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Quantification of Blood Flow

  • J. F. Debatin
  • M. Hauser
Part of the Medical Radiology book series (MEDRAD)

Abstract

Magnetic resonance techniques can go beyond the morphological assessment of the cardiovascular system by allowing direct quantitative characterization of flow dynamics. Reflecting the inherent motion sensitivity of MRI with regard to both amplitude and phase, two different MR techniques are available for flow measurements: one is based on the influence of motion on signal amplitude, the other on the influence of motion on signal phase. They can be combined with various gating schemes to achieve excellent temporal resolution throughout the cardiac cycle (Pelc et al. 1991a). Compared to Doppler ultrasound, both techniques are less operator dependent and do not require the presence of an appropriate acoustic window.

Keywords

Pulmonary Arterial Hypertension Magn Reson Image Peak Systolic Velocity False Lumen Portal Venous System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. AbuRahma AF, Diethrich EB (1988) Current noninvasive vascular diagnosis. PSG, New YorkGoogle Scholar
  2. Bogren HG, Klipstein RH, Firmin DN et al. (1989a) Quantitation of antegrade and retrograde blood flow in the human aorta by magnetic resonance velocity mapping. Am Heart J 117:1214PubMedCrossRefGoogle Scholar
  3. Bogren HG, KHpstein RH, Mohiaddin RH et al. (1989b) Pulmonary artery distensibility and blood flow patterns: a magnetic resonance study of normal subjects and of patients with pulmonary arterial hypertension. Am Heart J 118:990–999PubMedCrossRefGoogle Scholar
  4. Bornstein N, Krajewski A, Norris J (1988) Basilar artery blood flow in subclavian steal. Can J Neurol Sci 15:417–419PubMedGoogle Scholar
  5. Bosch J, Mastai R, Kravetz D, Bruix J, Rigau J Rodés J (1985) Measurement of azygos venous blood flow in the evaluation of protal hypertension in patients with cirrhosis. Clinical and haemodynamic correlations in 100 patients. J Hepatol 1:125–139PubMedCrossRefGoogle Scholar
  6. Bosch J, Mastai R, Kravetz D, Navasa M, Rodes J (1986) Hemodynamic evaluation of the patietn with portal hypertension. Semin Liver Dis 6:309–317PubMedCrossRefGoogle Scholar
  7. Bosch J, Pizcueta P, Feu F, Fernández M, García-Pagán JC (1992) Pathophysiology of portal hypertension. Gastroenterol Clin North AM 21:1–14PubMedGoogle Scholar
  8. Burkart DJ, Johnson CD, Ehman RL, Weaver AL, llstrup DM (1993a) Evaluation of portal venous hypertension with cine phase-contrast MR flow measurements: high association of hyperdynamic portal flow with variceal hemorrhage. Radiology 188:643–648PubMedGoogle Scholar
  9. Burkart DJ, Johnson CD, Morton MJ, Wolf RL, Ehman RL (1993b) Volumetric flow rates in the portal venous system: measurement with cine phase-contrast MR imaging. AJR 160:1113–1118PubMedGoogle Scholar
  10. Burt R, Witt R, Cikrit D, Reddy R (1992) Carotid artery disease: evaluation with acetazolamide-enhanced Tc-99m HMPAO SPECT. Radiology 182:461–466PubMedGoogle Scholar
  11. Caputo GR, Higgins CB (1992) Magnetic resonance angiography and measurement of blood flow in the peripheral vessels. Invest Radiol 27:897–8102CrossRefGoogle Scholar
  12. Caputo GR, Kondo C, Takayuki M et al. (1991) Right and left lung perfusion: in vitro and in vivo validation with ob- Hque-angle, velocity-encoded cine MR imaging. Radiology 180:693–698PubMedGoogle Scholar
  13. Caputo GR, Masui T, Gooding GAW, Chang J-M, Higgins CB (1992) Popliteal and tibioperoneal arteries: feasibility of two-dimensional time-of-flight MR angiography and phase velocity mapping. Radiology 182: 387–392PubMedGoogle Scholar
  14. Caro CG, Pedley TJ, Schröter RC, Seed WA (1978) The mechanics of the circulation. Oxford University Press, New YorkGoogle Scholar
  15. Chang J-M, Friese K, Caputo GR, Kondo C, Higgins CB (1991) MR measurement of blood flow in the true and false channel in chronic aortic dissection. J Comput Assist Tomogr 15:418–423PubMedCrossRefGoogle Scholar
  16. Debatin JF, Spritzer CE, Grist TM et al. (1991) Imaging of the renal arteries: value of MR angiography. AJR 157:981–990PubMedGoogle Scholar
  17. Debatin JF, Strong JA, Sostman HD (1993) MR characterization of blood flow in native and grafted internal mammary arteries. J Magn Reson Imaging 3:443–450PubMedCrossRefGoogle Scholar
  18. Debatin JF, Ting RH, Wegmüller H et al. (1994a) Renal artery blood flow: quantitation with phase-contrast MR imaging with and without breath holding. Radiology 190:371–378PubMedGoogle Scholar
  19. Debatin JF, Ting R, Krestin GP, Fredrickson JO, Sommer FG, Pelc NJ (1994b) Phase-contrast quantitation of renal arterial blood flow. Radiology 193(P):302Google Scholar
  20. Debatin JF, Leung DA, Wildermuth S, Botnar R, Felblinger J, McKinnon GC (to be published, a) Flow quantitation with echo planar phase contrast velocity mapping: in vitro and in vivo evaluation. AJRGoogle Scholar
  21. Debatin JF, Dalman R, Herfkens RJ, Harris EJ, Pelc NJ (to be published, b) Cine phase-contrast MRI assessment of pedal blood flow. Eur RadiolGoogle Scholar
  22. Duke M-C, Mostbeck GH, O’Sullivan M et al. (1992) Severity of aortic regurgitation: interstudy reproducibility of measurements with velocity-encoded cine MR imaging. Radiology: 185:235–240Google Scholar
  23. Edelman RR, Mattle HP, Kleefield J, Silver MS (1989a) Quantification of blood flow with Dynamic MR imaging and presaturation bolus tracking. Radilogy 171:551–556Google Scholar
  24. Edelman RR, Zhao B, Liu C, Wentz KU, Mattle HP, Finn JP, McArdle C (1989b) MR angiography and dynamic flow evaluation of the portal venous system. AJR 153:755–760PubMedGoogle Scholar
  25. Eichenberger AC, Jenni R, von Schulthess GK (1993) Aortic valve pressure gradients in patients with aortic valve stenosis: quantification with velocity-encoded cine MR imaging. AJR 160:971–977PubMedGoogle Scholar
  26. Evans AJ, Iwai F, Grist TA et al. (1993) Magnetic resonance imaging of blood flow with a phase subtraction technique: “in vitro” and “in vivo” vahdation. Invest Radiol 28:109-115PubMedCrossRefGoogle Scholar
  27. Fazekes F, Niederkom K, Schmidt R et al. (1988) White matter signal abnormalities in normal individuals: correlation with carotid ultrasonography, cerebral blood flow measurements, and cerebrovascular risk ractors. Stroke 19:1285–1288CrossRefGoogle Scholar
  28. Firmin DN, Nayler GL, Klipstein RH et al. (1987) In vivo vahdation of MR velocity imaging. JCAT 11:751–756Google Scholar
  29. Fredrickson JO, Pelc NJ (1994) Time-resolved MR imaging by automatic data segmentation. JMRI 4:189–196PubMedCrossRefGoogle Scholar
  30. Galambos JT (1979) Evaluation and therapy of portal hypertension. In: Galambos JT (ed) Cirrhosis. Saunders, Philadelphia, pp 253–287Google Scholar
  31. Galijee M, Van Rossum A, Kamp O et al. (1991) Reversed pulmonary venous flow measured by magnetic resonance phase velocity mapping: a marker in mitral insufficiency severity. In: Book of Abstracts, Society of Magnetic Resonance in Medicine 1991, Berkeley, Cahf, p 339Google Scholar
  32. Globits S, Frank H, Mayr H, Neuhold A, Glogar D (1992) Quantitative assessment of aortic requrgitation by magnetic resonance imaging. Eur Heart J 13:78–83PubMedGoogle Scholar
  33. Haacke EM, Smith AS, Lin W, Lewin JS, Finelli DA, Duerk JL (1991) Velocity quantification in magnetic resonance imaging. Top Magn Reson Imaging 3:34–49PubMedCrossRefGoogle Scholar
  34. Hatabu H, Gefter WB, Konishi J, Kressel HY (1991) Magnetic resonance approaches to the evaluation of pulmonary vascular anatomy and physiology. Magn Reson Q 7: 208–225PubMedGoogle Scholar
  35. Hausmann R, Lewin J, Laub G (1991) Phase contrast MR angiography with reduced acquisition time: new concepts in sequence design. J Magn Reson Imaging 1:415–422PubMedCrossRefGoogle Scholar
  36. Hillman BJ (1989) Imaging advances in the diagnosis of renovascular hypertension. AJR 153:5–14PubMedGoogle Scholar
  37. Honda N, Machida K, Hashimoto M (1993) Aortic regurgitation: quantitation with MR imaging velocity mapping. Radiology 186:189–194PubMedGoogle Scholar
  38. Jordan J, Pelc NJ, Enzmann D (1992) Velocity imaging and flow quantitation in the superior sagittal sinus and dural venous sinuses with ungated and cine gated 2D phase contrast MR. Presented at the 30th ASNR Meeting, St. Louis Mo. Book of Abstracts, ASNR Meeting: 58Google Scholar
  39. Kilner P, Firmin D, Simon R et al. (1991) Valve and great vessel stenosis: assessment with MR jet velocity mapping. Radiology 178:229–235PubMedGoogle Scholar
  40. Kondo C, Caputo GR, Semelka R et al. (1991) Right and left ventricular stroke volume measurements with velocity-encoded cine MR imaging: in vitro and in vivo validation. AJR 157:9–16PubMedGoogle Scholar
  41. Kondo C, Caputo GR, Masui T et al. (1992) Pulmonary hypertension: pulmonary flow quantification and flow profile analysis with velocity-encoded cine MR imaging. Radilogy 183:751–758Google Scholar
  42. Levine SM, Gibbons WJ, Bryan CL et al. (1990) Single lung transplantation for primary pulmonary hypertension. Chest 98:1107–1115PubMedCrossRefGoogle Scholar
  43. Li KCP, Whitney WS, McDonnell CH, Fredrickson JO, Pelc NJ, Dalman RL, Jeffrey RB Jr (1994) Chronic mesenteric ischemia: evaluation with phase-contrast cine MR imaging. Radiology 190:175–179PubMedGoogle Scholar
  44. Mahl TC, Groszmann RJ (1990) Pathophysiology of portal hypertension and variceal bleeding. Surg Chn North Am 70:251–266Google Scholar
  45. Maier SE, Meier D, Boesiger P, Moser UT, Vieh A (1989) Human abdominal aorta: comparative measurements of blood flow with MR imaging and multigated Doppler US. Radiology 171:487–492PubMedGoogle Scholar
  46. Marincek B, Debatin JF, Wetter DR, Meyenberger C, Schoepke WD (1994) Azygos blood flow: quantification with cine phase-contrast MR before and after transjugular intrahepatic portosystemic shunting. Radiology 193(P): 167Google Scholar
  47. Marks M, Pelc NJ, Ross M, Enzmann D (1992) Determination of cerebral blood flow with a phase contrast cine MR imaging technique: evaluation of normal subjects and patients with arteriovenous malformations. Radiology 182:467–476PubMedGoogle Scholar
  48. Meyer J, Haymen L, Amano T et al. (1981) Mapping local blood flow of human brain by CT scanning during stable xenon inhalation. Stroke 12:426–437PubMedCrossRefGoogle Scholar
  49. Mohiaddin RH, Amanuma M, Kilner PJ et al. (1991a) MR phase-shift velocity mapping of mitral and pulmonary venous flow. J Comput Assist Tomogr 15:237–243PubMedCrossRefGoogle Scholar
  50. Mohiaddin RH, Kilner PJ, Firmin DN et al. (1991b) Characterization of flow by cine magnetic resonance velocity mapping in the thoracic aorta of patients with aortic coarctation(abstr). In: Book of Abstracts: Soc of Magn Res in Med 1991. Berkeley, Calif.: SMRM 1991:340Google Scholar
  51. Mostbeck GH, Caputo GR, Higgins CB (1992) MR measurement of blood flow in the cardiovascular system. AJR 159:453–461PubMedGoogle Scholar
  52. Nayler GL, Firmin DN, Longmore DB (1986) Blood flow imaging by cine magnetic resonance. JCAT 10:715–722Google Scholar
  53. Pelc NJ, Herfkens RJ, Shimakawa A, Enzmann DR (1991a) Phase contrast cine magnetic resonance imaging. Magn Reson Q 7: 229–254PubMedGoogle Scholar
  54. Pelc NJ, Bernstein M, Shimakawa A, Glover G (1991b) Encoding strategies for three-direction phase contrast MR imaging of flow. J Magn Reson Imaging 1:405–413PubMedCrossRefGoogle Scholar
  55. Rees S, Firmin D, Mohiaddin R, Underwood R, Longmore D (1989) Applications of flow measurements by magnetic resonance velocity mapping to congenital heart disease. Am J Cardiol 64:953–956PubMedCrossRefGoogle Scholar
  56. Rigau J, Bosch J, Bordas JM et al. (1989) Endoscopic measurement of variceal pressure in cirrhosis: correlation with portal pressure and variceal hemorrhage. Gastroenterology 96:873–880PubMedGoogle Scholar
  57. Rimmer JM, Gennari FJ (1993) Atherosclerotic renovascular disease and progressive renal failure. Ann Intern Med 118:712–719PubMedGoogle Scholar
  58. Rubin DL, Herfkens RJ, Pelc NJ, Jeffrey RB (1992) MR measurement of portal blood flow in chronic liver disease: apphcation to predicting clinical outcome. Proc Soc Magn Reson Med, p 90Google Scholar
  59. Shirahata H, Henriksen L, Vorstrup S et al. (1985) Regional cerebral blood flow assessed by 133 xenon inhalation and emission tomography: normal values. J Comput Assist Tomogr 9:861–866PubMedCrossRefGoogle Scholar
  60. Sieverding L, Jung W, Kiose U, Apitz J (1992) Noninvasive blood flow measurement in quantification of shunt volume by cine magnetic resonance in congenita heart disease. Pediatr Radiol 22:48–54PubMedCrossRefGoogle Scholar
  61. Silverman JM, Julien PJ, Herfkens RJ, Pelc NJ (1993) Quantitative differential pulmonary perfusion: magnetic resonance imaging vs radionuclide lung scanning. Radiology 189:699–701PubMedGoogle Scholar
  62. Sondergaard L, Thomsen C, Stahlberg F et al. (1992) Mitral and aortic valvular flow: quantification with MR phase mapping. J magn Reson Imaging 2:295–302PubMedCrossRefGoogle Scholar
  63. Thomsen C, Stahlberg F, Henriksen O (1993) Quantification of portal venous blood flow during fasting and after a standardized meal — a MRI phase-mapping study. Eur Radiol 3:242–247CrossRefGoogle Scholar
  64. van Rossum AC, Visser FC, Hofman MBM et al. (1992) Global left ventricular perfusion: noninvasive measurement with cine MR imaging and phase velocity mapping of coronary venous outflow. Radiology 182:685–691PubMedGoogle Scholar
  65. Wehrli FW, Shimakawa A, Gullberg GT, MacFall JR (1986) Time-of-flight MR flow imaging: selective saturation recovery with gradient refocusing. Radiology 160:781–785PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • J. F. Debatin
    • 1
  • M. Hauser
    • 1
  1. 1.MRI Center, Department of Medical RadiologyZürich University HospitalZürichSwitzerland

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