Experimental Xenotransplantation in Rodents — I: Plasma Exchange and Splenectomy

  • R. Reding

Abstract

A variety of microsurgical transplantation models that are available in rodents for organ ahografting [1] have been used in xenograft research, particularly with rats as recipients of organs from size-matched xenogeneic donors. Among the 1687 species classified as rodents in the zoological taxonomy, only four have been used for xenotransplantation — the hamster, rat and mouse belong to the same suborder (Myomorpha), whereas the guinea pig (Hystricomorpha) is more distantly related [2]. Theoretically, a rough prediction of xenograft survival time can be made according to disparity in the zoological system — the more distantly related the donor and the recipient, the more aggressively and rapidly wdl the xenograft rejection process occur.

Keywords

Permeability Aspirin Histamine Cyclosporine Cyclophosphamide 

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© Springer-Verlag Berlin Heidelberg 1991

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  • R. Reding

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