Long-Term Use of Nitrates in Angina Pectoris
Several investigators have suggested that long-term treatment with nitrates in patients with angina pectoris is associated with development of tolerance. Although this theory is in contrast to the clinical experience of most cardiologists, it is supported by some evidence. In this chapter the subject is reviewed, with the conclusion that tolerance to the antianginal effect does not develop or can be reduced if the drugs are appropriately used. The topic is subdivided into three main areas:
tolerance to the antianginal effect
KeywordsAngina Pectoris Guanylate Cyclase Organic Nitrate Chronic Therapy Sublingual Nitroglycerin
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer-Verlag Berlin Heidelberg 1988