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Anästhesiologie pp 319–339Cite as

Interaktionen von Anästhetika und anderen Pharmaka

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Zusammenfassung

Eine sinnvolle pharmakologische Therapie ist einerseits in vielen Fällen nur durch das Zusammenspiel von 2 oder mehreren Medikamenten überhaupt erst möglich, andererseits können Wechselwirkungen zwischen verschiedenen Arzneimitteln lebensbedrohliche Folgen haben [3]. Gerade die moderne Anästhesie basiert ganz wesentlich auf der geplanten Anwendung von Wirkung und Wechselwirkung mehrerer Pharmaka. So ist beispielsweise die gegenseitige Verstärkung der relaxierenden Eigenschaften von volatilen Anästhetika und Muskelrelaxanzien eine routinemäßig genutzte Wechselwirkung. Als besonderer Gesichtspunkt von Arzneimittelinteraktionen in der Anästhesie ist hervorzuheben, daß der übliche Gebrauch pharmakologischer Substanzen gegenüber anderen Fachgebieten der Medizin anwendungsbedingte Unterschiede aufweist. Für die Narkose werden vorwiegende Medikamente verwendet, die eine steile Dosis-Wirkungs-Beziehung aufweisen. Hierbei ist es notwendig, die Dosis individuell den Reaktionen des Patienten anzupassen. In der Anästhesie sind daher Arzneimittelinteraktionen, die zu unbedeutenden Wirkungssteigerungen oder -abnahmen führen, von geringer Konsequenz und werden als Routine behandelt.

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  1. A. Hoeft
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  2. D. Kettler
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Editors and Affiliations

  1. Institut für experimentelle Anästhesiologie, Ludwig-Maximilians-Universität, Bereich Poliklinik, Pettenkoferstr. 8 a, D-80336, München, Deutschland

    Alfred Doenicke

  2. Zentrum Anästhesiologie, Rettungs- und Intensivmedizin, Universität Göttingen, Robert-Koch-Str. 40, D-37070, Göttingen, Deutschland

    Dietrich Kettler

  3. Universitätsklinik für Anästhesiologie, LKH Graz, Auenbruggerplatz, A-8036, Graz, Österreich

    Werner F. List

  4. Klinik für Anästhesiologie und Operative Intensivmedizin, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Straße 40, D-06097, Halle (Saale), Deutschland

    Joachim Radke

  5. Institut für klinische Anästhesiologie, Heinrich-Heine-Universität Düsseldorf, Moorenstr. 5, D-40001, Düsseldorf, Deutschland

    Jörg Tarnow

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Hoeft, A., Kettler, D. (1995). Interaktionen von Anästhetika und anderen Pharmaka. In: Doenicke, A., Kettler, D., List, W.F., Radke, J., Tarnow, J. (eds) Anästhesiologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97553-0_11

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