Agents that Increase Resistance to Diseases

  • Volker Schulz
  • Rudolf Hänsel
  • Varro E. Tyler


Herbal remedies fit very naturally into the natural and holistic system of medicine. As a result, all physicians and laypersons do not appreciate the kind of compartmentalized, organ-based approach to herbal healing that is followed in this book. Indeed, there are two classes of herbal remedies that do not fit into an anatomically oriented scheme: adaptogens and immune stimulants. Adaptogens are agents that are reputed to increase the body’s resistance to physical, chemical, and biological stressors. Immune stimulants are agents that activate the body’s nonspecific defense mechanisms against infectious organisms, particularly viral and bacterial pathogens.


Panax Ginseng Ginseng Root Ginseng Extract Viscum Album Echinacea Purpurea 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Ahn Y-J, Kim M-l, Yamamoto T, Fujisawa T, Mitsouka T (1990) Selective growth responses of human intestinal bacteria to Araliaceae extracts. Microbial Ecol Health Disease 3: 223–229.CrossRefGoogle Scholar
  2. Bajusz E, Selye H (1960) Über die durch Streß bedingte Nekroseresistenz des Herzens. Ein Beitrag zum Phänomen der “gekreuzten Resistenz”. Naturwissenschaft 47: 520–521.CrossRefGoogle Scholar
  3. Bauer R, Wagner H (eds) (1990) Echinacea. Wissenschaftliche Verlagsgesellschaft mbH Stuttgart.Google Scholar
  4. Beuth J, Ko HL, Gabius HJ, Burrichter H, Oette K, Pulverer G (1992) Behavior of lymphocyte subsets and expression of activation markers in response to immunotherapy with galactoside-speciflc lectin from mistletoe in breast cancer. Clin Invest 70: 658–661.CrossRefGoogle Scholar
  5. Bladt S, Wagner H, Woo WS (1990) Taiga-Wurzel. Dtsch Apoth Z 27: 1499–1508.Google Scholar
  6. Bohn B, Nebe C, Birr C (1987) Flow-cytometric studies with Eleutherococcus senticosus extract as an immunomodulatory agent. Arzneim Forsch (Drug Res) 37: 1193–1196.Google Scholar
  7. Bombardelli E, Morazzoni P (1995) Vitis vinifera L. Fitoterapia 66: 291–317.Google Scholar
  8. Brekhman II, Dardymov IV (1969) New substances of plant origin that increase nonspecific resistance. Ann Rev Pharmacol 9: 419–430.PubMedCrossRefGoogle Scholar
  9. Ciplea AG, Richter K-D (1988) The protective effect of Allium sativum and Crataegus on isoprena- line-induced tissue necrosis in rats. Arzneim Forsch/Drug Res 38: 1588–1592.Google Scholar
  10. Dold U, Edler L, Mäurer HC, Müller-Wening D, Sakellariou B, Trendelenburg F, et al. (1991) Krebszusatztherapie beim fortgeschrittenen nicht-kleinzelligen Bronchialkarzinom. Georg Thieme Verlag, Stuttgart.Google Scholar
  11. Dorn M (1989) Milderung grippaler Effekte durch ein pflanzliches Immunstimulans. Natur- und Ganzheitsmedizin 2: 314–319.Google Scholar
  12. Farrow JM, Leslie GB, Schwarzenbach FH (1978) The in vivo protective effect of a complex yeast preparation (Bio-Strath) against bacterial infections in mice. Medita (Solothurn) 8: 37–42.Google Scholar
  13. Gabius HJ, Gabius S, Joshi SS, Koch B, Schroeder M, Manzke WM, Westerhausen M (1994) From ill- defined extracts to the immunomodulatory lectin: Will there be a reason for oncological application of mistletoe? Planta Med 60: 2–7.PubMedCrossRefGoogle Scholar
  14. Gervais C (1973) Profitable effect of a lactic yeast in nutritionally deficient Biafran children. Bull Soc Pathol Exot 66: 445–447.Google Scholar
  15. Hajto T, Hostanka K, Frei K, Rordorf C, Gabins H-J (1990 a) Increased secretion of tumor necrosis factor α, interleukin 1, und interleukin 6 by Heiman mononuclear cells exposed to β-galactoside- specific lectin from clinically applied mistletoe extract. Cane Res 50: 3322.Google Scholar
  16. Hajto T, Hostanka K, Gabius HI (1990 b) Zytokine als Lectin-induzierte Mediatoren in der Misteltherapie. Therapeutikon 4: 136–145.Google Scholar
  17. Hajto T, Hostanka K, Gabius HI (1989) Modulatory potency of the β-galactoside-specific lectin from mistletoe extract (Iscador) and the host defense system in vivo in rabbits and patients. Cane Res 49: 4803.Google Scholar
  18. Hauser SP (1993) Mistel - Wunderkraut oder Medikament? Therapiewoche 43 (3): 76–81.Google Scholar
  19. Haustein KO (1995) Immuntherapeutika. In: Schwabe U, Paffrath D (eds) Arzneiverordnungs-Report’95. Wissenschaftliche Verlagsgesellschaft mbH Stuttgart.Google Scholar
  20. Hofecker, G (1987) Physiologie und Pathophysiologie des Alterns. Öster Apoth Z 41: 443–450.Google Scholar
  21. Hyo-Won B, Il-Heok K, Sa-Sek, H, Byung-Hun H, Mun-Hae H, Ze-Hun K, Nak-Du K (1987) Roter Ginseng. Schriftenreihe des Staatlichen Ginseng-Monopolamtes der Republik Korea.Google Scholar
  22. Kaemmerer K, Kietzmann M (1983) Untersuchungen über streßabschirmende Wirkungen von oral verabreichtem Zinkbacitracin bei Ratten. Zbl Vet Med A 30: 712–721.Google Scholar
  23. Kaemmerer K, Fink J (1980) Untersuchungen von Eleutherococcus-Extrakt auf trophanabole Wirkungen bei Ratten. Der praktische Tierarzt 61: 748–753.Google Scholar
  24. Kiene H (1989) Klinische Studien zur Misteltherapie karzinomatöser Erkrankungen. Eine Übersicht. Therapeutikon 3: 347–353Google Scholar
  25. Kleijnen J, Knipschild P (1994) Mistletoe treatment for cancer. Review of controlled trials in humans. Phytomedicine 1: 255–260.CrossRefGoogle Scholar
  26. Koch HP, Eidler S (1988) Eleutherococcus senticosus. Sibirischer Ginseng. Scientific report. Kooperation Phytopharmaka, Cologne.Google Scholar
  27. Lovett EJ, Schnitzer B, Keren DF et al. (1984) Application of flow cytometry to diagnostic pathology. Lab Invest 50: 115–140.PubMedGoogle Scholar
  28. Melchart D, Linde K, Worku F, Bauer R, Wagner H (1994) Immunomodulation with Echinacea - a systematic review of controlled clinical trials. Phytomedicine 1: 245–254.CrossRefGoogle Scholar
  29. Obermeier A (1980) Zur Analytik der Ginseng- und Eteutherococcusdroge. Dissertation Ludwig-Ma- ximilians-Universität, Munich.Google Scholar
  30. Palmer BV, Montgomery ACV, Monteiro JCMP (1978) Ginseng und mastalgia. Brit Med J 1: 284 (letter).Google Scholar
  31. Pichler WJ, Emmendörfer A, Peter HH et al. (1985) Analyse von T-Zell-Subpopulationen. Pathophy- siologisches Konzept und Bedeutung für die Klinik. Schweiz med Wschr 115: 534–550.PubMedGoogle Scholar
  32. Ploss E (1988) Panax ginseng C. A. Meyer. Scientific report. Kooperation Phytopharmaka, Cologne.Google Scholar
  33. Proksch A (1982) Über ein immunstimulierendes Wirkprinzip aus Echinacea purpurea. Dissertation, Ludwig-Maximilians-Universität, Munich.Google Scholar
  34. Ro HS, Lee SY, Han BH (1977) Studies on the lignan glycoside of Acanthopanax cortex. J Pharm Korea 21: 81–86.Google Scholar
  35. Schmidt Ch (1977) Unspezifische Steigerung der Phagozytoseaktivitäten von Peritoneal-Makropha- gen nach oraler Gabe verschiedener Hefepräparationen. Dissertation, Freie Universität Berlin.Google Scholar
  36. Schole J, Harisch G, Sallmann HP (1978) Belastung, Ernährung und Resistenz. Parey, Hamburg Berlin.Google Scholar
  37. Selye R (1946) The general adaptation syndrome and the disease of adaptation. J Clin Endocrinol 6: 117–130.CrossRefGoogle Scholar
  38. Siegl RK (1979) Ginseng abuse syndrome - problems with the panacea. J Amer Med Assoc 241: 1614–1615.CrossRefGoogle Scholar
  39. Siegl RK (1980) Ginseng and high blood pressure. J Am Med Assoc 243: 32.Google Scholar
  40. Sinai Y, Kaplan A, Hai Y et al. (1974) Enhancement of resistance to infectious disease by oral administration of brewer’s yeast. Infection Immunol 9: 781–787.Google Scholar
  41. Sonnenborn U, Proppert Y (1990) Ginseng (Panax ginseng C.A.Meyer). Z Phytotherapie 11: 35–49.Google Scholar
  42. Stimpel M, Proksch A, Wagner H et al. (1984) Macrophage activation and induction of macrophage cytotoxicity by purified polysaccharide fractions from the plant Echinacea purpurea. Infect Immunity 46: 845–849.Google Scholar
  43. Wagner H, Jordan E (1986) Structure and properties of polysaccharides from Viscum album (L.). Oncology (Suppl 1): 8–15.Google Scholar
  44. Wagner H, Jurcic K (1991) Immunologische Untersuchungen von pflanzlichen Kombinationspräparaten. Arzneim Forsch (Drug Res) 41: 1072–1076.Google Scholar
  45. Youn YS (1987) Analytisch vergleichende Untersuchungen von Ginsengwurzeln verschiedener Provenienzen. Dissertation, Freie Universität Berlin.Google Scholar
  46. Zorikov PS, Lyapustina TA (1974) Change in a concentration of protein and nitrogen in the reproductive organs of hens under the effect of Eleutherococcus extract. Deposited DOC VINI, 732–774, 5863, ref Chem Abstracts 86 (1977) 119732.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Volker Schulz
    • 1
  • Rudolf Hänsel
    • 2
  • Varro E. Tyler
    • 3
  1. 1.BerlinGermany
  2. 2.Institut für Pharmakognosie und Phytochemieder Freien Universität BerlinMünchenGermany
  3. 3.Purdue UniversityWest LafayetteUSA

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