Zusammenfassung
Morbus Crohn ist eine chronisch-entzündliche Darmerkrankung ungeklärter Ätiologie, die durch keine konservative oder chirurgische Maßnahme zu heilen ist. Die medikamentöse Therapie des Morbus Crohn hat das Ziel, durch Verringerung der Entzündungsaktivität die klinische Symptomatik zu verbessern, die Lebensqualität des Patienten zu steigern und das Auftreten von rezidivierenden Schüben zu verhindern. Es werden zunächst die Erfahrungen mit den verschiedenen Substanzen in der Therapie des Morbus Crohn diskutiert und schließlich praktische Therapieempfehlungen (17.10) gegeben.
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Literatur
Alfonso JJ, Rombeau JL (1990) Nutritional care for patients with Crohn’s disease. Hepatogastroenterol 37:32–41
Alun Jones V (1987) Comparison of total parenteral nutrition and elemental diet in induction of remission of Crohn’s disease. Dig Dis Sci 12:100S–107S
Brandes JW, Lorenz-Meyer H (1981) Zuckerfreie Diät: Eine neue Perspektive zur Behandlung des Morbus Crohn? Z Gastroenterol 19:1–12
Brandt LJ, Bernstein LH, Boley SJ et al. (1982) Metronidazole therapy for perineal Crohn’s disease: a follow-up study. Gastroenterology 83:383–387
Brignola C, Campieri M, Farruggia P et al. (1988) The possible utility of steroids in the prevention of relapse of Crohn’ disease in remission: a preliminary study. J Clin Gastroenterol 10:631–634
Brignola C, Iannone P, Pasquali S et al. (1992) Placebo-controlled trial of oral 5-ASA in relapse prevention of Crohn’s disease. Dig Dis Sci 37:29–32
Brynskov J, Freund L, Rasmussen SN et al. (1989) A placebo-controlled, double-blind, randomized trial fo cyclosporine therapy in active chronic Crohn’s disease. N Engl J Med 321:845–850
Brynskov, J, Freund L, Rasmussen SN et al. (1991) Final report on a placebo-controlled, double-blind, randomized, multicentre trial of cyclosporin treatment in active chronic Crohn’s disease. Scand J Gastroenterol 26:689–695
Ewe K, Herfarth C, Malchow H et al. (1989) Postoperative recurrence of Crohn’s disease in relation to radicality of operation and sulfsalazine prophylaxis: a multicenter trial. Digestion 42:224–232
Felder JB, Adler DJ, Korelitz BI (1991) The safety of corticosteroid therapy in Crohn’s disease with an abdominal mass. Am J Gastroenterol 86:1450–1455
Goldstein F, Farquhar S, Thornton JJ et al. (1987) Favorable effects of sulfsalazine on small bowel Crohn’s disease: a long-term study. Am J Gastroenterol 82:848–853
Greenberg GR, Fleming CR, Jeejeebhoy KN et al. (1988) Controlled trial of bowel rest and nutritional support in the management of Crohn’s disease. Gut 29:1309–1315
Harig JM, Soergel KH, Komorowski RA et al. (1989) Treatment of diversion colitis with short-chain-fatty acid irrigation. N Engl Med J 320:23–28
Korelitz BI, Present DH (1985) Favorable effect of 6-Mercaptopurine on fistulae of Crohn’s disease. Dig Dis Sci 30:58–64
Kozarek RA, Patterson DJ, Gelfand MD et al. (1989) Methotrexate induces clinical and histologic remission in patients with refractory inflammatory bowel disease. Ann Intern Med 110:353–356
Lashner BA, Evans AA, Hanauer SB (1989) Preoperative total parenteral nutrition for bowel resection in Crohn’s disease. Dig Dis Sci 34:741–746
Landi B, N’Guyen Anh T, Cortot A et al. (1992) Endoscopic monitoring of Crohn’s disease treatment: a prospective, randomized clinical trial. Gastroenterology 102:1647–1653
Lochs H, Steinhardt HJ, Klaus-Wentz B et al. (1991) Comparison of enteral nutrition and drug treatment in active Crohn’s disease. Gastroenterology 101:881–888
Lorenz-Meyer H, Purrmann J, Scheurlen C et al. (1992) Crohnstudie V; Ergebnisse der Studie zur Erhaltung der Remission bei M. Crohn mit Ω-3-FS bzw. einer kohlenhydratarmen Kost. Z Gastroenterol 30:654
Malchow H, Ewe K, Brandes JW et al. (1984) European cooperative Crohn’s disease study (ECCDS): Results of drug treatment. Gastroenterology 86:249–266
Malchow H, Steinhardt HJ, Lorenz-Meyer H et al. (1990) Feasibility and effectiveness of a defined-formula diet regimen in treating active Crohn’s disease. Scand J Gastroenterol 25:235–244
Martin F, Sutherland L, Beck IT et al. (1990) Oral 5-ASA versus prednisone in short term treatment of Crohn’s disease: A multicentre controlled trial. Can J Gastroenterol 4:452–457
Modigliani R, Mary JY, Simon JF et al. (1990) Clinical, biological and endoscopic picture of attacks of Crohn’s disease. Gastroenterology 98:811–818
O’Brien JJ, Bayless TM, Bayless JA (1991) Use of azathioprine or 6-mercaptopurine in the treatment of Crohn’s disease. Gastroenterology 101:39–46
Prantera C, Pallone F, Brunetti G et al. (1992) Oral 5-aminosalicylic acid (Asacol) in the maintenance treatment of Cron’s disease. Gastroenterology 103:363–368
Present DH (1989) 6-Mercaptopurine and other immunosuppressive agents in the treatment of Crohn’s disease and ulcerative colitis. Gastroenterol Clin North Am 18:57–71
Ritchie JK, Wadsworth J, Lennard-Jones JE et al. (1987) Controlled multicentre therapeutic trial of an unrefined carbohydrate, fibre rich diet in Crohn’s disease. Br Med J 295:517–520
Salomon P, Kronbluth A, Aisenberg J et al. (1992) How effective are current drugs for Crohn’s disease? J Clin Gastroenterol 14:211–215
Schölmerich J, Jenss H, Hartmann F et al. (1990) Oral 5-aminosalicylic acid versus 6-methylprednisolone in active Crohn’s disease. Can J Gastroenterol 4:446–451
Scott ADN, Ritchie JK, Phillips RKS (1991) Blood transfusion and recurrent Crohn’s disease. Br J Surg 78:455–458
Seidman EG (1989) Nutritional management of inflammatory bowel disease. Gastroenterol Clin North America 17:129–155
Shepherd HA, Barr GD, Jewel DP (1986) Use of an intravenous steroid regimen in the treatment of acute Crohn’s disease. J Clin Gastroenterol 8:154–159
Sitzmann JV, Converse RL Jr, Bayless TM (1990) Favorable response to parenteral nutrition and medical therapy in Crohn’s colitis. Gastroenterology 99:1647–1652
Summers RW, Switz DM, Sessions JT Jr et al. (1979) National cooperative Crohn’s disease study: Results of drug treatment. Gastroenterology 77:847–869
Sutherland L, Singleton J, Sessions J et al. (1991) Double blind, placebo controlled trial of metronidazole in Crohn’s disease. Gut 32:1071–1075
Ursing B, Alm T, Barany F et al. (1982) A comparative study of metronidazole and sulfasalazine for active Crohn’s disease: the cooperative Crohn’s disease study in Sweden. Gastroenterology 83:550–562
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© 1993 Springer-Verlag Berlin Heidelberg
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Adler, G. (1993). Medikamentöse Therapie des Morbus Crohn. In: Morbus Crohn Colitis ulcerosa. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97440-3_17
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DOI: https://doi.org/10.1007/978-3-642-97440-3_17
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