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Mehrlinge

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Book cover Geburtshilfe
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Zusammenfassung

In den letzten 15–20 Jahren war in allen Industrieländern eine steigende Anzahl an Mehrlingsgeburten zu verzeichnen. Dieser Trend wird auf die zunehmende Anwendung der Methoden der assistierten Reproduktion und das steigende Lebensalter der Gebärenden zurückgeführt. In Mitteleuropa finden sich rund 110 Zwillings- und 2 Drillingsgeburten auf 10000 Lebendgeburten.

Von besonderer klinischer Bedeutung ist einerseits die Unterscheidung in dizygote und monozygote und andererseits in dichorial-diamniale, monochorialdiamniale und monochorial-monoamniale Zwillingsschwangerschaften, da sie mit einer unterschiedlichen Morbididät und Mortalität der Mutter und des Kindes einhergehen. In diesem Zusammenhang kommt der möglichst frühen Ultraschalldifferenzierung besondere Bedeutung zu.

Neben dem besonderen Risiko durch mehrlingsassoziierte Syndrome besteht die klinische Problematik der Mehrlingsschwangerschaft vor allem in der erhöhten Rate an Frühgeburten und intrauteriner Wachstumretardierung, die wesentlich die erhöhte Morbidität und Mortalität dieser Schwangerschaften bedingen.

Die Problematik der speziellen Betreuung der Mehrlingsschwangeren liegt im Fehlen relevanter prospektiver Studien, so daß derzeit weder beim unauffälligen noch beim pathologischen Verlauf Konsens über die verbindliche Auswahl von Überwachungsmethoden und die Häufigkeit ihrer Anwendung besteht.

Der Geburtsmodus wird hauptsächlich durch die Lage der Feten und durch das zu erwartende Geburtsgewicht bestimmt. Während bei Schädellage beider Zwillinge prinzipiell die vaginale Geburt angestrebt wird, besteht bei allen anderen Varianten der Kindslagen ein zunehmender Trend, die primäre Sectio zu indizieren. Dies zeigt sich um so mehr für höhergradige Mehrlingsgeburten.

In Anbetracht der hohen Morbidität und Mortalität von höhergradigen Mehrlingen stellt die selektive Reduktion eine Alternative dar. In diesem Fall und bei Mehrlingsschwangeren insgesamt und den oftmals beobachteten mehrlingsassoziierten Pathologien ist die psychische Betreuung von besonderer Bedeutung.

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Literatur

  • Aisenbrey GA, Catanzarite VA, Hurley TJ, Spiegel JH, Schrimmer DB, Mendoza A (1995) Monoamniotic and pseudoamniotie twins: sonographie diagnosis, detection of cord entanglernent, and obstetrie management. Obstet Gynecol 86: 218–222

    Article  PubMed  CAS  Google Scholar 

  • American College of Obstetricians and Gynecologists (1989) Multiple Gestation. ACOG Techn Bull 131

    Google Scholar 

  • American Society for Reproductive Medicine (1996) Assisted reproductive technology in the United States and Canada: 1994 results generated from the American Society for Reproductive Medicine/Society for Assisted Reproductive Technology Registry. Fertil Steril 66: 697–705

    Google Scholar 

  • Baldwin VJ (1994 a) Pathology of multiple pregnancy. Springer, Berlin Heidelberg New York Tokyo, S 49

    Book  Google Scholar 

  • Baldwin VJ (1994 b) Pathology of multiple pregnancy. Springer, Berlin Heidelberg New York Tokyo, S 231

    Book  Google Scholar 

  • Blickstein I (1990) The twin-twin transfusion syndrome. Obstet Gynecol 76: 414–721

    Article  Google Scholar 

  • Blickstein I (1991) The definition, diagnosis, and management of growth-discordant twins: an international census survey. Acta Genet Med Gemellol 40:345–351

    PubMed  CAS  Google Scholar 

  • Botting BJ, Macfarlane AJ, Bryan E, Murphy GF, Richards MPM (1990) Background. In: Botting BJ, Macfarlane AJ, Price FV (eds) Three,four and more. A study of triplet and higher order births. HMSO, London, pp 15–30

    Google Scholar 

  • Brambati B, Tului L (1995) First trimester fetal reduction: its role in the management of twin and higher order multiple pregnancies. Hum Reprod Update 1: 397–408

    Article  PubMed  CAS  Google Scholar 

  • Bronshtein M, Rottem S, Yoffe N, Blumenfeld Z, Brandes JM (1990) Early determination of fetal sex using transvaginal sonography: technique and pitfalls. J Clin Ultrasound 18: 302–306

    Article  PubMed  CAS  Google Scholar 

  • Bronsteen R, Goyert G, Bottoms S (1989) Classification of twins and neonatal morbidity. Obstet Gynecol 74: 98–101

    PubMed  CAS  Google Scholar 

  • Callahan TL, Hall JE, Ettner SL, Christiansen CL, Greene MF, Crowley WF (1994) The economic impact of multiple-gestation pregnancies and the contribution of assisted-reproduction techniques to their incidence. N Engl J Med 331: 244–249

    Article  PubMed  CAS  Google Scholar 

  • Campbell DM, Smith AP, Wilson AW (1990) Estimated fetal weight in twin pregnancy: how good are we? Acta Genet Med Gemellol 39: 395–399

    PubMed  CAS  Google Scholar 

  • Caravello JW, Chauhan SP, Morrison J C, Magann EF, Martin JN, Devoe LD (1997) Sonographic examination does not predict twin growth discordance accurately. Obstet Gynecol 89: 529–33

    Article  PubMed  CAS  Google Scholar 

  • Chervenak FA, Johnson RE, Youcha S, Hobbins JC, Berkowitz RL (1985) Intrapartum management of twin gestation. Obstet Gynecol 65: 119–124

    PubMed  CAS  Google Scholar 

  • Chauhan SP, Washburne JF, Martin JN, Roberts WE, Roach H, Morrison JC (1993) Intrapartum assessment by house staff of birth weight among twins. Obstet Gynecol 82: 523–526

    Article  PubMed  CAS  Google Scholar 

  • Chauhan SP, Roberts WE, McLaren RA, Roach H, Morrison JC, Martin JN (1995) Delivery of the nonvertex second twin: breech extraction versus external cephalic version. Am J Obstet Gynecol 173: 1015–1020

    Article  PubMed  CAS  Google Scholar 

  • Chauhan SP, Cowan BD, Brost BD, Washburne JF, Magann EF, Morrison JC (1996) Estimating birth weight in twins. Comparison of eight sonographic models. J Reprod Med 41: 403–408

    PubMed  CAS  Google Scholar 

  • Chauhan SP, Roberts WE (1996) Intrapartum management. In: Gall SA (ed) Multiple pregnancy and delivery. Mosby, St. Louis, pp 243–280

    Google Scholar 

  • Danskin FH, Neilson JP (1989) Twin-to-twin transfusion syndrome: what are appropriate diagnostic criteria? Am J Obstet Gynecol 161: 365–369

    PubMed  CAS  Google Scholar 

  • Davison L Easterling TR, Jackson JC, Benedetti TJ (1992) Breech extraction of low-birth-weigth second twins: can cesarean section be justified? Am J Obstet Gynecol 166: 497–502

    Google Scholar 

  • De Jong MW, Van Lingen RA, Wildschut J, Van Eijck J (1992) Delayed interval delivery of two remaining fetuses in quintuplet pregnancy after embryo reduction: report and review of the literature. Acta Genet Med Gemellol 41: 49–52

    PubMed  Google Scholar 

  • De Lia JE, Kuhlmann RS, Harstad TW, Cruikshank DP (1995) Fetoscopic laser ablation of placental vessels in severe previable twin-twin transfusion syndrome. Am J Obstet Gynecol 172: 1202–1208

    Article  PubMed  Google Scholar 

  • Derom R, Derom C, Vlietinck R (1995 a) Placentation. In: Keith LG, Papiernik E, Keith DM, Luke B (eds) Multiple pregnancy. Parthenon, Lancaster, pp 113–132

    Google Scholar 

  • Derom R, Orlebeke J, Eriksson A, Thiery M (1995 b) The epidemiology of multiple births in Europe. In: Keith LG, Papiernik E, Keith DM, Luke B (eds) Multiple pregnancy. Parthenon, Lancaster, pp 145–162

    Google Scholar 

  • Devoe LD, Ware DJ (1995) Antenatal assessment of twin gestation. Semin Perinat 19: 413–423

    Article  CAS  Google Scholar 

  • Dickey RP, Olar TT, Curole DN, Taylor SN, Rye PH, Matulich EM (1990) The probability of multiple birth when multiple gestational sacs or viable embryos are diagnosed at first trimester ultrasound. Hum Reprod 5: 880–882

    PubMed  CAS  Google Scholar 

  • Evans MI, Dommergues M, Wapner RJ, Goldberg JD, Lynch L, Zador IE et al. (1996) International, collaborative experience of 1789 patients having multifetal pregnancy reduction: a plateauing of risks and outcomes. J Soc Gynecol Invest 3: 23–26

    Article  CAS  Google Scholar 

  • Friedler S, Mashiach S, Laufer N (1992) Births in Israel resulting from in-vitro fertilization/embryo transfer, 1982–1989: National Registry of the Israeli Association for Fertility Research. Hum Reprod 7: 1159–1163

    PubMed  CAS  Google Scholar 

  • Friedler S, Mordel N, Lipitz S, Mashiach S, Glezerman M, Laufer N (1994) Perinatal outcome of triplet pregnancies following assisted reproduction. J Assist Reprod Genet 9: 459–462

    Article  Google Scholar 

  • Gabbe SG, Turner LP (1997) Reproductive hazards of the American lifestyle: work during pregnancy. Am J Obstet Gynecol 176: 826–832

    Article  PubMed  CAS  Google Scholar 

  • Gleicher N, Campbell DP, Chan CL, Karande V, Rao R, Balin M, Pratt D (1995) The desire for multiple births in couples with infertility problems contradicts present practice patterns. Hum Reprod 10: 1079–1084

    PubMed  CAS  Google Scholar 

  • Gocke SE, Nageotte MP, Garite T, Towers CV, Dorcester W (1989) Management of the nonvertex second twin: primary cesarean section, exernal version, or primary breech extraction. Am J Obstet Gynecol 161: 111–114

    PubMed  CAS  Google Scholar 

  • Goldenberg RL, Iams JD, Miodovnik M, Van Dorsten JP, Thurnau G, Bottoms S et al. (1996) The preterm prediction study: risk factors in twin gestations. Am J Obstet Gynecol 175: 1047–1053

    Article  PubMed  CAS  Google Scholar 

  • Goldfarb JM, Austin C, Lisbona H, Peskin B, Clapp M (1996) Cost-effectiveness of in vitro fertilization. Obstet Gynecol 87: 18–21

    Article  PubMed  CAS  Google Scholar 

  • Gounsoulin W, Moise KJ, Kirshon B, Cotton DB, Wheeler SM, Carpenter RJ (1990) Outcome of twin-twin transfusion diagnosed before 28 weeks of gestation. Obstet Gynecol 75: 214–216

    Google Scholar 

  • Kidd SA, Lancaster PAL, Anderson JC, Boogert A, Fisher CC, Robertson R, Wass DM (1996) Fetal death after exposure to methylene blue dye during mid-trimester amniocentesis in twin pregnancy. Prenat Diagn 16: 39–47

    Article  PubMed  CAS  Google Scholar 

  • Kiely JL (1990) The epidemiology of perinatal mortality in multiple births. Bull N Y Acad Med 66: 618–637

    PubMed  CAS  Google Scholar 

  • Kol S, Levron J, Lewit N, Drugan A, Itskovitz-Eldor J (1993) The natural history of multiple pregnancies after assisted reproduction: is spontaneous fetal demise a clinically significant phenomenon? Fertil Steril 60: 127–130

    PubMed  CAS  Google Scholar 

  • Landy HJ, Nies BM (1995) The vanishing twin. In: Keith LG, Papiernik E, Keith DM, Luke B (eds) Multiple pregnancy. Parthenon, Lancaster, pp 59–72

    Google Scholar 

  • Lichtenstein P, Olausson PO, Källen AJB (1996) Twin births to mothers who are twins: a registry based study. BMJ 312: 879–881

    Article  PubMed  CAS  Google Scholar 

  • Liu S, Benirschke K, Scioscia AL, Mannino FL (1992) Intrauterine death in multiple gestation. Acta Genet Med Gemellol 41: 5–26

    PubMed  CAS  Google Scholar 

  • Luke B, Minogue J, Witter FR (1993) The role of fetal growth restriction and gestational age on length of hospital stay in twin infants. Obstet Gynecol 81: 949–953

    PubMed  CAS  Google Scholar 

  • Mahony BS, Petty CN, Nyberg DA, Luthy DA, Hickok DE, Hirsch J H. (1990) The „stuck twin“ phenomen: ultrasonographic findings, pregnancy outcome, and management with serial amniocenteses. Am J Obstet Gynecol 163: 1513–1522

    PubMed  CAS  Google Scholar 

  • Manzur A, Goldsman M, Stone SC, Frederick JL, Balmaceda JP, Asch RH (1995) Outcome of triplet pregnancies after assisted reproductive techniques: how frequent are the vanishing embryos? Fertil Steril 63: 252–257

    PubMed  CAS  Google Scholar 

  • Meyers C, Adam R, Dungan J, Prenger V (1997) Aneuploidy in twin gestations: when is maternal age advanced? Obstet Gynecol 89: 248–251

    Article  PubMed  CAS  Google Scholar 

  • Monteagudo A, Timor-Tritsch IE, Sharma S (1994) Early and simple determination of chorionic and amniotic type in multifetal gestations in the first fourteen weeks by high-frequency transvaginal ultrasonography. Am J Obstet Gynecol 170: 824–829

    PubMed  CAS  Google Scholar 

  • Neumann PK, Gharib SD, Weinstein MC (1994) The cost of successful delivery with in vitro fertilization. N Engl J Med 331: 239–243

    Article  PubMed  CAS  Google Scholar 

  • Newman RB, Hamer C, Miller MC (1989) Outpatient triplet management: a contempory review. Am J Obstet Gynecol 161: 547–555

    PubMed  CAS  Google Scholar 

  • Newman RB, Ellings JM (1995) Antepartum management of the multiple gestation: the case for specialized care. Semin Perinat 19: 387–403

    Article  CAS  Google Scholar 

  • Österreichisches Statistisches Zentralamt (1996) Demographisches Jahrbuch 1993/94/95. Österreichische Staatsdruckerei, Wien

    Google Scholar 

  • Papiernik E, Keith LG (1990) The cost effectiveness of preventing preterm delivery in twin pregnancies. Acta Genet Med Gemellol 39: 361–369

    PubMed  CAS  Google Scholar 

  • Papiernik E (1991) Costs of multiple pregnancies. In: Harvey D, Bryan E (eds) The stress of multiple births. Multiple Birth Foundation, London, pp 22–34

    Google Scholar 

  • Pergament E, Schulman J, Copeland K (1992) The risk of and efficacy of chorionic villus sampling in multiple gestations. Prenat Diagn 12: 377–384

    Article  PubMed  CAS  Google Scholar 

  • Porter TF, Dildy GA, Blanchard JR, Kochenour NK, Clark SL (1996) Normal values for amniotic fluid index during uncomplicated twin pregnancy. Obstet Gynecol 87: 699–702

    Article  PubMed  CAS  Google Scholar 

  • Rayburn WF, Lavin JP, Miodovnik M, Varner MW (1984) Multiple gestation: time interval between delivery of the first and second twins. Obstet Gynecol 63: 502–506

    PubMed  CAS  Google Scholar 

  • Reece EA, Yarkoni S, Abdalla M, Gabrielli S, Holford T, O’Connor TZ et al. (1991) A prospective longitudinal study of grwth in twin gestations compared with growth in singelton pregnancies. I. The fetal head et II. The fetal limbs. J Ultrasound Med 10: 439–443 et 445–450

    PubMed  CAS  Google Scholar 

  • Reisner DP, Mahony BS, Petty CN et al. (1993) Stuck twin syndrome: outcome in thirty-seven consecutive cases. Am J Obstet Gynecol 169: 991–995

    PubMed  CAS  Google Scholar 

  • Rodis JF, Vintzileos AM, Campbell WA, Deaton JL, Fumia F, Nochimson DJ (1987) Antenatal diagnosis and management of monoamniotic twins. Am J Obstet Gynecol 157: 1255–1257

    PubMed  CAS  Google Scholar 

  • Rodis JF, Vintzileos AM, Campbell WA, Nochimson DJ (1990): Intrauterine fetal growth in discordant twin gestations. J Ultrasound Med 9: 443–448

    PubMed  CAS  Google Scholar 

  • Rydhström H (1994) Discordant birthweight and late fetal death in like-sexed and unlike-sexed twin pairs: a population based study. Br J Obstet Gynaecol 101: 765–769

    Article  PubMed  Google Scholar 

  • Saacks CB, Thorp JM, Hendricks CH (1995) Cohort study of twinning in an academic health center: changes in management and outcome over fourty years. Am J Obstet Gynaecol 173: 432–439

    Article  CAS  Google Scholar 

  • Saari-Kemppainen A, Karjalainen O, Ylostalo P, Heinonen OP (1990) Ultrasound screening and perinatal mortality: controlled trial of systematic one-stage screening in pregnancy. The Helsinki ultrasound trial. Lancet 336: 387–391

    Article  PubMed  CAS  Google Scholar 

  • Seoud MAF, Toner JP, Kruithoff C, Muasher SJ (1992) Outcome of twin, triplet, and quadruplet in vitro fertilization pregnancies: the Norfolk experience. Fertil Steril 57: 825–834

    PubMed  CAS  Google Scholar 

  • Sepulveda W, Sebire NI, Hughes K, Kalogeropoulos A, Nicolaides KH (1997) Evolution of the lambda or twin-chorionic peak sign in dichorionic twin pregnancies. Obstet Gynecol 89: 439–441

    Article  PubMed  CAS  Google Scholar 

  • Sherman SJ, Kovacs BW, Medearis AL, Bear MB, Paul RH (1992) Nonstress test assessment of twins. J Reprod Med 37: 804–808

    PubMed  CAS  Google Scholar 

  • Spellacy WN, Handler A, Ferre C (1990) A case-control study of 1253 twin pregnancies from a 1982–1987 perinatal data base. Obstet Gynecol 75: 168–171

    PubMed  CAS  Google Scholar 

  • Staessen C, Camus M, Bollen N, Devroey P, Van Steirteghem AC (1992) The relationship between embryo quality and the occurrence of multiple pregnancies. Hum Reprod 57: 626–630

    CAS  Google Scholar 

  • Staessen C, Janssenswillen C, Van den Abbeel E, Devroey P, Van Steirteghem AC (1993) Avoidance of triplet pregnancies by elective transfer of two good quality embryos. Hum Reprod 8: 1650–1653

    PubMed  CAS  Google Scholar 

  • Stone J, Berkowitz (1996) Mulitple pregnancy reduction and selective termination. In Gall SA (ed) Multiple pregnancy and delivery. Mosby, St. Louis, pp 181–197

    Google Scholar 

  • Tong S, Caddy D, Short RV (1997) Use of dizygotic to monozygotic twinning ratio as a measure of fertility. Lancet 439: 843–845

    Article  Google Scholar 

  • Vayssiere CF, Heim N, Camus EP, Hillion YE, Nisand IF (1996) Determination of chorionicity in twin gestations by high-frequency abdominal ultrasonography: counting the layers of the dividing membrane. Am J Obstet Gynecol 175: 1529–1533

    Article  PubMed  CAS  Google Scholar 

  • Ville Y, Hyett J, Hecher K, Nicolaides K (1995) Preliminary experience with endoscopic laser surgery for severe twin-twin transfusion syndrome. N Engl J Med 332: 224–227

    Article  PubMed  CAS  Google Scholar 

  • Wapner RJ (1995) Genetic diagnosis in multiple pregnancies. Semin Perinat 19: 351–362

    Article  CAS  Google Scholar 

  • Wenstrom KD, Tessen JA, Zlatnik FJ, Sipes SL (1992) Frequency, distribution, and theoretical mechanisms of hematologic and weight discordance in monochorionic twins. Obstet Gynecol 80: 257–261

    PubMed  CAS  Google Scholar 

  • Wenstrom KD, Syrop CH, Hammitt DG, Van Voorhis BJ (1993) Increased risk of monochorionic twinning associated with assisted reproduction. Fertil Steril 60: 510–514

    PubMed  CAS  Google Scholar 

  • Wilcox LS, Kiely JL, Melvin CL, Martin MC (1996) Assisted reproductive technologies: estimates of their contribution to multiple births and newborn hospital days in the United States. Fertil Steril 65: 361–366

    PubMed  CAS  Google Scholar 

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Strohmer, H. (2000). Mehrlinge. In: Schneider, H., Husslein, P., Schneider, K.T.M. (eds) Geburtshilfe. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-98004-6_40

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