Kutane Paraneoplasien

  • Constantin E. Orfanos
  • Claus Garbe

Zusammenfassung

Paraneoplasien im allgemeinen können mit metabolischen Störungen verbunden sein, z.B. Hyper- und Hypokalzämie, Hyperurikämien, Hormonsekretionsstörungen, oder auch als neuromuskuläre Syndrome auftreten (Neuropathien, Polymyositis), Darüber hinaus können Körperreaktionen auf Tumorantigene systemische Autoimmunkrankheiten imitieren wie rheumatische bzw. LE-ähnliche Krankheitsbil-der, Vaskulitis, Sjögren-Syndrom etc.

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Literatur

  1. Aldridge RD, Main RA, Daly BM (1984) Multicentric reticulohistiocytosis and cancer. J Am Acad Dermatol 10: 296–297PubMedGoogle Scholar
  2. Ehrsam EPJ, Thomas PC, Marrakchi S et al. (1993) Sweet’s syndrome associated with ovarian carcinoma. J Eur Acad Denn Venereol 2: 235–238Google Scholar
  3. Hatch ME, Farber SS, Superfon NP et al. (1989) Sweet’s syndrome associated with chronic myelogenous leukemia. J Am Osteopath Assoc 89: 363–370PubMedGoogle Scholar
  4. Husz S, Korom I (1987) Kutane paraneoplastische Syndrome der Haut. Z Hautkr 62: 206–212PubMedGoogle Scholar
  5. Lindmaier A, Raff M, Seidl G, Jurecka W (1989) Pachydermoperiostose. Klinik, Klassifikation und Pathogenese. Hautarzt 40: 752–757Google Scholar
  6. Longley S, Caldwell JR, Pannish RS (1986) Paraneoplastic vasculitis. Unique syndrome of cutaneous angiitis and arthritis associated with myeloproliferative disorders. Am J Med 80: 1027–1030Google Scholar
  7. Lookingbill DP, Spangler N, Sexton FM (1990) Skin involvement as the presenting sign of internal carcinoma: a retrospective study of 7316 cancer patients. J Am Acad Dermatol 22: 19–26PubMedGoogle Scholar
  8. McLean DI (1986) Cutaneous paraneoplastic syndrome. Arch Dermatol 122: 765–767PubMedGoogle Scholar
  9. Niebauer G (1983) Paraneoplasien der Haut. In: Luger A, Gschnait F (Hrsg) Dermatologische Onkologie. Urban & Schwarzenberg, Wien, S 41–59Google Scholar
  10. Niebauer G (1988) Paraneoplasias of the skin. In: Orfanos CE, Stadler R, Gollnick H (eds) Dermatology in five continents. Springer, Berlin Heidelberg New York, pp 62–65Google Scholar
  11. Poole S, Fenske NA (1993) Cutaneous markers of internal malignancy. I. Malignant involvement of the skin and the genodermatoses. J Am Acad Dermatol 28: 1–13Google Scholar
  12. Rauh G, Gresser U, Meurer M, Dorfler H (1989) Sweet-Syndrom bei chronisch myeloischer Leukämie. Klin Wochenschr 65: 506–510Google Scholar
  13. Smolle J, Kresbach H (1990) Akute febrile neutrophile Dermatose (Sweet-Syndrom). Eine retrospektive klinische und histologische Analyse. Hautarzt 41: 549–566Google Scholar
  14. Thiers BH, Callen GP (1991) Dermatologie manifestations in internal malignancy. In: Friedman RJ, Rigel DS, Kopf AW, Harris MN, Baker D (eds) Cancer of the skin. Saunders, Philadelphia, pp 364–375Google Scholar
  15. Atieler W, Plewig G (1987) Acanthosis nigricans maligna und Leser-Trélat-Zeichen bei Doppelmalignom von Mamma und Magen. Z Hautkr 62: 344–366Google Scholar
  16. Bonnekoh B, Thiele B, Merk H, Mahrle G (1989) Systemische Photochemotherapie (PUVA) bei Acanthosis nigricans maligna: Regression von Keratose, Hyperpigmentierung und Pruritus. Z Hautkr 64: 1059–1062Google Scholar
  17. Gheeraert P, Goens J, Schwartz RA et al. (1991) Florid cutaneous papillomatosis, malignant acanthosis nigricans, and pulmonary squamous cell carcinoma. Int J Dermatol 30: 193–197PubMedGoogle Scholar
  18. Mikhail GR, Fachnie DM, Drukker BH et al. (1979) Generalized malignant acanthosis nigricans. Arch Dermatol 115: 201–202PubMedGoogle Scholar
  19. Oppolzer G, Schwarz T, Zechner G, Gschnait F (1986) Acanthosis nigricans bei Plattenepithelcarcinom des Larynx. Z Hautkr 61: 1229–1237PubMedGoogle Scholar
  20. Rendon MI, Cruz PD, Sontheimer RD (1989) Acanthosis nigricans: a cutaneous marker of tissue resistance to insulin. J Am Acad Dermatol 21: 461–469PubMedGoogle Scholar
  21. Bologna JL, Brewer YP, Cooper DL (1991) Bazex’s syndrome (acrokeratosis paraneoplastica). An analytic review. Med 70: 269–280Google Scholar
  22. Grimwood LE, Lekan C (1987) Acrokeratosis paraneoplastica with esophageal squamous cell carcinoma. J Am Acad Dermatol 17: 685–686PubMedGoogle Scholar
  23. Hintzenstern J, Kiesewetter F, Simon M et al. (1990) Paraneoplastische Akrokeratose Bazex–Verlauf unter palliativer Therapie eines Zungengrundkarzinoms. Hautarzt 41: 490–493Google Scholar
  24. Hoepffner N, Albrecht HP, Haagen G et al. (1992) Sonderform einer Acrokeratose Bazex bei kleinzelligem Bronchialkarzinom. Hautarzt 43: 496–499PubMedGoogle Scholar
  25. Jacobsen FK, Abildtrup N, Laursen SO et al. (1984) Acrokeratosis paraneoplastica. Arch Dermatol 120: 502–504PubMedGoogle Scholar
  26. Levi L, Crippa D, Beneggi M, Sala GP (1982) Erythrodermie transitoire au cours d’une acrokératose paranéoplasique de Bazex. Ann Dermatol Venereol 109: 497–500PubMedGoogle Scholar
  27. Pecora AL, Landsman L, Imgrund SP, Lambert WC (1983) Acrokeratosis paraneoplastica ( Bazex’ syndrome ). Arch Dermatol 119: 820–826Google Scholar
  28. Richard M, Giroux JM (1987) Acrokeratosis paraneoplastica. J Am Acad Dermatol 16: 178–183PubMedGoogle Scholar
  29. Schulz C, Lörz M, Sarkar B (1993) Acrokeratosis para-neoplastica (Bazex syndrome): a case report. Eur J Dermatol 3: 484 486Google Scholar
  30. Stolp A, Poweleit H (1987) Akrokeratosis Bazex bei metastasierendem Bronchialkarzinom. Dermatol Monatsschr 173: 258–263PubMedGoogle Scholar
  31. Thiel W, Plog B, Schreiber G, Wollina U (1987) Para-neoplastische Akrokeratose ( Bazex-Syndrom ). Hautarzt 38: 304–307Google Scholar
  32. Wishart JM (1986) Bazex paraneoplastic acrokeratosis: a case report and response to Tigason. Br J Dermatol 115: 595–599PubMedGoogle Scholar
  33. Witkowski JA, Parish LC (1982) Bazex’s syndrome: Paraneoplastic acrokeratosis. JAMA 248: 2883–2884Google Scholar
  34. Gammel JA (1952): Erythema gyratum repens: Skin manifestations in a patient with carcinoma of the breast. Arch Dermatol Syphilol 66: 494–505Google Scholar
  35. Gurrett STJ, Roenigk HH (1992): Erythema gyratum repens in a healthy woman. J Am Acad Dermatol 26: 121–122Google Scholar
  36. Juhlin L, Lacour JP, Larrouy JC et al (1989): Episodic erythema gyratum repens with ichthyosis and palmo-plantar hyperkeratosis without signs of internal malignancy. Clin Exper Dermatol 14: 223–226Google Scholar
  37. Skolnick M, Mainman ER (1975): Erythema gyratum repens with metastatic adenocarcinoma. Arch Dermatol 111: 227–229PubMedGoogle Scholar
  38. Teller H (1971): Erythema gyratum repens Gammel. In: Kutane paraneoplastische Syndrome. Herzberg JJ, Fischer, StuttgartGoogle Scholar
  39. Altimari A, Bhoopalam N, O’Dorsio T et al. (1986) Use of a somatostatin analog (SMS 201–995) in the glucagonoma syndrome. Surgery 100: 989–996PubMedGoogle Scholar
  40. Altman AR, Tschen JA, Rice L (1989) Treatment of malignant carcinoid syndrome with a long-acting somatostatin analogue. Arch Dermatol 125: 394–396PubMedGoogle Scholar
  41. Camisa C (1989) Somatostatin and a long-acting analogue octreotide acetate. Arch Dermatol 125: 407–412PubMedGoogle Scholar
  42. Edney JA, Hofmann S, Thompson JS, Kessinger A (1990) Glucagonoma syndrome is an underdiagnosed clinical entity. Am J Surg 160: 625–628PubMedGoogle Scholar
  43. Harris AG (1990) Future medical prospects for Sandostatin. Metabolism 39: 180–185PubMedGoogle Scholar
  44. Haskell CM (1990) Drugs used in cancer chemotherapy. In: Haskell CM (ed) Cancer treatment, 3rd ed. Saunders, Philadelphia, pp 44–102Google Scholar
  45. Hunt SJ, Narus VT, Abell E (1991) Necrolytic migratory erythema: dyskeratotic dermatitis, a clue to early diagnosis. J Am Acad Dermatol 24: 473–477PubMedGoogle Scholar
  46. Jeanmougin M, Civatte J (1988) Glucagonoma syndrome: successful DTIC treatment with complete remission. In: Wilkinson DS, Mascaro JM, Orfanos CE (eds) Clinical dermatology. The CMD Case Collection. Schattauer, Stuttgart New York, pp 71–72Google Scholar
  47. Kasper CS, McMurry K (1991) Necrolytic migratory erythema without glucagonoma versus canine superficial necrolytic dermatitis: is hepatic impairment a clue to pathogenesis? J Am Acad Dermatol 25: 534–541PubMedGoogle Scholar
  48. Kessinger A, Foley JF, Lemon HM (1983) Therapy of malignant cell tumors. Effectiveness of DTIC. Cancer 51: 790–794Google Scholar
  49. Kvols LK, Moertel CG, O’Connell MJ et al. (1986) Treatment of the malignant carcinoid syndrome. New Engl J Med 315: 663–666PubMedGoogle Scholar
  50. Loos T van der, Lambrecht M, Lambers J (1987) Successful treatment of glucagonoma-related migratory erythema with dacarbazine. J Amer Acad Dermatol 16: 468–472Google Scholar
  51. Rappersberger K, Wolff-Schreiner E, Konrad K, Wolff K (1987) Das Glukagonom-Syndrom. Hautarzt 38: 589–598PubMedGoogle Scholar
  52. Sohier J, Jeanmougin M, Lombrail P, Passa P (1980) Rapid improvement of skin lesions in glucagonomas with intravenous somatostatin infusion. Lancet 8158: 40Google Scholar
  53. Stacpoole PW (1981) The glucagonoma syndrome: clinical features, diagnosis and treatment. Endocr Rev 2: 347–361PubMedGoogle Scholar
  54. Swenson KH, Amon RB, Hanifin JM (1978) The gluca- gonoma syndrome. Arch Dermatol 114: 224–228PubMedGoogle Scholar
  55. Weiss RB (1982) Streptozocin. Cancer Treat Rep 66: 427–438Google Scholar
  56. Foon KA (1984) Increased growth of eyelashes in a patient given leucocyte A interferon. New Engl J Med 311: 1259PubMedGoogle Scholar
  57. Gollnick H, Blume U, Orfanos CE (1990) Unerwünschte Arzneimittelwirkungen am Haar. Z Hautkr 65: 1128–1134PubMedGoogle Scholar
  58. Herzberg JJ (1990) Paraneoplastic changes of the hair. In: Orfanos CE, Happle R (eds) Hair and hair diseases. Springer, Berlin Heidelberg New York Tokyo, pp 763–776Google Scholar
  59. Jemec GBE (1986) Hypertrichosis lanuginosa acquisita: report of a case and review of the literature. Arch Dermatol 122: 805–808PubMedGoogle Scholar
  60. McLean D, Macaulay JC (1977) Hypertrichosis lanuginosa acquisita associated with pancreatic carcinoma. Br J Dermatol 96: 313–316PubMedGoogle Scholar
  61. Merk HF (1990) Drugs affecting hair growth. In: Orfanos CE, Happle R (eds) Hair and hair diseases. Springer, Berlin Heidelberg New York Tokyo, pp 601–609Google Scholar
  62. Rampen FHJ (1983) Hypertrichosis in PUVA-treated patients. Br J Dermatol 109: 657–660PubMedGoogle Scholar
  63. Rousseau C, Willcox D, Bourlond A et al. (1989) Hypertrichosis induced by diazoxide in idiopathic hypoglycemia of infancy. Dermatologica 179: 221PubMedGoogle Scholar
  64. Samson MK, Busoker TR, Henderson MD et al. (1975) Acquired hypertrichosis lanuginosa: Report of two cases and review of the literature. Cancer 36: 1519–1521Google Scholar
  65. Valda-Rodriguez L, Torrico-Velasco J, Zeballos-Vasconcellos R (1990) Hypertrichose lanugineuse acquisé paranéoplasique associée à sclérodermie. Ann Dermatol Venereol 117: 605–610PubMedGoogle Scholar
  66. Wysocki GP, Daley TD (1987) Hypertrichosis in patients receiving cyclosporine therapy. Clin Exp Dermatol 12: 191–196PubMedGoogle Scholar
  67. Basset-Seguin N, Roujeau JC, Gherardi R (1990) Prognostic factors and predictive signs of malignancy in adult dermatomyositis. Arch Dermatol 126: 633–637PubMedGoogle Scholar
  68. Bernard P, Bonnetblanc J-M (1993) Dermatomyositis and malignancy. J Invest Dermatol 100: 128S - 132SPubMedGoogle Scholar
  69. Bonnetblanc JM, Bernard P, Fayol BJ (1990) Dermatomyositis and malignancy; a multicenter cooperative study. Dermatologica 180: 212–216PubMedGoogle Scholar
  70. Callen JP (1982) The value of malignancy evaluation in patients with dermatomyositis. J Am Acad Dermatol 6: 253–259PubMedGoogle Scholar
  71. Callen JP (1986) Dermatomyositis and female malignancy. J Surg Oncol 32: 121–124PubMedGoogle Scholar
  72. Callen JP, Hyla JF, Bole GG, Kay DR (1980) The relationship of dermatomyositis and polymyositis to internal malignancy. Arch Dermatol 116: 295–298PubMedGoogle Scholar
  73. Dau PC, Bennington JL (1981) Plasmapheresis in childhood dermatomyositis. J Pediatr 98: 237–240PubMedGoogle Scholar
  74. Euwer RL, Sontheimer RD (1993) Amyopathic dermatomyositis: A review. J Invest Dermatol 100: 124–127Google Scholar
  75. Gabay C, Delaloye B, Laurencet FL (1989) Association dermatomyosite et cancer: mythe où réalité? Schweiz Med Wochenschr 119: 1119–1123PubMedGoogle Scholar
  76. Ganta R, Campbell IT, Mostafa SM (1988) Anaesthesia and acute dermatomyositis/polymyositis. Br J Anaesth 60: 854–858PubMedGoogle Scholar
  77. Heckwatt J, Hasson N, Saunders C et al. (1982) Cyclosporin in juvenile dermatomyositis. Lancet I: 1063–1066Google Scholar
  78. Lok C, Herson S, Roujeau JC et al. (1989) Plasma exchange therapy in dermatomyositis: A retrospective study in 21 patients. Ann Dermatol Venereol 116: 219–224PubMedGoogle Scholar
  79. Lyon MG, Bloch DA, Hollak B, Fries JF (1989) Predisposing factors in dermatomyositis-polymyositis: results of a nationwide survey. J Rheumatol 16: 1218–1224PubMedGoogle Scholar
  80. Manchul LA, Jin A, Pritchard KI et al. (1985) The frequency of malignant neoplasms in patients with polymyositis-dermatomyositis. Arch Int Med 145: 1835–1839Google Scholar
  81. Miller G, Heckmatt JZ, Dubowitz V (1983) Drug treatment of juvenile dermatomyositis. Arch Dis Child 58: 445–450PubMedGoogle Scholar
  82. Mordel N, Margalioth EJ, Harats N et al. (1988) Concurrence of ovarian cancer and dermatomyositis. A report of two cases and literature review. J Reprod Med 33: 649–655Google Scholar
  83. Richardson JB, Callen JP (1989) Dermatomyositis and malignancy. Med Clin North Am 73: 1211–1220PubMedGoogle Scholar
  84. Rowland LP, Clarck C, Olarte M (1977) Therapy for dermatomyositis and polymyositis. Adv Neurol 17: 63–97PubMedGoogle Scholar
  85. Sigurgeirson B, Lindelöf B, Edhag O,Allander E (1992) Risk of cancer in patients with dermatomyositis or polymyositis. N Engl J Med 326: 363–367Google Scholar
  86. Skon M, Monden M, Fujimoto Y et al. (1989) Gastric carcinoma associated with dermatomyositis. Case report. Acta Chir Scand 155: 365–366Google Scholar
  87. Tymms KE, Webb J (1985) Dermatomyositis and other connective tissue diseases: a review of 105 cases. J Rheumatol 12: 1140–1148PubMedGoogle Scholar
  88. Zabel P, Leimenstoll G, Gross WL (1984) Cyclosporin for acute dermatomyositis. Lancet I: 343Google Scholar
  89. Barron LA, Prendville JS (1992) The sign of Leser-Trélat in a young woman with osteogenic sarcoma. J Am Acad Dermatol 26: 344–347PubMedGoogle Scholar
  90. Curry SS, King LE (1980) The sign of Leser-Trélat. Arch Dermatol 116: 1059–1060PubMedGoogle Scholar
  91. DeBersaques J (1985) Sign of Leser-Trélat. J Am Acad Dermatol 12: 724Google Scholar
  92. Ellis DL, Kafka SP, Chow JC et al. (1987) Melanoma, growth factors, acanthosis nigricans, the sign of Leser-Trélat and multiple acrochordons. A possible role for alpha-transforming growth factor in cutaneous paraneoplastic syndromes. New Engl J Med 317: 1582–1587Google Scholar
  93. Holdiness MR (1986) The sign of Leser-Trélat. Int J Dermatol 25: 564–673PubMedGoogle Scholar
  94. Holdiness MR (1988) On the classification of the sign of Leser-Trélat. J Am Acad Dermatol 19: 754–757PubMedGoogle Scholar
  95. Kilmer SL, Berman B, Morhenn VB (1990) Eruptive seborrheic keratoses in a young woman with acromegaly. J Am Acad Dermatol 23: 991–994PubMedGoogle Scholar
  96. Wieselthier JS, Bhawan J, Koh HK (1990) Transformation of Sézary syndrome and the sign of Leser-Trélat: a histopathologic study. J Am Acad Dermatol 23: 520–522PubMedGoogle Scholar
  97. James WD (1984) Trousseau’s syndrome. Int J Dermatol 23: 205–206PubMedGoogle Scholar
  98. Poole GV (1989) Trousseau’s syndrome caused by malignant degeneration of a choledochal cyst. South Med J 82: 1283–1284PubMedGoogle Scholar
  99. Bönniger F, Happle R (1976) Erythema annulare centrifugum als Symptom einer akuten myeloischen Leukämie. Z Hautkr 52: 77–80Google Scholar
  100. Everall JD, Dowd PM, Ardalan B (1975) Unusual cutaneous associations of a malignant carcinoid tumour of the bronchus — erythema annulare centrifugum and white banding of the toe nails Br J Dermatol 93: 341–345Google Scholar
  101. Mahood JM (1983) Erythema annulare centrifugum. A review of 44 cases with special reference to its association with underlying disease. Clin Exp Dermatol 8: 383–387PubMedGoogle Scholar
  102. Zultak M, Blanc D, Merle C et al. (1989) Erythème annulaire centrifuge et leucémie aigue myéloblastique. Ann Dermatol Venereol 116: 477–480PubMedGoogle Scholar
  103. DiBisceglie AM, Hodkinson HJ, Berkowitz I et al. (1986) Pityriasis rotunda: A cutaneous marker of hepatocellular carcinoma in South African blacks. Arch Dermatol 122: 802–804Google Scholar
  104. Dykes PJ, Marks R (1977) Acquired ichthyosis: multiple causes for an acquired generalized disturbance in desquamation. Br J Dermatol 97: 327–334PubMedGoogle Scholar
  105. Flint GL, Flam M, Soter NA (1975) Acquired ichthyosis. A sign of non-lymphoproliferative malignant disorders. Arch Derm 111: 1446–1447Google Scholar
  106. Ikada J, Old M (1974) Concurrent pityriasis rotunda and acquired ichthyosis with IgG myeloma. Br J Dermatol 91: 585–586PubMedGoogle Scholar
  107. Krakowski A, Brenner S, Covo J et al. (1973) Acquired Ichthyosis in Kaposi’s Sarcoma. Dermatologica 147: 348–351PubMedGoogle Scholar
  108. Leibowitz MR, Weiss R, Smith EH (1983) Pityriasis rotunda. Arch Dermatol 119: 607–609PubMedGoogle Scholar
  109. Polisky RB, Bronson DM (1986) Acquired ichthyosis in a patient with adenocarcinoma of the breast. Cutis 38: 359–360PubMedGoogle Scholar
  110. Bennion SD, Patterson JW (1984) Keratosis punctata palmaris et plantaris and adenocarcinoma of the colon. J Am Acad Dermatol 10: 587–591PubMedGoogle Scholar
  111. Cuzick J, Harris R, Mortimer PS (1984) Palmar keratoses and cancers of the bladder and lung. Lancet I: 530–533Google Scholar
  112. Dobson RL, Young MR, Pinto J (1965) Palmarkeratoses and cancer. Arch Derm 92: 553–556PubMedGoogle Scholar
  113. Howel-Evans W, McConnell RB, Clarke CA, Sheppard RM (1958) Carcinoma of the esophagus with keratosis palmaris et plantaris (tylosis). Quart J Med 27: 413–417PubMedGoogle Scholar
  114. Perry HO (1976) Less common skin markers of visceral neoplasms. Int J Dermatol 15: 19–25PubMedGoogle Scholar
  115. Anhalt W, Kim SC, Stanley JR et al. (1990) Paraneoplastic pemphigus. An autoimmune mucocutaneous disease associated with neoplasia. N Engl J Med 323: 1729–1735Google Scholar
  116. Freeman HJ, Weinstein WW, Shnitka TK et al. (1977) Primary abdominal lymphoma: Presenting manifestation of celiac-sprue or complicating dermatitis herpetiformis. Amer J Med 63: 585–594Google Scholar
  117. Gould DJ, Howell R (1977) Dermatitis herpetiformis and reticulum-cell sarcoma, a rare complication. Brit J Derm 96: 561–562PubMedGoogle Scholar
  118. Ikai K, Imamura S, Ogino A et al. (1978) Bullous pemphigoid and metastatic skin cancer. Dermatologica 156: 55–58PubMedGoogle Scholar
  119. Jablonska S, Chorzelski T, Blaszczyk M et al. (1984) Bullous diseases and malignancy. Sem Dermatol 3: 316–323Google Scholar
  120. Joost T van, Vuzevski VD, Menke HE (1989) Benign papular acantholytic non-dyskeratotic eruption: a new paraneoplastic syndrome? Br J Dermatol 121: 147–148PubMedGoogle Scholar
  121. Lindelöf B, Islam N, Eklund G et al. (1990) Pemphigoid and cancer. Arch Dermatol 126: 66–68PubMedGoogle Scholar
  122. Monti M, Cavicchinis, Caputo R (1988) Pemphigus herpetiformis in a patient with bronchial carcinoma. In: Wilkinson DS, Mascaró J, Orfanos CE (eds) Clinical dermatology, The CMD Case Collection. Schattauer, Stuttgart New York, pp 203–204Google Scholar
  123. Naysmith A, Hancock BW (1976) Hodgkin’s disease and pemphigus. Brit J Derm 94: 695–696PubMedGoogle Scholar
  124. Poppel H van, Aswarie H, Baert L et al. (1988) Bullöses Pemphigoid bei Hypernephrom. Hautarzt 39: 121 Schroeter AL (1987) Pemphigoid and malignancy. Clin Dermatol 5: 60–63Google Scholar
  125. Silk JA, Mowat NAG, Riddel RH, Kirby JD (1977) Intestinal lymphoma complicating dermatitis herpetiformis. Brit J Derm 96: 555–560PubMedGoogle Scholar
  126. Sood VD, Pasricha JS (1974) Pemphigus and Hodgkin’s disease. Br J Dermatol 90: 575–578PubMedGoogle Scholar
  127. Walton S, Marks J, Ive FA, Ince PG (1984) Atypical dermatitis herpetiformis in two patients with internal malignancy. Clin Exp Dermatol 9: 402–406PubMedGoogle Scholar
  128. Deffer TA, Overton-Keary PP, Koette DK (1985) Erythroderma secondary to esophageal carcinoma. J Am Acad Dermatol 13: 311–313PubMedGoogle Scholar
  129. Faure M, Bertrand C, Mauduit G et al. (1985) Les érythrodermies paranéoplasiques: à propos d’un cas. Dermatologica 170: 147–151PubMedGoogle Scholar
  130. Harper TG, Latuska RF, Sperling HV (1984) An unusual association between erythroderma and an occult gastric carcinoma. Am J Gastroenterol 79: 921–923PubMedGoogle Scholar
  131. Hasan T, Jansén CT (1983) Erythroderma: A follow-up of fifty cases. J Am Acad Dermatol 8: 836–840Google Scholar
  132. King LE, Dufresne RG, Lovett GL, Rosin MA (1986) Erythroderma: review of 82 cases. South Med J 79: 1210–1215PubMedGoogle Scholar
  133. Tebbe B, Schlippert U, Garbe C, Orfanos CE (1991) Erythrodermie „en nappes claires“ als Marker eines metastasierenden Nierenkarzinoms. Hautarzt 42: 324–327PubMedGoogle Scholar
  134. Burnett JW, Goldner R, Calton GJ (1975) Cowden disease. Br J Dermatol 93: 329–336Google Scholar
  135. Kullnig P, Steiner H, Porsch G, Smolle J (1987) Gastrointestinale Polypose bei Cowden-Syndrom. Radiologe 27: 232–234PubMedGoogle Scholar
  136. Lazar AP, Lazar P (1986) Cowden’s disese (multiple hamartoma and neoplasia syndrome) treated with isotretinoin. J Am Acad Dermatol 14: 142–144PubMedGoogle Scholar
  137. Nuss DD, Aeling JL, Clemons DE, Weber WN (1978) Multiple hamartoma syndrome (Cowden’s disease) 114: 743–746Google Scholar
  138. Petritsch W,’ Pristautz H, Schreiber F at al. (1990) Cowden-Syndrom. Z Gastroenterol 28: 358–362Google Scholar
  139. Salem OS, Steck WD (1983) Cowden’s disease (multiple hamartoma and neoplasia syndrome). A case report and review of the English literature. J Am Acad Dermatol 8: 686–696Google Scholar
  140. Starink TM (1984) Cowden’s disease: analysis of fourteen new cases. J Am Acad Dermatol 11: 1127–1141PubMedGoogle Scholar
  141. Starink TM, van der Veen JPW, Arwert F et al. (1986) The Cowden syndrom: a clinical. and genetic study in 21 patients. Clin Genet 29: 222–233PubMedGoogle Scholar
  142. Weary PE, Gorlin RJ, Gentry WC et al. (1972) Multiple hamartoma syndrome (Cowden’s disease) 106: 682–690Google Scholar
  143. Wheeland RG, McGillis ST (1988) Cowden’s disease: treatment of cutaneous lesions using carbon dioxide laser vaporization. J Dermatol Surg Oncol 15: 1055–1059Google Scholar
  144. Gardner EJ, Richards RC (1953) Multiple cutaneous and subcutaneous lesions occurring simultaneously with hereditary polyposis and osteomatosis. Am J Hum Genet 5: 139–147PubMedGoogle Scholar
  145. Gregory B, Ho VC (1992) Cutaneous manifestations of gastrointestinal disorders. J Am Acad Dermatol 26: 158–166Google Scholar
  146. Oertel H, Sackmann M, Zwiebel FM (1988) Familiäre Adenomatosis coli ( Gardner-Syndrom ). Internist 29: 699–703Google Scholar
  147. Rütten A, Wenzel P, Goos M (1990) Gardner-Syndrom mit pilomatrixomartigen Haarfollikelzysten. Hautarzt 41: 326–328PubMedGoogle Scholar
  148. Török L, Fazekas A, Domjan L, Budai S, Kasa M (1990) Gardner-Syndrom. Hautarzt 41: 83–86PubMedGoogle Scholar
  149. Alessi E, Brambilla L, Luporini G et al. (1985) Multiple sebaceous tumours and carcinoma of the colon: Torre syndrome. Cancer 55: 2566–2574Google Scholar
  150. Gregory B, Ho VC (1992) Cutaneous manifestations of gastrointestinal disorders. J Am Acad Dermatol 26: 153–166PubMedGoogle Scholar
  151. Hagedorn M, Bauknecht T, Russwurm R (1987) TorreMuir-Syndrom. Hautarzt 38: 683–686PubMedGoogle Scholar
  152. Housholder MS, Zeligman I (1980) Sebaceous neoplasms associated with visceral carcinomas. Arch Dermatol 116: 61–64PubMedGoogle Scholar
  153. Karsten U, Christophers E, Sterry W (1987) Das TorreMuir-Syndrom. Talgdrüsentumoren signalisieren Kolonkarzinome und andere interne Malignome. Dtsch Med Wochenschr 112: 1296–1301Google Scholar
  154. Stone MS, Duncan WC, McGarvan MH (1986) Torre’s syndrome: exacerbation of cutaneous manifestation with immunosuppression. J Am Acad Dermatol 15: 1101–1103PubMedGoogle Scholar
  155. Benedict LM, Cohen B (1991) Treatment of PeutzJeghers lentigines with the carbon dioxide laser. J Dermatol Surg Oncol 17: 954–955PubMedGoogle Scholar
  156. Bumbic S, Stepanovic R, Nestorovic B (1986) PeutzJeghers’ syndrome — juvenile intestinal polyposis — review of five cases. Z Kinderchir 41: 178–180PubMedGoogle Scholar
  157. Burt RW, Bishop DT, Lynch HT et al. (1990) Risk and surveillance of individuals with heritable factors for colorectal cancer. WHO collaboration centre for the prevention of colorectal cancer. Bull WHO 68: 655–665Google Scholar
  158. Coevorden F van, Mathus-Vliegen EM, Brummelkamp WH (1986) Combined endoscopie and surgical treatment in Peutz-Jeghers syndrome. Surg Gynecol Obstr 162: 426–428Google Scholar
  159. Dippolito AD, Aburano A, Bezouska CA, Happ RA (1987) Enteritis cystica profunda in Peutz-Jeghers syndrome. Report of a case and review of the literature. Dis Colon Rectum 30: 192–198Google Scholar
  160. Foley TR, McGarrity TJ, Abt AB (1988) Peutz-Jeghers syndrome: a clinicopathologic survey of the „Harrisburg family“ with a 49-year follow-up. Gastroenterology 95: 1535–1540PubMedGoogle Scholar
  161. Giardiello FM, Welsh SB, Hamilton SR et al. (1987) Increased risk of cancer in the Peutz-Jeghers syndrome. N Engl J Med 316: 1511–1514PubMedGoogle Scholar
  162. Hochstetter AR v, Ess D, Bannwart F, Buhler H (1987) Adenokarzinom der Zervix bei Peutz-Jeghers-Syndrom. Fallbericht und Literaturübersicht. Schweiz Med Wochenschr 117: 1910–1914Google Scholar
  163. Konishi F, Wyse NE, Muto T et al. (1987) Peutz-Jeghers polyposis associated with carcinoma of the digestive organs. Dis Colon Rectum 30: 790–799PubMedGoogle Scholar
  164. Mathus-Vliegen EMH, Tytgat GNJ (1985) PeutzJeghers syndrome: Clinical presentation and new therapeutic strategy. Endoscopy 17: 102–104Google Scholar
  165. Narita T, Eto T, Ito T (1987) Peutz-Jeghers syndrome with adenomas and adenocarcinomas in colonic polyps. Am J Surg Pathol 11: 76–81PubMedGoogle Scholar
  166. Perzin KH, Bridge MF (1982) Adenomatous and carcinomatous changes in hamartomatous polyps of the small intestine ( Peutz-Jeghers syndrome ). Cancer 49: 971–983Google Scholar
  167. Traboulsi EI, Maumenee IH, Drush AJ et al. (1988) Pigmented ocular fundus lesions in the inherited gastrointestinal polyposis syndromes and in hereditary nonpolyposis colorectal cancer. Ophthalmology 95: 964–969PubMedGoogle Scholar
  168. Williams CB, Goldblatt M, Delaney PV (1982) „Top and tail endoscopy“ and followup of Peutz-Jeghers Syndrome. Endoscopy 14: 82–84Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Constantin E. Orfanos
    • 1
  • Claus Garbe
    • 1
  1. 1.Universitäts-Hautklinik und PoliklinikKlinikum Benjamin Franklin der Freien Universität BerlinBerlinDeutschland

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