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Botulinustoxin A

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Analgetika Antinozizeptiva Adjuvanzien

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Zusammenfassung

Das Botulinustoxin A (Mr um 150 000) hemmt präsynaptische cholinerge Nerventerminals u. a. durch Hemmung der Acetylcholinfreisetzung und durch sekundären Verlust von ACh-Rezeptoren. Der betroffene Muskel ist funktioneil temporär denerviert und atrophiert. Kompensatorisch werden extrasynaptische ACh-Rezeptoren gebildet. Das denervierte Axon bildet ebenfalls neue synaptische Verbindungen. Dringt das Toxin in das ZNS ein, hemmt es unspezifisch Neurotransmitter.

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Authors and Affiliations

  1. La Forestière, F-74500, St. Paul en Chablais, Frankreich

    Dr. med. Herman Hans Waldvogel

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  1. Dr. med. Herman Hans Waldvogel
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© 1996 Springer-Verlag Berlin Heidelberg

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Waldvogel, H.H. (1996). Botulinustoxin A. In: Analgetika Antinozizeptiva Adjuvanzien. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97649-0_21

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  • DOI: https://doi.org/10.1007/978-3-642-97649-0_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-97650-6

  • Online ISBN: 978-3-642-97649-0

  • eBook Packages: Springer Book Archive

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