The Dynamics of Primary Comedo Formation
Two tactics have been of inestimable value for observing the anatomical changes of the evolving disease: these are biopsying and serial sectioning the apparently uninvolved areas of acne-bearing skin. Without the latter the earliest changes cannot be seen and without serial sections one can obtain only glimpses, not a full picture. One section of the same specimen may almost look normal while elsewhere there may be startling alterations. Asymmetry is quite characteristic of acne lesions.
KeywordsAgar Sewage Staphylococcus Acne Ceramides
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