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Disorders of Lipoprotein and Lipid Metabolism

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Dermatology

Abstract

Abnormalities of lipid metabolism are one of the major health problems facing most developed countries. The combination of genetic factors, overeating, inappropriate balance of diet, lack of physical activity, smoking and alcohol consumption have led to an almost epidemic increased in cardiovascular disease, primarily coronary artery disease. In the USA, coronary artery disease is the leading cause of death, even though mortality is decreasing because of more effective medical and surgical treatment.

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Bibliography

Basic Science Aspects

  • Borgia MC, Medici F (1998) Perspectives in the treatment of dyslipidemias in the prevention of coronary heart disease. Angiology 49:339 – 348

    Article  PubMed  CAS  Google Scholar 

  • Davignon J, Genest J Jr (1998) Genetics of lipoprotein disorders. Endocrinol Metab Clin North Am 27:521 – 550

    Article  PubMed  CAS  Google Scholar 

  • Fredrickson DS, Levy RI, Lees RS (1967) Fat transport in lipoproteins — an integrated approach to mechanisms and disorders. N Eng J Med 276:34 – 42

    Article  CAS  Google Scholar 

  • Scriver CR, Beaudet AL, Sly WS et al. (eds) (1995) The metabolic and molecular bases of inherited disease, 7th edn. McGraw-Hill, New York

    Google Scholar 

Xanthomas

  • Ahrens EH, Kunkel HG (1949) The relationship between serum lipids and skin xanthoma in eighteen patients with primary biliary cirrhosis. J Clin Invest 28:1565 – 1575

    Article  PubMed  CAS  Google Scholar 

  • Braun-Falco O (1973)Origin, structure and function of the xanthoma cell. Nutr Metab 15:68 – 88

    Article  PubMed  CAS  Google Scholar 

  • Braun-Falco O, Keller C, Zöllner N (eds) (1973) Xanthoma formation and other tissue reactions to hyperlipidemias. Karger, Basel

    Google Scholar 

  • Cruz PD Jr, East C, Bergstresser PR (1988) Dermal, subcutaneous and tendon xanthomas: diagnostic markers for specific lipoprotein disorders. J Am Acad Dermatol 19: 95–111

    Article  PubMed  Google Scholar 

  • Miller DM, Brodejl RT (1995) Eruptive xanthomatosis with linear koebnerization. J Am Acad Dermatol 33:834–835

    Article  PubMed  CAS  Google Scholar 

  • Miwa N, Kanzaki T (1992) The Koebner phenomenon in eruptive xanthoma. J Dermatol 19:48 – 50

    PubMed  CAS  Google Scholar 

  • Parker F (1985) Xanthomas and hyperlipidemias. J Am Acad Dermatol 13:1–30

    Article  PubMed  CAS  Google Scholar 

Xanthelasmas

  • Bergman R (1994) The pathogenesis and clinical significance of xanthelasma palpebrarum. J Am Acad Dermatol 30:236 – 242

    Article  PubMed  CAS  Google Scholar 

  • Douste-Blazy P, Marcel YL, Cohen L et al. (1982) Increased frequency of Apo E-ND phenotype and hyperapobeta-lipoproteinemia in normolipidemic subjects with xanthelasmas of the eyelids. Ann Intern Med 96:164–169

    PubMed  CAS  Google Scholar 

  • Eedy DJ (1996) Treatment of xanthelasma by excision with secondary intention healing. Clin Exp Dermatol 21:273–275

    Article  PubMed  CAS  Google Scholar 

Familial Hyperlipoproteinemia

  • Alagille D, Odievre M, Gautier M et al. (1975) Hepatic duc-rular hypoplasia associated with characteristic facies, vertebral malformations, retarded physical, mental, and sexual development, and cardiac murmur. J Pediatr 86:63–71

    Article  PubMed  CAS  Google Scholar 

  • Brown MS, Goldstein JL (1974) Expression of the familial hypercholesterolemia gene in heterozygotes: mechanism for a dominant disorder in man. Science 185:61 – 63

    Article  PubMed  CAS  Google Scholar 

  • Bürger M, Grütz O (1932) Über hepatosplenomegale Lipoidose mit Xanthomatösen Veränderungen in Haut und Schleimhaut. Arch Dermatol Syph 166:542 – 575

    Article  Google Scholar 

  • Frederickson DS, Altrocchi PH, Avioli LV et al. (1961) Tangier disease — combined clinical staff conference at the National Institutes of Health. Ann Intern Med 55:1016–1031

    Google Scholar 

  • Innerarity TL, Weisgraber KH, Arnold KS et al. (1987) Familial defective apolipoprotein B-100: low density lipoproteins with abnormal receptor binding. Proc Natl Acad Sci USA 84:6919–6923

    Article  PubMed  CAS  Google Scholar 

  • Knopp RH (1999) Drug treatment of lipid disorders. NEJM 341:498–511

    Article  PubMed  CAS  Google Scholar 

  • Thannhauser SJ, Magendantz H (1939) The different clinical groups of xanthomatous diseases: a clinical physiological study of 22 cases. Ann Intern Med 11:1662 – 1746

    Google Scholar 

  • Utermann G, Jaeschke M, Menzel J (1975) Familial hyperlipoproteinemia type III: deficiency of a specific apolipoprotein (apo E-III) in the very-low-density lipoproteins. FEBS Lett 56:352–355

    Article  PubMed  CAS  Google Scholar 

  • Watson GH, Miller V (1973) Arteriohepatic dysplasia: familial pulmonary arterial stenosis with neonatal liver disease. Arch Dis Child 48:459 – 466

    Article  PubMed  CAS  Google Scholar 

  • Weston CF, Burton JL (1987) Xanthomas in the Watson-Alagille syndrome. J Am Acad Dermatol 16:1117 – 1121

    Article  PubMed  CAS  Google Scholar 

Normolipemic Xanthomatosis

  • Bhattacharyya AK, Connor WE (1974)β-Sitosterolemia and xanthomasosis. A newly described lipid storage disease in two sisters. J Clin Invest 53:1033 – 1043

    Article  PubMed  CAS  Google Scholar 

  • Parker F (1986) Normocholesterolemic xanthomatosis. Arch Dermatol 122:1253 – 1257

    Article  PubMed  CAS  Google Scholar 

  • van Bogaert L, Scherer H J, Epstein E (1937) Une forme cérébrale de la cholesterinose généralisée. Masson and Cic, Paris

    Google Scholar 

Verruciform Xanthoma

  • Kimura S (1984) Verruciform xanthoma of the scrotum. Arch Dermatol 120:1378 – 1379

    Article  PubMed  CAS  Google Scholar 

  • Kraemer BB, Schmidt WA, Foucar E et al. (1981) Verruciform xanthoma of the penis. Arch Dermatol 117:516 – 518

    Article  PubMed  CAS  Google Scholar 

  • Meyers DC, Woosley JT, Reddick RL (1992) Verruciform xanthoma in association with discoid lupus erythematosus. J Cutan Pathol 19:156 – 158

    Article  PubMed  CAS  Google Scholar 

  • Neville B (1986) The verruciform xanthoma. A review and report of eight new cases. Am J Dermatopathol 8:247–253

    Article  PubMed  CAS  Google Scholar 

  • Nowparast B, Howell FV, Rick GM (1981) Verruciform xanthoma: A clinicopathologic review and report of fifty-four cases. Oral Surg Oral Med Oral Pathol 51:619–625

    Article  PubMed  CAS  Google Scholar 

  • Shafer WG (1971) Verruciform xanthoma. Oral Surg Oral Med Oral Pathol 31:784 – 789

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto T, Katayama I, Nishioka K (1995) Verruciform xanthoma in a psoriatic patient under PUVA Therapy. Dermatology 191:254 – 256

    Article  PubMed  CAS  Google Scholar 

Diffuse Normolipemic Plane Xanthomas

  • Altman J, Winkelmann RK (1962) Diffuse normolipidemic plane xanthoma. Arch Dermatol 85:633 – 640

    Article  PubMed  CAS  Google Scholar 

  • Ginarte M, Peteiro C, Toribio J (1997) Generalized plane xanthoma and idiopathic Bence-Jones proteinuria. Clin Exp Dermatol 22:192 – 194

    Article  PubMed  CAS  Google Scholar 

  • Lynch PJ, Winkelmann RK (1966) Generalized plane xanthoma and systemic disease. Arch Dermatol 93:639–646

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Dermatology and Allergology, Ludwig Maximilians University, Frauenlobstraße 9-11, D-80337, Munich, Germany

    Prof. Dr. med. Dr. h.c.mult. Otto Braun-Falco (Emeritus Professor and Chairman), Prof. Dr. med. Gerd Plewig (Professor and Chairman) & Walter H. C. Burgdorf M.D. (Clinical Lecturer)

  2. Department of Dermatology and Venerology, University of Lübeck, Ratzeburger Allee 160, D-23562, Lübeck, Germany

    Prof. Dr. med. Helmut H. Wolff (Professor and Chairman)

Authors
  1. Prof. Dr. med. Dr. h.c.mult. Otto Braun-Falco
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  2. Prof. Dr. med. Gerd Plewig
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  3. Prof. Dr. med. Helmut H. Wolff
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  4. Walter H. C. Burgdorf M.D.
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© 2000 Springer-Verlag Berlin Heidelberg

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Braun-Falco, O., Plewig, G., Wolff, H.H., Burgdorf, W.H.C. (2000). Disorders of Lipoprotein and Lipid Metabolism. In: Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97931-6_37

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  • DOI: https://doi.org/10.1007/978-3-642-97931-6_37

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-97933-0

  • Online ISBN: 978-3-642-97931-6

  • eBook Packages: Springer Book Archive

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