Skip to main content
SpringerLink
Log in

Nicht-Opioidanalgetika

  • Chapter
Pharmakologie und Toxikologie

Part of the book series: Springer-Lehrbuch ((SLB))

  • 124 Accesses

Zusammenfassung

Die früher übliche Einteilung von Schmerzmitteln in zentral wirksame, starke Opioidanalgetika einerseits und peripher wirksame, schwache antipyretische Analgetika andererseits ist heute aus mehreren Gründen nicht mehr haltbar: Opioidanalgetika wirken nicht nur im Zentralnervensystem, sondern haben auch periphere Wirkungen. Umgekehrt wurde für viele der sog. peripheren Analgetika eine zentrale (spinale und/oder supraspinale) Wirkkomponente nachgewiesen. Auch das früher für alle antipyretischen Analgetika angenommene Wirkprinzip der Prostaglandinsynthesehemmung ist in dieser allgemeinen Form nicht zutreffend. Außerdem sind einige Analgetika wie Nefopam oder Flupirtin in das alte Schema nicht einzuordnen. Deshalb findet die Einteilung in Opioidanalgetika und Nicht-opioidanalgetika, die keine Wirkmechanismen unterstellt, immer mehr Akzeptanz.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Björkman R, Hallman KM, Hedner J, Hedner T, Henning M (1994) Acetaminophen blocks spinal hyperalgesia induced by NMDA and substance P. Pain 57:259–264

    Article  PubMed  Google Scholar 

  • Brogden RN (1986) Pyrazolone derivatives. Drugs 32 [Suppl 4]:60–70

    Article  PubMed  Google Scholar 

  • Brogden RN, Heel RC, Pakes GE (1980) Diflunisal: A review of its pharmacological properties and therapeutic use in pain and musculoskeletal strains and sprains and pain in osteoarthritis. Drugs 19:84–106

    Article  PubMed  CAS  Google Scholar 

  • Brune K (1994) Spinal cord effects of antipyretic analgesics. Drugs 47 [Suppl 5)] 21–27

    Article  PubMed  CAS  Google Scholar 

  • Brune K, Beck WS, Geisslinger G, Menzel-Soglowek S, Peskar BM, Peskar BA (1991) Aspirin-like drugs may block pain indepently of prostaglandin synthesis inhibition. Experientia 47:257–261

    Article  PubMed  CAS  Google Scholar 

  • Coquoz D, Porchet HC, Dayer P (1993) Central analgesic effects of desipramine, fluvoxamine, and moclobemide after single oral dosing: A study in healthy volunteers. Clin Pharmacol Ther 54:339–344

    Article  PubMed  CAS  Google Scholar 

  • Czlonkowski A, Stein C, Herz A (1993) Peripheral mechanisms of opioid antinociception in inflammation: involvement of cytokines. Eur J Pharmacol 242:229–235

    Article  PubMed  CAS  Google Scholar 

  • De Broe ME, Elseviers MM (1993) Analgesic nephropathy -still a problem? Nephron 64:505–513

    Article  PubMed  Google Scholar 

  • Dray A, Perkins M (1993) Bradykinin and inflammatory pain. Trends Neurosci 16:99–104

    Article  PubMed  CAS  Google Scholar 

  • Dray A, Urban L, Dickenson A (1994) Pharmacology of chronic pain. Trends Pharmacol Sci 15:190–197

    Article  PubMed  CAS  Google Scholar 

  • Hackenthal E (1990) Die Salizylate. Der Schmerz 4:166–172

    Article  PubMed  CAS  Google Scholar 

  • Hackenthal E (1993) Therapie mit Analgetika und nicht-steroidalen Antirheumatika. In: Platt D (Hrsg) Pharmakotherapie im Alter, 2. Aufl. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Hackenthal E, Wörz R (Hrsg) (1985) Medikamentöse Schmerzbehandlung in der Praxis. Fischer, Stuttgart

    Google Scholar 

  • Hu XH, Tang HW, Li QS, Huang XF (1994) Central mechanism of indomethacin analgesia. Eur J Pharmacol 263:53–57

    Article  PubMed  CAS  Google Scholar 

  • Jurna I (1992) Zentrale Schmerzdämpfung durch peripher wirkende Analgetika. Der Schmerz 6:61–66

    Article  PubMed  CAS  Google Scholar 

  • Jurna I, Brune K (1990) Central effect of the non-steroid antiinflammatory agents, indometacin, ibuprofen, and diclofenac, determined in C fibre-evoked activity in single neurones of the rat thalamus. Pain 41:71–80

    Article  PubMed  CAS  Google Scholar 

  • Kelly J P, Kaufman D, Shapiro S. Risk of agranulocytosis and aplastic anemia in relation to the use of cardiovascular drugs. The international agranulocytosis ana aplastic anemia study. (1991) Clin Pharmacol Ther 49:330–341

    Article  PubMed  CAS  Google Scholar 

  • Kluger MJ (1992) Fever revisited. Pediatrics 90:846–850

    PubMed  CAS  Google Scholar 

  • Leung R, Plomley R, Czarny D (1992) Paracetamol anaphylaxis. Clin Exp Allergy 22:831–833

    Article  PubMed  CAS  Google Scholar 

  • Levine JD, Fields HL, Basbaum AI (1993) Peptides and the primary afferent nociceptor. J Neurosci 13:2273–2286

    PubMed  CAS  Google Scholar 

  • Levy M (1984) Aspirin use in patients with major upper gastrointestinal bleeding and peptic ulcer disease. N Engl J Med 290:1158–1162

    Article  Google Scholar 

  • Levy M, Glusser D, Zylber-Katz E, Granit L (1984) Plasma kinetics of dipyrone metabolites in rapid and slow acetylators. Eur J Pharmacol 27:453–458

    Article  CAS  Google Scholar 

  • Lindblad P, McLaughlin JK, Mellemgaard A, Adami HO (1993) Risk of kidney cancer among patients using analgesics and diuretics: a population-based cohort study. Int J Cancer 55:5–9

    Article  PubMed  CAS  Google Scholar 

  • Maier C (1990) Calcitonin. Der Schmerz 4:47–53

    Article  PubMed  CAS  Google Scholar 

  • McCormack KJ (1994) The spinal actions of nonsteroidal anti-inflammatory drugs and the dissociation between their anti-inflammatory and analgesic effects. Drugs 47 [Suppl 5]:28–43

    Article  PubMed  CAS  Google Scholar 

  • McCormack K, Brune K (1991) Dissociation between the antinociceptive and anti-inflammatory effects of nonsteroidal anti-inflammatory drugs. A survey of their analgesic efficacy. Drugs 41:533–547

    Article  PubMed  CAS  Google Scholar 

  • Menges K (1987) Paracetamol (Acetaminophen). Der Schmerz 1:130–134

    Article  PubMed  CAS  Google Scholar 

  • Mihatsch MJ (Hrsg) (1986) Das Analgetikasyndrom. Thieme, Stuttgart

    Google Scholar 

  • Morlans M, Laporte JR, Vidal X, Cabeza D, Stolley PD (1990) End-stage renal disease and non-narcotic analgesics: a case control study. Br J Clin Pharmacol 30:717–723

    PubMed  CAS  Google Scholar 

  • Motsch J (1991) Epidurale und intrathekale Applikation von alpha-2-Agonisten zur Therapie akuter und tumorassoziierter Schmerzen. Fortsch Anästh 5:89–95

    Google Scholar 

  • Nanra RS (1993) Analgesic nephropathy in the 1990 s — an Australian perspective. Kidney Int 44 [Suppl 42]:S86–S92

    Google Scholar 

  • Neuvonen PJ, Tokola O, Toivonen ML, Simell O (1985) Methionine in paracetamol tablets, a tool to reduce paracetamol toxicity. Int J Clin Pharmacol Ther Toxicol 23:497–500

    PubMed  CAS  Google Scholar 

  • Patrono C (1989) Aspirin and human platelets: from clinical trials to acetylation of cyclooxygenase and back. Trends Pharmacol Sci 10:453–458

    Article  PubMed  CAS  Google Scholar 

  • Penn RD, Paice JA, Kroin JS (1992) Octreotide: a potent new non-opiate analgesic for intrathecal infusion. Pain 49:13–19

    Article  PubMed  CAS  Google Scholar 

  • Perneger TV, Whelton PK, Klag MJ (1994) Risk of kidney failure associated with the use of acetaminophen, aspirin and nonsteroidal antiinflammatory drugs. N Engl J Med 331:1675–1679

    Article  PubMed  CAS  Google Scholar 

  • Pommer W, Glaeske G, Molzahn M (1987) Analgetika-Verbrauch in der Bundesrepublik Deutschland. Ausmaß und Risikogruppen. Dtsch Med Wochenschr 112:787–793

    Article  PubMed  CAS  Google Scholar 

  • Seeff LB, Cuccherini BA, Zimmerman HJ, Adler E, Benjamin SB (1986) Acetaminophen hepatotoxicity in Alcoholics. Ann Internal Med 104:399–404

    CAS  Google Scholar 

  • Slattery JT, Wilson JM, Kalhorn TF, Nelson SD (1987) Dose-dependent pharmacokinetics of acetaminophen: evidence of glutathione depletion in humans. Clin Pharmacol Ther 41:413–418

    Article  PubMed  CAS  Google Scholar 

  • Soyka D (Hrsg) (1995) Schmerz, Pathophysiologie und Therapie. Schattauer, Stuttgart

    Google Scholar 

  • Tatsuo MAKF, Carvalho WM, Silva CV, Miranda AEG, Ferreira SH, Francischi JN (1994) Analgesie and antiinflammatory effects of dipyrone in rat adjuvant arthritis model. Inflammation 18:399–408

    Article  PubMed  CAS  Google Scholar 

  • The International Agranulocytosis and Aplastic Anaemia Study (1986) A first report of their relation to drug use with special reference to analgesics. J Am Med Ass 256:1149–1157

    Article  Google Scholar 

  • Visentin M, Salmona M, Tacconi MT (1995) Reye’s and Reye-like syndroms, drug related diseases? Drug Metab Rev 27:517–539

    Article  PubMed  CAS  Google Scholar 

  • Vlahov V, Badian M, Verho, M, Bacracheva N (1990) Pharmacokinetics of metamizol metabolite in healthy subjects after a single oral dose of metamizol sodium. Eur J Pharmacol 38:61–65

    Article  CAS  Google Scholar 

  • Zenz M, Jurna I (Hrsg) (1993) Lehrbuch der Schmerztherapie. Wiss Verlagsgesellschaft, Stuttgart

    Google Scholar 

Download references

Authors
  1. E. Hackenthal
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Fachbereich Humanmedizin — Institut für Pharmakologie, Freie Universität Berlin, Thielallee 67-73, 14195, Berlin, Deutschland

    Eckard Oberdisse

  2. Pharmakologisches Institut, Universität Heidelberg, Im Neuenheimer Feld 366, 69120, Heidelberg, Deutschland

    Eberhard Hackenthal

  3. Institut für Pharmakologie und Toxikologie, Universität Marburg/Lahn, Ketzerbach 63, 35032, Marburg, Deutschland

    Klaus Kuschinsky

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Hackenthal, E. (1999). Nicht-Opioidanalgetika. In: Oberdisse, E., Hackenthal, E., Kuschinsky, K. (eds) Pharmakologie und Toxikologie. Springer-Lehrbuch. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-98030-5_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-98030-5_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-98031-2

  • Online ISBN: 978-3-642-98030-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation