Advertisement

Pharmaka mit Wirkung auf den glatten Muskel

  • E. Oberdisse
Part of the Springer-Lehrbuch book series (SLB)

Zusammenfassung

Von der Elektrophysiologie, der Rezeptorausstattung und der Wirkung von Pharmaka her lassen sich 2 Gruppen der glatten Muskulatur differenzieren: intestinaler und vaskulärer Typ, Die glatte Muskulatur des Bronchialsystems nimmt eine Mittelstellung ein.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Ahlner J, Andersson RGG, Torfgard K, Axelsson KL (1991) Organic nitrate esters: Clinical use and mechanisms of actions. Pharmacol Rev 43:351–423PubMedGoogle Scholar
  2. Anggard E (1994) Nitric oxide: Mediator, murderer, and medicine. Lancet 343:1199–1206PubMedCrossRefGoogle Scholar
  3. Atwal KS (1992) Modulation of potassium channels by organic molecules. Med Res Rev 12:569–591PubMedCrossRefGoogle Scholar
  4. Beavo JA (1995) Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms. Physiol Rev 75:725–748PubMedGoogle Scholar
  5. Berridge MJ (1993) Inositol trisphosphate and calcium signalling. Nature 361:315–325Google Scholar
  6. Bootman MD, Berridge MJ (1995) The elemental principles of calcium signaling. Cell 83:675–678PubMedCrossRefGoogle Scholar
  7. Callewaert G (1992) Excitation-contraction coupling in mammalian cardiac cells. Cardiovasc Res 26:923–932PubMedCrossRefGoogle Scholar
  8. Cantin M, Genest J (1985) The heart and the atrial natriuretic factor. Endocr Rev 6:107–127PubMedCrossRefGoogle Scholar
  9. Catterall WA (1995) Structure and function of voltage-gated ion channels. Annu Rev Biochem 64:493–531PubMedCrossRefGoogle Scholar
  10. Catterall WA, Striessnig J (1992) Receptor sites for Ca2+ channel antagonists. Trends Pharmacol Sci 13:256–262PubMedCrossRefGoogle Scholar
  11. Conti M, Jin S-LC, Monaco L, Repaske DR, Swinnen JV (1991) Hormonal regulation of cyclic nucleotide phosphodiesterases. Endocr Rev 12:218–234PubMedCrossRefGoogle Scholar
  12. Davies NM, Standen NB, Stanfield PR (1991) ATP-dependent potassium channels of muscle cells: Their properties, regulation, and possible functions. J Bioenerg Biomembr 23:509–535CrossRefGoogle Scholar
  13. De Weille JR (1992) Modulation of ATP sensitive potassium channels. Cardiovasc Res 26:1017–1020PubMedCrossRefGoogle Scholar
  14. De Zeeuw D, Janssen WMT, De Jong PE (1992) Atrial natriuretic factor: Its (patho)physiological significance in humans. Kidney Int 41:1115–1133PubMedCrossRefGoogle Scholar
  15. Dolphin AC (1991) Regulation of calcium channel activity by GTP binding proteins and second messengers. Biochim Biophys Acta 1091:68–80PubMedCrossRefGoogle Scholar
  16. Elkayam U (1991) Tolerance to organic nitrates: Evidence, mechanisms, clinical relevance, and strategies for prevention. Ann Intern Med 114:667–677PubMedGoogle Scholar
  17. Fasolato C, Innocenti B, Pozzan T (1994) Receptor-activated Ca2+ influx: How many mechanisms for how many channels. Trends Pharmacol Sci 15:77–83PubMedCrossRefGoogle Scholar
  18. Ferro CJ, Webb DJ (1996) The clinical potential of endothelin receptor antagonists in cardiovascular medicine. Drugs 51:12–27PubMedCrossRefGoogle Scholar
  19. Fleckenstein A (1983) History of calcium antagonists. Circ Res 52 [Suppl I]:3–16Google Scholar
  20. Galen PJM van, Stiles GL, Michaels G, Jacobson KA (1992) Adenosin A1 and A2 receptors: Structure-function relationships. Med Res Rev 12:423–471PubMedCrossRefGoogle Scholar
  21. Garbers DL, Koesling D, Schultz G (1994) Guanylyl cyclase receptors. Mol Biol Cell 5:1–5PubMedGoogle Scholar
  22. Gerzer R (1985) Das Herz, ein endokrines Organ: Die Entdeckung eines neuen Hormons. Klin Wochenschr 63:529–536PubMedCrossRefGoogle Scholar
  23. Glossmann H, Striessnig J (1990) Molecular properties of calcium channels. Rev Physiol Biochem Pharmacol 114:1–105PubMedCrossRefGoogle Scholar
  24. Goldmann B, Stoltefuss J (1991) 1,4-dihydropyridines: Effects of chirality and conformation on the calcium antagonist and calcium agonist activities. Angew Chem (Int Ed Engl) 30:1559–1578CrossRefGoogle Scholar
  25. Grobecker H (1994) Calciumantagonisten. Med Monatsschr Pharm 17:130–139PubMedGoogle Scholar
  26. Hellwig B (1994) Kaliumagonisten. Med Monatsschr Pharm 17:164–167PubMedGoogle Scholar
  27. Hess P (1990) Calcium channels in vertebrate cells. Annu Rev Neurosci 13:337–356.PubMedCrossRefGoogle Scholar
  28. Hofmann F, Biel M, Flockerzi V (1994) Molecular basis for Ca2+ channel diversity. Annu Rev Neurosci 17:399–418PubMedCrossRefGoogle Scholar
  29. Hollenberg MD (1994) Tyrosine kinase pathways and the regulation of smooth muscle contractility. Trends Pharmacol Sci 15:108–114PubMedCrossRefGoogle Scholar
  30. Kam PCA, Govendeer G (1994) Nitric oxide: Basic science and clinical applications. Anaesthesia 49:515–521PubMedCrossRefGoogle Scholar
  31. Kamm KE, Stull JT (1985) The function of myosin and myosin light chain kinase phosphorylation in smooth muscle. Annu Rev Pharmacol Toxicol 25:593–620PubMedCrossRefGoogle Scholar
  32. Levin ER (1995) Endothelins. N Engl J Med 333:356–363PubMedCrossRefGoogle Scholar
  33. Masaki T (1995) Possible role of endothelin in endothelial regulation of vascular tone. Annu Rev Pharmacol Toxicol 35:235–255PubMedCrossRefGoogle Scholar
  34. Masaki T, Yanagisawa M (1992) Physiology and pharmacology of endothelins. Med Res Rev 12:391–421PubMedCrossRefGoogle Scholar
  35. Mayer B, John M, Heinzel B, Werner ER, Wachter H, Schultz G, Böhme E (1991) Brain nitric oxide synthase is a biopterin- and flavin-containing multi-functional oxido-reductase. FEBS Lett 288:187–191PubMedCrossRefGoogle Scholar
  36. Means AR, Van Berkum MFA, Bagchi I, Lu KP, Rasmussen CD (1991) Regulatory functions of calmodulin. Pharmacol Ther 50:255–270PubMedCrossRefGoogle Scholar
  37. Moncada S (1992) The 1991 Ulf von Euler Lecture, The L-argi-nine:nitric oxide pathway. Acta Physiol Scand 145:201–227PubMedCrossRefGoogle Scholar
  38. Moneada S, Higgs A (1993) The L-arginine-nitric oxide pathway. N Engl J Med 329:2002–2012CrossRefGoogle Scholar
  39. Nathan C, Xie QW (1994) Regulation of biosynthesis of nitric oxide. J Biol Chem 269:13725–13728PubMedGoogle Scholar
  40. Pelzer D, Pelzer S, McDonald TF (1990) Properties and regulation of calcium channels in muscle cells. Rev Physiol Biochem Pharmacol 114:107–207PubMedCrossRefGoogle Scholar
  41. Pfaffendorf M (1992) Atriales natriuretisches Peptid als Angiotensin-II-Antagonist: Eine neues therapeutisches Prinzip? Med Monatsschr Pharm 15:169–177PubMedGoogle Scholar
  42. Pietrobon D, Di Virgilio F, Pozzan T (1990) Structural and functional aspects of calcium homeostasis in eukaryotic cells. Eur J Biochem 193:599–622PubMedCrossRefGoogle Scholar
  43. Pongs O (1992) Structural basis of voltage-gated K+-channel pharmacology. Trends Pharmacol Sci 13:359–365PubMedCrossRefGoogle Scholar
  44. Porzig H (1990) Pharmacological modulation of voltage-dependent calcium channels in intact cells. Rev Physiol Biochem Pharmacol 114:209–262PubMedCrossRefGoogle Scholar
  45. Quast U, Guillon JM, Cavero I (1994) Cellular pharmacology of potassium channel openers in vascular smooth muscle. Cardiovasc Res 28:805–810PubMedCrossRefGoogle Scholar
  46. Quayle JM, Standen NB (1994) K-ATP channels in vascular smooth muscle. Cardiovasc Res 28:797–804PubMedCrossRefGoogle Scholar
  47. Rembold CM (1992) Regulation of contraction and relaxation in arterial smooth muscle. Hypertension 20:129–137PubMedGoogle Scholar
  48. Reynen K (1993) Nitrate. Dtsch Med Wochenschr 118:1532–1539PubMedCrossRefGoogle Scholar
  49. Ruskoaho H (1992) Atrial natriuretic peptide: Synthesis, release, and metabolism. Pharmacol Rev 44:480–602Google Scholar
  50. Saccomano NA, Ganong AH (1991) Diversity of neuronal calcium channels. Annu Rev Med Chem 26:33–41CrossRefGoogle Scholar
  51. Sanguinetti MC (1992) Modulation of potassium channels by antiarrhythmic and antihypertensive drugs. Hypertension 19:228–236PubMedGoogle Scholar
  52. Scherübl H, Hescheler J (1992) Patch-clamp-Technik und Ionenkanäle: Bedeutung in der Medizin. Dtsch Ärztebl 89:B-215–B-218Google Scholar
  53. Schmidt HHHW (1994) NO, endogener Botenstoff und Zellgift. Med Monatsschr Pharm 17:168–185PubMedGoogle Scholar
  54. Schröder H (1992) Organische Nitrate: Neue Erkenntnisse zum Wirkungsmechanismus einer alten Substanzklasse. Med Monatsschr Pharm 15:134–139PubMedGoogle Scholar
  55. Smyth EM, Keenan AK (1994) The vascular ANF-C receptor: Role in atrial peptide signalling. Cell Signal 6:125–133PubMedCrossRefGoogle Scholar
  56. Tang W-J, Gilman AG (1992) Adenylyl cyclases. Cell 70:869–872PubMedCrossRefGoogle Scholar
  57. Thompson WJ (1991) Cyclic nucleotide phosphodiesterases: Pharmacology, biochemistry and function. Pharmacol Ther 51:13–33PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • E. Oberdisse

There are no affiliations available

Personalised recommendations