Interstitial pneumonitis is usually defined as a nonbacterial, nonfungal pneumonitis. The disease process involves mostly the pulmonary interstitium in the form of mononuclear cell infiltration and fluid accumulation with a relative sparing of air spaces. Because of this, there is only little productive cough, and it may be difficult to establish the diagnosis on the basis of sputum cultures or bronchoalveolar lavage. Radiographically, the process can be localized or diffuse with a prominent interstitial pattern. Although the clinical picture with shortness of breath, hypoxemia, and radiographic findings is rather typical, a definitive diagnosis often requires an open lung biopsy.
KeywordsBone Marrow Transplantation Total Body Irradiation Acute GVHD Chronic GVHD Interstitial Pneumonitis
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- Griffiths PD, Stirk PR, Blacklock HA, Milburn HJ, du Bois RM, Prentice HG (1987) Rapid diagnosis and treatment of cytomegalovirus pneumonitis. Progress in Bone Marrow Transplantation RP Gale and R Champlin (eds) Alan R Liss, Inc., New York pp. 583Google Scholar
- Kubanek B, Ernst P, Ostendorf P, Schafer U, Wolf H (1985) Preliminary data of a controlled trial of intravenous hyperimmune globulin in the prevention of cytomegalovirus infection in bone marrow transplant recipients. Transplant Proc 17: 468Google Scholar
- Meyers JD, Shepp DH, Bowden RA, Reed EC (1987) Viral infections in marrow transplant recipients. Progress in Bone Marrow Transplantation RP Gale and R Champlin (eds) Alan R Liss, Inc., New York, pp 545Google Scholar
- Teshima, H, Masaoka T, Inoue T, Kato S, Naito K, Mori T, Kanamaru A, Saito Y, Ohira M, Moryama Y, Kodera Y, Harada M, Baba M, Nakade Y, Tasaka H, Yoshikawa S (1986) Interstitial pneumonitis in allogeneic bone marrow transplantation: a report from the Japanese BMT study group. Bone Marrow Transplantation 1: 179PubMedGoogle Scholar
- Winston DJ, Ho WG, Gale RP, Champlin RE (1987) Treatment and prevention of interstitial pneumonia after bone marrow transplantation. Progress in Bone Marrow Transplantation RP Gale and R Champlin (eds) Alan R Liss, Inc., New York, pp 525Google Scholar
- Zaia J A and Churchill M A (1987) The biology of human cytomegalovirus infection after marrow transplation. Progress in Bone Marrow Transplantation. Progress in Bone Marrow Transplantation R. P. Gale and R. Champlin (eds) Alan R. Liss, Inc., New York pp 563Google Scholar