The term mononitrates refers in general to the two metabolites of ISDN, namely, IS-5-MN and IS-2-MN. These metabolites are formed in the liver. The process of denitration of ISDN to these metabolites was suggested in 1972 to be associated with inefFicacy of orally administered ISDN.
KeywordsPlacebo Depression Ischemia Morphine Nifedipine
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