The Dynamics of Primary Comedo Formation

  • Gerd Plewig
  • Albert M. Kligman


Two tactics have been of inestimable value for observing the anatomical changes of the evolving disease: these are biopsying and serial sectioning the apparently uninvolved areas of acne-bearing skin. Without the latter the earliest changes cannot be seen and without serial sections one can obtain only glimpses, not a full picture. One section of the same specimen may almost look normal while elsewhere there may be startling alterations. Asymmetry is quite characteristic of acne lesions.


Stratum Corneum Sebaceous Follicle Propionibacterium Acne Horny Layer Acne Lesion 
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  1. Chapman SJ, Walsh A (1990) Desmosomes, corneosomes and desquamation. An ultrastructure study of adult pig epidermis. Arch Dermatol Res 282:304–310PubMedCrossRefGoogle Scholar
  2. Lavker RM, Leyden JJ, McGinley KJ (1981) The relationship between bacteria and the abnormal follicular keratinization in acne vulgaris. J Invest Dermatol 77:325–330PubMedCrossRefGoogle Scholar
  3. Leyden JJ, Kligman AM (1972) Hairs in acne comedones. Arch Dermatol 106:851–853PubMedCrossRefGoogle Scholar
  4. Plewig G, Fulton JE, Kligman AM (1971) Cellular dynamics of comedo formation in acne vulgaris. Arch Dermatol Forsch 242:12–29PubMedCrossRefGoogle Scholar
  5. Plewig G, Wolff HH (1976) Follikel-Filament. Arch Dermatol Forsch 255:9–21Google Scholar
  6. Wolff HH, Plewig G (1976) Ultrastruktur der Mikroflora in Follikeln und Komedonen. Hautarzt 27:432–440PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Gerd Plewig
    • 1
  • Albert M. Kligman
    • 2
  1. 1.Dermatologische Klinik und PoliklinikUniversität MünchenMünchen 2Germany
  2. 2.School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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