Dermatology pp 1087-1097 | Cite as

Diseases of the Eccrine Sweat Glands

  • Otto Braun-Falco
  • Gerd Plewig
  • Helmut H. Wolff
  • Walter H. C. Burgdorf


The eccrine glands are free-standing adnexal structures that have no relationship to the hair follicle. They are distributed over the entire body, but are especially numerous on the palms, soles and forehead. The total number of eccrine glands is 2–3 million. The secretory part of the gland is a coiled structure lying deep in the dermis, often at the border with the subcutaneous fat. A straight duct leads to the epidermis, where the intraepi-dermal portion of the eccrine duct is known as the acrosyringium. The acrosyringium is corkscrewlike, usually with three clockwise turns in the epidermis and several additional turns in the stratum corneum. On most skin the orifice of the eccrine gland is slit-like and not noticeable; on the palms and soles, the openings are more funnel like and arranged along the dermatoglyphic ridges so they can be seen on close examination.


Botulinum Toxin Sweat Gland Ectodermal Dysplasia Eccrine Sweat Gland Palmar Hyperhidrosis 
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General Reading

  1. Christophers E, Plewig G (1973) Formation of the acrosyringium. Arch Dermatol 107: 378–382PubMedCrossRefGoogle Scholar
  2. Pinkus H (1939) Notes on the anatomy and pathology of the skin appendages. I. The wall of the intra-epidermal part of the sweat duct. J Invest Dermatol 2: 175–186CrossRefGoogle Scholar
  3. Sato KT (1989) Biology of sweat glands and their disorders. I. Normal sweat gland function. J Am Acad Dermatol 20: 537–563PubMedCrossRefGoogle Scholar
  4. Sato K, Kang WH, Saga K et al. (1989) Biology of sweat glands and their disorders. II. Disorders of sweat gland function. J Am Acad Dermatol 20: 713–726PubMedCrossRefGoogle Scholar
  5. Watanabe S, Ichikawa E, Takanashi S (1993) Immunhisto-chemical localization of cytokeratins in normal eccrine glands with monoclonal antibodies in routinely processed, formalin-fixed, paraffin-embedded sections. J Am Acad Dermatol 28: 203–212PubMedCrossRefGoogle Scholar
  6. Wenzel FG, Horn TD (1998) Non-neoplastic disorders ot the eccrine glands. J Am Acad Dermatol 38: 1–17PubMedCrossRefGoogle Scholar


  1. Chan P, Kao GF, Pierson DL et al. (1985) Episodic hyper-hidrosis on the dorsum of hands. J Am Acad Dermatol 12: 937–942PubMedCrossRefGoogle Scholar
  2. Edmondson RA, Banerjec AK, Rennie JA (1992) Endoscopic transthoracic sympathoectomy in the treatment of hyperhidrosis. Ann Surg 215: 289–293PubMedCrossRefGoogle Scholar
  3. Heckmann M, Ceballos-Baumann A, Schaller M et al. (1997) Botulinum beyond wrinkles. Dermatol Surg 23: 1221–1222PubMedGoogle Scholar
  4. Heckmann M, Schaller M, Ceballos-Baumann A et al. (1998) Optimizing botulinum toxin therapy for hyperhidrosis. Br J Dermatol 138: 553–554PubMedCrossRefGoogle Scholar
  5. Heckmann M, Breit S, Ceballos-Baumann A et al. (1999) Side-controlled intradermal injection of Botulinum toxin A in recalcitrant axillary hyperhidrosis. J Am Acad Dermatol 41: 987–990PubMedCrossRefGoogle Scholar
  6. Hölzle E, Neubert U (1982) Antimicrobial effects of anti-perspirant formulation containing aqueous aluminium chloride hexahydrate. Arch Dermatol Res 272: 321–329PubMedCrossRefGoogle Scholar
  7. Hölzle E, Alberti N (1987) Long-term efficacy and side effects of tap water iontophoresis of palmoplantar hyperhidrosis — the usefulness of home therapy. Dermatologica 175: 126–135PubMedCrossRefGoogle Scholar
  8. James WD, Schoomaker EB, Rodman OG (1987) Emotional eccrine sweating. A heritable disorder. Arch Dermatol 123: 925–929PubMedCrossRefGoogle Scholar
  9. Jensen O, Nielsen E (1979) “Ruster”. The corrosive action of palmar sweat. II. Physical and chemical factors in palmar hyperhidrosis. Acta Derm Venereol (Stockh) 59: 139–143Google Scholar
  10. Lillis PJ, Coleman W (1990) Liposuction for treatment of axillary hyperhidrosis. Dermatol Clin 8: 479–482PubMedGoogle Scholar
  11. Orteu CH, McGregor JM, Almeyda JR et al. (1995) Recurrence of hyperhidrosis after endoscopic transthoracic sympathectomy — case report and review of the literature. Clin Exp Dermatol 20: 230–233PubMedCrossRefGoogle Scholar
  12. Schnider P, Binder M, Auff E et al. (1997) Double blind trial of botulinum A toxin for the treatment of focal hyperhidrosis of the palms. Br J Dermatol 136: 548–553PubMedCrossRefGoogle Scholar
  13. Shelley WB, Talanin NY, Shelley ED (1998) Botulinum toxin therapy for palmar hyperhidrosis J Am Acad Dermatol 38: 227–229PubMedCrossRefGoogle Scholar
  14. Sloan JB, Soltani K (1986) Iontophoresis in dermatology. A review. J Am Acad Dermatol 15: 671–684PubMedCrossRefGoogle Scholar
  15. Watkins PJ (1973) Facial sweating after food: a new sign of diabetic autonomic neuropathy. Br Med J 1: 583–587PubMedCrossRefGoogle Scholar

Frey Syndrome

  1. Dobrik C, Laskawi R (1995) Frey’s syndrome: treatment with botulinum toxin. Acta Otolaryngol (Stockh) 115: 459–461CrossRefGoogle Scholar
  2. Frey L (1923) Le syndrome du nerf auriculo-temporal. Rev Neurol (Paris) 2: 98–104Google Scholar

Hypohidrotic Ectodermal Dysplasia

  1. Advisory Board of the National Foundation for Ectodermal Dysplasia (1989) Scaling skin in the neonate: a clue to the early diagnosis of X-linked hypohidrotic ectodermal dysplasia (Christ-Siemens-Touraine syndrome). J Pediatr 114: 600–602CrossRefGoogle Scholar
  2. Cambiaghi S, Restano L, Pääkkönen K et al. (2000) Clinical findings in mosaic carriers of hypohidrotic ectodermal dysplasia. Arch Dermatol 136: 217–224PubMedCrossRefGoogle Scholar
  3. Christ J (1913) Über die kongenit. ektodermalen Defekte und ihre Beziehung zu einander; vikariirendes Pigment für Haartbildung. Arch Dermatol Syph 116: 685–703CrossRefGoogle Scholar
  4. Clouston HRA (1929) A hereditary ectodermal dystrophy. Canad Med Assoc J 21: 18–31PubMedGoogle Scholar
  5. Kere J, Srivastava AK, Montonen O et al. (1996) X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein. Nat Genet 13: 409–416PubMedCrossRefGoogle Scholar
  6. Rapp RS, Hodgkin WE (1968) Anhidrotic ectodermal dysplasia: autisomal dominant inheritance with palate and lip anomalies. J Med Genet 5: 269–272PubMedCrossRefGoogle Scholar

Ross Syndrome

  1. Reinauer S, Schauf G, Hölzle E (1993) Ross syndrome: treatment of segmental compensatory hyperhidrosis by a modified iontophoretic device. J Am Acad Dermatol 28: 308–312PubMedCrossRefGoogle Scholar
  2. Ross AT (1958) Progressive selective sudomotor denervation. Neurol 8: 808–817Google Scholar


  1. Dobson RL, Lobitz WC Jr (1957) Some histochemical observations on the human eccrine sweat glands. II. The pathogenesis of miliaria. Arch Dermatol 75: 653–666CrossRefGoogle Scholar
  2. Hölzle E, Kligman AM (1978) The pathogenesis of miliaria rubra. Role of the resident microflora. Br J Dermatol 99: 117–137PubMedCrossRefGoogle Scholar
  3. Robinson AF (1884) Miliaria and sudamina. J Cutan Venereol Dis 2: 362–365Google Scholar
  4. Shelley WB, Horvath PN (1950) Experimental miliaria in man. II. Production of sweat retention. Anhidrosis and miliaria crystallina by various kinds of injury. J Invest Dermatol 14: 19–20Google Scholar
  5. Shelley WB, Horvath PN (1950) Experimental miliaria in man. III. Production of miliaria rubra (prickly heat). J Invest Dermatol 14: 193–204Google Scholar
  6. Sulzberger MB, Emik LO (1946) Studies on prickly heat. I. Clinical and statistical findings. J Invest Dermatol 7: 53–59CrossRefGoogle Scholar
  7. Sulzberger MB, Griffin TB (1969) Induced miliaria, postmi-liarial hypohidrosis, and some potential sequelae. Arch Dermatol 99: 145–151PubMedCrossRefGoogle Scholar
  8. Sulzberger MB, Griffin TB, Wiley HS (1967) Miliaria and anhidrosis. I. Experimental production in volunteers. Dermatologica 135: 414–420PubMedCrossRefGoogle Scholar

Neutrophilic Eccrine Hidradenitis

  1. Brehler R, Reimann S, Bonsmann G et al. (1997) Neutrophilic hidradenitis induced by chemotherapy involves eccrine and apocrine glands. Am J Dermatopathol 19: 73–78PubMedCrossRefGoogle Scholar
  2. Gross PR, Margolis D (1999) Neutrophilic dermatosis versus neutrophilic eccrine hidradenitis (letter). N Engl J Med 340: 1371PubMedCrossRefGoogle Scholar
  3. Harrist TJ, Finde JD, Berman RS et al. (1982) Neutrophilic eccrine hidradenitis. A distinct type of neutrophilic dermatosis associated with myelogenous leukemia and chemotherapy. Arch Dermatol 118: 263–266PubMedCrossRefGoogle Scholar
  4. Krischer J, Rutschmann O, Roten SV et al. (1998) Neutrophil eccrine hidradenitis in a patient with AIDS. J Dermatol 25: 199–200PubMedGoogle Scholar

Eccrine Squamous Syringometaplasia

  1. King DT, Barr RJ (1979) Synringometaplasia: mucinous and squamous variants. J Cutan Pathol 6: 284–291PubMedCrossRefGoogle Scholar
  2. Munoz E, Valks R, Fernandez HJ et al. (1997) Herpetic syringitis associated with eccrine squamous synrigometa-plasia in HIV-positive Patients. J Cutan Pathol 24: 425–428PubMedCrossRefGoogle Scholar
  3. Valks R, Fraga J, Porras LJ et al. (1997) Chemotherapy-induced eccrine squamous syringometaplasia. A distinctive eruption in patients receiving hematopoietic progenitor cells. Arch Dermatol 133: 873–878PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Otto Braun-Falco
    • 1
  • Gerd Plewig
    • 1
  • Helmut H. Wolff
    • 2
  • Walter H. C. Burgdorf
    • 1
  1. 1.Department of Dermatology and AllergologyLudwig Maximilians UniversityMunichGermany
  2. 2.Department of Dermatology and VenerologyUniversity of LübeckLübeckGermany

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