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Xenotolerance Through Bone Marrow Transplantation

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Xenotransplantation

Abstract

The use of xenogeneic bone marrow transplantation (BMT) may provide an approach to induction of specific hyporeactivity toward a xenogeneic organ donor, while preserving otherwise normal immune function. Numerous studies in allogeneic animal models have demonstrated that specific transplantation tolerance can be produced by transplanting hematopoietic cehs across full major histocompatibility (MHC) barriers [1–7]. This approach obviates the need for chronic immunosuppressive therapy with its attendant risks, and the likelihood that donor-type grafts will be rejected is minimized while chimerism is maintained [8-10].

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Authors
  1. M. Sykes
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  2. I. Aksentijevich
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  3. Y. Sharabi
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  4. D. H. Sachs
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Editor information

Editors and Affiliations

  1. Baptist Medical Center, Oklahoma Transplantation Institute, 3300 N. W. Expressway, 73112, Oklahoma City, OK, USA

    D. K. C. Cooper M. D. Ph. D.

  2. Department of Nephrology, Odense University Hospital, DK-5000, Odense, Denmark

    Ejvind Kemp M. D.

  3. Department of Surgery, Columbia-Presbyterian Medical Center, 622 West 168th Street, 10032, New York, NY, USA

    Keith Reemtsma M. D.

  4. Department of Surgery, Addenbrooke’s Hospital, Hills Road, CB2 2QQ, Cambridge, UK

    D. J. G. White Ph. D., MRC Path.

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© 1991 Springer-Verlag Berlin Heidelberg

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Sykes, M., Aksentijevich, I., Sharabi, Y., Sachs, D.H. (1991). Xenotolerance Through Bone Marrow Transplantation. In: Cooper, D.K.C., Kemp, E., Reemtsma, K., White, D.J.G. (eds) Xenotransplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97323-9_8

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  • DOI: https://doi.org/10.1007/978-3-642-97323-9_8

  • Publisher Name: Springer, Berlin, Heidelberg

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