Several malignancies, such as the leukemias and lymphomas, manifest as generalized neoplastic diseases not amenable to surgery or radiotherapy. Other cancers metastasize before they have been diagnosed and patients have clinical evidence of spread which does not allow curative surgical removal or irradiation of primary tumors. The commonest situation, however, is that many solid tumors have aggressive biological characteristics and have developing micrometastases by the time of diagnosis. Such high-risk patients could benefit from effective prophylactic therapy. For these reasons effective systemic therapy is needed in a large proportion of cancer patients.
KeywordsToxicity Estrogen Pancreatitis Methotrexate Folic Acid
Unable to display preview. Download preview PDF.