Androgen Excess in Men

  • Gerd Plewig
  • Albert M. Kligman

Abstract

Dermatologists are always delighted when skin lesions lead to the correct diagnosis of systemic disease or genetic disorders. It appears that acne conglobata is an important phenotypic feature of men with an extra Y chromosome. The XYY genotype first came to light in a penal survey of criminals and psychopaths. Three features were almost always present. Height was in excess of 180 cm, there was mental retardation or at least subnormal intelligence, and aggressive behavior. It later became known that some of these patients also had acne conglobata. The first investigators of this disorder were not dermatologists and could have overlooked skin lesions and scars. The incidence of XYY in newborn boys is about 1:1000 and that of acne conglobata in white adolescent men about 3%.

Keywords

Propionate Sedimentation Testosterone Androgen Prednisolone 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Gerd Plewig
    • 1
  • Albert M. Kligman
    • 2
  1. 1.Dermatologische Klinik und PoliklinikUniversität MünchenMünchen 2Germany
  2. 2.School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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