Skip to main content

Medikamentöse Therapie des Morbus Crohn

  • Chapter
Morbus Crohn Colitis ulcerosa
  • 60 Accesses

Zusammenfassung

Morbus Crohn ist eine chronisch-entzündliche Darmerkrankung ungeklärter Ätiologie, die durch keine konservative oder chirurgische Maßnahme zu heilen ist. Die medikamentöse Therapie des Morbus Crohn hat das Ziel, durch Verringerung der Entzündungsaktivität die klinische Symptomatik zu verbessern, die Lebensqualität des Patienten zu steigern und das Auftreten von rezidivierenden Schüben zu verhindern. Es werden zunächst die Erfahrungen mit den verschiedenen Substanzen in der Therapie des Morbus Crohn diskutiert und schließlich praktische Therapieempfehlungen (17.10) gegeben.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Alfonso JJ, Rombeau JL (1990) Nutritional care for patients with Crohn’s disease. Hepatogastroenterol 37:32–41

    Google Scholar 

  • Alun Jones V (1987) Comparison of total parenteral nutrition and elemental diet in induction of remission of Crohn’s disease. Dig Dis Sci 12:100S–107S

    Google Scholar 

  • Brandes JW, Lorenz-Meyer H (1981) Zuckerfreie Diät: Eine neue Perspektive zur Behandlung des Morbus Crohn? Z Gastroenterol 19:1–12

    PubMed  CAS  Google Scholar 

  • Brandt LJ, Bernstein LH, Boley SJ et al. (1982) Metronidazole therapy for perineal Crohn’s disease: a follow-up study. Gastroenterology 83:383–387

    PubMed  CAS  Google Scholar 

  • Brignola C, Campieri M, Farruggia P et al. (1988) The possible utility of steroids in the prevention of relapse of Crohn’ disease in remission: a preliminary study. J Clin Gastroenterol 10:631–634

    Article  PubMed  CAS  Google Scholar 

  • Brignola C, Iannone P, Pasquali S et al. (1992) Placebo-controlled trial of oral 5-ASA in relapse prevention of Crohn’s disease. Dig Dis Sci 37:29–32

    Article  PubMed  CAS  Google Scholar 

  • Brynskov J, Freund L, Rasmussen SN et al. (1989) A placebo-controlled, double-blind, randomized trial fo cyclosporine therapy in active chronic Crohn’s disease. N Engl J Med 321:845–850

    Article  PubMed  CAS  Google Scholar 

  • Brynskov, J, Freund L, Rasmussen SN et al. (1991) Final report on a placebo-controlled, double-blind, randomized, multicentre trial of cyclosporin treatment in active chronic Crohn’s disease. Scand J Gastroenterol 26:689–695

    Article  PubMed  CAS  Google Scholar 

  • Ewe K, Herfarth C, Malchow H et al. (1989) Postoperative recurrence of Crohn’s disease in relation to radicality of operation and sulfsalazine prophylaxis: a multicenter trial. Digestion 42:224–232

    Article  PubMed  CAS  Google Scholar 

  • Felder JB, Adler DJ, Korelitz BI (1991) The safety of corticosteroid therapy in Crohn’s disease with an abdominal mass. Am J Gastroenterol 86:1450–1455

    PubMed  CAS  Google Scholar 

  • Goldstein F, Farquhar S, Thornton JJ et al. (1987) Favorable effects of sulfsalazine on small bowel Crohn’s disease: a long-term study. Am J Gastroenterol 82:848–853

    PubMed  CAS  Google Scholar 

  • Greenberg GR, Fleming CR, Jeejeebhoy KN et al. (1988) Controlled trial of bowel rest and nutritional support in the management of Crohn’s disease. Gut 29:1309–1315

    Article  PubMed  CAS  Google Scholar 

  • Harig JM, Soergel KH, Komorowski RA et al. (1989) Treatment of diversion colitis with short-chain-fatty acid irrigation. N Engl Med J 320:23–28

    Article  CAS  Google Scholar 

  • Korelitz BI, Present DH (1985) Favorable effect of 6-Mercaptopurine on fistulae of Crohn’s disease. Dig Dis Sci 30:58–64

    Article  PubMed  CAS  Google Scholar 

  • Kozarek RA, Patterson DJ, Gelfand MD et al. (1989) Methotrexate induces clinical and histologic remission in patients with refractory inflammatory bowel disease. Ann Intern Med 110:353–356

    PubMed  CAS  Google Scholar 

  • Lashner BA, Evans AA, Hanauer SB (1989) Preoperative total parenteral nutrition for bowel resection in Crohn’s disease. Dig Dis Sci 34:741–746

    Article  PubMed  CAS  Google Scholar 

  • Landi B, N’Guyen Anh T, Cortot A et al. (1992) Endoscopic monitoring of Crohn’s disease treatment: a prospective, randomized clinical trial. Gastroenterology 102:1647–1653

    PubMed  CAS  Google Scholar 

  • Lochs H, Steinhardt HJ, Klaus-Wentz B et al. (1991) Comparison of enteral nutrition and drug treatment in active Crohn’s disease. Gastroenterology 101:881–888

    PubMed  CAS  Google Scholar 

  • Lorenz-Meyer H, Purrmann J, Scheurlen C et al. (1992) Crohnstudie V; Ergebnisse der Studie zur Erhaltung der Remission bei M. Crohn mit Ω-3-FS bzw. einer kohlenhydratarmen Kost. Z Gastroenterol 30:654

    Google Scholar 

  • Malchow H, Ewe K, Brandes JW et al. (1984) European cooperative Crohn’s disease study (ECCDS): Results of drug treatment. Gastroenterology 86:249–266

    PubMed  CAS  Google Scholar 

  • Malchow H, Steinhardt HJ, Lorenz-Meyer H et al. (1990) Feasibility and effectiveness of a defined-formula diet regimen in treating active Crohn’s disease. Scand J Gastroenterol 25:235–244

    PubMed  CAS  Google Scholar 

  • Martin F, Sutherland L, Beck IT et al. (1990) Oral 5-ASA versus prednisone in short term treatment of Crohn’s disease: A multicentre controlled trial. Can J Gastroenterol 4:452–457

    Google Scholar 

  • Modigliani R, Mary JY, Simon JF et al. (1990) Clinical, biological and endoscopic picture of attacks of Crohn’s disease. Gastroenterology 98:811–818

    Article  PubMed  CAS  Google Scholar 

  • O’Brien JJ, Bayless TM, Bayless JA (1991) Use of azathioprine or 6-mercaptopurine in the treatment of Crohn’s disease. Gastroenterology 101:39–46

    PubMed  Google Scholar 

  • Prantera C, Pallone F, Brunetti G et al. (1992) Oral 5-aminosalicylic acid (Asacol) in the maintenance treatment of Cron’s disease. Gastroenterology 103:363–368

    PubMed  CAS  Google Scholar 

  • Present DH (1989) 6-Mercaptopurine and other immunosuppressive agents in the treatment of Crohn’s disease and ulcerative colitis. Gastroenterol Clin North Am 18:57–71

    PubMed  CAS  Google Scholar 

  • Ritchie JK, Wadsworth J, Lennard-Jones JE et al. (1987) Controlled multicentre therapeutic trial of an unrefined carbohydrate, fibre rich diet in Crohn’s disease. Br Med J 295:517–520

    Article  CAS  Google Scholar 

  • Salomon P, Kronbluth A, Aisenberg J et al. (1992) How effective are current drugs for Crohn’s disease? J Clin Gastroenterol 14:211–215

    Article  PubMed  Google Scholar 

  • Schölmerich J, Jenss H, Hartmann F et al. (1990) Oral 5-aminosalicylic acid versus 6-methylprednisolone in active Crohn’s disease. Can J Gastroenterol 4:446–451

    Google Scholar 

  • Scott ADN, Ritchie JK, Phillips RKS (1991) Blood transfusion and recurrent Crohn’s disease. Br J Surg 78:455–458

    Article  PubMed  CAS  Google Scholar 

  • Seidman EG (1989) Nutritional management of inflammatory bowel disease. Gastroenterol Clin North America 17:129–155

    Google Scholar 

  • Shepherd HA, Barr GD, Jewel DP (1986) Use of an intravenous steroid regimen in the treatment of acute Crohn’s disease. J Clin Gastroenterol 8:154–159

    Article  PubMed  CAS  Google Scholar 

  • Sitzmann JV, Converse RL Jr, Bayless TM (1990) Favorable response to parenteral nutrition and medical therapy in Crohn’s colitis. Gastroenterology 99:1647–1652

    PubMed  CAS  Google Scholar 

  • Summers RW, Switz DM, Sessions JT Jr et al. (1979) National cooperative Crohn’s disease study: Results of drug treatment. Gastroenterology 77:847–869

    PubMed  CAS  Google Scholar 

  • Sutherland L, Singleton J, Sessions J et al. (1991) Double blind, placebo controlled trial of metronidazole in Crohn’s disease. Gut 32:1071–1075

    Article  PubMed  CAS  Google Scholar 

  • Ursing B, Alm T, Barany F et al. (1982) A comparative study of metronidazole and sulfasalazine for active Crohn’s disease: the cooperative Crohn’s disease study in Sweden. Gastroenterology 83:550–562

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Adler, G. (1993). Medikamentöse Therapie des Morbus Crohn. In: Morbus Crohn Colitis ulcerosa. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97440-3_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-97440-3_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-97441-0

  • Online ISBN: 978-3-642-97440-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics