Zusammenfassung
Urtikarielle Gewebsreaktionen sind vorwiegend Folge einer IgE-mediierten (sog. „bridging“) histaminabhängigen Vasodilatation, die von einer Erhöhung der Gefäßpermeabilität in der Haut begleitet ist und sich klinisch mit Quaddelbildurig (Ödem) und Juckreiz manifestiert. Im Bereich der Weichteile und der hautnahen Schleimhäute kann es zu massiven Schwellungen kommen. Solche Reaktionen können einmalig akut auftreten und nach wenigen Tagen verschwinden (akute Urtikaria) oder auch über mehrere Jahre persistieren bzw. immer wieder Rückfälle zeigen (chronisch-rezidivierende Urtikaria). Die auslösende Ursache ist sehr unterschiedlich oder bleibt oft ungeklärt. Doch sehr häufig spielen oral eingenommene Noxen, z. B. Nahrungsmittelallergene aber auch Medikamente, eine wichtige Rolle.
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Orfanos, C.E., Garbe, C. (1995). Urtikaria und Nahrungsmittelallergien bzw. -intoleranzen. In: Therapie der Hautkrankheiten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97602-5_15
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