Abstract
A treatment strategy including total body irradiation (TBI) or total lymphoid irradiation (TLI) in combination with cyclosporine (CsA) would seem to be a promising method for prolonging xenograft survival in the rodent [1-6]. The most impressive resuhs have been reported by Knechtle et al. where graft survival after TLI + CsA treatment was prolonged for more than 100 days in a Syrian hamster-to-Lewis rat model [7, 8]. Several attempts by other groups, however, to reproduce these results have not been successful [4,5,9].
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Steinbruchel, D.A., Nielsen, B., Kemp, E. (1991). Experimental Xenotransplantation in Rodents — III: Total Lymphoid Irradiation, Cyclosporine, and Monoclonal Antibodies. In: Cooper, D.K.C., Kemp, E., Reemtsma, K., White, D.J.G. (eds) Xenotransplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97323-9_20
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DOI: https://doi.org/10.1007/978-3-642-97323-9_20
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