• Gerd Plewig
  • Albert M. Kligman


Sulfonamides are rarely used in acne and only trimethoprim-sulfamethoxazole is presently advocated. There are two dosage forms containing a fixed combination of 80 mg trimethoprim with 400 mg sulfamethoxazole, or a double-strength combination containing 160 mg trimethoprim with 800 mg sulfamethoxazole. The latter is given twice daily.


Microbe Acne Trimethoprim Sulfamethoxazole Oxytetracycline 


  1. Feingold DS, Wagner RF (1986) Antibacterial therapy. J Am Acad Dermatol 14:535–548PubMedCrossRefGoogle Scholar
  2. Cotterill JA, Cunliffe WJ, Forster RA, Williamson DM, Bulusu L (1971) A comparison of trimetho-prim-sulphamethoxazole with Oxytetracycline in acne vulgaris. Br J Dermatol 84:366–369PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Gerd Plewig
    • 1
  • Albert M. Kligman
    • 2
  1. 1.Dermatologische Klinik und PoliklinikUniversität MünchenMünchen 2Germany
  2. 2.School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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