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Xenotransplantation pp 297–312Cite as

Experimental Xenotransplantation of Encapsulated Cells

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Abstract

Transplantation of xenogeneic tissues of widely divergent species is difficult due to vigorous humoral and cellular immune responses. A possible solution to this problem might be the use of microencapsulation as an immunoisolation procedure. The unique ability of cellular grafts to be enclosed in artificial membranes that permit crossover of low molecular weight substances such as nutrients and oxygen, but not of cells or high molecular weight components, provides a distinct advantage of isolated xenogeneic tissue over whole engrafted organs, and many, in the long run, prove the only way to establish prolonged survival of xenografts in patients with diseases caused by the loss or malfunction of specific cells in the body.

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Authors
  1. R. P. Lanza
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  2. P. Soon-Shiong
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Editor information

Editors and Affiliations

  1. Baptist Medical Center, Oklahoma Transplantation Institute, 3300 N. W. Expressway, 73112, Oklahoma City, OK, USA

    D. K. C. Cooper M. D. Ph. D.

  2. Department of Nephrology, Odense University Hospital, DK-5000, Odense, Denmark

    Ejvind Kemp M. D.

  3. Department of Surgery, Columbia-Presbyterian Medical Center, 622 West 168th Street, 10032, New York, NY, USA

    Keith Reemtsma M. D.

  4. Department of Surgery, Addenbrooke’s Hospital, Hills Road, CB2 2QQ, Cambridge, UK

    D. J. G. White Ph. D., MRC Path.

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© 1991 Springer-Verlag Berlin Heidelberg

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Lanza, R.P., Soon-Shiong, P. (1991). Experimental Xenotransplantation of Encapsulated Cells. In: Cooper, D.K.C., Kemp, E., Reemtsma, K., White, D.J.G. (eds) Xenotransplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97323-9_17

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  • DOI: https://doi.org/10.1007/978-3-642-97323-9_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-97325-3

  • Online ISBN: 978-3-642-97323-9

  • eBook Packages: Springer Book Archive

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