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Dermatology pp 1401-1406 | Cite as

Disorders with Hypereosinophilia

  • Otto Braun-Falco
  • Gerd Plewig
  • Helmut H. Wolff
  • Walter H. C. Burgdorf

Abstract

Paul Ehrlich first described the eosinophil in 1879, choosing the name because of the cell granules’ affinity for eosin. Eosinophils are bone marrow-derived cells formed from colony forming unit and granulocyte macrophage (CFU-GM) precursor cells. They account typically for 1–5% of the peripheral leukocytes. In normal individuals, the absolute count ranges between 0.015 and 0.65 x io9/1. The eosinophil level shows a circadian rhythm, dropping in the morning, when serum Cortisol values are highest. Treatment with systemic corticosteroids also suppresses the eosinophil count. However, eosinophils are primarily tissue cells; the ratio of tissue cells to circulating cells is about 100:1.

Keywords

Atopic Dermatitis Bullous Pemphigoid Hypereosinophilic Syndrome Major Basic Protein Peripheral Blood Eosinophilia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Otto Braun-Falco
    • 1
  • Gerd Plewig
    • 1
  • Helmut H. Wolff
    • 2
  • Walter H. C. Burgdorf
    • 1
  1. 1.Department of Dermatology and AllergologyLudwig Maximilians UniversityMunichGermany
  2. 2.Department of Dermatology and VenerologyUniversity of LübeckLübeckGermany

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