Mechanism of Humoral Xenograft Rejection

  • L. C. Paul


During the 1960s, as allogeneic clinical organ transplantation became to some extent successful while the supply of organs was limited, a few clinical xenotransplants were performed with organs from subhuman primates [1-3]. The increased availability of human organs after the introduction of brain death criteria, together with failure to achieve any long-term success with xenogeneic organs, however, dampened enthusiasm for xenotransplantation considerably. The current success rate of allotransplantation together with the wider acceptance of high-risk patients has, however, caused a tremendous increase in demands for organs and stimulated a renewed interest in the possibility of xenotransplantation.


Membrane Attack Complex Hyperacute Rejection Xenograft Rejection Cobra Venom Factor Classical Route 
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