Interaktionen von Anästhetika und anderen Pharmaka

  • A. Hoeft
  • D. Kettler

Zusammenfassung

Eine sinnvolle pharmakologische Therapie ist einerseits in vielen Fällen nur durch das Zusammenspiel von 2 oder mehreren Medikamenten überhaupt erst möglich, andererseits können Wechselwirkungen zwischen verschiedenen Arzneimitteln lebensbedrohliche Folgen haben [3]. Gerade die moderne Anästhesie basiert ganz wesentlich auf der geplanten Anwendung von Wirkung und Wechselwirkung mehrerer Pharmaka. So ist beispielsweise die gegenseitige Verstärkung der relaxierenden Eigenschaften von volatilen Anästhetika und Muskelrelaxanzien eine routinemäßig genutzte Wechselwirkung. Als besonderer Gesichtspunkt von Arzneimittelinteraktionen in der Anästhesie ist hervorzuheben, daß der übliche Gebrauch pharmakologischer Substanzen gegenüber anderen Fachgebieten der Medizin anwendungsbedingte Unterschiede aufweist. Für die Narkose werden vorwiegende Medikamente verwendet, die eine steile Dosis-Wirkungs-Beziehung aufweisen. Hierbei ist es notwendig, die Dosis individuell den Reaktionen des Patienten anzupassen. In der Anästhesie sind daher Arzneimittelinteraktionen, die zu unbedeutenden Wirkungssteigerungen oder -abnahmen führen, von geringer Konsequenz und werden als Routine behandelt.

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© Springer-Verlag Berlin Heidelberg 1995

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  • A. Hoeft
  • D. Kettler

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