Long-Term Use of Nitrates in Angina Pectoris

  • Adam Schneeweiss
  • Marija Weiss


Several investigators have suggested that long-term treatment with nitrates in patients with angina pectoris is associated with development of tolerance. Although this theory is in contrast to the clinical experience of most cardiologists, it is supported by some evidence. In this chapter the subject is reviewed, with the conclusion that tolerance to the antianginal effect does not develop or can be reduced if the drugs are appropriately used. The topic is subdivided into three main areas:
  1. 1.

    vascular tolerance

  2. 2.

    tolerance to the antianginal effect

  3. 3.

    cross tolerance



Angina Pectoris Guanylate Cyclase Organic Nitrate Chronic Therapy Sublingual Nitroglycerin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • Adam Schneeweiss
    • 1
  • Marija Weiss
    • 2
  1. 1.Tel AvivIsrael
  2. 2.Köln 71Germany

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