    Article  PubMed  CAS  Google Scholar 

  • Mayer B, John M, Heinzel B, Werner ER, Wachter H, Schultz G, Böhme E (1991) Brain nitric oxide synthase is a biopterin- and flavin-containing multi-functional oxido-reductase. FEBS Lett 288:187–191

    Article  PubMed  CAS  Google Scholar 

  • Means AR, Van Berkum MFA, Bagchi I, Lu KP, Rasmussen CD (1991) Regulatory functions of calmodulin. Pharmacol Ther 50:255–270

    Article  PubMed  CAS  Google Scholar 

  • Moncada S (1992) The 1991 Ulf von Euler Lecture, The L-argi-nine:nitric oxide pathway. Acta Physiol Scand 145:201–227

    Article  PubMed  CAS  Google Scholar 

  • Moneada S, Higgs A (1993) The L-arginine-nitric oxide pathway. N Engl J Med 329:2002–2012

    Article  Google Scholar 

  • Nathan C, Xie QW (1994) Regulation of biosynthesis of nitric oxide. J Biol Chem 269:13725–13728

    PubMed  CAS  Google Scholar 

  • Pelzer D, Pelzer S, McDonald TF (1990) Properties and regulation of calcium channels in muscle cells. Rev Physiol Biochem Pharmacol 114:107–207

    Article  PubMed  CAS  Google Scholar 

  • Pfaffendorf M (1992) Atriales natriuretisches Peptid als Angiotensin-II-Antagonist: Eine neues therapeutisches Prinzip? Med Monatsschr Pharm 15:169–177

    PubMed  CAS  Google Scholar 

  • Pietrobon D, Di Virgilio F, Pozzan T (1990) Structural and functional aspects of calcium homeostasis in eukaryotic cells. Eur J Biochem 193:599–622

    Article  PubMed  CAS  Google Scholar 

  • Pongs O (1992) Structural basis of voltage-gated K+-channel pharmacology. Trends Pharmacol Sci 13:359–365

    Article  PubMed  CAS  Google Scholar 

  • Porzig H (1990) Pharmacological modulation of voltage-dependent calcium channels in intact cells. Rev Physiol Biochem Pharmacol 114:209–262

    Article  PubMed  CAS  Google Scholar 

  • Quast U, Guillon JM, Cavero I (1994) Cellular pharmacology of potassium channel openers in vascular smooth muscle. Cardiovasc Res 28:805–810

    Article  PubMed  CAS  Google Scholar 

  • Quayle JM, Standen NB (1994) K-ATP channels in vascular smooth muscle. Cardiovasc Res 28:797–804

    Article  PubMed  CAS  Google Scholar 

  • Rembold CM (1992) Regulation of contraction and relaxation in arterial smooth muscle. Hypertension 20:129–137

    PubMed  CAS  Google Scholar 

  • Reynen K (1993) Nitrate. Dtsch Med Wochenschr 118:1532–1539

    Article  PubMed  CAS  Google Scholar 

  • Ruskoaho H (1992) Atrial natriuretic peptide: Synthesis, release, and metabolism. Pharmacol Rev 44:480–602

    Google Scholar 

  • Saccomano NA, Ganong AH (1991) Diversity of neuronal calcium channels. Annu Rev Med Chem 26:33–41

    Article  CAS  Google Scholar 

  • Sanguinetti MC (1992) Modulation of potassium channels by antiarrhythmic and antihypertensive drugs. Hypertension 19:228–236

    PubMed  CAS  Google Scholar 

  • Scherübl H, Hescheler J (1992) Patch-clamp-Technik und Ionenkanäle: Bedeutung in der Medizin. Dtsch Ärztebl 89:B-215–B-218

    Google Scholar 

  • Schmidt HHHW (1994) NO, endogener Botenstoff und Zellgift. Med Monatsschr Pharm 17:168–185

    PubMed  CAS  Google Scholar 

  • Schröder H (1992) Organische Nitrate: Neue Erkenntnisse zum Wirkungsmechanismus einer alten Substanzklasse. Med Monatsschr Pharm 15:134–139

    PubMed  Google Scholar 

  • Smyth EM, Keenan AK (1994) The vascular ANF-C receptor: Role in atrial peptide signalling. Cell Signal 6:125–133

    Article  PubMed  CAS  Google Scholar 

  • Tang W-J, Gilman AG (1992) Adenylyl cyclases. Cell 70:869–872

    Article  PubMed  CAS  Google Scholar 

  • Thompson WJ (1991) Cyclic nucleotide phosphodiesterases: Pharmacology, biochemistry and function. Pharmacol Ther 51:13–33

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. E. Oberdisse
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Fachbereich Humanmedizin — Institut für Pharmakologie, Freie Universität Berlin, Thielallee 67-73, 14195, Berlin, Deutschland

    Eckard Oberdisse

  2. Pharmakologisches Institut, Universität Heidelberg, Im Neuenheimer Feld 366, 69120, Heidelberg, Deutschland

    Eberhard Hackenthal

  3. Institut für Pharmakologie und Toxikologie, Universität Marburg/Lahn, Ketzerbach 63, 35032, Marburg, Deutschland

    Klaus Kuschinsky

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Oberdisse, E. (1999). Pharmaka mit Wirkung auf den glatten Muskel. In: Oberdisse, E., Hackenthal, E., Kuschinsky, K. (eds) Pharmakologie und Toxikologie. Springer-Lehrbuch. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-98030-5_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-98030-5_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-98031-2

  • Online ISBN: 978-3-642-98030-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation