Skip to main content
SpringerLink
Log in

Immunosuppression, Lupus Nephritis, Multiple Sclerosis, and Organ Transplantation

  • Chapter
Radiation Therapy of Benign Diseases

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

  • 106 Accesses

Abstract

The current use of Total Lymphoid Irradiation (TLI) as immunosuppressive therapy for non-malignant diseases is experimental and has been utilized (1) in preparation for allogeneic organ transplantation (i.e., kidney, pancreas, etc.; 26% of radiation oncologists in the national survey would not treat), (2) in the treatment of autoimmune diseases (i.e., rheumatoid arthritis, systemic lupus erythematosus, etc.; 94% of radiation oncologists in the national survey would not treat), and (3) in the treatment of neurological disorders considered to have an immune-mediated pathogenesis (i.e., multiple sclerosis, chronic demyelinating polyneuropathy, etc.; 93% of radiation oncologists in our national survey would not treat).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Godfrey AM and Salaman J (1976) Radiotherapy in the treatment of acute rejection of human renal allografts. Lancet 1: 938–939.

    Article  PubMed  CAS  Google Scholar 

  2. Hume DM and Wolf JS (1967) Abrogation of the immune response: irradiation therapy and lymphocyte depletion. Modification of renal homograft rejection by irradiation. Transplantation 5: 1174–1191.

    Article  PubMed  Google Scholar 

  3. Woodruff MF (1966) The management of patients given whole body irradiation or antimetabolites to promote the survival of a renal homotransplant. Clin Radiol 15: 30–40.

    Article  Google Scholar 

  4. Hamburger J, Crosnier J and Dormont J (1965) Experience with 45 renal homotransplants in man. Lancet 1: 985–992.

    Article  PubMed  CAS  Google Scholar 

  5. Morgan R (1964) Clinical experience of whole body radiation in man as a preliminary to renal transplantation. Clinic Radio! 15: 35–40.

    Article  CAS  Google Scholar 

  6. Hume DM, Magee JH, Kauffman HM, Rittenbury MS and Prout GR (1963) Renal homotransplantation in man in modified recipients. Ann Surg 158: 608–644.

    Article  PubMed  CAS  Google Scholar 

  7. Shackman R, Dempstu WJ and Wrong OM (1963) Kid-ney homotransplantation in the human. Br J Urol 35: 222–225.

    Article  PubMed  CAS  Google Scholar 

  8. Woodruff MFA, Robson JS, Nolan B, Lambie AT, Wilson TI and Clark JH (1963) Homotransplantation of kidney in patients treated by preoperative local irradiation and postoperative administration of an antimetabolite (Imuran). Report of six cases. Lancet 2: 675–682.

    Article  PubMed  CAS  Google Scholar 

  9. Hamburger J, Vayesse J, Crosnier J, Avvert J, Lalanne CM and Hopper J (1962) Renal homotransplantation in man after radiation of the recipient. Am J Med 32: 854–871.

    Article  PubMed  CAS  Google Scholar 

  10. Murray JE, Merrill JP, Dammin GJ, Dealy JB, Alexandre GW and Harrison JH (1962) Kidney transplantation in modified recipients. Ann Surg 156: 337–355.

    Article  PubMed  CAS  Google Scholar 

  11. Tubiana M, Lalanne CM and Surmont J (1961) Total body irradiation for organ transplantation. Proc Roy Soc Med 54: 1143–1150.

    PubMed  CAS  Google Scholar 

  12. Murray JE, Merrill JP, Dammin GH, Dealy JB, Walter CW, Brooke MS and Wilson RE (1960) Study on transplantation immunity after total body irradiation: clinical and experimental investigation. Surg 48: 272–284.

    CAS  Google Scholar 

  13. Devereux CK, Vidaver R, Hafstein MP, Zita G, Troiano R, Dowling PC, Cook SD (1988) Total lymphoid irradiation for multiple sclerosis. Int J Radiation Oncol Biol Phys 14: 197–203.

    Article  CAS  Google Scholar 

  14. Cook SD, Devereux C, Troiano R, Zito G, Hafstein M, Lavenhar M, Hernandez E, Dowling PC (1987) Total lymphoid irradiation in multiple sclerosis: blood lymphocytes and clinical course. Annal Neurology 22: 634–638.

    Article  CAS  Google Scholar 

  15. Strober S, Farinas C, Field E, Solovera JJ, Kiberd BA, Myers BD and Hoppe RT (1987) Lupus nephritis after total lymphoid irradiation: persistent improvement and reduction of steroid therapy. Ann Intern Med 107: 689–690.

    PubMed  CAS  Google Scholar 

  16. Ben-Chetrit E, Gross DJ, Braverman A, Weshler Z, Fuks Z, Slavin S and Eliakim M (1986) Total lymphoid irradiation in refractory systemic lupus erythematosus. Ann Intern Med 105: 58–60.

    PubMed  CAS  Google Scholar 

  17. Cook SD, Devereux C, Troiano R, Hafstein MP, Zito G, Hernandez E, Lavenhar M, Vidaver R and Dowling PC (1986) Effect of total lymphoid irradiation in chronic progressive multiple sclerosis. Lancet 1: 1405–1409.

    Article  PubMed  CAS  Google Scholar 

  18. Kolar OJ and Hornback NB (1986) Total lymphoid irradiation in multiple sclerosis. Lancet 2: 453.

    Article  PubMed  CAS  Google Scholar 

  19. Ang KK, Vanrenterghem Y, Waer M, Vandeputte M, Michielsen P and Van der Shueren E (1985) Kidney allograft tolerance in diabetic patients after total lymphoid irradiation (TLI). Radiotherapy and Oncology 3: 192–199.

    Google Scholar 

  20. Levin B, Hoppe RT, Collins G, Miller E, Waer M, Bieber C, Girinsky T and Strober S (1985) Treatment of cadaveric renal transplant recipients with total lymphoid irradiation, antithymocyte globulin and low-dose prednisone. Lancet 2: 1321–1325.

    Article  PubMed  CAS  Google Scholar 

  21. Strober S, Field E, Hoppe RT, Kotzin BL, Shemesh O, Engleman E, Ross JC and Myers BD (1985) Treatment of intractable lupus nephritis with total lymphoid irradiation. Ann Intern Med 102: 450–458.

    PubMed  CAS  Google Scholar 

  22. Waer M, Vanrenterghem Y, Roels L, Ang KK, Bouillon R, Lerut T, Gruwez J, Michielsen P, Van der Schueren F and Vandeputte M (1985) Total lymphoid irradiation in renal cadaveric transplantation in diabetes. Lancet 2: 1354.

    Article  PubMed  CAS  Google Scholar 

  23. Halperin EC, Delmonico FL, Nelson PW, Shipley WU and Cosini AB (1984) The use of local allograft irradiation following renal transplantation. Int J Radiat Oncol Biol Phys 10: 987.

    Article  PubMed  CAS  Google Scholar 

  24. Vanrenterghem Y, Waer M, Ang KK, Van der Schueren E, Gruwez J, Bouillon R and Michielsen P (1984) Cadaveric kidney transplantation in diabetes after total lymphoid irradiation (TLI). Transplantation Proc 16: 636–639.

    CAS  Google Scholar 

  25. Pilepich MV, Sicard GA, Breaux SR, Etheredge EE, Blum J and Anderson CB (1983) Renal graft irradiation in acute rejection. Transplantation 35: 208–211.

    Article  PubMed  CAS  Google Scholar 

  26. Besarab A, Jarrell B, Ihle BU, Colberg JE, Burke JF and Wesson L (1982) Adverse effects of prophylactic irradiation and acute tubular necrosis on renal graft function and survival. Nephron 31: 347–353.

    Article  PubMed  CAS  Google Scholar 

  27. Najarian JS, Ferguson RM, Sutherland DER, Slavin S, Kim T, Kersey K and Simmonds RL (1982) Fractionated total lymphoid irradiation as preparative immunosuppression in high-risk renal transplantation: clinical and immunological studies. Ann Surg 196: 442–452.

    Article  PubMed  CAS  Google Scholar 

  28. Peeples WJ, Wombalt DG, El-Mandi AM and Turalba CIC (1982) Radiation therapy for renal transplant rejection reactions. South Med J 75: 30–32.

    Article  PubMed  CAS  Google Scholar 

  29. Tourtellotte WW, Potvin AR, Baumhefner RW, Potvin JH, Ma BI, Syndulko K and Petrovich Z (1980) Multiple sclerosis de novo CNS IgG synthesis. Effect of CNS irradiation. Arch Neuro1 37: 620–624.

    Article  CAS  Google Scholar 

  30. Drenguis B, Griffin T, Gerdes A and Marchioro T (1977) Effect of local irradiation on the acute rejection process in transplanted kidneys. Acta Radio! Ther Phys Biol 16: 241–244.

    CAS  Google Scholar 

  31. Godfrey AM and Salaman JR (1977) Is graft irradiation of value in renal transplant rejection? Transplant Proc 9: 1005–1006.

    PubMed  CAS  Google Scholar 

  32. Nakajima N, Streepada-Rao TK, Sakai A, Butt KH and Kountz SL (1977) Effects of intravenous bolus dosages of methylprednisolone and local radiation on renal allograft rejection and patient mortality. Surg Gynecol Obstet 144: 63–66.

    PubMed  CAS  Google Scholar 

  33. Fairris GM, Jones DH, Mack DP and Rowell NR (1984) Superficial x-ray therapy in the treatment of palmoplantar pustulosis. Br J Dermatol 111: 499–500.

    Article  PubMed  CAS  Google Scholar 

  34. Gorrin-Yehudain J, Moscona AR and Hirshowitz B (1983) Treatment of acute suppurative perichondritis of the external ear by low dose x-ray irradiation. Burns Intl Therm Inj 10: 140–144.

    Article  Google Scholar 

  35. Barker DJ and Gould DJ (1978) A pustular eruption of the chin (a variant of pyoderma faciale?) Acta Derm Verrol (Stockh) 58: 549–551.

    CAS  Google Scholar 

  36. Lukacs S, Braun-Falco O and Goldschmidt H (1978) Radiotherapy of benign dermatoses: Indications, practice and results. J Dermatol Surg Onco1 4: 620–625.

    CAS  Google Scholar 

  37. Webber BM (1977) Radiation therapy for pertussis: A possible etiologic factor in thyroid carcinoma. Ann Intern Med 86: 449–450.

    PubMed  CAS  Google Scholar 

  38. Rook A (1986) Textbook of Dermatology, Fourth Edition.

    Google Scholar 

  39. Saner (1985) Manual of Skin Diseases.

    Google Scholar 

  40. Veien NK, Nrholm A, Hattel T and Justesen O (1982) Late effects of x-ray treatment of warts. J Dermatol Surg Oncol 8: 275–281.

    PubMed  CAS  Google Scholar 

  41. Danoff DS, Holden S, Thompson RW and David R (1981) New treatment for extensive condylomata acuminata: external radiation therapy. Urology 18: 47–49.

    Article  PubMed  CAS  Google Scholar 

  42. Shair HM, Hanshaw WJ and Grayson CD (1978) Radiation therapy for plantar warts. J Dermatol Surg Onco1 4: 635–637.

    CAS  Google Scholar 

  43. Lukacs S, Braun-Falco O and Goldschmidt H (1978) Radiotherapy of benign dermatoses: Indications, practice and results. J Dermatol Surg Oncol 4: 620–625.

    PubMed  CAS  Google Scholar 

  44. Macht SH and Cordero JM (1977) Superficial radiotherapy of warts: Results of treating 531 warts. Radiology 122: 231–232.

    PubMed  CAS  Google Scholar 

  45. Bunnly MH (1976) An assessment of method of treating warts by comparative treatment trials based on a standard design. British J Dermatology 94: 667.

    Article  Google Scholar 

  46. Sanders B and Stretcher Jr G (1976) Warts: Diagnosis & Treatment. JAMA 235: 2859–2861.

    Article  PubMed  CAS  Google Scholar 

  47. Broughton RH (1974) A personal approach to the treatment of verrucae. J Roy Naval Med Ser 60: 130–132.

    CAS  Google Scholar 

  48. Aguino JA (1972) Warts and radiotherapy. Nova Scotia Med Bulletin.

    Google Scholar 

  49. Dunham HH (1972) Radiation treatment of plantar warts. J Ind State Med Assn.

    Google Scholar 

  50. Linton WT (1970) Concepts on wart treatment. Applied Therapeutics 12: 16–18.

    PubMed  CAS  Google Scholar 

  51. Reymann F (1969) The sensitivity of plantar warts to roentgen radiation. Acta Derm-Venereol 49: 171–175.

    PubMed  CAS  Google Scholar 

  52. Hazel J and Bouchard J (1962) The value of radiation therapy in the treatment of verrucae plantar warts. J Canad Assn Radiol 13: 70–71.

    CAS  Google Scholar 

  53. Vickers CFH (1961) Treatment of plantar warts in children. British Med J 13: 743.

    Article  Google Scholar 

  54. Reeves RJ and Jackson MT (1956) Roentgen therapy of plantar warts. Am J Roentgeno 176: 997–998.

    Google Scholar 

  55. Pipkin JL et al (1949) The treatment of plantar warts by single dose method of roentgen ray. Southern Med J 42: 193.

    Article  PubMed  CAS  Google Scholar 

  56. Pendergrass EP and Hodes PJ (1941) Roentgen irradiation in treatment of inflammations. Am J Roentgenol & Rad Therapy 45: 74–105.

    Google Scholar 

  57. Review of the Use of Ionizing Radiation for the Treatment of Benign Disease. U.S. DHEW, HEW Publication (FDA) 78–8043.

    Google Scholar 

  58. Junaid AJ (1986) Treatment of cutaneous leishmaniasis with infrared heat. Int J Dermatol 25: 470–472.

    Article  PubMed  CAS  Google Scholar 

  59. Davidorf FH, Makley TA, Bruce RA, Batley F and Wasserstrom JP (1983) Irradiation of the central lesion of presumed histoplasmic chorioretinitis. Int Ophthamol Clin 23: 101–109.

    Article  CAS  Google Scholar 

  60. Skromne-Kadlubik G and Celis C (1981) Cysticercosis of the nervous system. Treatment by means of specific internal radiation. Arch Neurol 38: 288.

    Article  PubMed  CAS  Google Scholar 

  61. Nagpal RD, Gokhale SD and Parikh VR (1975) Ossification of spinal arachnoid with unrelated syringomyelia. J Neurosurg 42: 222–225.

    Article  PubMed  CAS  Google Scholar 

  62. Jackson FE (1974) Optic chiasmatic arachnoiditis: improvement of rapidly failing vision following surgical lysis of chiasmatic adhesions and postoperative steroid therapy. Milit Med 139: 127–128.

    CAS  Google Scholar 

  63. Duke RI and Hashimoto S (1973) Familial spinal arachnoiditis–a new entity. Trans Am Neurol Assoc 98: 98–102.

    PubMed  CAS  Google Scholar 

  64. Kaufman AB and Dunsmore RH (1971) Clinicopathological considerations in spinal meningeal calcification and ossification. Neurology 21: 1243–1248.

    PubMed  CAS  Google Scholar 

  65. Coyle JT (1969) Chiasmatic arachnoiditis. A case report and a review. Am J Opth 68: 345–349.

    CAS  Google Scholar 

  66. Cant JS and Harrison MT (1968) Chiasmatic arachnoiditis with growth failure. Am J Ophth 65: 432–434.

    PubMed  CAS  Google Scholar 

  67. Savastano AA (1968) Operative arachnoiditis. Rhode Island Med J 51: 337–343.

    PubMed  CAS  Google Scholar 

  68. Wise BL and Smith M (1965) Spinal arachnoiditis ossificans. Arch Neuroll 3: 391–394.

    Article  Google Scholar 

  69. Feder BH and Smith JL (1962) Roentgen therapy in chronic spinal arachnoiditis. Radiology 78: 192–198.

    PubMed  CAS  Google Scholar 

  70. Slager UT (1960) Arachnoiditis ossificans. Report of a case and review of the subject. Arch Path 70: 322–327.

    PubMed  CAS  Google Scholar 

  71. Dickmann GH, Cramer FC and Kaplan AD (1951) Optochiasmatic arachnoiditis. J Neurosurg 8: 355–359.

    Article  PubMed  CAS  Google Scholar 

  72. Selinsky H (1936) Disseminated spinal arachnoiditis. Its diagnosis and treatment with roentgen rays. Arch Neurol and Psychiat 35: 1262–1279.

    Google Scholar 

  73. Papapetrov Pd, Lazarus JH, MacSween RNM and Harden R (1972) Long-term treatment of Hashimoto’s thyroiditis with thyroxine. Lancet 2: 1045–1048.

    Article  Google Scholar 

  74. Strahan RW, Calcaterra TC and Ward PH (1971) Thyroiditis. A classification and review. Laryngoscope 81: 1388–1400.

    Article  PubMed  CAS  Google Scholar 

  75. Heimann P (1970) Treatment of thyroiditis. Acta Med Scand 187: 323–329.

    Article  PubMed  CAS  Google Scholar 

  76. Vagenakis AG, Abreau, CM and Braverman LE (1970) Prevention of recurrence in acute thyroiditis following corticosteroid withdrawal. J Clin Endocr and Metabol 31: 705–708.

    Article  CAS  Google Scholar 

  77. Lindem MC and Clark JH (1969) Indications for survey in thyroiditis. Am J Surg 118: 829–831.

    Article  PubMed  Google Scholar 

  78. Varl B, Kastelic B and Porenta M (1968) The therapeutic effect of a diagnostic dose of radioactive iodine on the subacute De Quervain thyroiditis. Strahlentherapie 36: 162–169.

    Google Scholar 

  79. Thomson JA, Jackson IMD and Duguid WP (1968) The effect of steroid therapy on Riedel’s thyroiditis. Scot Med J 13: 13–16.

    PubMed  CAS  Google Scholar 

  80. Blizzard RM, Hung W, Chandler, RW, Aceto T, Kyle M and Winship T (1962) Hashimoto’s thyroiditis. N Engl J Med 267: 1015–1020.

    Article  PubMed  CAS  Google Scholar 

  81. Murray JPC (1958) The effect of prednisone on Hashimoto’s thyroiditis. Scot Med J 3: 341–345.

    PubMed  CAS  Google Scholar 

  82. Furr WE and Crile G (1954) Struma lymphomatosa: clinical manifestations and response to therapy. J Clin Endocr and Metabol 14: 79.

    Article  Google Scholar 

  83. Lindsay S and Dailey ME (1954) Granulomatous or giant cell thyroiditis. A clinical and pathologic study of thirty seven patients. Surg Gyn Obst 98: 197–212.

    PubMed  CAS  Google Scholar 

  84. Crile G and Schneider RW (1952) Diagnosis and treatment of thyroiditis with special reference to the use of cortisone and ACTH. Cleveland Clin Qtly 19: 219–224.

    Google Scholar 

  85. Volpe R (1975) Thyroiditis. Current views of pathogenesis. Med Clin N Am 59: 1163–1175.

    PubMed  CAS  Google Scholar 

  86. Mendenhall WM, Million RR, Cassisi NJU and Pierson KK (1985) Biologically aggressive papillomas of the nasal cavity: the role of radiation therapy. Laryngoscope 95: 344–347.

    Article  PubMed  CAS  Google Scholar 

  87. Levendag PC, Annyas AA, Escajadillo JR and Elema JD (1984) Radiotherapy for inverted papilloma: A case report. Radiotherapy and Oncol 2: 13–17.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Johns Hopkins Hospital, 21205, Baltimore, MD, USA

    Stanley E. Order MD, ScD, FACR (Director Radiation Oncology)

  2. School of Medicine, Stanford University, 94305, Stanford, CA, USA

    Sarah S. Donaldson MD, FACR (Professor of Radiation Oncology)

Authors
  1. Stanley E. Order MD, ScD, FACR
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sarah S. Donaldson MD, FACR
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Order, S.E., Donaldson, S.S. (1990). Immunosuppression, Lupus Nephritis, Multiple Sclerosis, and Organ Transplantation. In: Radiation Therapy of Benign Diseases. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97160-0_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-97160-0_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-97162-4

  • Online ISBN: 978-3-642-97160-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation