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Disorders of Hemostasis

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Dermatology

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Abstract

Hemostasis is a complex problem. Endothelial cells, megakaryocytes and platelets, clotting factors, fibrinolysis components and their inhibitors are all intertwined in a system designed to rapidly seal off vessel damage without producing extensive clotting or occlusion. Normally, there is a delicate balance between the factors favoring hemostasis and those opposing it. If the hemostatic system is inappropriately activated, a thrombosis results. If on the other hand the system fails to function effectively, hemorrhage occurs. Since the skin is often the first site where hemorrhage is seen, dermatologists must have a basic understanding of hemostasis. We have deliberately simplified this chapter, leaving out rare disorders and only touching on the basic scientific aspects of platelet function, the coagulation cascade, and fibrinolysis.

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Authors and Affiliations

  1. Department of Dermatology and Allergology, Ludwig Maximilians University, Frauenlobstraße 9-11, D-80337, Munich, Germany

    Prof. Dr. med. Dr. h.c.mult. Otto Braun-Falco (Emeritus Professor and Chairman), Prof. Dr. med. Gerd Plewig (Professor and Chairman) & Walter H. C. Burgdorf M.D. (Clinical Lecturer)

  2. Department of Dermatology and Venerology, University of Lübeck, Ratzeburger Allee 160, D-23562, Lübeck, Germany

    Prof. Dr. med. Helmut H. Wolff (Professor and Chairman)

Authors
  1. Prof. Dr. med. Dr. h.c.mult. Otto Braun-Falco
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  2. Prof. Dr. med. Gerd Plewig
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  3. Prof. Dr. med. Helmut H. Wolff
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  4. Walter H. C. Burgdorf M.D.
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© 2000 Springer-Verlag Berlin Heidelberg

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Braun-Falco, O., Plewig, G., Wolff, H.H., Burgdorf, W.H.C. (2000). Disorders of Hemostasis. In: Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97931-6_23

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  • DOI: https://doi.org/10.1007/978-3-642-97931-6_23

  • Publisher Name: Springer, Berlin, Heidelberg

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