Abstract
In diagnostic imaging, a distinction is made between negative X-ray (air, O2,CO2), positive X-ray (barium BaSO4; iodine, I), paramagnetic, and ultraso-nographic contrast media (CM). Barium sulphate (BaSO4) had already been used in 1896 for investigations on peristalsis, but it was forgotten again once the study was concluded. It was only about a decade later that BaSO4, “newly” developed by the pharmacist and final-year medical student Fritz Munk, was introduced into X-ray investigations of the gastrointestinal tract as the so-called Rieder meal (barium mixed with gruel). It has been able to maintain its predominant position up to the present day, albeit with certain modifications such as taste corrigents and changes in density and particle size, though occasionally it is replaced by tri-iodinated ionic or nonionic X-ray CM, which are used, for example, in suspected fistulae, ileus, or for an array of purposes in children.
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References
Almén T (1969) Contrast agent design. Some aspects of the synthesis of water-soluble agents of low osmolality. J Theor Biol 24: 216–226
Binz A, Räth A, von Lichtenberg A (1931) The chemistry of proselectan. Z Urol 25: 297–301
Grainger RG (1982) Intravascular contrast media — the past, the present and the future. Br J Radiol 55: 1–18
Katayama H, Yamaguchi K, Kozuka T, Takashima T, Seez P, Matsuura K (1990) Adverse reactions to ionic and nonionic contrast media. A report from the Japanese Committee on the Safety of Contrast Media. Radiology 175: 621–628
Langecker H, Harwart A, Junkmann K (1954) 3,5-Diacetylamino-2,4,6-triiodbenzoe-säure als Röntgenkontrastmittel. Naunyn-Schmiedebergs Arch Exp Pathol 222: 584–590
Lichtenberg A von, Swick M (1929) Klinische Prüfung des Uroselectans. Klin Wochenschr 8: 2089–2091
Moniz E (1934) L’angiographic cérébrale. Masson, Paris
Osborne ED, Sutherland CG, Scholl AF, Rowntree LG (1923) Roentgenography of urinary tract during excretion of sodium iodide. JAMA 80: 368–373
Palmer FJ (1988) The RACR survey of intravenous contrast media reactions: final report. Austral Radiol 32: 426–428
Schrott KM, Behrends B, Clauß W, Kaufmann J, Lehnert J (1986) Iohexol in der Ausscheidungsurographic: Ergebnisse des Drug monitorings. Fortschr Med 7: 53–156
Swick M (1929) Darstellung der Niere und Harnwege im Röntgenbild durch intravenöse Einbringung eines neuen Kontraststoffes, des Uroselectans. Klin Wochenschr 8: 2087–2089
Wallingford VH (1953) The development of organic iodide compounds as X-ray contrast media. J Am Pharmacol Assoc (Sci Ed) 42: 721–728
Almén T (1989) Relations between chemical structure, animal toxicity and clinical adverse effects of contrast media. In: Enge I, Edgren J (eds) Patient safety and adverse events in contrast medium examinations. Elsevier/Excerpta Medica, Amsterdam (International Congress Series 816)
Sovak M (ed) (1984) Radiocontrast agents. Springer, Berlin Heidelberg New York (Handbook of Experimental Pharmacology vol 73)
Ahlgren P (1973) Long term side effects after myelography with watersoluble contrast media: Conturex, Conray Meglumine 282 and Dimer-X. Neuroradiology 6: 206–211
Ahlgren P (1975) Amipaque myelography. The side effects compared with Dimer X. Neuroradiology 9: 197–202
Ahlgren P (1980) Early and late side effects of water-soluble contrast media for myelography and cisternography: a short review. Invest Radiol 15 (Suppl): S264–S266
Battenfeld R (1980) Licht-und elektronenmikroskopische Untersuchungen der osmotischen Nephrose nach Applikation eines Röntgenkontrastmittels. Inaugural Dissertation, Tierärztliche Hochschule Hannover
Cigarroa RG et al (1989) Dosing of contrast material to prevent contrast nephropathy in patients with renal disease. Am J Med 86: 649–652
Chronqvist S (1977) Examination of the subarachnoid space with a water-soluble contrast medium (Amipaque). J Neuroradiol 4: 13–27
Ennis M et al (1989) Histamine release from canine lung and liver mast cells induced by radiographic contrast media. Agents Actions 27: 101–103
Gräser C et al (1979) Zur Myélographie mit Metrizamid. Dtsch Med Wochenschr 104: 511–514
Günzel P (1990) Schließen vom präklinischen Experiment auf den Menschen. In: Kuemmerle HP et al (eds) Klinische Pharmakologie, Bd 1, II-2.4.8, 4. Aufl, 24. Erg Lfg 2/90. Ecomed, Landsberg
Günzel P (1990) Grundsätzliche Überlegungen zur Durchführung experimenteller toxikologischer Untersuchungen. In: Kuemmerle HP et al (eds) Klinische Pharmakologie, Bd 1, II-2.4.1, 4. Aufl, 24. Erg Lfg 2/90. Ecomed, Landsberg
Günzel P, Schöbel C (1984) Systemische Verträglichkeitsprüfung bei einmaliger Verabreichung — akute Toxizitätsprüfung. In: Kuemmerle HP et al (eds) Klinische Pharmakologie, Bd 1, II-2.4.2, 4. Aufl. Ecomed, Landsberg
Günzel P et al (1986) Zur toxikologischen Prüfung von Kontrastmitteln. In: Burger OK et al (eds) Aktuelle Probleme der Biomedizin. Gruyter, Berlin, pp 275–288
Günzel P (1991) Diagnostika (Röntgen-u.a. Kontrastmittel). In: Hess R (eds) Arzneimitteltoxikologie, Anforderungen, Verfahren, Bedeutung. Thieme, Stuttgart, pp 397–404
Hansen EB et al (1978) Late meningeal effects of myelographic contrast media with special reference to metrizamide. Br J Radiol 51: 321–327
Haughton VM et al (1977) Arachnoiditis following myelography with metrizamide in monkeys. Effect of blood in the cerebrospinal fluid. Acta Radiol Suppl 355: 373–378
Hauhgton VM et al (1977) Experimental production of arachnoiditis with water-soluble myelographic media. Radiology 123: 681–685
Haughton VM et al (1977) Arachnoiditis following myelography with water-soluble agents. Radiology 125: 731–733
Haughton VM et al (1978) Comparison of arachnoiditis produced by meglumine locarmate and metrizamide myelography in an animal mdoel. Am J Roentgenol 131: 129–132
Haughton VM, Ho KC (1980) The risk of arachnoiditis from experimental nonionic contrast media. Radiology 136: 395–397
Haughton VM, Ho KC (1982) Arachnoid response to contrast media: a comparison of iophendylate and metrizamide in experimental animals. Radiology 143: 699–702
Haughton VM et al (1982) Experimental study of arachnoiditis from iohexol, and investigational nonionic aqueous contrast medium. Am J Neuroradiol 3: 375–377
Haughton VM, Ho KC (1982) Effect of blood on arachnoiditis from aqueous myelographic contrast media. Am J Roentgenol 139(3): 569–570
Haughton VM (1985) Intrathecal toxicity of iohexol vs. metrizamide. Survey and current state. Invest Radiol 20 (Suppl 1): S14–S17
Irstam L, Rosencrantz M (1974) Water-soluble contrast media and adhesive arachnoiditis. Acta Radiol 15: 1–15
Irstam L (1978) Lumbar myelography with amipaque. Spine 3: 70–82
Irstam L et al (1974) Lumbar myelography and adhesive arachnoiditis. Acta Radiol Diagn 15: 356–368
Johansen JG et al (1984) Arachnoiditis from myelography and laminectomy in experimental animals. Am J Neuroradiol 5: 97–99
Jorgensen J et al (1975) A clinical and radiological study of chronic lower spinal arachnoiditis. Neuroradiology 9: 139–144
Kröpelin T et al (1983) The risk liability of nephrotropic contrast media: clinical and experimental results. In: Taenzer V, Zeitler E (eds) Contrast media in urography, angiography and computerized tomography. Thieme, Stuttgart, pp 129–142
Lang JH et al (1976) Activation of serum complement by contrast media. Invest Radiol 11: 303–308
Lang R (1990) Prüfung auf genotoxische Wirkung. In: Kuemmerle HP et al (eds) Klinische Pharmakologie, Bd 1, II-2.4.5, 4. Aufl, 24. Erg Lfg 2/90. Ecomed, Landsberg
Liliequist B, Lundström B (1974) Lumbar myelography and arachnoiditis. Neuroradiology 7: 91–94
McCormick CC et al (1981) Myelography with metrizamide. An analysis of the complications encountered in cervical, thoracic and lumbar myelography. Aust NZ J Med 11: 645–650
McNeill TW et al (1976) A new advance in water-soluble myelography. Spine 1: 72–84
Moreau JF et al (1980) Tubular nephrotoxicity of water-soluble iodinated contrast media. Invest Radiol 15 (Suppl 6): S54–S60
Muetzel W, Speck U (1983) Tolerance and biochemical pharmacology of iopromide. In: Taenzer V, Zeitler E (eds) Contrast media in Urography, Angiography and Computerized Tomography. Thieme, Stuttgart, New York, pp 11–17
Muetzel W, Speck U (1983) Tolerance and biochemical pharmacology of iopromide. Fortschr Geb Röntgenstr Nuklearmed 118: 11–17
Muetzel W, Speck U (1983) Pharmacochemical profile of iopromide. Am J Neuroradiol 4: 350–352
Müller N et al (1991) Results of a comparative pulmonary tolerance study in the dog following a single intrapulmonal application of three iodine-containing X-ray contrast media (Isovist-300, Ultravist-300, Angiografin). (in press)
Pasaouglu A et al (1988) An experimental evaluation of response to contrast media. Pantopaque, iopamidol, and iohexol in the subarachnoid space. Invest Radiol 23: 762–766
Poggel HA (1984) Reproduktionstoxikologische Untersuchungen. In: Kuemmerle HP et al (eds) Klinische Pharmakologie, Bd 1, II-2.4.6, 4. Aufl. Ecomed, Landsberg
Press WR et al (1989) Tolerance to iotrolan after subarachnoid injection in animals. Fortschr Geb Röntgenstr Nuklearmed 128: 126–133
Scherberich JE et al (1991) Unerwünschte Kontrastmittelwirkungen an der Niere. In: Peters PE, Zeitler E (eds) Röntgenkontrastmittel. Springer, Berlin Heidelberg New York, pp 65–69
Schöbel C, Günzel P (1984) Systemische Verträglichkeitsprüfungen bei wiederholter Verabreichung — subakute und chronische Toxizitätsprüfung. In: Kuemmerle HP et al (eds) Klinische Pharmakologie, Bd 1, II-2.4.3, 4. Aufl. Ecomed, Landsberg
Schöbel C, Siegmund F (1984) Lokale Verträglichkeitsprüfungen. In: Kuemmerle HP et al (eds) Klinische Pharmakologie, Bd 1, II-2.4.7, 4. Aufl. Ecomed, Landsberg
Schöbel, C, Günzel P (1991) Methoden und Ergebnisse toxikologischer Prüfungen von nichtionischen Röntgenkontrastmitteln. In: Peters PE, Zeitler E (eds) Röntgenkontrastmittel. Springer, Berlin Heidelberg New York, pp 5–7
Schmidt RC (1980) Mental disorders after myelography with metrizamide and other water-soluble contrast media. Neuroradiology 19: 153–157
Skalpe IO (1978) Adhesive arachnoiditis following lumbar myelography. Spine 3: 61–64
Skalpe IO (1977) Lumbale Myélographie mit wasserlöslichen Kontrastmitteln (Metrizamid). Akt Neurol 4: 179–183
Slätis P et al (1974) Hyperosmolality of the cerebrospinal fluid as a cause of adhesive arachnoiditis in lumbar myelography. Acta Radiol Diagn 15: 619–629
Tirone P, Boldrini E (1983) Effects of radiographic contrast media on the serum complement system. Arch Toxicol (Suppl 6): 37–41
Grainger RG (1987) Osmolality and osmolality-related side effects. In: Contrast media from the past to the future. Berlin, March 27–28. Thieme, Stuttgart
Katayama H, Tanaka T (1988) Clinical survey of adverse reactions to contrast media. Invest Radiol 23: S88–S89
Knoefel PK, Huang KC (1956) The biochemorphology of renal tubular transport: iodinated benzoic acids. J Pharm Exp Ther 117: 307–316
Mitchell DG, Friedman AC (1985) Viscosity of iodinated contrast agents: significance for peripheral venous injection. J Comput Tomogr 9: 77–78
Morris TW, Kern MA, Katzberg RW (1982) The effects of media viscosity on hemo-dynamics in selective arteriography. Invest Radiol 17: 70–76
Morris TW, Sahler LG, Fischer HW (1982) Calcium binding by radiopaque media. Invest Radiol 17: 501–505
Nauert CM, Langer M, Mützel W (1989) Hemorrheologic effects of Iotrolan after intra-arterial injection in rabbits: comparison with other types of contrast media. Fortschr Geb Röntgenstrahl Nuklearmed Suppl 128: 40–45
Speck U (1987) Newer perspectives in contrast media chemistry. In: Parvez Z, Mon-cada R, Sovak M (eds) Contrast media: biological effects and clinical application, vol 1. CRC Press, Boca Raton
Ackrill P, Mclntosh S, Nimmon C et al (1976) A comparison of the clearance ofurographic contrast medium sodium diatrizoate by peritoneal and haemodialysis. Clin Sci Med 50: 69–74
Barnhart JL (1984) Hepatic disposition and elimination of biliary contrast media. In: Sovak M (ed) Radiocontrast agents. Springer, Berlin Heidelberg New York, pp 367–418
Bennett PN, Bath FRCP (1988) Drugs and human lactation. Elsevier, Amsterdam
Choyke PL, Austin AH, Frank JA et al (1992) Hydrated clearance of gadolinium-DTPA as a measurement of glomerular filtration rate. Kidney Int 41: 1595–1598
Corradi A, Menta R, Cambi V et al (1990) Pharmacokinetics of iopamidol in adults with renal failure. Arzneimittelforschung/Drug Res 40(II): 830–832
Effersoe H, Rosenkilde R, Groth S et al (1990) Measurement of renal function with iohexol or a comparison of iohexol, 99mTc-DTPA, and 51Cr-EDTA clearance. Invest Radiol 25: 778–782
Kierdorf H, Kindler J, Winterscheid R et al (1989) Elimination of the nonionic contrast medium iopromide in end-stage renal failure by haemodialysis. In: Taenzer V, Wende S (eds) Recent developments in nonionic contrast media. Thieme, Stuttgart New York, pp 119–123
Lackner K, Krahe T, Götz R, Haustein J (1990) The dialysability of gadolinium-DTPA. In: Bydder G, Felix R, Büchler E et al (eds) Contrast media in MRI. Medicom Europe, Bussum, pp 321–326
Lim KL, Stark DD, Leese PT et al (1991) Hepatobiliary MR imaging: first human experience with MnDPDP. Radiology 178: 79–82
Lin KS, Moss AA, Riegelmann S (1979) Kinetics of drug-drug interactions: biliary excretion of iodoxamic acid and iopanoic acid in rhesus monkeys. J Pharm Sci 68: 1430–1433
Mützel W, Nagel R, Kemper JD, Clauß W (1984) Pharmakokinetik des nichtionischen Röntgenkontrastmittels Iohexol. Akt Urol 15: 154–156
Schmiedl U, Maravilla KR, Gerlach R, Dowling CA (1990) Excretion of gadopente-tate dimeglumine in human breast milk. AJR 154: 1305–1306
Schuhmann-Giampieri G, Krestin G (1991) Pharmacokinetics of Gd-DTPA in patients with chronic renal failure. Invest Radiol 26: 975–979
Schuhmann-Giampieri G, Schmitt-Willich H, Press WR et al (1992) Preclinical evaluation of Gd-EOB-DTPA as a contrast agent in MR imaging of the hepatobiliary system. Radiology 183: 59–64
Speck U, Mützel W, Herz-Hübner U, Siefert HM (1978) Pharmakologie der Iotro-xinsäure eines neuen intravenösen Cholegraphikums. Arzneimittelforschung/Drug Res 28(II): 2143–2149
Taenzer V, Speck U, Wolf R (1977) Pharmakokinetik and Plasmaeiweißbindung von Iotroxinsäure. Fortschr Röntgenstr 126: 262–267
Vogl TJ, Pegios W, McMahon C et al (1992) Gadobenate dimeglumine — a new contrast agent for MR imaging: preliminary evaluation in healthy volunteers. AJR 158: 887–892
Waaler A, Svaland M, Fauchald P et al (1990) Elimination of iohexol, a low osmolar nonionic contrast medium, by hemodialysis in patients with chronic renal failure. Nephron 56: 81–85
Weinmann HJ, Laniado M, Mützel W (1984) Pharmacokinetics of Gd-DTPA/dimeg-lumine after intravenous injection into healthy volunteers. Physiol Chem Phys Med NMR 16: 167–172
Wolf KJ, Steidle B, Skutta T, Mützel W (1983) Iopromide. Clinical experience with a new non-ionic contrast medium. Acta Radiol 24: 55–62
Andrew E (1989) Clinical relevance of toxicological experiments on drugs (in Norwegian, English summary). Nor Lægeforening 106: 1935–1938)
Andrew E (1990) Adverse reactions of x-ray contrast media in pre-registration trials versus post-marketing surveillance (PMS). 2nd international symposium of CM, Osaka, Japan, November 1990
Good clinical practice for trials on medicinal products in the European Community. COMEUR, Brussels, 1990
Katayama H, Yamaguchi K, Kozuka T et al (1990) Adverse reactions to ionic and non-ionic contrast media. A report from the Japanese Committee on the Safety of Contrast Media. Radiology 11: 52–66
Palmer FJ (1989) The Royal Australian College of Radiologists (RACR) survey of reactions to intravenous ionic and non-ionic media. In: Enge I, Edgren J (eds) Patient safety and adverse events in contrast medium examination. Elsevier, Amsterdam, pp 137–141 (Excerpta medica international Congress series, vol 816)
Schmitt KM, Behrends B, Clauß W, Kaufmann J, Lehnert J (1986) Iohexol in der Ausscheidungsurographic. Ergebnisse des Drug-monitoring. Fortschr Med 7: 153–156
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Maurer, H.J. et al. (1993). General Fundamentals. In: Dawson, P., Clauß, W. (eds) Contrast Media in Practice. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97530-1_1
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