• Gerd Plewig
  • Albert M. Kligman


Before the age of really effective topical or systemic acne treatment modalities, cryotherapy was en vogue in the management of acne patients. The procedure involved swabbing the skin with a slush prepared with acetone and carbon dioxide. Freshly prepared in front of the patient, impressively supported by the noise of escaping carbon dioxide, the snow-like crystals were thinly applied to the affected area, mostly the face, just long enough to create an erythema. This was performed two to four times weekly, resulting in a superficial desquamation.


Dioxide Ethyl Acetone Diox Acne 


  1. Leyden JJ, Mills OH, Kligman AM (1974) Cry-oprobe treatment of acne conglobata. Br J Dermatol 90:335–341PubMedCrossRefGoogle Scholar
  2. Colver GB, Dawber RPR (1989) Cryosurgery — the principles and simple practice. Clin Exp Dermatol 14:1–6PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Gerd Plewig
    • 1
  • Albert M. Kligman
    • 2
  1. 1.Dermatologische Klinik und PoliklinikUniversität MünchenMünchen 2Germany
  2. 2.School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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