Thoraxtumoren pp 366-373 | Cite as

Das primär mediastinale/thymische B-Zell-Lymphom — ein neuer Mediastinaltumortyp junger Erwachsener

  • P. Möller
  • N. Beck
  • H. Schmitteckert
  • M. Schlüter
  • W. J. Hofmann
  • H. F. Otto

Zusammenfassung

Das Mediastinum ist häufig Primärsitz von malignen Lymphomen, sowohl des Morbus Hodgkin als auch von Non-Hodgkin-Lymphomen (Lichtenstein et al. 1980). Während die nosologische Abgrenzung des Morbus Hodgkin bis in letzter Zeit keine größeren Probleme bot, unterlagen die zytologische Zuordnung und die Interpretation der Non-Hodgkin-Lymphome in den letzten 2 Jahrzehnten einem erheblichen Wandel. So beschrieben Lichtenstein et al. 1980 mediastinale Non-Hodgkin-Lymphome auf dem Hintergrund der überwiegend deskriptiven Rappaport-Klassifikation als durchweg „diffus“ wachsend und zu einem Teil als „lymphoblastisch“, zum anderen Teil als „histiozytisch“.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Addis BJ, Isaacson PG (1986) Large cell lymphoma of the mediastinum: a B-cell tumour of probable thymic origin. Histopathology 10:379–390PubMedCrossRefGoogle Scholar
  2. Bennett MH (1975) Sclerosis in Non-Hodgkin’s lymphomata. Br J Cancer 31 [Suppl II]:44–52Google Scholar
  3. Bernard A, Boumsell L, Reinherz EL et al. (1981) Cell surface characterization of malignant T cells from lymphoblastic lymphoma using monoclonal antibodies: evidence for phenotypic differences between malignant T cells from patients with acute lymphoblastic leukemia and lymphoblastic lymphoma. Blood 57:1105–1110PubMedGoogle Scholar
  4. Bitran JD, Kinzie J, Sweet DL etal. (1977) Survival of patients with localized histiocyytic lamphoma. Cancer 39:342–346PubMedCrossRefGoogle Scholar
  5. Brandter LB, Smith CIE, Hammarström L, Lindemalm C, Christensson B (1989) Clonal Immunoglobulin gene rearrangements in primary mediastinal clear cell lymphoma. Leukemia 3:122–129PubMedGoogle Scholar
  6. Hofmann WJ, Momburg F, Müller P, Otto HF (1988a) Intra-and extrathymic B cells in physiologic and pathologic conditions. Immunhistochemical study on normal thymus and lymphofollicular hyperplasia of the thymus. Virchows Arch [A] 412:431–442CrossRefGoogle Scholar
  7. Hofmann WJ, Momburg F, Möller P (1988b) Thymic medullary cells expressing B lymphocyte antigens. Hum Pathol 19:1280–1287PubMedCrossRefGoogle Scholar
  8. Isaacson PG, Norton AJ, Addis BJ (1987) The human thymus contains a novel population of B lymphocytes. Lancet 11:1488–1490CrossRefGoogle Scholar
  9. Isaacson PG, Chan JKC, Tang C, Addis BJ (1990) Low-grade B-cell lymphoma of mucosaassociated lymphoid tissue arising in the thymus. Am J Surg Pathol 14:342–351PubMedCrossRefGoogle Scholar
  10. Jacobson JO, Alsenberg AC, Lamarre L, Willett CG, Linggood RM, Miketic LM, Harris NL (1988) Mediastinal large cell lymphoma. An uncommon subset of adult lymphoma curable with combined modality therapy. Cancer 62:1893–1898PubMedCrossRefGoogle Scholar
  11. Knapp W, Rieber P, Dörken B, Schmidt RE, Stein H, v.d. Borne AEGKr (1989) Towards a better defmition of human leucocyte surface molecules. Immunol Today 10:253–258PubMedCrossRefGoogle Scholar
  12. Knauf WU, Möller P, Ho AD, Dörken B, Heger G, Hunstein W (1989) Mediastinal clear cell lymphoma — a distinct entity of B-cell derived lymphoma as shown by immunotyping and analysis of gene rearrangements. Blut 59:243CrossRefGoogle Scholar
  13. Lamarre L, Jacobson JO, Alsenberg AC, Harris NL (1989) Primary large cell lymphoma of the mediastinum. Am J Surg Pathol 13:730–739PubMedCrossRefGoogle Scholar
  14. Lennert K, Feller AC (1990) Histopathologie der Non-Hodgkin-Lymphome, 2. Aufl. Springer, Berlin Heidelberg New York Tokyo, S 230–237Google Scholar
  15. Levitt LJ, Alsenberg AC, Harris NL, Linggood RM, Poppema S (1982) Primary Non-Hodgkin’s lymphoma of the mediastinum. Cancer 50:2486–2492PubMedCrossRefGoogle Scholar
  16. Lichtenstein AK, Levine A, Taylor OR, Boswell W, Rossman S, Feinstein DI, Lukes RJ (1980) Primary mediastinal lymphoma in adults. Am J Med 68:509–514PubMedCrossRefGoogle Scholar
  17. Menestrina F, Chilosi M, Bonetti F etal. (1986) Mediastinal large-cell lymphoma of B-type, with sclerosis: Histopathological and irnmunhistochemical study of eight cases. Histopathology 10:589–600PubMedCrossRefGoogle Scholar
  18. Miller JB, Variakojis D, Bitran JD, Sweet DL, Kinzie JJ, Golomb HM, Ultmann JE (1981) Diffuse histiocytic lymphoma with sclerosis: a clinicopathologic entity frequently causing superior venacaval obstruction. Cancer 47:748–756PubMedCrossRefGoogle Scholar
  19. Möller P, Lämmler B, Eberlein-Gonska M, Feichter GE, Hofmann WJ, Schmitteckert H, Otto HF (1986a) Primary mediastinal clear cell lymphoma of B-cell type. Virchows Arch [A] 409:79–92CrossRefGoogle Scholar
  20. Möller P, Lämmler B, Herrmann B, Otto HF, Moldenhauer G, Momburg F (1986b) The primary mediastinal clear cell lymphoma of B-cell type has variable defects in MHC antigen expression. Immunology 59:411–417PubMedGoogle Scholar
  21. Möller P, Moldenhauer G, Momburg F, Lämmler B, Eberlein-Gonska M, Kiesel S, Därken B (1987a) Mediastinal lymphoma of clear cell type is a tumor corresponding to terminal steps of B cell differentiation. Blood 69:1087–1095PubMedGoogle Scholar
  22. Möller P, Herrmann B, Moldenhauer G, Momburg F (1987b) Defective expression of MHC class I antigens is frequent in B-cell lymphomas of high-grade malignancy. Int J Cancer 40:32–39PubMedCrossRefGoogle Scholar
  23. Möller P, Hofmann WJ, Mielke B, Otto HF (1989a) Das primär mediastinale, hellzellige BZell-Lymphom ist ein epithelassoziiertes Thymuslymphom. Pathologe 10:234–239PubMedGoogle Scholar
  24. Möller P, Matthaei-Maurer DU, Hofmann WJ, Dörken B, Moldenhauer G (1989b) Immunophenotypic similarities of mediastinal clear-cell lymphoma and sinusoidal (monocytoid) B cells. Int J Cancer 43:10–16PubMedCrossRefGoogle Scholar
  25. Möller P, Mielke B (1989c) Extrafollicular peripheral B-cells report. In: Knapp W etal. (eds) Leucocyte typing IV. White all differentiation antigens. Oxford Univ Press, Oxford, pp 213–215Google Scholar
  26. Momburg F, Herrmann B, Moldenhauer G, Möller P (1987) B-cell lymphomas of high-grade malignancy frequently lack HLA-DR,-DP, and-DQ antigens and associated invariant chain. Int J Cancer 40:598–603PubMedCrossRefGoogle Scholar
  27. Nathwani BN, Kim H, Rappaport H (1976) Malignant lymphoma, lymphoblastic. Cancer 38:964–983PubMedCrossRefGoogle Scholar
  28. Perrone T, Frizzera G, Rosai J (1986) Mediastinal diffuse large-cell lymphoma with sclerosis. Am J Surg Pathol 10:176–191PubMedCrossRefGoogle Scholar
  29. Rosen PJ, Feinstein DI, Pattengale PK et al. (1987) Convoluted lymphocytic lymphoma in adults. A clinico-pathologic entity. Ann Intern Med 89:319–324Google Scholar
  30. Scarpa A, Bonetti F, Menestrina F, Menegazzi M et al. (1987) Mediastinal large-cell lymphoma with sclerosis. Virch Arch [A] 412:17–21CrossRefGoogle Scholar
  31. Trump DL, Mann RB (1982) Diffuse large cell and undifferentiated lymphomas with prominent mediastinal involvement. Cancer 50:277–282PubMedCrossRefGoogle Scholar
  32. Waldron JA Jr, Dohring EJ, Farber LR (1985) Primary large cell lymphomas of the mediastinum: an analysis of 20 cases. Sem Diagn Pathol 2:281–295Google Scholar
  33. Yousem SA, Weiss LM, Warnke RA (1985) Primary mediastinal Non-Hodgkin lymphomas: a morphologic and immunologic study of 19 cases. Am J Clin Pathol 84:676–680Google Scholar

Copyright information

© Springer-Verlag, Berlin Heidelberg 1991

Authors and Affiliations

  • P. Möller
  • N. Beck
  • H. Schmitteckert
  • M. Schlüter
  • W. J. Hofmann
  • H. F. Otto

There are no affiliations available

Personalised recommendations