Paul Ehrlich first described the eosinophil in 1879, choosing the name because of the cell granules’ affinity for eosin. Eosinophils are bone marrow-derived cells formed from colony forming unit and granulocyte macrophage (CFU-GM) precursor cells. They account typically for 1–5% of the peripheral leukocytes. In normal individuals, the absolute count ranges between 0.015 and 0.65 x io9/1. The eosinophil level shows a circadian rhythm, dropping in the morning, when serum Cortisol values are highest. Treatment with systemic corticosteroids also suppresses the eosinophil count. However, eosinophils are primarily tissue cells; the ratio of tissue cells to circulating cells is about 100:1.
KeywordsAtopic Dermatitis Bullous Pemphigoid Hypereosinophilic Syndrome Major Basic Protein Peripheral Blood Eosinophilia
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Basic Science Aspects
Idiopathic Hypereosinophilic Syndrome
- Griffin HZ (1919) Persistent eosinophilia with hyperleuko-cytosis and splenomegaly. Am J Med 158:618–629Google Scholar
- Malbrain ML, Van den Bergh H, Zachee P (1996) Further evidence for the clonal nature of the idiopathic hypereosinophilic syndrome: complete hematologic and cytogenetic remission induced by interferon-α in a case with a unique chromosomal abnormality. Br J Haematol 92:176–183PubMedCrossRefGoogle Scholar
Nodular Eosinophilic Infiltration with Immunoglobulin Isotype Imbalance
Eosinophilic Cellulitis (Wells Syndrome)
- Brehmer Andersson E, Kaaman T, Skog E et al. (1986) The histopathogenesis of the flame figure in Wells’ syndrome based on five cases. Acta Derm Venereol (Stockh) 66:213–219Google Scholar
- Perret C (1988) Eosinophilic Zellulitis unter dem Bild einer Prurigo diabetica. Aktuel Dermatol 14:61–63Google Scholar
- Wells GC (1971) Recurrent granulomatous dermatitis with eosinophilia. Trans St John’s Hosp Dermatol Soc 57: 46–56Google Scholar