Skip to main content
SpringerLink
Log in

Physiologie der Koronardurchblutung

  • Chapter
Herzkrankheiten

  • 75 Accesses

Zusammenfassung

Genaue funktionelle Parameter der Koronardurchblutung und der regionalen Myokardperfusion sind überwiegend im Tierexperiment erhoben worden. Für Untersuchungen am Menschen können meistens keine ausreichend kontrollierten Ausgangsbedingungen geschaffen werden, die Empfindlichkeit der Meßmethoden — insbesondere für den Koronarfluß und die regionale Myokardperfusion — ist nicht hoch genug und die einzelnen Determinanten der myokardialen Perfusion können nicht adäquat separiert werden, in den letzten Jahren konnte aber in einer Reihe mittels genauer invasiver Verfahren (z. B intrakoronarer Führungsdraht mit ültraschalldopplermeßapparatur) gewonnener Meßdaten die weitgehende Übertragbarkeit von früheren tierexperimentellen Ergebnissen auf die Verhältnisse am Menschen gesichert werden.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Anrep GV (1936) Lane medical lectures: Studies in cardiovascular regulation. Stanford Univ Press, Stanford

    Google Scholar 

  • Arnold G, Morgenstern C, Lochner W (1970) The autoregula-tion of the heart work by the coronary perfusion pressure. Pflügers Arch 321:34

    Article  PubMed  CAS  Google Scholar 

  • Ashton JH, Benedict CR, Fitzgerald C et al (1986) Serotonin as a mediator of cyclic flow variations in stenosed canine coronary arteries. Circulation 73:572

    Article  PubMed  CAS  Google Scholar 

  • Bai XJ, Williams AGJ, Fan WL, Downey F (1994) Coronary pressure-flow autoregulation protects myocardium from Gregg’s phenomenon. Am J Physiol 266:H2359

    PubMed  CAS  Google Scholar 

  • Bardenheuer H, Schrader J (1983) Relationship between myocardial oxygen consumption, coronary flow, and adenosine release in an improved isolated working heart preparation of guinea pigs. Circ Res 51:263

    Google Scholar 

  • Bassenge E (1994) Coronary vasomotor responses: Role of endothelium and nitrovasodilators. Cardiovasc Drugs Ther 8:601

    Article  PubMed  CAS  Google Scholar 

  • Bassenge E (1995) Control of coronary blood flow by autacoids. Basic Res Cardiol 90:125

    Article  PubMed  CAS  Google Scholar 

  • Bassenge E, Busse R, Pohl U (1987) Abluminal release and asymmetrical response of the rabbit arterial wall to endothe-lium-derived relaxing factor. Circ Res 61:1168

    Google Scholar 

  • Bassenge E, Busse R, Pohl U (1989) Hemmung der Thrombozytenaggregation und -adhäsion durch EDRF und deren pathophysiologische Bedeutung (Inhibition of plateletag-gregation and -adhesion by EDRF: pathophysiological significance). Z Kardiol 78:54

    PubMed  CAS  Google Scholar 

  • Bassenge E, Heusch G (1990) Endothelial and neuro-humoral control of coronary blood flow in health and disease. Rev Physiol Biochem Pharmacol 116:77

    PubMed  CAS  Google Scholar 

  • Bellamy RF (1980) Calculation of coronary vascular resistance. Cardiovasc Res 14:261

    Article  PubMed  CAS  Google Scholar 

  • Berkenboom GM, Unger P (1990) Alpha-adrenergic coronary constriction in effort angina. Basic Res Cardiol 85:359

    PubMed  Google Scholar 

  • Berne RM (1963) Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. Am J Physiol 204:317

    PubMed  CAS  Google Scholar 

  • Berne RM, Blackmon JR, Gardner TH (1957) Hypoxemia and coronary blood flow. J Clin Invest 1101

    Google Scholar 

  • Berne RM, Rubio R (1979) Coronary circulation. The cardiovascular system. Handbook of physiology, sec 2 (ed by Anonymous), p 873. Am Physiol Society Bethesda, Maryland

    Google Scholar 

  • Boeynaems JM (1988) Drugs influencing the vascular production of prostacyclin. Prostaglandins 34:197

    CAS  Google Scholar 

  • Bolli R (1992) Myocardial ‘Stunning’ in man. Circulation 86:1671

    PubMed  CAS  Google Scholar 

  • Borchard F (1978) The adrenergic nerves of the normal and the hypertrophied heart. Thieme Verlag Stuttgart, 1978, Thieme Verlag, Stuttgart

    Google Scholar 

  • Busse R, Lückhoff A, Bassenge E (1987) Endothelium-derived relaxant factor inhibits platelet activation. Naunyn-Schmiedebergs Arch Pharmacol 336:566

    PubMed  CAS  Google Scholar 

  • Chierchia S, DeCaterina R, Brunelli C et al (1982) Failure of thromboxane A 2 blockade to prevent attacks of vasospastic angina. Circulation 66:702

    Article  PubMed  CAS  Google Scholar 

  • Chilian WM, Harrison DG, Haws CW et al (1986) Adrenergic coronary tone during submaximal exercise in the dog is produced by circulating catecholamines. Evidence for adrenergic denervation supersensitivity in the myocardium but not in coronary vessels. Circ Res 58:68

    PubMed  CAS  Google Scholar 

  • Cohen R (1986) Role of autonomic nerves and endothelium in coronary vasospasm. Recent advances in arterial diseases: atherosclerosis, hypertension, and vasospasm (ed by T. Tulenko) p 353. Liss, New York

    Google Scholar 

  • Cohen RA, Shepherd JT, Vanhoutte PM (1984) Effects of the adrenergic transmitter on epicardial coronary arteries. Fed Proc 43:2862

    PubMed  CAS  Google Scholar 

  • Criqui MH, Heiss G, Cohn R et al (1993) Plasma triglyceride level and mortality from coronary heart disease. N Engl J Med 328:1220

    Article  PubMed  CAS  Google Scholar 

  • Doucette JW, Cori PD, Payne HM et al (1992) Validation of a doppler guide wire for intravascular measurement of coronary artery flow velocity. Circulation 85:1899

    PubMed  CAS  Google Scholar 

  • Downey JM, Kirk ES (1975) Inhibition of coronary blood flow by a vascular waterfall mechanism. Circ Res 36:753

    PubMed  CAS  Google Scholar 

  • Dusting GJ (1984) Coronary vasomotor tone: the role of prostanoids re-examined. Biblthca Cardiol 38:178

    CAS  Google Scholar 

  • Edlund A, Berglund B, VanDorne D, Kaijser L et al (1985) Coronary flow regulation in patients with ischemic heart disease: release of purines and prostacyclin and the effect of inhibitors of prostaglandin formation. Circulation 71: 1113

    Article  PubMed  CAS  Google Scholar 

  • Evers AS, Murphee S, Saffitz JE, Jakschik BA, Needleman P (1985) Effects of endogenously produced leukotrienes, thromboxane and prostaglandins on coronary vascular resistance in rabbit myocardial infarction. J Clin Invest 75: 992

    Article  PubMed  CAS  Google Scholar 

  • Fauler J, Fröhlich JC (1989) Cardiovascular effects of leukotrienes. Cardiovasc Drugs Ther, 3:499

    Article  PubMed  CAS  Google Scholar 

  • Feigl EO, Neat GW, Huang AH (1990) Interrelations between coronary artery pressure, myocardial metabolism and coronary blood flow. J Mol Cell Cardiol 22:375

    Article  PubMed  CAS  Google Scholar 

  • Fitscha P, Kaliman J, Sinzinger H (1985) Gamma-camera imaging after autologous human platelet labeling with 111 In-oxine-sulfate: a key for assessing the efficacy of prostacyclin treatment in active atherosclerosis? Prostaglandins and other eicosanoids in the cardiovascular system (ed by K Schrör), p 352. Karger, Basel

    Google Scholar 

  • Fitzgerald GA, Smith B, Pederson AK, Brash AR (1984) Prostacyclin biosynthesis is increased in patients with severe atherosclerosis and platelet activation. N Engl J Med 310: 1065

    Article  PubMed  CAS  Google Scholar 

  • Fleckenstein-Grün G, Fleckenstein A (1980) Kalziumantagonismus, ein Grundprinzip der Vasodilatation. Calcium-Antago-nismus. In: Fleckenstein A, Roskamm H (eds) Springer, Berlin Heidelberg New York, p 191

    Chapter  Google Scholar 

  • Folts JD, Crowell ED, Rowe GG (1976) Platelet aggregation in partially obstructed vessels and its elimination with aspirin. Circulation 54:365

    PubMed  CAS  Google Scholar 

  • Försters W (1980) Effects of various agents on prostaglandin biosynthesis and the antiaggregatory effect. Acta Med Scand 642:35

    Google Scholar 

  • Franklin D, Baker D, Ellis R, Rushmer R (1959) A pulsed ultrasonic flowmeter. IRE transact, ME-6, 204

    Google Scholar 

  • Franklin D, Schlegel E, Rushmer R (1961) Blood flow measured by Doppler frequency shift of back scattered ultrasound. Science, 134:564

    Article  PubMed  CAS  Google Scholar 

  • Friedmann P, Brown E, Günther S, Alexander R, Barry W, Mudge G, Grossmann W (1981) Coronary vascoconstrictor effect of indomethacin in patients with coronary artery dese-ase. N Engl J Med 305:1171

    Article  Google Scholar 

  • Fulton WFM (1965) The coronary arteries: Arteriography, microanatomy, and pathogenesis of obliterative coronary artery disease. Thomas, Springfield

    Google Scholar 

  • Gage JE, Hess OM, Murakami T, Ritter M, Grimm J, Krayen-buehl HP (1986) Vasoconstriction of stenotic coronary arteries during dynamic exercise in patients with classic angina pectoris: reversibility by nitroglycerin. Circulation 73: 865

    Article  PubMed  CAS  Google Scholar 

  • Gamble W, LaFarge C, Fyler D, Weisul J, Monro R (1974) Regional coronary venous oxygen saturations and myocardial oxygen tension following abrupt changes in ventricular pressure in the isolated dog heart. Circ Res 34:672

    PubMed  CAS  Google Scholar 

  • Ganz W, Tamura K, Marcus HS, Donoso R, Yoshida S, Swan HJC (1971) Measurement of coronary sinus blood flow by continuous thermodilution in man. Circulation 44:181

    PubMed  CAS  Google Scholar 

  • Gerlings ED, Miller DT, Gilmore JP (1969) Oxygen availability: a determinant of myocardial potassium balance. Am J Physiol 216:559

    PubMed  CAS  Google Scholar 

  • Gewirtz H, Weeks G, Nathanson M, Sharaf B et al (1989) Tissue acidosis — role in sustained arteriolar dilatation distal to a coronary stenosis. Circulation 79:890

    Article  PubMed  CAS  Google Scholar 

  • Gregg DE (1963) Effect of coronary perfusion pressure or coronary flow on oxygen usage of the myocardium. Circ Res 13:497

    PubMed  CAS  Google Scholar 

  • Griggs D (1979) Blood flow and metabolism in different layers of the left ventricle. Physiologist 22:36

    PubMed  Google Scholar 

  • Guth BD, Heusch G, Seitelberger R, Ross J Jr (1987) Elimination of exercise-induced regional myocardial dysfunction by a bradycardic agent in dogs with chronic coronary stenosis. Circulation 75:661

    Article  PubMed  CAS  Google Scholar 

  • Haddy FJ, Scott JB (1975) Metabolic factors in peripheral circulatory regulation. Fed Proc 34:2006

    PubMed  CAS  Google Scholar 

  • Halbrugge T, Lutsch K, Thyen A, Graefe KH (1991) Role of nitric oxide formation in the regulation of haemodynamics and the release of noradrenaline and adrenaline. Naunyn Schmiedebergs Arch Pharmacol 344:720

    Article  PubMed  CAS  Google Scholar 

  • Harder DR (1987) Pressure-induced myogenic activation of cat cerebral arteries is dependent on intact endothelium. Circ Res 60:102

    PubMed  CAS  Google Scholar 

  • Harrison DG (1993) Neurohumoral and pharmacologic regulation of collateral perfusion. Collateral circulation. In: Schaper W, Schaper J (eds) Kluwer Acadmic Publishers, p 329

    Chapter  Google Scholar 

  • Heiss HW, Barmeyer J, Wink K et al (1976) Studies on regulation of myocardial blood flow in man. I. Training effects on blood flow and metabolism of the healthy heart at rest and during standardized heavy exercise. Basic Res Cardiol 71:658

    Article  PubMed  CAS  Google Scholar 

  • Hennekens CH, Peto R, Hutchison GB, Doll R (1988) An overview of the british and american aspirin studies. N Engl J Med 318:923

    Article  PubMed  CAS  Google Scholar 

  • Henquell L, Honig C (1976) Intercapillary distances and capillary reserve in right and left ventricles: significance for control of tissue p02. Microvasc Res 12:35

    Article  PubMed  CAS  Google Scholar 

  • Hess OM, McGillem MJ, DeBoe SF et al (1990) Determination of coronary flow reserve by parametric imaging. Circulation 82:1438

    Article  PubMed  CAS  Google Scholar 

  • Heusch G, Yoshimoto N (1983) Effects of heart rate and perfusion pressure on segmental coronary resistances and collate-al perfusion. Pfluegers Arch 397:284

    Article  CAS  Google Scholar 

  • Heusch G, Deussen A (1983) The effects of cardiac sympathetic nerve stimulation on the perfusion of stenotic coronary arteries in the dog. Circ Res 53:8

    PubMed  CAS  Google Scholar 

  • Heusch G, Deussen A, Schipke J, Thämer V (1984) α1- and α2-adrenoceptor-mediated vasoconstriction of large and small canine coronary arteries in vivo. J Cardiovasc Pharmacol 6: 961

    Article  PubMed  CAS  Google Scholar 

  • Heusch G, Guth BD (1989) Neurogenic regulation of coronary vasomotor tone. Eur Heart J 10:6

    PubMed  Google Scholar 

  • Heusch G, Seitelberger R, Guth BD, Ross J Jr (1986) Adrenergic mechanisms in myocardial ischemia. J Appi Cardiol 1:125

    CAS  Google Scholar 

  • Heyndrickx GR, Muylaert P, Pannier JL (1982) α-adrenergic control of oxygen delivery to myocardium during exercise in conscious dogs. Am J Physiol, 242:H805

    PubMed  CAS  Google Scholar 

  • Hilton R, Eichholtz F (1925) The influence of chemical factors on the coronary circulation. J Physiol, London, 59:413

    CAS  Google Scholar 

  • Hirsh PD, Hillis D, Campbell WB et al (1981) Release of prostaglandins and thromboxane into the coronary circulation in patients with ischemic heart disease. N Engl J Med 304: 685

    Article  PubMed  CAS  Google Scholar 

  • Hodgson JM, Cohen MD, Szentpetery S, Thames MD (1989) Effects of regional alpha-blockade and beta-blockade on resting and hyperemic coronary blood flow in conscious, unstressed humans. Circulation 79:797

    Article  PubMed  CAS  Google Scholar 

  • Hoffman B, Lefkowitz R (1980) Alpha-adrenergic receptor subtypes. N Engl J Med 302:1390

    Article  PubMed  CAS  Google Scholar 

  • Holtz J, Bassenge E, von Restorff W, Mayer E (1976) Transmural differences in myocardial blood flow and in coronary dilatory capacity in hemodiluted conscious dogs. Basic Res Cardiol 71:36

    Article  PubMed  CAS  Google Scholar 

  • Holtz J, Förstermann U, Pohl U et al (1984) Flow-dependent, endothelium-mediated dilation of epicardial coronary arteries in conscious dogs: effects of cyclooxygenase inhibition. J Cardiovasc Pharmacol 6:1161

    PubMed  CAS  Google Scholar 

  • Holtz J, von Restorff W, Bard P, Bassenge E (1977) Transmural distribution of myocardial blood flow and of coronary reserve in canine left ventricular hypertrophy. Basic Res Cardiol 72:286

    Article  PubMed  CAS  Google Scholar 

  • Honig C, Bourdeau-Martini J (1973) Role of O 2 in control of the coronary capillary reserve. Adv Exp Med Biol 39:55

    PubMed  CAS  Google Scholar 

  • Huckstorf C, Zanzinger J, Fink B, Bassenge E (1994) Reduced nitric oxide formation causes coronary vasoconstriction and impaired dilator responses to endogenous agonists and hypoxia in dogs. Naunyn-Schmiedbergs Arch Pharmacol 349:367

    CAS  Google Scholar 

  • Indolfi C, Piscione F, Villari B et al (1992) Role of a2-adreno-ceptors in normal and atherosclerotic human coronary circulation. Circulation 86:1116

    PubMed  CAS  Google Scholar 

  • James TN (1971) Functional anatomy of the coronary blood vessels. Cardiac and vascular diseases, Vol 1. In:Conn JHL, Horwitz O (eds) Lea & Febiger, Philadelphia, p 24

    Google Scholar 

  • Johansson B, Meilander S (1975) Static and dynamic components in the vascular myogenic response to passive changes in length as revealed by electrical and mechanical recordings from the rat portal vein. Circ Res 36:76

    PubMed  CAS  Google Scholar 

  • Jugdutt BI, Hutchins GM, Bulkley BH, Becker LC (1981) Dissimilar effects of prostacyclin, prostaglandin E1 and prostaglandin E 2 on myocardial infact size after coronary occlusion in conscious dogs. Circ Res 49:685

    PubMed  CAS  Google Scholar 

  • Kety SS, Schmidt CF (1945) The determination of cerebral blood flow in man by the use of nitrous oxide in low concentrations. Am J Physiol 143:53

    CAS  Google Scholar 

  • Knabb R, Ely S, Bacchus A et al (1983) Consistent parallel relationships among myocardial oxygen consumption, coronary blood flow, and pericardcial infusate adenosine concentration with various interventions and b-blockade in the dog. Circ Res 53:33

    PubMed  CAS  Google Scholar 

  • Kreuzer H, Schoeppe W (1963) Das Verhalten des Druckes in der Herzwand. Pfluegers Arch 278:181

    Article  CAS  Google Scholar 

  • Kuzuya T, Tada M, Ohmori M, Inui M et al (1981) Altered metabolism of thromboxane A 2 and prostaglandin 12 in patients with angina pectoris. Circulation 64:143:XX

    Google Scholar 

  • Masferrer JL, Seibert K, Zweifel B, Needleman P (1992) Endogenous glucocorticoids regulate an inducible cycloxygenase enzyme. Proc Natl Acad Sci USA 89:3917

    Article  PubMed  CAS  Google Scholar 

  • Matsuzaki M, Patritti J, Tajimi T, Miller M et al (1984) Effects of b-blockade on regional myocardial flow and function during exercise. Am J Physiol 247:H52

    PubMed  CAS  Google Scholar 

  • Mellander S, Johansson B (1968) Control of resistance, exchange, and capacitance functions in the peripheral circulation. Pharmacol Rev 20:117

    PubMed  CAS  Google Scholar 

  • Miwa K, Kambara H, Kawai C (1981) Exercise-induced angina pectoris provoced by aspirin administration in patients with variant angina. Am J Cardiol 47:1210

    Article  PubMed  CAS  Google Scholar 

  • Moir TW, Eckstein RW, Driscol TE (1963) Thesbesian drainage of the septal artery. Crit Res 12:212

    Google Scholar 

  • Monroe RG, Gamble WJ, LaFarge CG et al (1972) The Anrep effect reconsidered. J Clin Invest 51:2573

    Article  PubMed  CAS  Google Scholar 

  • Mosher P, Ross J (1964) Control of coronary blood flow by an autoregulatory mechanism. Circ Res 14:250

    PubMed  CAS  Google Scholar 

  • Mosher R, Ross J Jr, McFate PA, Shaw RF (1964) Control of coronary blood flow by an autoregulatory mechanism. Circ Res 14:250

    PubMed  CAS  Google Scholar 

  • Murray PA, Belloni FL, Sparks HV (1979) The role of potassium in the metabolic control of coronary vascular resistance of the dog. Circ Res 44:767

    PubMed  CAS  Google Scholar 

  • Münzel T, Stewart DJ, Holtz J, Bassenge E (1988) Preferential venoconstriction by cyclooxygenase inhibition in vivo without attenuation of nitroglycerin venodilation. Circulation 78:407

    Article  PubMed  Google Scholar 

  • Nichols WW, Mehta JL. Thompson L, Donnelly WH (1988) Synergistic effects of LTC4 and TxA2 on coronary flow and myocardial function. Am J Physiol 255:H153

    Google Scholar 

  • Nissen S, Gurley J (1990) Assessment of the functional significance of coronary stenoses. Is digital angiography the answer? Circulation 81:1431

    Article  PubMed  CAS  Google Scholar 

  • Orlick AE; Ricci DR, Alderman EL, Stinson EB, Harrison DC (1978) Effects of alpha adrenergic blockade upon coronary hemodynamics. J Clin Invest 62:459

    Article  PubMed  CAS  Google Scholar 

  • Pitt B, Shea M J, Romson JL, Lucchesi BR (1983) Prostaglandins and prostaglandin inhibitors in ischemic heart disease. Ann Intern Med 99:83

    PubMed  CAS  Google Scholar 

  • Pohl U, Lamontagne D, Bassenge E; Busse R (1994) Attenuation of coronary autoregulation in the isolated rabbit heart by endothelium derived nitric oxide. Cardiovasc Res 28:414

    Article  PubMed  CAS  Google Scholar 

  • Prinzmetal M, Kennamer R, Merliss R, Wada T, Bor N (1957) Angina pectoris. A variant from angina pectoris. Am J Med 27:375

    Article  Google Scholar 

  • Rahimtoola SH (1985) A perspective on the three large multi-center randomized clinical trials of coronary bypass surgery for chronic stable angina. Circulation 72:(Suppl V) 123

    Google Scholar 

  • Rau G (1969) Messung der Koronardurchblutung mit der Argon-Fremdgasmethode. Arch Kreislaufforschung 58:322

    Article  CAS  Google Scholar 

  • Restorff W von, Bassenge E (1977) Transient effects of norepinephrine on myocardial oxygen balance. Pfluegers Arch 370:131

    Article  Google Scholar 

  • Restorff W von, Holtz J, Bassenge E (1977) Exercise induced augmentation of myocardial oxygen extraction in spite of normal coronary dilatory capacity in dogs. Pflügers Arch 372:181

    Article  Google Scholar 

  • Restorff W von, Höflilng B, Holtz J, Bassenge E (1975) Effect of increased blood fluidity through hemodilution on coronary circulation at rest and during exercise in dogs. Pflügers Arch 357:15

    Article  Google Scholar 

  • Robertson RM, Robertson D, Roberts LJ, Maas RL, Fitzgerald GA, Friesinger GC, Oates JA (1981) Thromboxane A2 in vasotonic angina pectoris. N Engl J Med 304:998

    Article  PubMed  CAS  Google Scholar 

  • Ross JJ (1991) Myocardial perfusion-contraction matching. Implications for coronary heart disease and hibernation. Circulation 83:1076

    PubMed  Google Scholar 

  • Saito D, Steinhart CR, Nixon DG, Olsson RA (1981) Intracoro-nary adenosine deaminase reduces canine myocardial reactive hyperemia. Circ Res 49:1262

    PubMed  CAS  Google Scholar 

  • Salisbury P, Cross C, Rieben P (1960) Influence of coronary artery pressure upon myocardial elasticity. Circ Res 8:796

    Google Scholar 

  • Salisbury P, Cross C, Rieben P (1962) Intramyocardial pressure and strength of left ventricular contraction. Circ Res 10:608

    PubMed  CAS  Google Scholar 

  • Sarnoff S, Mitchell J, Gilmore J, Remensnyder J (1960) Homeo-metric autoregulation in heart. Circ Res 8:1077

    PubMed  CAS  Google Scholar 

  • Schaper W (1993) Coronary Collateral Development: Concepts and Hypotheses. Colatemi Circulation. In: Schaper W, Schaper J (eds) Kluwer Academic Publishers, Boston, p 41

    Chapter  Google Scholar 

  • Scheidegger M, Hess OM, Boesiger P et al (1993) MR coronary angiography before and after PTCA. Circulation 88:1–649 (Abstract)

    Google Scholar 

  • Schmid-Schönbein H (1982) Blood rheology and cardiac microcirculation: is there a place for hemodilution in coronary insufficiency? Microcirculation of the heart. In: Tillmanns H, Kubier W, Zebe H (eds) Springer, Berlin Heidelberg New York, p 325

    Chapter  Google Scholar 

  • Schrader J (1981) Sites of action and production of adenosine in the heart. Purinergic receptors. In: Burnstock G (ed) Chapman & Hall, London, p 121

    Google Scholar 

  • Schror K (1990) Tromboxane A 2 and platelets as mediators of coronary arterial vasoconstriction in myocardial ischemia. Eur Heart J 11

    Google Scholar 

  • Schrör K (1990) Converting-enzyme inhibitors and the interaction between kinins and eicosanoids. J Cardiovasc Pharmacol 15:S60

    PubMed  Google Scholar 

  • Schuff-Werner P, Schütz E, Seyde WC et al (1989) Improved haemorheology associated with a reduction in plasma fibrinogen and LDL in patients being treated by heparin-induced extracorporeal LDL precipitation (HELP). Eur J Clin Invest 19:30

    PubMed  CAS  Google Scholar 

  • Schulz R, Rose J, Martin C et al (1993) Development of short-term myocardial hibernation by the severity of ischemia and inotropic stimulation. Circulation 88:684

    PubMed  CAS  Google Scholar 

  • Schumacher WA, Heran CL, Goldenberg HJ et al (1989) Magnitude of thromboxane receptor antagonism necessary for antithrombotic activity in monkeys. Am J Physiol 256: H726

    PubMed  CAS  Google Scholar 

  • Seitelberger R, Guth BD, Heusch G et al (1988) Intracoronary alpha 2-adrenergic receptor blockade attenuates ischemia in conscious dogs during exercise. Circ Res 62:436

    PubMed  CAS  Google Scholar 

  • Siegel G, Schneider W (1981) Anions, cations, membrane potential, and relaxation. Vasodilatation. In: Vanhoutte PM, Leusen I (eds) Raven Press, New York, p 285

    Google Scholar 

  • Sigmund-Duchanova H, Bailer D, Bretschneider HJ et al (1979) Experimental validation of methods for the measurement of coronary sinus blood flow in man. Basic Res Cardiol 74: 277

    Article  Google Scholar 

  • Simmet T, Peskar BA (1986) Eicosanoids and the coronary circulation. Rev Physiol Biochem Pharmacol, 104:1

    Article  PubMed  CAS  Google Scholar 

  • Smith JB, Araki H, Lefer AM (1980) Thromboxane A2, prostacyclin and aspirin: effects on vascular tone and platelet aggregation. Circulation 62:V19

    PubMed  CAS  Google Scholar 

  • Spaan J, Laird J (1982) Intramyocardial compliance cannot be neglected in the coronary circulation. Proc Vth Intern Conf of Cardiovasc System Dynamics Soc 28.9.–1.10.1982. In: Anonymous, Oxford, p 40

    Google Scholar 

  • Spiller P, Schmiel FK, Pölitz B et al (1983) Measurement of systolic and diastolic flow rates in the coronary system by x-ray densitometry. Circulation 68:337

    Article  PubMed  CAS  Google Scholar 

  • Steering Committee of the Physicians’ Health Study Research Group (1989) Final report on the aspirin component of the ongoing Physicians’ Health Study. N Engl J Med 321:129

    Article  Google Scholar 

  • Strauer B (1982) Rheological concepts applied to clinical management in myocardial ischaemia. Proc Vth Intern Conf of Cardiovasc System dynamics Soc 28.9.–1.10.1982. In: Anonymous, Oxford, p 22

    Google Scholar 

  • Streeter D, Spotnitz H, Patel D et al (1969) Fiber orientation in the canine left ventricle during diastole and systole. Circ Res 24:339

    PubMed  Google Scholar 

  • Thaulow E, Guth BD, Schulz R, Ross Jr J (1989) Selective thromboxane A 2 receptor blockade in experiment exercise-induced myocardial ischaemia in dogs. Acta Physiol Scand 136:321

    Article  PubMed  CAS  Google Scholar 

  • Tillmans H, Steinhausen M, Leinberger H et al (1981) Pressure Measurements of the terminal vascular bed of the epimyo-cardium of rats and cats. Circ Res 49:1202

    Google Scholar 

  • Tillmans H, Steinhausen M, Leinberger H et al (1981) Hämodynamik der koronaren Mikrozirkulation während Myokardischämie. Z Kardiol 70:265

    Google Scholar 

  • Tillmanns H, Steinhausen M, Leinberger H et al (1982) The effect of coronary vasodilators on the microcirculation of the ventricular myocardium. Microcirculation of the heart. In: Tillmanns H, Kubier W, Zebel H (eds) Springer, Berlin Heidelberg New York, p 305

    Chapter  Google Scholar 

  • Török B, Babotai I, Largiader F, Senning A (1968) Experimentelle Coronarflowumkehr im Descendensgebiet des Hundeherzens. Z Ges Exp Med 148:81

    Article  Google Scholar 

  • Vasko JS, Gutelius J, Sabiston DC (1961) A study of predominance of human coronary arteries determined by artériographie and perfusion techniques. Am J Cardiol 8:379

    Article  PubMed  CAS  Google Scholar 

  • Vatner S, Monroe R, McRitchie R (1974) Effects of anethesia, tachycardia and autonomic blockade on the Anrep effect in intact dogs. Am J Physiol 226:1450

    PubMed  CAS  Google Scholar 

  • Vatner SF, Hintze TH (1983) Mechanism of constriction of large coronary arteries by b-adrenergic receptor blockade. Circ Res 53:389

    PubMed  CAS  Google Scholar 

  • Vlahakes GJ, Baer RW, Uhlig PN et al (1982) Adrenergic influence in the coronary circulation of conscious dogs during maximal vasodilation with adenosine. Circ Res 51:371

    PubMed  CAS  Google Scholar 

  • Wainwright CL, Parratt JR (1988) The effect of L655,240, a selective thromboxane and prostaglandin endoperoxide antagonist, on ischemia- and reperfusion-induced cardiac arrhythmias. J Cardiovasc Pharmacol 12:264

    Article  PubMed  CAS  Google Scholar 

  • Weiss HR, Neubauer JA, Lipp JA, Sinha AK (1978) Quantitative determination of regional oxygen consumption in the dog heart. Circ Res 42:394

    PubMed  CAS  Google Scholar 

  • Wu KK (1995) Molecular regulation and augmentation of prostacyclin biosynthesis. Agents Actions Suppl 45:11

    PubMed  CAS  Google Scholar 

  • Wu KK (1992) Endothelial cells in hemostasis, thrombosis and inflammation. Hospital Practice 27:145

    PubMed  CAS  Google Scholar 

  • Xu X, Ohashi H, Sanduja SK, Ruan K, Wang L (1993) Enhanced prostacyclin synthesis in endothelial cells by retro-virus-mediated transfer of prostaglandin H synthase cDNA. J Clin Invest 91:1843

    Article  PubMed  CAS  Google Scholar 

  • Zanzinger J, Feelisch M, Bassenge E (1994) Novel organic nitrates are potent dilators of large coronary arteries with reduced development of tolerance during long-term infusion in dogs. Role of sulfydryl moiety. J Cardiovasc Pharmacol 23:772

    Article  PubMed  CAS  Google Scholar 

  • Zanziger J, Zheng X, Bassenge E (1994) Endothelium-depen-dent vasomotor responses to endogenous agonists are potentiated following ACE-inhibition by a bradykinin-dependent mechanism. Cardiovasc Res 28:209

    Article  Google Scholar 

  • Zeiher AM, Drexler H, Wollschläger H, Just HJ (1991) Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation 83:391

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. E. Bassenge
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Bassenge, E. (1996). Physiologie der Koronardurchblutung. In: Herzkrankheiten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97605-6_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-97605-6_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-97606-3

  • Online ISBN: 978-3-642-97605-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation