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Magnetresonanztomographie pp 665–690Cite as

In-vivo-MR-Spektroskopie

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Zusammenfassung

Mit der Magnetresonanzspektroskopie (MRS) können nichtinvasiv zelluläre Metaboliten und deren Umsatzraten beobachtet werden. Mangels geeigneter Magnetsysteme mit großen Bohrungen wurden In-vivo-MRS-Untersuchungen mit konventionellen MR-Spektrometern zunächst an Tieren und den Extremitäten des Menschen durchgeführt.

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Literatur

  1. Aue WP (1986) Localisation methods for in vivo nuclear magnetic resonance spectroscopy. Rev Magn Reson Med 1: 21–72

    Google Scholar 

  2. Auffermann W, Chew WM, Wolfe CL, Tavares NJ, Parmley WM, Semelka RC, Donnelly T, Chatterjee K, Higgins CB (1991) Normal and diffusely abnormal myocardium in humans: Functional and metabolic characterization with P-31 MR spectroscopy and cine MR imaging. Radiology 179: 253–259

    PubMed  CAS  Google Scholar 

  3. Argov Z, Bank WJ, Maris J, Peterson P, Chance B (1987) Bioenergetic heterogeneity of human mitochondrial myopathies: phosphorous magnetic resonance spectroscopy study. Neurology 37: 257–262

    PubMed  CAS  Google Scholar 

  4. Avison MJ, Hetherington HP, Shulman RG (1986) Application of NMR to studies of tissue metabolism. Annu Rev Biophys Chem 15: 377–401

    Article  CAS  Google Scholar 

  5. Boesch C, Gruetter R, Martin E, Duc G, Wüthrich K (1989) Variations in the in vivo P-31 MR spectra of the developing human brain during postnatal life. Radiology 172: 197–199

    PubMed  CAS  Google Scholar 

  6. Bottomley PA, Foster TH, Darrow RD (1984) Depth resolved surface coil spectroscopy (DRESS) for in vivo 1H, 31p and 13C NMR. J Magn Reson 59: 338–342

    CAS  Google Scholar 

  7. Bottomley PA, Drayer BP, Smith LS (1986) Chronic adult cerebral infarction studied by phosphorus NMR spectroscopy. Radiology 160: 763–766

    PubMed  CAS  Google Scholar 

  8. Bottomley PA, Herfkens RJ, Smith LS, Bashore TM..(1987) Altered phosphate metabolism in myocardial infarction: P-31 MR spectroscopy. Radiology 165: 703–707

    PubMed  CAS  Google Scholar 

  9. Bottomley PA (1989) Human in vivo NMR spectroscopy in diagnostic medicine: Clinical tool or research probe? Radiology 170: 1–15

    PubMed  CAS  Google Scholar 

  10. Brown TR, Kincaid BM, Ugurbil K (1982) NMR chemical shift imaging in three dimensions. Proc Natl Acad Sci USA 79: 3523–3526

    Article  PubMed  CAS  Google Scholar 

  11. Bruhn H, Frahm J, Gyngell ML, Merboldt KD, Hanicke W, Sauter R, Hamburger C (1989) Noninvasive differentiation of tumors with use of localized H-1 MR spectroscopy in vivo: inital experience in patients with cerebral tumors. Radiology 172: 541–548

    PubMed  CAS  Google Scholar 

  12. Bruhn H, Frahm J, Gyngell ML, Merboldt KD, Hanicke W, Sauter R (1989) Cerebral metabolism in man after acute stroke: new observations using localized proton NMR spectroscopy. Magn Reson Med 9: 126–131

    Article  PubMed  CAS  Google Scholar 

  13. Chance B (1989) What are the goals of magnetic resonance research? NMR Biomed 2: 5–6

    Article  Google Scholar 

  14. Cox IJ, Bryant DJ, Collins AG et al..(1988) Four dimensional chemical shift MR imaging of phosphorus metabolites of normal and diseased human liver. J Comput Ass Tomogr 12: 369–376

    Article  CAS  Google Scholar 

  15. Frahm J, Merboldt KD, Hänicke W (1987) Localized proton spectroscopy using stimulated echoes. J Magn Reson 72: 502–508

    CAS  Google Scholar 

  16. Gademann G, Semmler W, Bachert-Baumann P, Gückel F, Zabel H-J, Lenarz T, van Kaick G (1988) 31P MR spectroscopy and lH MR tomography of cervicallymphnode metastases under chemotherapy in short-term follow-up studies. Soc Mag Reson Med, San Francisco. Book of abstracts, p 715

    Google Scholar 

  17. Grodd W, Krägeloh-Mann I, Petersen D, Trefz FK, Harzer K (1990) In vivo assessment of N-acetylaspartate in brain in spongy degeneration (Canavan’s disease) by proton spectroscopy. Lancet 336: 437–438

    Article  PubMed  CAS  Google Scholar 

  18. Hamilton PA, Cady EB, Wyatt JS, Hope z PL, Delpy DT, Reynolds ED (1986) Impaired energy metabolism in brains of newborn infants with increased cerebral echodensities. Lancet 1: 1242–1246

    Article  PubMed  CAS  Google Scholar 

  19. Heindel W, Bunke J, Glathe S, Steinbrich W, Mollevanger L (1988) Combined 1H-MR imaging and localized 31P-spectroscopy of intracranial tumors in 43 patients. J Comp Assist Tomogr 12: 907–916

    Article  CAS  Google Scholar 

  20. Komoroski RA, Newton JEO, Walker E, Cardwell D, Jagannathan NR, Ramaprasad S, Sprigg J (1990) In vivo NMR spectroscopy of Lithium-7 in humans. Magn Reson Med 15: 347–356

    Article  PubMed  CAS  Google Scholar 

  21. Meyerhoff DJ, Boska MD, Thomas AM, Weiner MW (1989) Alcoholic liver disease: quantitative image-guided P-31 MR spectroscopy. Radiology 173: 393–400

    PubMed  CAS  Google Scholar 

  22. Narayana PA, Hazle JD, Jackson EF, Fotedar LK, Kulkarni MY (1988) In vivo 1H spectroscopic studies of human gastrocnemius muscle at 1.5 T. Magn Reson Imag 6: 481–485

    Article  CAS  Google Scholar 

  23. Ng TC, Vijayakumar S, Majors AW, Thomas FJ, Meaney TF, Baldwin NJ (1987) Response of a Non Hodgkin lymphoma to 60CO therapy monitored by 31P MRS in situ. Int J Rad Oncol Bioi Phys 13: 1545–1551

    Article  CAS  Google Scholar 

  24. Oberhansli RD, Galloway GJ, Taylor DJ, Bore PJ, Rajagopalan B, Radda G (1986) First year of experience with P-31 magnetic resonance studies of human liver. Magn Reson Imag 4: 413–416

    Article  Google Scholar 

  25. Oberhansli RD, Galloway GJ, Hilton-Jones D et al...(1987) The study of human organs by phosphorus-31 topical magnetic resonance spectroscopy. Br J Radiol 60: 367–373

    Article  Google Scholar 

  26. Ordidge RJ, Connelly A, Lohman JAB (1986) Image-selected in vivo spectroscopy (ISIS). A new technique for spatially selective NMR spectroscopy. J Magn Reson 66: 283–294

    CAS  Google Scholar 

  27. Ott D, Ernst T, Hennig J (1990) Clinical value of 1H spectroscopy of brain tumors. Soc Magn Reson Med, New York. Book of abstracts, p 105

    Google Scholar 

  28. Radda GK, Rajagopalan B, Taylor DJ (1989) Biochemistry in vivo: an appraisal of clinical magnetic resonance spectroscopy. Magn Reson Quart 5: 122–151

    CAS  Google Scholar 

  29. Redmond O, Stack J, Scully M, Dervan P, Carney D, Ennis JT (1988) Tissue characterisation and spectral analysis of malignant tumours following chemotherapy. Soc Magn Reson Med, San Francisco. Book of abstracts, p 432

    Google Scholar 

  30. Rexroth W, Semmler W, Giickel F, Stadtlander M, Weicker H, Hild R, van Kaick G (1989) Assessment of muscular metabolism in peripheral arterial occlusive disease using 31P nuclear magnetic resonance. Klin Wochenschr 67: 804–812

    Article  PubMed  CAS  Google Scholar 

  31. van Rijen PA, Luyten PR, Berkelbach van der Sprenkel JW, Kraaier V, van Huffelen AC, Tulleken CAP, den Hollander JA (1989) 1H and 31P NMR measurement of cerebral lactate, high-energy phosphate levels, and pH in humans during voluntary hyperventilation: associated EEG, capnographic, and Doppler findings. Magn Reson Med 10: 182–193

    Article  PubMed  Google Scholar 

  32. Ross BD, Radda GK, Gadian GD, Rocker G, Esiri M, Falconer-Smith J (1981) Examination of a case of suspected McArdle’s syndrome by 31P nuclear magnetic resonance. N Engl J Med 304: 1338–1342

    Article  PubMed  CAS  Google Scholar 

  33. Roth K, Hubesch B, Meyerhoff DJ et al (1989) Noninvasive quantitation of phosphorus metabolites in human tissue by NMR spectroscopy. J Magn Reson 81: 299–311

    CAS  Google Scholar 

  34. Sauter R, Müller S, Weber H (1987) Localization in in vivo 31P NMR spectroscopy by combining surface coils and slice-selective saturation. J Magn Reson 75: 167–173

    CAS  Google Scholar 

  35. Schilling A, Gewiese B, Stiller D, Romer T, Wolf KJ..(1990) Einfluß der Ernährungslage auf das 31P-MR-Spektrum der gesunden Leber. ROFO 153: 369–372

    Article  PubMed  CAS  Google Scholar 

  36. Segebarth CM, Grivegnee AR, Luyten PR, den Hollander AJ (1989) Quantitative 31P NMR spectroscopy of phosphate metabolism in the human liver following fructose administration. Soc Magn Reson Med, Amsterdam. Book of abstracts, p 263

    Google Scholar 

  37. Semmler W, Gademann G, Schlag P, Bachert-Baumann P, Zabel H-J, Lorenz WJ, van Kaick G (1988) Impact of hyperthermic regional perfusion therapy on cell metabolism of malignant melanoma monitored by 31P MR spectroscopy. Magn Reson Imag 6: 335–340

    Article  CAS  Google Scholar 

  38. Semmler W, Gademann G, Bachert-Baumann P, Zabel H-J, Lorenz WJ, van Kaick G (1988) Monitoring human tumor response to therapy by means of P-31 MR spectroscopy. Radiology 166: 533–539

    PubMed  CAS  Google Scholar 

  39. Semmler W, Bachert-Baumann P, Gückel F, Ermark F, Schlag P, Lorenz WJ, van Kaick G (1990) Realtime follow-up of 5-fluorouracil metabolism in the liver of tumor patients by means of F-19 MR spectroscopy. Radiology 174: 141–145

    PubMed  CAS  Google Scholar 

  40. Sostman HD, Charles HC, Rockwell S et al. (1990) Soft-tissue sarcomas: detection of metabolic heterogeneity with P-31 MR spectroscopy. Radiology 176: 837–843

    PubMed  CAS  Google Scholar 

  41. Steudel A, Harder T, Traber F, Gieseke J (1990) 31P Spektroskopie der Leber unter Polychemotherapie von Hodentumoren. In: Lissner J, Doppman JL, Margulis AR (Hrsg) Symposiumsband MR’89, 3. Int Kernspintomographie Symposium. Deutscher Ärzte-Verlag, Köln, S 261–264

    Google Scholar 

  42. Weiss RG, Bottomley PA, Christopher JH, Gerstenblith G (1990) Regional myocardial metabolism of high-energy phosphates during isometric exercise in patients with coronary artery disease. N Engl J Med 323:1593–1600

    Article  PubMed  CAS  Google Scholar 

  43. Wolf W, Albright MJ, Silver MS, Weber H, Reichardt U, Sauer R (1987) Fluorine-19 NMR spectroscopic studies of the metabolism of 5-fluorouracil in the liver of patients undergoing chemotherapy. Magn Reson Imag 5: 165–169

    Article  CAS  Google Scholar 

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Authors
  1. W. Semmler
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  2. P. Bachert
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Editor information

Editors and Affiliations

  1. Radiologische Universitätsklinik, Sigmund-Freud-Straße 25, W-5300, Bonn, Deutschland

    Maximilian Reiser

  2. Forschungsschwerpunkt Radiologische Diagnostik und Therapie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, W-6900, Heidelberg, Deutschland

    Wolfhard Semmler

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© 1992 Springer-Verlag Berlin Heidelberg

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Semmler, W., Bachert, P. (1992). In-vivo-MR-Spektroskopie. In: Reiser, M., Semmler, W. (eds) Magnetresonanztomographie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97167-9_10

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  • DOI: https://doi.org/10.1007/978-3-642-97167-9_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-97168-6

  • Online ISBN: 978-3-642-97167-9

  • eBook Packages: Springer Book Archive

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