Advertisement

Collection, Processing and Infusion of Marrow

  • H. Joachim Deeg
  • Hans-Georg Klingemann
  • Gordon L. Phillips

Abstract

One of the functions of the preparative or conditioning regimen before marrow infusion is to create space for the transplanted autologous or allogeneic donor marrow. Marrow for transplantation can be obtained from a healthy related or unrelated donor, or in some cases the patient’s own “autologous” marrow may be used. In both situations, the marrow is harvested, and certain manipulations may be performed, before infusion into the patient after the conditioning regimen has been completed. Intravenously-infused donor or autologous marrow cells reseed in the marrow cavity of the recipient, a process known as “homing”, and start to replicate and differentiate.

Keywords

Unrelated Donor Peripheral Blood Stem Cell Transplantation Umbilical Cord Blood Cell Stem Cell Collection Allogeneic Marrow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Areman EM, Deeg HJ, Sacher RA (1992) Bone Marrow and Stem Cell Processing: A Manual of Current Techniques, I.A. Davis & Co., PhiladelphiaGoogle Scholar
  2. Bell AJ, Hamblin TJ, Oscier DG (1986) Circulating stem cell autografts. Bone Marrow Transplant 1:103PubMedGoogle Scholar
  3. Buckner CD, Clift RA, Sanders JE, Stewart P, Bensinger WI, Doney KC, Sullivan KM, Witherspoon RP, Deeg HJ, Appelbaum FR, Storb R, Thomas ED (1984) Marrow harvesting from normal donors. Blood 64:630PubMedGoogle Scholar
  4. Davis JM, Rowley SD, Braine HG, Piantadosi S, Santos GW (1990) Clinical toxicity of cryopreserved bone marrow graft infusion. Blood 75:781PubMedGoogle Scholar
  5. Gorin NC (1986) Collection, manipulation and freezing of haemopoietic stem cells. Clin Haematol 15:19PubMedGoogle Scholar
  6. Lasky LC, Van Buren N, Weisdorf DJ, Filipovich A, McGlave P, Kersey JH, McCullough J, Ramsay NKC, Blazar BR (1989) Successful allogeneic cryopreserved marrow transplantation. Transfusion 29:182PubMedCrossRefGoogle Scholar
  7. Thomas ED, Storb R (1970) Technique for human marrow grafting. Blood 36:507PubMedGoogle Scholar
  8. Treleaven JG, Kemshead JT (1985) Removal of tumor cells from bone marrow: An evaluation of the available techniques. Hematol Oncol 3:65PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • H. Joachim Deeg
    • 1
  • Hans-Georg Klingemann
    • 2
  • Gordon L. Phillips
    • 3
  1. 1.Clinical Research DivisionFred Hutchinson Cancer Research CenterSeattleUSA
  2. 2.Department of MedicineThe University of British ColumbiaVancouverCanada
  3. 3.Division of HematologyThe University of British ColumbiaVancouverCanada

Personalised recommendations