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Störungen der Hämostase

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Zusammenfassung

Die normale Thrombozytopoese erfolgt im Knochenmark107. Im Verlauf ihrer Entwicklung aus pluripotenten Stammzellen entwickeln die Megakaryozyten ihre enzymatischen und antigenen Merkmale39. Durch Endomitose entsteht eine Polyploidie bis 32 N. Der Megakaryozyt reift, indem er Granula und Demarkationsmembranen ausbildet, und setzt Thrombozyten durch Fragmentation frei. Aus jedem Megakaryozyten (Gesamtbestand 15 × 106/kg Körpergewicht) können 1000–1500 Blutplättchen entstehen. Thrombozyten zirkulieren als scheibenförmige kernlose Zellen (Durchmesser 3 μm, Dicke 1 μm, mittleres Zellvolumen 9,5 ± 1,2 fl) in einer Zahl von 250000/μl ± 100000 und haben eine mittlere Überlebenszeit von 9–10 Tagen.

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Literatur

Weiterführende Literatur

  1. Begemann H (1975) Klinische Hämatologie. Thieme, Stuttgart

    Google Scholar 

  2. Bick RL (1983) Disseminated intravascular coagulation and related syndromes. CRC Press, Boca Raton (Florida)

    Google Scholar 

  3. Biggs R (1976) Human Blood Coagulation, Haemostasis and Thrombosis. Blackwell Oxford, London etc

    Google Scholar 

  4. Bloom AL, Thomas DP (1981) Haemostasis and Thrombosis. Churchill Livingstone, Edinburgh

    Google Scholar 

  5. Colman RW, Hirsh J, Marder UJ, Salzman EW (1982) Hemostasis and Thrombosis: Basic principles and clinical practice. JB Lippincott, Philadelphia

    Google Scholar 

  6. Gordon JL (1976) Platelets in Biology and Pathology. Elsevier/North-Holland Biomedical Press

    Google Scholar 

  7. Harker LA, Zimmermann TS (ed) (1983) Platelet disorders. Clinics in haematology, Vol 12, No 1

    Google Scholar 

  8. Kühn HA, Lasch HG (1982) Untersuchungsmethoden und Funktionsprüfungen in der inneren Medizin. 2. Aufl Thieme, Stuttgart

    Google Scholar 

  9. Kwaan HC, Bowie EJW (1982) Thrombosis. Saunders, Philadelphia

    Google Scholar 

  10. Lechner K (1982) Blutgerinnungsstörungen. Springer, Berlin Heidelberg New York

    Google Scholar 

  11. Murano G, Bick RL (1980) Basic concepts of hemostasis and thrombosis. CRC Press, Boca Raton (Florida)

    Google Scholar 

  12. Ogston D, Bennett B (1977) Haemostasis, biochemistry, physiology and pathology. Wiley & Sons, London

    Google Scholar 

  13. Prentice CRM (ed) (1981) Thrombosis. Clinics in haematology, Vol 10, No 2

    Google Scholar 

  14. Seegers WH (1967) Blood Clotting Enzymology. Academic Press, New York London

    Google Scholar 

  15. Spaet TH (1972–1982) Progress in Hemostasis and Thrombosis, Vol 1–6. Grune and Stratton, New York

    Google Scholar 

  16. Thomson JM (1980) A practical guide to blood coagulation and haemostasis. Churchill Livingstone, Edinburgh

    Google Scholar 

  17. Weiss HJ (1982) Platelets: Pathophysiology and antiplatelet drug therapy. Alan R Liss, New York

    Google Scholar 

  18. William WJ, Beutler E, Erslev AJ, Rundles RW (1977) Hematology. McGraw-Hill, New York London San Francisco etc

    Google Scholar 

  19. Wintrobe MM, Lee GR, Boggs DR et al (1981) Clinical hematology. Lea and Febiger, Philadelphia

    Google Scholar 

Literatur

  1. Ǻberg M, Hedner U, Bergentz (1979) Effect of dextran on factor VIII (antihemophilic factor) and platelet function. Ann Surg 189:243–247

    PubMed  Google Scholar 

  2. Alter BP, Potter NU, Li FP (1978) Classification and aetiology of the aplastic anaemias. Clin Haematol 7:431–465

    PubMed  CAS  Google Scholar 

  3. Ansell J, Deykin D (1980) Heparin-induced thrombocytopenia and recurrent thromboembolism. Am J Hematol 8:325–332

    PubMed  CAS  Google Scholar 

  4. Baker NM, Mills AE, Rachmann J, Thomas JEP (1974) Haemolytic uraemic syndrome in typhoid fever. Br Med J 2:84–87

    PubMed  CAS  Google Scholar 

  5. Banatvala JE, Horstmann DM, Payne MC, Gluck L (1965) Rubella syndrome and thrombocytopenic purpura in newborn infants. N Engl J Med 273:474–478

    PubMed  CAS  Google Scholar 

  6. Behrens WE von (1975) Mediterranean macrothrombocytopenia. Blood 46:199–205

    PubMed  CAS  Google Scholar 

  7. Bell WR, Royall RM (1980) Heparin-associated thrombocytopenia: a comparison of three heparin preparations. N Engl J Med 303:902–907

    PubMed  CAS  Google Scholar 

  8. Berkowitz LR, Dalldorf FG, Blatt PM (1978) Thrombotic thrombocytopenic purpura: a pathology review. J Am Med Ass 241:1709–1710

    Google Scholar 

  9. Bernard J, Caen JP, Maroteaux P (1957) La dystrophie thrombocytaire hémorrhagipare congenitale. Revue d’Hématologie. 12:222–249

    PubMed  CAS  Google Scholar 

  10. Brain MC, Neame PB (1982) Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome. Sem Thromb Hemostas 8:186–197

    CAS  Google Scholar 

  11. Brown CH III, Bradshaw MW, Natelson EA, Alfrey CP, Williams TW (1976) Defective platelet function following the administration of penicillin compounds. Blood 47:949–956

    PubMed  CAS  Google Scholar 

  12. Carloss HW, McMillan R, Corsby WH (1980) Management of pregnancy in women with immune thrombocytopenic purpura. J Am Med Ass 244:2756–2758

    CAS  Google Scholar 

  13. Caen J (1972) Glanzmann thrombasthenia. Clin. Haematol. 1:383–392

    Google Scholar 

  14. Caen JP, Nurden AT, Jeanneau C, Michel H, Tobelem G, Levy-Toledano S, Sultan Y, Valensi F, Bernard J (1976) Bemard-Soulier-Syndrome – a new platelet glycoprotein abnormality. Its relationship with platelet adhesion to subendothelium and with the factor VIII von Willebrand protein. J Lab Clin Med 87:586–596

    PubMed  CAS  Google Scholar 

  15. Chediak M (1952) Nouvelle anatomie leucocytaire de caractére constitutionnel et familial. Revue d’Hématologie, Paris 7:362–367

    CAS  Google Scholar 

  16. Cines D B, Schreiber A D (1979) Immune thrombocytopenia: use of a Coombs antiglobulin test to detect IgG and C3 on platelets. N Engl J Med 300:106–111

    PubMed  CAS  Google Scholar 

  17. Clarke B F, Davies S H (1964) Severe thrombocytopenia in infectious mononucleosis. Am J Med Sci 248:703–708

    PubMed  CAS  Google Scholar 

  18. Coblyn J S, Weinblatt N D, Holds worth D, Glass D (1984) Gold induced thrombocytopenia. A clinical and immunogenetic study of twenty-three patients. Ann Intern Med 95:178–181

    Google Scholar 

  19. Cohen J R (1978) Idiopathic thrombocytopenic purpura in Hodgkin’s disease. Cancer 41:743–746

    PubMed  CAS  Google Scholar 

  20. Collen D (1980) On the regulation and control of fibrinolysis. Thromb Haemost 43:77–89

    PubMed  CAS  Google Scholar 

  21. Cooper BA, Bigelow FS (1960) Thrombocytopenia associated with the administration of diethylstilbestrol in man. Ann Int Med 52:907–909

    PubMed  CAS  Google Scholar 

  22. Ebbe S (1976) Biology of megakaryocytes. Prog Hemost Thromb 3:211–229

    PubMed  CAS  Google Scholar 

  23. Epstein CJ, Sahud MA, Piel CF, Goodman JR, Bernfield MK, Kushner JH, Abblin AR (1972) Hereditary macrothrombocytopenia, nephritis and deafness. Am J Med 52:299–310

    PubMed  CAS  Google Scholar 

  24. Evans RJ, Gordon JL (1974) Mechanisms of the antithrombotic action of dextran. N Engl J Med 290:748

    PubMed  CAS  Google Scholar 

  25. Feldman JD, Mardiney MR, Unanue ER, Cutting H (1966) The vascular pathology of thrombotic thrombocytopenic purpura: an immunohistochemical and ultrastructural study. Lab Invest 15:927–946

    PubMed  CAS  Google Scholar 

  26. Gerrard JM, Phillips DR, Rao GHR, Plow EF, Walz DW, Ross R, Harker LA, White JG (1980) Biochemical studies of two patients with the grey platelet syndrome. Selective deficiency of platelet alpha granules. J Clin Invest 66:102–109

    PubMed  CAS  Google Scholar 

  27. Grottum KA, Solum NO (1969) Congenital thrombocytopenia with giant platelets: a defect in the platelet membrane. Br J Haematol 16:277–290

    PubMed  CAS  Google Scholar 

  28. Hackett Th, Kelton JG, Powers P (1982) Drug-induced platelet destruction. Sem Thromb Hemostas 8:116–137

    CAS  Google Scholar 

  29. Hardisty RM (1977) Disorders of platelet function. Brit Med Bull 33:207–212

    PubMed  CAS  Google Scholar 

  30. Harker LA (1970) Thrombokinetics in idiopathic thrombocytopenic purpura. Br J Haemat 19:95–104

    CAS  Google Scholar 

  31. Henry RL (1977) Platelet function. Sem Thromb Hemostas 4:93–122

    CAS  Google Scholar 

  32. Hermansky F, Pudlak P (1959) Albinism associated with haemorrhagic diathesis and unusual pigmented reticular cells in the bone marrow: report of two cases with histochemical studies. Blood 14:162–169

    PubMed  CAS  Google Scholar 

  33. Howard MA, Hutton RA, Hardisty RM (1973) Hereditary giant platelet syndrome: a disorder of a new aspect of platelet function. Br J Med 2:586–588

    CAS  Google Scholar 

  34. Hymes K, Blum M, Lackner H, Karpatkin S (1981) Easy bruising, thrombocytopenia and elevated platelet immunoglobulin G in Graves’ disease and Hashimoto’s thyreoiditis. Ann Int Med 94:27–30

    PubMed  CAS  Google Scholar 

  35. Ingermann CM, Smith JB, Shapiro S, Sedar A, Silver MJ (1978) Hereditary abnormality of platelet aggregation attributable to nucleotide storage pool deficiency. Blood 52:332–344

    Google Scholar 

  36. Jackson CM, Nemerson Y (1980) Blood coagulation. Ann Rev Biochem 49:765–811

    PubMed  CAS  Google Scholar 

  37. Jamieson GA, Okumura T, Fishback B, Johnson MM, Egan JJ, Weiss HJ (1979) Platelet membrane glycoproteins in thrombasthenia, Bemard-Soulier-syndrome and storage pool disease. J Lab Clin Med 93:652–660

    PubMed  CAS  Google Scholar 

  38. Kaplan BS, Chesney RW, Drummond KN (1975) Hemolyticuremic syndrome in families. N Engl J Med 292:1090–1093

    PubMed  CAS  Google Scholar 

  39. Karpatkin S (1980) Autoimmune thrombocytopenic purpura. Blood 56:329–343

    PubMed  CAS  Google Scholar 

  40. Kelton JG, Gibbons S (1982) Autoimmune platelet destruction: Idiopathic thrombocytopenic purpura. Sem Thromb Hemostas 8:83–104

    CAS  Google Scholar 

  41. Kelton J, Keystone J, Proctor E, Neame P (1980) Malaria-induced immune thrombocytopenia. 16th Congress of the International Society of Hematology, 1494A

    Google Scholar 

  42. Kennedy SS, Zacharsky LR, Beck JR (1980) Thrombotic thrombocytopenic purpura: analysis of 48 unselected cases. Semin Thromb Hemostas 6:341–349

    CAS  Google Scholar 

  43. Kernoff LM, Malan E, Gunston K (1979) Neonatal thrombocytopenia complicating autoimmune thrombocytopenia in pregnancy: evidence for transplacental passage of antiplatelet antibody. Ann Int Med 90:55–56

    PubMed  CAS  Google Scholar 

  44. Klein CA, Blajchman MA (1982) Alloantibodies and platelet destruction. Sem Thromb Hemostas 8:105–115

    CAS  Google Scholar 

  45. Koster F, Levin J, Walker L, Tung KSK, Gilman RH, Rahaman MM, Majid MA, Islam S, Williams RC (1978) Hemolytic uremic syndrome after shigellosis. N Engl J Med 298:927–933

    PubMed  CAS  Google Scholar 

  46. Kutti J, Weinfeld A (1968) The frequency of thrombocytopenia in patients with heart disease treated with oral diuretics. Acta Med Scand 183:245–250

    PubMed  CAS  Google Scholar 

  47. Kwaan HC (1979) The pathogenesis of thrombotic thrombocytopenic purpura. Sem Thromb Hemostas 5:184–198

    CAS  Google Scholar 

  48. Lacey JV, Penner JA (1977) Management of idiopathic thrombocytopenic purpura in the adult. Sem Thromb Hemostas 3:160–174

    CAS  Google Scholar 

  49. Lagarde M, Bryon PA, Vargaftig BB, Dechavanne M (1978) Impairment of platelet thromboxane A2 generation and of the platelet release reaction in two patients with congenital deficiency of platelet cyclo-oxygenase. Br J Haemat 38:251—266

    CAS  Google Scholar 

  50. Lee SH, Wainscoat JS, Zeitlin H, Bolton FG, Leaver HA, Seawright A, Preece JM (1981) Prostacyclin and thromboxane A2 in thrombotic thrombocytopenic purpura. Br Med J 283:1351–1352

    CAS  Google Scholar 

  51. Lukens JN (1978) Neonatal haematological abnormalities associated with maternal disease. Clin Haematol 7:155–173

    PubMed  CAS  Google Scholar 

  52. Lusher JM, Barnhart MI (1977) Congenital disorders affecting platelets. Sem Thromb Hemostas 4:123–186

    CAS  Google Scholar 

  53. Lusher JM, Iyer R (1977) Idiopathic thrombocytopenic purpura in children. Sem Thromb Hemostas 3:179–199

    Google Scholar 

  54. Mammen EF (ed) (1979–81) Thrombotic thrombocytopenic purpura. Sem Thromb Hemostas 5:184–242; 6:330–429; 7:1–51

    Google Scholar 

  55. McDonald TP (1981) Assay and site of production of thrombopoetin. Brit J Haemat 49:493–499

    PubMed  CAS  Google Scholar 

  56. McMillan R (1977) The pathogenesis of immune thrombocytopenic purpura. Crit Rev Clin Lab Sci 8:303–321

    CAS  Google Scholar 

  57. McMillan R (1981) Chronic idiopathic thrombocytopenic purpura. N Engl J Med 304:1135–1147

    PubMed  CAS  Google Scholar 

  58. McWilliams NB, Maurer HM (1979) Acute idiopathic thrombocytopenic purpura in children. Am J Hemat 7:87–96

    PubMed  CAS  Google Scholar 

  59. Moake JL, Rudy CK, Troll JH, Weinstein MJ, Colannino NM, Azocar J, Seder RH, Hong SL, Deykin D (1982) Unusually large plasma factor VIII: von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpura. N Engl J Med 307:1432–1435

    PubMed  CAS  Google Scholar 

  60. Moncada S, Vane JR (1979) Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls. N Engl J Med 300:1142–1147

    PubMed  CAS  Google Scholar 

  61. Mueller-Eckhardt C (1977) Idiopathic thrombocytopenic purpura (ITP): clinical and immunologic considerations. Sem Thromb Hemostas 3:125–159

    CAS  Google Scholar 

  62. Mueller-Eckhardt C, Lechner K, Heinrich D, Marks HJ, Mueller-Eckhardt G, Bettelheim P, Breithaupt H (1980) Posttransfusion thrombocytopenic purpura: immunological and clinical studies in two cases and review of the literature. Blut 40:249–257

    PubMed  CAS  Google Scholar 

  63. Mueller-Eckhardt C, Mahn I, Schulz G, Mueller-Eckhardt G (1978) Detection of platelet autoantibodies by a radioactive antiimmunoglobulin test. Vox Sang 35:357–365

    PubMed  CAS  Google Scholar 

  64. Murano G (1980) A basic outline of blood coagulation. Sem Thromb Hemostas 6:140–162

    CAS  Google Scholar 

  65. Mustard JF, Kinlough-Rathbone RL, Packham MA, Perry D, Harfenist EJ, Pai KRM (1979) Comparison of fibrinogen association with normal and thrombasthenic platelets on exposure to ADP or chymotrypsin. Blood 54:987–993

    PubMed  CAS  Google Scholar 

  66. Nissenson AR, Krumlovsky FA, del Greco F (1979) Postpartum hemolytic uremic syndrome. Late recovery after prolonged maintenance hemodialysis. J Am Med Ass 242:173–175

    CAS  Google Scholar 

  67. Nurden AT, Caen JP (1979) The different glycoprotein abnormalities in thrombasthenic and Bemard-Soulier-platelets. Sem Hematol 16:234–250

    CAS  Google Scholar 

  68. Ochs HD, Slichter SJ, Harker LA, von Behrens WE, Clark RA, Wedgwood RJ (1980) The Wiscott-Aldrich-syndrome: studies of lymphocytes, granulocytes and platelets. Blood 55:243–252

    PubMed  CAS  Google Scholar 

  69. Oski FA, Naiman JL, Allen DM, Diamond LK (1962) Leucocytic inclusions – Döhle bodies – associated with platelet abnormality (the May-Hegglin anomaly): report of a family and review of the literature. Blood 20:657–667

    PubMed  CAS  Google Scholar 

  70. Papp AC, Hall ER, Upshaw JD, Wu KK (1982) Congenital microangiopathic hemolysis and thrombocytopenia associated with deficiency of a prostacyclin stabilizing factor. Clin Res 30:326

    Google Scholar 

  71. Pearson HA, McIntosh S (1978) Neonatal thrombocytopenia. Clin Haematol 7:111–122

    PubMed  CAS  Google Scholar 

  72. Pearson HA, Shulman NR, Marder VJ, Cone TE Jr (1964) Isoimmune neonatal thrombocytopenic purpura. Clinical and therapeutic considerations. Blood 23:154–177

    PubMed  CAS  Google Scholar 

  73. Peterson OV, Olsen TS (1971) Late renal transplant failure due to the hemolytic uremic syndrome. Acta Med Scand 189:377–380

    Google Scholar 

  74. Pfueller SL, Hosseinzadek PK, Firkin BG (1981) Quinine- and quinidine dependent antiplatelet antibodies. J Clin Invest 67:907–910

    PubMed  CAS  Google Scholar 

  75. Pochedly C (1971) Thrombocytopenic purpura of the newborn. Obstet. Gynecol Surv 26:63–103

    Google Scholar 

  76. Post RM, Desforges JF (1968) Thrombocytopenia and alcoholism. Ann Int Med 68:1230–1236

    PubMed  CAS  Google Scholar 

  77. Reichert N, Seligsohn U, Ramot B (1975) Clinical and genetic aspects of Glanzmann’s thrombasthenia in Israel:report of 22 cases. Thromb Diath Haemorrh 34:806–820

    PubMed  CAS  Google Scholar 

  78. Schoolwerth AC, Sandler RS, Klahr S, Kissane JM (1976) Nephrosclerosis postpartum and in women taking oral contraceptives. Arch Int Med 136:178–185

    CAS  Google Scholar 

  79. Shulman NR, Aster RH, Leitner A, Miller MC (1961) Immunoreactions involving platelets. Post-transfusion purpura due to a complement-fixing antibody against a genetically controlled platelet antigen. A proposed mechanism for thrombocytopenia and its relevance in auto-immunity. J Clin Invest 40:1597–1620

    PubMed  CAS  Google Scholar 

  80. Shulman NR, Weinrach RS, Libre EP, Andrews HL (1965) The role of the reticuloendothelial system in the pathogenesis of idiopathic thrombocytopenic purpura. Transact Ass Am Phys 78:374–390

    CAS  Google Scholar 

  81. Slichter SJ, Harker LA (1978) Thrombocytopenia: mechanisms and management of defects in platelet production. Clin Haematol 7:523–539

    PubMed  CAS  Google Scholar 

  82. Upshaw JD (1978) Congenital deficiency of a factor in normal plasma that reverses microangiopathy, hemolysis and thrombocytopenia. N Engl J Med 298:1350–1352

    PubMed  Google Scholar 

  83. Vane JR (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biology 231:232–235

    PubMed  CAS  Google Scholar 

  84. Wautier JL, Caen JP (1979) Pharmacology of platelet-suppressive agents. Sem Thromb Hemostas 5:293–315

    CAS  Google Scholar 

  85. Webster J, Rees AJ, Lewis PJ, Heustry CN (1980) Prostacyclin deficiency in haemolytic uraemic syndrome. Br Med J 281:271

    PubMed  CAS  Google Scholar 

  86. Weiss HJ (1975) Platelet physiology and abnormalities of platelet function. N Engl J Med 293:531–541, 580–588

    PubMed  CAS  Google Scholar 

  87. Weiss HJ, Lages BA (1977) Possible congenital defect in platelet thromboxane synthetase. Lancet 1:760–761

    PubMed  CAS  Google Scholar 

  88. Weiss HJ, Vicic WJ, Lages BA, Rogers J (1978) Isolated deficiency of platelet procoagulant activity. Am J Med 67:206–213

    Google Scholar 

  89. Weiss HJ, Witte LD, Kaplan KL, Lages BA, Chemoff A, Nossel HL, Goodman PS, Baumgartner HR (1979) Heterogeneity in storage pool deficiency: Studies on granule-bound substances in 18 patients including variants deficient in α-granules, platelet factor 4, ß-thromboglobulin and platelet derived growth factor. Blood 54:1296–1319

    PubMed  CAS  Google Scholar 

  90. Williams N, Levine RF (1982) The origin, development and regulation of megakaryocytes. Br J Haemat 52:173

    CAS  Google Scholar 

  91. Wilson JJ, Neame PB, Kelton JG (1982) Infection-induced thrombocytopenia. Sem Thromb Hemostas 8:217–233

    CAS  Google Scholar 

Literatur

  1. Abildgaard CF, Suzuki Z, Harrison J, Jefcoat K, Zimmerman TS (1980) Serial studies in von Willebrand disease: variability versus variants. Blood 56:712–716

    PubMed  CAS  Google Scholar 

  2. Aledort LM (1976) Blood clotting abnormalities in liver disease. Prog Liver Dis 5:350–362

    PubMed  CAS  Google Scholar 

  3. Aledort LM (1982) Current concepts in diagnosis and management in hemophilia. Hosp Pract 17 (10):77–92

    CAS  Google Scholar 

  4. Al-Mondhiry HAB, Bilezikian SB, Nossel HL (1975) Fibrinogen New York, an abnormal fibrinogen associated with thromboembolism. Blood 45:607–619

    PubMed  CAS  Google Scholar 

  5. Aoki N, Moroi M, Sakata Y, Yoshida N, Matsuda M (1978) Abnormal plasminogen. A hereditary molecular abnormality found in a patient with recurrent thrombosis. J Clin Invest 61:1186–1195

    PubMed  CAS  Google Scholar 

  6. Aoki N, Saito H, Kamiya T, Koie K, Sakata Y, Kobakura M (1979) Congenital deficiency of α2-plasmin inhibitor associated with severe hemorrhagic tendency. J Clin Invest 63:877–884

    PubMed  CAS  Google Scholar 

  7. Arnold WD, Hilgartner MW (1977) Hemophilic arthropathy. J Bone Joint Surg 59 A:287

    Google Scholar 

  8. Barry A, Delage JM (1965) Congenital deficiency of fibrin stabilizing factor. N Engl J Med 272:943–946

    PubMed  CAS  Google Scholar 

  9. Beck EA (1979) Congenital abnormalities of fibrinogen. Clin Haematol 8:169–181

    PubMed  CAS  Google Scholar 

  10. Beck EA, Charache P, Jackson DP (1965) A new inherited coagulation disorder caused by an abnormal fibrinogen („fibrinogen Baltimore“). Nature (London) 208:143–145

    CAS  Google Scholar 

  11. Bell WR (1980) Disseminated intravascular coagulation. Johns Hopkins Med J 146:289–299

    PubMed  CAS  Google Scholar 

  12. Bergquist D, Nilsson IM (1979) Hereditary alpha2-macroglobulin deficiency. Scand J Haemat 23:433–436

    Google Scholar 

  13. Bertina RM, Broekmans AW, van der Linden IK, Mertens K (1982) Protein C deficiency in a Dutch family with thrombotic disease. Thromb Haemost 48:1–5

    PubMed  CAS  Google Scholar 

  14. Bick RL (1978) Alterations of hemostasis associated with malignancy: etiology, pathophysiology, diagnosis and management. Sem Thromb Hemostas 5:1–26

    CAS  Google Scholar 

  15. Bick RL (1978) Vascular disorders associated with thrombo-hemorrhagic phenomena. Sem Thromb Hemostas 5:167–183

    Google Scholar 

  16. Biggs R (1978) The treatment of haemphilia A and B and von Willebrand’s disease. Blackwell Scientific, Oxford

    Google Scholar 

  17. Biggs R (1979) Recent advances in the management of haemophilia and Christmas disease. Clin Haematol 8:95

    PubMed  CAS  Google Scholar 

  18. Bleyl U (1977) Morphologic diagnosis of disseminated intravascular coagulation: histological, histochemical and electron-microscopic studies. Sem Thromb Hemostas 3:247–267

    Google Scholar 

  19. Blombäck M, Blombäck B, Mammen E, Prasad AS (1968) Fibrinogen Detroit: a molecular defect in the N-terminal disulphide knot of human fibrinogen. Nature (London) 218:134–137

    Google Scholar 

  20. Bloom AL (1981) Factor VIII inhibitors revisited. Br J Haemat 49:319–324

    CAS  Google Scholar 

  21. Bloom AL (1980) The von Willebrand syndrome. Semin Haematol 17:215–227

    CAS  Google Scholar 

  22. Breddin K, Lechner K, Kröhl (1975) Störungen der Blutgerinnung und Plättchenfunktion bei Lebererkrankungen. Therapiewoche 25:3113–3118

    Google Scholar 

  23. Briet E, Loeliger EA, van Tilburg NH, Veitkamp JJ (1976) Molecular variants of factor VII. Thromb Haemostas 42:289–294

    Google Scholar 

  24. Brinkhouse KM, Hemker HC (1975) Handbook of hemophilia. Excerpta Medica Amsterdam

    Google Scholar 

  25. Broekmans AW, Bertina RM, Loeliger EA, Hofmann V, Klingemann H-G (1983) Protein C and the development of skin necrosis during anticoagulant therapy. Thromb Haemostas 49:251

    CAS  Google Scholar 

  26. Bick RL (1982) Clinical relevance of antithrombin III. Sem Thromb Hemostas 8:276–287

    CAS  Google Scholar 

  27. Damus PA, Wallace GA (1975) Immunologic measurement of antithrombin III-heparin cofactor in disseminated intravascular coagulation and hepatic coagulopathy. Thromb Res 6:27–38

    PubMed  CAS  Google Scholar 

  28. Duthie RB, Matthews JM, Rizza CR, Steel WM (1972) The management of musculo-skeletal problems in the haemophilias. Blackwell Scientific Publications Oxford

    Google Scholar 

  29. Carvalho ACA (1983) Bleeding in uremia – a clinical challenge. N Engl J Med 308:38–39

    PubMed  CAS  Google Scholar 

  30. Colman RW, Robboy SJ, Minna JD (1978) Disseminated intravascular coagulation: A reappraisal. Ann Rev Med 30:359–374

    Google Scholar 

  31. Colvin BT, Lloyd MJ (1977) Severe coagulation defect due to a dietary deficiency of vitamin K. J Clin Pathol 30:1147–1148

    PubMed  CAS  Google Scholar 

  32. Corrigan JJ (1979) Disseminated intravascular coagulopathy. Pediatr Rev 1:37–45

    Google Scholar 

  33. Denson KWE, Biggs R, Haddon ME, Borrett R, Cobb K (1969) Two types of haemophilia (A+ and A-). A study of forty-eight cases. Br J Haemat 17:163–171

    CAS  Google Scholar 

  34. Desforges JF (1983) AIDS and preventive treatment in hemophilia. N Engl J Med 308:94–95

    PubMed  CAS  Google Scholar 

  35. Deutsch E, Gabbe F (1976) Die Leber als Syntheseorgan für Gerinnungs- und Fibrinolysefaktoren. Z Med Labor Tech 29:23–35

    CAS  Google Scholar 

  36. Dymock JW, Tucker JS, Woolf IL, Poller L, Thomson JM (1975) Coagulation studies as a prognostic index in acute liver failure. BrJ Haemat 29:385–395

    CAS  Google Scholar 

  37. Egbring R, Andrassy K, Egli H, Meyer-Lindenberg J (1971) Diagnostische und therapeutische Probleme bei kongenitaler Afibrinogenämie. Blut 22:175–201

    PubMed  CAS  Google Scholar 

  38. Eyster ME, Gill FM, Blatt PM, Hilgartner MW, Ballard JO, Kinney TR (1978) Central nervous system bleeding in hemophiliacs. Blood 51:1179–1188

    PubMed  CAS  Google Scholar 

  39. Fratantoni J, Aronson DL (Ed) (1976) Unsolved therapeutic problems in hemophilia. DHEW Publication No (NIH) 77, 1089

    Google Scholar 

  40. Furie E, Voo L, McAdam KPWJ, Furie B (1981) Mechanism of factor X deficiency in systemic amyloidosis. N Engl J Med 304:827–830

    PubMed  CAS  Google Scholar 

  41. Gilbert MS (1977) Musculoskeletal manifestations of hemophilia. Mount Sinai Journal of Medicine 44:339

    PubMed  CAS  Google Scholar 

  42. Girolami A, Bareggi G, Borsata N (1975) Factor X Friuli: an immunological study in plasma and serum using several methods. Blut 30:203–212

    PubMed  CAS  Google Scholar 

  43. Girolami A, Cattarozzi G, Dal BA, Zanon R, Cella G, Toffanin F (1979) Factor VII Padua 2: another factor VII abnormality with defective ox brain thromboplastin activation and a complex hereditary pattern. Blood 54:46–53

    PubMed  CAS  Google Scholar 

  44. Greipp PR, Kyle RA, Bowie EJW (1979) Factor X deficiency in primary amyloidosis. Resolution after splenectomy. N Engl J Med 301:1050–1051

    PubMed  CAS  Google Scholar 

  45. Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ, Wideman C (1981) Deficiency of protein C in congenital thrombotic disease. J Clin Invest 40:1370–1373

    Google Scholar 

  46. Harmon DC (1979) Disseminated intravascular coagulation with the peritoneovenous shunt. Ann Intern Med 90:774–776

    PubMed  CAS  Google Scholar 

  47. Hathaway WE, Beihasen LP, Hathaway HS (1965) Evidence for a new plasma thromboplastin factor: A case report: Coagulation studies and physiochemical properties. Blood 26:521–532

    PubMed  CAS  Google Scholar 

  48. Heene DL (1975) Verbrauchskoagulopathie bei Lebererkrankungen. Med Welt 26:2133–2136

    PubMed  CAS  Google Scholar 

  49. Helske T, Ikkala E, Myllylä G, Nevanlinna HR, Rasi V (1982) Joint involvement in patients with severe haemophilia A in 1957–59 and 1978–79. Br J Haemat 51:643–647

    CAS  Google Scholar 

  50. Hoyer LW, Shainoff JR (1980) Factor VIII-related protein circulates in normal human plasma as high molecular weight multimers. Blood 55:1056–1059

    PubMed  CAS  Google Scholar 

  51. Hoyer LW (1981) The factor VIII complex: structure and function. Blood 58:1–13

    PubMed  CAS  Google Scholar 

  52. Ikkala E, Helske T, Myllylä G, Nevanlinna HR, Pitkänen P, Rasi V (1982) Changes in the life expectancy of patients with severe haemophilia A in Finland in 1930–79. Br J Haemat 52:7–12

    CAS  Google Scholar 

  53. Italian Working Group (1977) Spectrum of von Willebrand’s disease: a study of 100 cases. Br J Haemat 35:101–112

    Google Scholar 

  54. Jaenecke J (1982) Antikoagulantien- und Fibrinolysetherapie, Aufl. Thieme, Stuttgart New York

    Google Scholar 

  55. Jaffe HL (1972) Hemophilia. In: Metabolic degenerative and in flammatory diseases of bones and joints. Lea and Febiger, Philadelphia, pp 728–732

    Google Scholar 

  56. Jones RR, Cunningham J (1979) Warfarin skin necrosis. Brit J Dermat 100:561–565

    Google Scholar 

  57. Kluft C, Vellenga E, Brommer EJP, Wijngaards G (1982) A familial hemorrhagic diathesis in a dutch family: an inherited deficiency of α2-antiplasmin. Blood 59:1169–1180

    PubMed  CAS  Google Scholar 

  58. Lackner H (1973) Hemostatic abnormalities associated with dysproteinaemias. Sem Hematol 10:125–133

    CAS  Google Scholar 

  59. Lane DA, Scully MF, Thomas DP, Kakkar W, Woolf JL, Williams R (1977) Acquired dysfibrinogenaemia in acute and chronic liver disease. Br J Haemat 35:301–308

    CAS  Google Scholar 

  60. Lasch HG, Huth K, Heene DL, Müller-Berghaus G, Hörder MH, Janzarik H, Mittermeyer G, Sandritter W (1971) Die Klinik der Verbrauchskoagulopathie. Dtsch Med Wschr 96:715–727

    PubMed  CAS  Google Scholar 

  61. Lechner K (1974) Acquired inhibitors in non-haemophilic patients. Haemostasis 3:65–93

    PubMed  CAS  Google Scholar 

  62. Lechner K (1977) Coagulation abnormalities in liver disease. Sem Thromb Hemostas 4:40–56

    CAS  Google Scholar 

  63. Ledermann ML, Ratnoff OD, Scillian JJ, Jones PK, Schacter B (1983) Impaired cell-mediated immunity in patients with classic hemophilia. N Engl J Med 308:79–83

    Google Scholar 

  64. Lesesne HR, Morgan JE, Blatt PM, Webster WP, Roberts HR (1977) Liver biopsy in hemophilia A. Ann Int Med 86:703–707

    PubMed  CAS  Google Scholar 

  65. Lipinski B, Lipinska A, Nowak A, Gurewich V (1977) Abnormal fibrinogen heterogeneity and fibrinolytic activity in advanced liver disease. J Lab Clin Med 90:187–194

    PubMed  CAS  Google Scholar 

  66. Lisiewicz J (1978) Mechanism of hemorrhage in leukemias. Sem Thromb Hemostas 4:241–267

    CAS  Google Scholar 

  67. Lorand L, Losowsky MS, Miloszewski KJM (1980) Human factor XIII: Fibrin stabilising factor. Prog Hemost Thromb 5:245–290

    PubMed  CAS  Google Scholar 

  68. Mainardi CL, Levine PH, Werb Z, Harris ED Jr (1978) Prolife-rative synovitis in hemophilia: biochemical and morphologic observations. Arthr Rheum 21:137–144

    CAS  Google Scholar 

  69. Mammen EF (1975) von Willebrand’s disease – history, diagnosis and management. Sem Thromb Hemostas 2:61–84

    CAS  Google Scholar 

  70. Mammen EF (1983) Congenital coagulation disorders. Sem Thromb Hemostas 9:1–72

    CAS  Google Scholar 

  71. Mannucci PM, Ronchi G, Rota L, Colombo M (1978) A clinical pathological study of liver disease in haemophiliacs. J Clin Pathol 31:779–783

    PubMed  CAS  Google Scholar 

  72. Marder VI, Shulman NR (1964) Clinical aspects of congenital factor VII deficiency. Am J Med 37:182–194

    PubMed  CAS  Google Scholar 

  73. Marlar RA, Kleiss AJ, Griffin JH (1982) Mechanism of action of human activated protein C, a thrombin-ependent anticoagulant enzyme. Blood 59:1067–1072

    PubMed  CAS  Google Scholar 

  74. Meyer D, Obert B, Pietu G, Lavergne JM, Zimmerman TS (1980) Multimeric structure of factor VIII-von Willebrand factor in von Willebrand’s disease. J Lab Clin Med 95:590–602

    PubMed  CAS  Google Scholar 

  75. Miles LA, Plow EF, Donnelly KJ, Hougie C, Griffin JH (1982) A bleeding disorder due to deficiency of α2-antiplasmin. Blood 59:1246–1251

    PubMed  CAS  Google Scholar 

  76. Miller JL, Castella A (1982) Platelet-type von Willebrand’s disease: characterization of a new bleeding disorder. Blood 60:790–794

    PubMed  CAS  Google Scholar 

  77. Müller-Berghaus G (1977) Pathophysiology of generalized in travascular coagulation. Sem Thromb Hemostas 3:209–246

    Google Scholar 

  78. Nalbandian RM, Mader IJ, Barrett JL, Pearce JF, Rupp EC (1965) Petechiae, ecchymoses, and necrosis of skin induced by coumarin congeners. Am J Med Ass 192:107–112

    Google Scholar 

  79. Natelson EA, Lynch EC, Hettig RA, Alfrey CPJr (1970) Acquired factor IX deficiency in nephrotic syndrome. Ann Int Med 73:373–378

    PubMed  CAS  Google Scholar 

  80. Nilsson IM, Holmberg L (1979) von Willebrand’s disease today. Clin Haematol 8:147–168

    PubMed  CAS  Google Scholar 

  81. Nileln JL, Nilsson IM (1966) Coagulation studies in different types of myeloma. Acta Med Scand 179: Suppl 45,178–194

    Google Scholar 

  82. Owen CA, Bowie EJW (1977) Chronic intravascular coagulation and fibrinolysis (ICF) syndromes (DIC). Sem Thromb Hemostas 3:268–290

    Google Scholar 

  83. Owen CA, Henriksen RA, McDuffie FC, Mann KG (1978) Prothrombin Quick: a newly identified dysprothrombinemia. Mayo Clinic Proc 53:29–33

    Google Scholar 

  84. Pachter MR, Johnson SA, Neblett TR, Truant JP (1959) Bleeding, platelets and macroglobulinemia. Am J Clin Path 31:467–482

    PubMed  CAS  Google Scholar 

  85. Palaszak JE, Martinez J (1977) Dysfibrinogenemia associated with liver disease. J Clin Invest 60:89–95

    Google Scholar 

  86. Parekh VR, Mannucci PM, Ruggeri ZM (1978) Immunological heterogeneity of haemophilia B: a multicentre study of 98 kindreds. Br J Haemat 40:643–655

    CAS  Google Scholar 

  87. Penner JA, Kelly PE (1975) Management of patients with factor VIII or IX inhibitors. Sem Thromb Hemostas 1:386–399

    Google Scholar 

  88. Perkins HA, MacKenzie MR, Fudenberg HM (1970) Hemostatic defects in dysproteinemias. Blood 35:695–707

    PubMed  CAS  Google Scholar 

  89. Pettersson H, Ahlberg A, Nilsson IM (1980) A radiologic classification of haemophilic arthropathy. Clinical Orthopedics and Related Research 149:153

    Google Scholar 

  90. Pickering NJ, Brody JI, Barrett MJ (1981) von Willebrand syndromes and mitral valve prolapse: linked mesenchymal dysplasias. N Engl J Med 305:131–134

    PubMed  CAS  Google Scholar 

  91. Rabiner SF (1972) Uremic bleeding. Prog Hemost Thromb 1:233–250

    PubMed  CAS  Google Scholar 

  92. Ratnoff OD, Busse RJ, Sheon RP (1968) The demise of John Hageman. N Engl J Med 279:760–761

    Google Scholar 

  93. Rizza CR, Matthews JM (1982) Effect of frequent factor VIII replacement on the level of factor VIII antibodies in haemophiliacs. Br J Haemat 52:13–24

    CAS  Google Scholar 

  94. Robboy SJ, Major MC, Colman RW, Minna JD (1972) Pathology of disseminated intravascular coagulation (DIC): Analysis of 26 cases. Hum Pathol 3:327–343

    PubMed  CAS  Google Scholar 

  95. Roberts HR (1981) Hemophiliacs with inhibitors: therapeutic options. N Engl J Med 305:757–758

    PubMed  CAS  Google Scholar 

  96. Roos J (1966) Organisation und Erfahrungen des holländischen Thrombosedienstes. Z Ges Inn Med 34:363–367

    Google Scholar 

  97. Ruggeri Z, Nilsson IM, Lombardi R, Holmberg L, Zimmerman TS (1982) Aberrant multimeric structure of von Willebrand factor in a new variant of von Willebrand’s disease (Type IIC). J Clin Invest 70:1124–1127

    PubMed  CAS  Google Scholar 

  98. Ruggeri ZM, Pareti FI, Mannucci PM, Ciavarella N, Zimmerman TS (1980) Heightened interaction between platelets and factor VIII von Willebrand factor in a new subtype of von Willebrand’s disease. N Engl J Med 302:1047–1051

    PubMed  CAS  Google Scholar 

  99. Ruggeri ZM, Zimmerman TS (1980) Variant of von Willebrand’s disease: characterization of two subtypes by analysis of multimeric composition of factor VIII von Willebrand factor in plasma and platelets. J Clin Invest 65:1318–1325

    PubMed  CAS  Google Scholar 

  100. Saito HS, Goodnough LT, Soria J, Soria C, Aznar J, Espana F (1981) Heterogeneity of human prekallikrein deficiency (Fletcher trait). N Engl J Med 305:910–914

    PubMed  CAS  Google Scholar 

  101. Salzman EW, Neri LC (1966) Adhesiveness of blood platelets in uremia. Thromb Diath Haemorrh 15:84–92

    PubMed  CAS  Google Scholar 

  102. Samama M, Horellou MH, Soria J, Conard J, Nicolas G (1984) Successful progressive anticoagulation in a severe protein C deficiency and previous skin necrosis at the initiation of oral anticoagulant treatment. Thromb Haemostas 51:132–133

    CAS  Google Scholar 

  103. Schimpf K, Zimmermann K, Rudel J, Thamer G, Zeltsch P (1977) Results of liver biopsies, rate of icteric hepatitis and frequency of antiHBs and HBs-antigen in patients of the Heidelberg Haemophilia Centre. Thromb Haemost 38:340

    Google Scholar 

  104. Schleider MA, Nachman RC, Jaffe EA, Coleman RW (1976) A clinical study of the lupus anticoagulant. Blood 48:499–509

    PubMed  CAS  Google Scholar 

  105. Seeff LB, Hoofnagle J (1977) Chronic hepatitis in hemophilia. Ann Intern Med 86:818–820

    PubMed  CAS  Google Scholar 

  106. Seligsohn U (1978) High gene frequency of factor XI (PTA) deficiency in Ashkenazi Jews. Blood 51:1223–1228

    PubMed  CAS  Google Scholar 

  107. Shapiro SS (1979) Antibodies to blood coagulation factors. Clin Haematol 8:207–214

    PubMed  CAS  Google Scholar 

  108. Shapiro SS, Hultin M (1975) Acquired inhibitors to the blood coagulation factors. Sem Thromb Hemostas 1:336–385

    Google Scholar 

  109. Shoa’i, Lavergne JM, Ardaillo N, Obert B, Ala F, Meyer D (1977) Heterogeneity of von Willebrand’s disease. Study of 40 Iranian cases. Br J Haemat 37:67–83

    Google Scholar 

  110. Soff GA, Levin J (1981) Familial multiple coagulation factor deficiences. Sem Thromb Hemostas 7:112–148

    CAS  Google Scholar 

  111. Soref J, Blombäck M (1980) Arthropathy in children with severe hemophilia A. Acta Paediatr Scand 69:667

    Google Scholar 

  112. Spero JA, Lewis JH, Fisher SE, Hasiba U, van Thiel D (1979) The high risk of chronic liver disease in multitransfused juvenile hemophilic patients. J Ped 94:875–878

    CAS  Google Scholar 

  113. Spero JA, Lewis JH, van Thiel DH, Hasibe KTE, Rabin BS (1978) Asymptomatic structural liver disease in hemophilia. N Engl J Med 298:1373–1378

    PubMed  CAS  Google Scholar 

  114. Spero JA, Lewis JH, Hasiba U (1980) Disseminated intravascular coagulation. Findings in 346 patients. Thromb Haemost 43:28–33

    PubMed  CAS  Google Scholar 

  115. Stauffer M (1961) Nephrogenic hepatosplenomegaly. Gastroenterology 40:694

    Google Scholar 

  116. Steiner RW, Coggins C, Carvalko AC A (1979) Bleeding time in uremia: a useful test to assess clinical bleeding. Am J Hematol 7:107

    PubMed  CAS  Google Scholar 

  117. Stenbjerg S (1981) Inherited alpha2 macroglobulin deficiency. Thromb Res 22:491–495

    PubMed  CAS  Google Scholar 

  118. Straub PW (1977) Diffuse intravascular coagulation in liver disease? Sem Thromb Hemostas 4:29–39

    CAS  Google Scholar 

  119. Takahashi H, Nagayama R, Hattori A, Ihzumi T, Tsukada T, Shibata A (1981) von Willebrand disease associated with familial thrombocytopenia and increased ristocetin-induced platelet aggregation. J Am Hematol 10:89

    CAS  Google Scholar 

  120. Thaler E, Lechner K (1981) Antithrombin III deficiency and thromboembolism. Clin Haematol 10:369–390

    PubMed  CAS  Google Scholar 

  121. Veltkamp JJ, van Tilburg NH (1974) „Autosomal haemophilia“: a variant of von Willebrand’s disease. Br J Haemat 26:141–152

    CAS  Google Scholar 

  122. Verstraete M, Vermylen J, Collen D (1974) Intravascular coagulation in liver disease. Ann Rev Med 25:447–454

    PubMed  CAS  Google Scholar 

  123. Waldermann R, Abraham JB (1974) Fitzgerald factor: a heretofore unrecognised coagulation factor. Blood 44:934

    Google Scholar 

  124. Weiss HJ, Ball AP, Mannucci PM (1982) Incidence of severe von Willebrand’s disease. N Engl J Med 307:–127

    PubMed  CAS  Google Scholar 

  125. Weiss HJ, Meyer D, Rabinowitz R, Pietu G, Girma JP, Vicic WJ, Rogers J (1982) Pseudo- von Willebrand’s disease. An intrinsic platelet defect with aggregation by unmodified human factor VIII von Willebrand factor and enhanced adsorption of its high-molecular-weight multimers. N Engl J Med 305:326–333

    Google Scholar 

  126. Wright FW, Matthews JM, Brock LG (1977) Complications of haemophilic disorders affecting the renal tract. Radiology 98:471–476

    Google Scholar 

  127. Zimmerman TS, Abildgaard CF, Meyer D (1978) The factor VIII abnormality in severe von Willebrand’s disease. N Engl J Med 30:1307–1310

    Google Scholar 

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Authors
  1. Th. Eckhardt
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  2. T. H. Schöndorf
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  3. H. G. Lasch
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  1. Kliniken der Landeshauptstadt, Institut für Pathologie, Ludwig Erhard-Straße 100, 6200, Wiesbaden, Deutschland

    Wolfgang Remmele

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Eckhardt, T., Schöndorf, T.H., Lasch, H.G. (1984). Störungen der Hämostase. In: Remmele, W. (eds) Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97874-6_7

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