Preparation for Marrow Transplantation

  • H. Joachim Deeg
  • Hans-Georg Klingemann
  • Gordon L. Phillips

Abstract

This section deals with the logistics of readying a patient for marrow transplantation; the elements of this process are outlined in Table 7. Not all of these elements will be universally applicable, but will depend on diagnosis and type of marrow to be utilized. Since the use of normal marrow donor transplantation is often the standard, this approach will be used as a model; the elements are clearly different, to a degree, for autologous marrow transplant patients, and such will also be discussed.

Keywords

Toxicity Leukemia Oncol Malaria Neutropenia 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Andrykowski MA, Altmaier EM, Barnett RL, Otis ML, Gingrich R, Henslee-Downey PJ (1990) The quality of life in adult survivors of allogeneic bone marrow transplantation. Transplantation 50:399PubMedCrossRefGoogle Scholar
  2. Appelbaum FR, Sullivan KM, Buckner CD, Clift RA, Deeg HJ, Fefer A, Hill R, Mortimer J, Neiman PE, Sanders JE, Singer J, Stewart P, Storb R, Thomas ED (1987) Treatment of malignant lymphoma in 100 patients with chemotherapy, total body irradiation, and marrow transplantation. J Clin Oncol 5:1340PubMedGoogle Scholar
  3. Bearman SI, Appelbaum FR, Back A, Petersen FB, Buckner CD, Sullivan KM, Schoch HG, Fisher LD, Thomas ED (1989) Regimen-related toxicity and early posttransplant survival in patients undergoing marrow transplantation for lymphoma. J Clin Oncol 7:1288PubMedGoogle Scholar
  4. Bearman SI, Appelbaum FR, Buckner CD, Petersen FB, Fisher LD, Clift RA, Thomas ED (1988) Regimen-related toxicity in patients undergoing bone marrow transplantation. J Clin Oncol 6:1562PubMedGoogle Scholar
  5. Beatty PG, Clift RA, Mickelson EM, Nisperos BB, Flournoy N, Martin PJ, Sanders JE, Stewart P, Buckner CD, Storb R, Thomas ED, Hansen JA (1985) Marrow transplantation from related donors other than HLA-identical siblings. N Engl J Med 313:765PubMedCrossRefGoogle Scholar
  6. Brack G, LaClave L, Blix S (1988) The psychological aspects of bone marrow transplant: A staff’s perspective. Cancer Nurs 11:221PubMedCrossRefGoogle Scholar
  7. Crossreacting groups of HLA-A and B antigens. (1987) Tissue Typing Reference Manual (edition 2), South-Eastern Organ Procurement Foundation, Richmond, Virginia: p. 4.14Google Scholar
  8. Deeg HJ (1990) Delayed complications and long-term effects after bone marrow transplantation. Hematol Oncol Clin North Am 4:641PubMedGoogle Scholar
  9. Dermatis H, Lesko LM (1991) Psychosocial correlates of physician-patient communication at time of informed consent for bone marrow transplantation. Cancer Invest 9:621PubMedCrossRefGoogle Scholar
  10. Futterman AD, Wellisch DK (1990) Psychodynamic themes of bone marrow transplantation. When I becomes thou. Hematol Oncol Clin North Am 4:699PubMedGoogle Scholar
  11. Hinterberger-Fischer M, Kier P, Kalhs P, Marosi C, Geissler K, Schwarzinger I, Pabinger I, Huber J, Spona J, Kolbabek H, Koren H, Muller G, Hawliczek R, Lechner K, Hayek-Rosenmayr A, Hinterberger W (1991) Fertility, pregnancies and offspring complications after bone marrow transplantation. Bone Marrow Transplant 7:5PubMedGoogle Scholar
  12. Hows JM, Bradley BA (1990) The use of unrelated marrow donors for transplantation. Br J Haematol 76:1PubMedCrossRefGoogle Scholar
  13. Jones RJ, Ambinder RF, Piantadosi S, Santos GW (1991) Evidence of a graft-versus-lymphoma effect associated with allogeneic bone marrow transplantation. Blood 77:649PubMedGoogle Scholar
  14. Kersey JH, Weisdorf D, Nesbit ME, LeBien TW, Woods WG, McGlave PB, Kim T, Vallera DA, Goldman AI, Bostrom B, Hurd D, Ramsay NKC (1987) Comparison of autologous and allogeneic bone marrow transplantation for treatment of high-risk refractory acute lymphoblastic leukemia. N Engl J Med 317:461PubMedCrossRefGoogle Scholar
  15. Lasky LC, Warkiniin PI, Kersey JH, Ramsay NKC, McGlave PB, McCullough J (1983) Hemotherapy in patients undergoing blood group incompatible bone marrow transplantation. Transfusion 23:277PubMedCrossRefGoogle Scholar
  16. Phillips GL (1992) Autologous bone marrow transplantation for hematologic malignancy. Drug Resistance as a Biochemical Target in Cancer Chemotherapy, Tsuruo T, Ogawa M, Carter WK (eds), Academic Press, San Diego, CA:295Google Scholar
  17. Singer DA, Donnelly MB, Messerschmidt GL (1990) Informed consent for bone marrow transplantation: Identification of relevant information by referring physicians. Bone Marrow Transplant 6:431PubMedGoogle Scholar
  18. Slichter SJ (1988) Transfusion and bone marrow transplantation. Transfusion Med Rev 2:1CrossRefGoogle Scholar
  19. Wingard JR, Curbow B, Baker F, Piantadosi S (1991) Health, functional status, and employment of adult survivors of bone marrow transplantation. Ann Intern Med 114:113PubMedGoogle Scholar
  20. Wingard JR, Plotnick LP, Freemer CS, Zahurak M, Piantadosi S, Miller DF, Vriesendorp HM, Yeager AM, Santos GW (1992) Growth in children after bone marrow transplantation: Busulfan plus cyclophosphamide versus cyclophosphamide plus total body irradiation. Blood 79:1068PubMedGoogle Scholar
  21. Wolcott DL, Wellisch DK, Fawzy FI, Landsverk J (1986) Adaptation of adult bone marrow transplant recipient long-term survivors. Transplantation 41:478PubMedCrossRefGoogle Scholar
  22. Wolcott DL, Wellisch DK, Fawzy FI, Landsverk J (1986) Psychological adjustment of adult bone marrow transplant donors whose recipient survives. Transplantation 41:484PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • H. Joachim Deeg
    • 1
  • Hans-Georg Klingemann
    • 2
  • Gordon L. Phillips
    • 3
  1. 1.Clinical Research DivisionFred Hutchinson Cancer Research CenterSeattleUSA
  2. 2.Department of MedicineThe University of British ColumbiaVancouverCanada
  3. 3.Division of HematologyThe University of British ColumbiaVancouverCanada

Personalised recommendations