Dermatology pp 1401-1406 | Cite as

Disorders with Hypereosinophilia

  • Otto Braun-Falco
  • Gerd Plewig
  • Helmut H. Wolff
  • Walter H. C. Burgdorf


Paul Ehrlich first described the eosinophil in 1879, choosing the name because of the cell granules’ affinity for eosin. Eosinophils are bone marrow-derived cells formed from colony forming unit and granulocyte macrophage (CFU-GM) precursor cells. They account typically for 1–5% of the peripheral leukocytes. In normal individuals, the absolute count ranges between 0.015 and 0.65 x io9/1. The eosinophil level shows a circadian rhythm, dropping in the morning, when serum Cortisol values are highest. Treatment with systemic corticosteroids also suppresses the eosinophil count. However, eosinophils are primarily tissue cells; the ratio of tissue cells to circulating cells is about 100:1.


Atopic Dermatitis Bullous Pemphigoid Hypereosinophilic Syndrome Major Basic Protein Peripheral Blood Eosinophilia 
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Basic Science Aspects

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Eosinophilic Cellulitis (Wells Syndrome)

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Eosinophilic Histiocytosis

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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Otto Braun-Falco
    • 1
  • Gerd Plewig
    • 1
  • Helmut H. Wolff
    • 2
  • Walter H. C. Burgdorf
    • 1
  1. 1.Department of Dermatology and AllergologyLudwig Maximilians UniversityMunichGermany
  2. 2.Department of Dermatology and VenerologyUniversity of LübeckLübeckGermany

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