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EEG-Veränderungen unter Valproinsäure

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Valproinsäure

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Zusammenfassung

Die auffälligsten EEG-Veränderungen durch VPA bestehen in einer Reduktion krankheitsspezifischer generalisierter Spike-wave-Paroxys-men, wohingegen fokale epilepsieassoziierte Potentiale unbeeinflußt bleiben. Ein Einfluß auf die Grundaktivität des EEG durch VPA besteht nicht. Zu Beginn einer Behandlung kann es jedoch zu einer Zunahme langsamer (δ) und rascher (β) Aktivität kommen, die möglicherweise im Zusammenhang mit einer asymptomatischen Ammoniakerhöhung steht. Ausgeprägte EEG-Verlangsamungen finden sich bei klinisch manifesten metabolischen Enzephalopathien durch Erhöhung der Ammoniakspiegel und bei VPA-Intoxikationen. Sie sind somit nicht substanzspezifisch. Eine generalisierte Amplitudendepression scheint ein typischer Befund zu sein, wenn sich ein diffuses Hirnödem entwickelt. Das Schlaf-EEG wird durch VPA weder bei Gesunden noch bei Epilepsiepatienten verändert.

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Literatur

  • Adams DJ, Lüders H, Pippinger C (1978) Sodium valproate in the treatment of intractable seizure disorders: A clinical and electroencephalography study. Neurology 28:152–157

    Article  PubMed  CAS  Google Scholar 

  • Benninger C, Matthis P, Scheffner D (1985) Spectral analysis of the EEG in children during the introduction of antiepileptic therapy with valproic acid. Neuropsychobiology 13:93–96

    Article  PubMed  CAS  Google Scholar 

  • Bigler D (1985) Neurological sequelae after intoxication with sodium valproate. Acta Neurol Scand 72:351–352

    Article  PubMed  CAS  Google Scholar 

  • Braathen G, Theorell K, Persson A, Rane A (1988) Valproate in the treatment of absence epilepsy in children: A study of dose-response relationship. Epilepsia 29:548–552

    Article  PubMed  CAS  Google Scholar 

  • Bruni J, Wilder BJ, Baumann AW, Willmore LJ (1980) Clinical efficacy and longterm effects of valproic acid therapy on spike-and-wave dischargers. Neurology 30:42–46

    Article  PubMed  CAS  Google Scholar 

  • Chadwick DW, Cumming WJK, Livingston I, Cartlidge NEF (1978) Acute intoxication with sodium valproate. Ann Neurol 6:552–553

    Article  Google Scholar 

  • Drake ME, Pakalnis A, Bogner JE, Andrews JM (1990) Outpatient sleep recording during antiepileptic drug monotherapy. Clin Electroencephal 21:170–173

    Google Scholar 

  • Duncan JS, Smith SJ, Forster A, Shorvon SD, Trimble MR (1989) Effects of the removal of phenytoin, carbamezepine, and valproate on the electroencephalogramm. Epilepsia 30:590–596

    Article  PubMed  CAS  Google Scholar 

  • Gram L, Wulff K, Rasmusen KE, Flachs H, Wlirtz-Jörgensen A, Sommerbeck KW, Lohren V (1977) Valproate sodium: A controlled clinical trial including monitoring of drug levels. Epilepsia 18:141–148

    Article  PubMed  CAS  Google Scholar 

  • Harding GFA, Herrick CE, Jeavons PM (1978) A controlled study of the effect of sodium valproate on photosensitive epilepsy and its prognosis. Epilepsia 19:555–565

    Article  PubMed  CAS  Google Scholar 

  • Harding GFA, Alford CA, Powell TE (1985) The effect of sodium valproate on sleep, reaction time, and visual evoked potentials in normal subjects. Epilepsia 26:597–601

    Article  PubMed  CAS  Google Scholar 

  • Hintze G, Klein HH, Prange H, Kreuzer H (1987) A case of valproate intoxication with excessive brain edema. Klin Wchschr 65:424–427

    Article  CAS  Google Scholar 

  • Marescaux C, Wärter JM, Micheletti G, Rumbach L, Coquillat G, Kurtz D (1982) Stuporous episodes during treatment with sodium valproate: Report of seven cases. Epilepsia 23:297–305

    Article  PubMed  CAS  Google Scholar 

  • Miribel J, Marinier R (1968) Modifications électroencéphalographiques chez des enfants épileptiques traités par le Dépakène. Rev Neurol (Paris) 119:313–320

    PubMed  CAS  Google Scholar 

  • Murphy JV, Marquardt K (1982) Symptomatic hyperammonemia in patients receiving valproic acid. Arch Neurol 39:591–592

    Article  PubMed  CAS  Google Scholar 

  • Pedersen B, Juul-Jensen P (1984) Electroencephalographic alterations during intoxication with sodium valproate: A case report. Epilepsia 25:121–124

    Article  CAS  Google Scholar 

  • Röder UU, Wolf P (1981) Effects of the treatment with dipropylacetate and ethosuximide on sleep organization in epileptic patients. In: Dam M, Gram L, Penry JK (eds) Advances in epileptology. The Xllth International Symposium, Raven, New York, pp 145–157

    Google Scholar 

  • Sackellares JC, Lee SI, Dreifuss FE (1979) Stupor following administration of valproic acid to patients receicing other antiepileptic drugs. Epilepsia 20:697–703

    Article  PubMed  CAS  Google Scholar 

  • Sackellares JC, Dreifuss FE, Penry JK (1980) The effect of valproic acid on the EEG background. In: Wada JA, Penry JK (eds) Advances in epileptology. The Xth Epilepsy International Symposium, Raven, New York, p 132

    Google Scholar 

  • Sannita WG, Gervasio L, Zagnoni P (1989) Quantitative EEG effects and plasma concentrations of sodium valproate: Acute and long term administration to epileptic patients. Neuropsychobiology 22:231–235

    Article  PubMed  CAS  Google Scholar 

  • Schnabel R, Rambeck B, Janssen F (1984) Fatal intoxication with sodium valproate. Lancet I:221–222

    Article  Google Scholar 

  • Schneider E, Ziegler B, Maxion H (1977) Gamma-aminobutyric acid (GABA) and sleep. The influence of di-n-propylacetic acid on sleep in man. Eur Neurol 15:146–152

    Article  PubMed  CAS  Google Scholar 

  • Stefan H, Hoffmann F, Fichsel H, Burr W, Bülau P, Fröscher W, Penin H (1983) Therapie generalisierter Epilepsien mit Langzeit-EEG-gesteuerter Einmalgabe von Natrium-Valproat. Nervenarzt 54:430–434

    PubMed  CAS  Google Scholar 

  • Villarreal HJ, Wilder BJ, Willmore LJ, Baumann AW, Hammond EJ, Bruni J (1978) Effect of valproic acid on spike and wave discharges in patients with absence seizures. Neurology 28:886–891

    Article  PubMed  CAS  Google Scholar 

  • Völzke E, Doose H (1973) Dipropylacetate (Depakine, Ergenyl) in the treatment of epilepsy. Epilepsia 14:185–193

    Article  PubMed  Google Scholar 

  • Zaccara G, Paganini M, Camprostini R, Arnetoli G, Zappoli R, Moroni F (1984) Hyperammonemia and valproate-induced alterations of the state of consciousness. Eur Neurol 23:104–112

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. R. Besser
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Editors and Affiliations

  1. Neurologische Universitätsklinik, Langenbeckstraße 1, Mainz, 6500, Deutschland

    Günter Krämer

  2. Neuropädiatrische Abteilung, Behandlungszentrum Vogtareuth, Krankenhausstraße 20, Vogtareuth, 8097, Deutschland

    Michael C. Laub

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© 1992 Springer-Verlag Berlin Heidelberg

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Besser, R. (1992). EEG-Veränderungen unter Valproinsäure. In: Krämer, G., Laub, M.C. (eds) Valproinsäure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97843-2_9

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  • DOI: https://doi.org/10.1007/978-3-642-97843-2_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-97844-9

  • Online ISBN: 978-3-642-97843-2

  • eBook Packages: Springer Book Archive

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